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SPIRO COMPOUNDS A comprehensive treatment of the latest research
in, and applications of, spiro compounds Spiro Compounds: Synthesis
and Applications combines discussions of the latest advances in
spiro compound research with the most cutting-edge, real-world
applications of that knowledge. This book provides in-depth
coverage of the history, significance, properties, synthetic
methods, and applications of spiro compounds. As interest in spiro
compounds grows due to their unique conformational features and
their structural implications on biological systems, Spiro
Compounds delivers fulsome treatments of advances in spiro compound
synthesis (including stereoselective synthesis) methodologies. With
a special focus on the mechanisms of the reactions that lead to the
synthesis of spiro compounds, chapters in the book cover topics
such as: The history, significance, and unique properties of spiro
compounds The most important methodologies for their synthesis The
applications of spiro compounds in organic chemistry, biology, drug
discovery The most important syntheses of natural products bearing
a spiro ring Perfect for academic and industrial chemists, this
comprehensive discussion of spirocycles is an indispensable
resource for those practicing in the field.
Indole derivatives are the most common heterocycle compounds
present in nature, for this reason, they have been referred to as
'privileged structures'. In fact, many approved drugs - and natural
products - belong to this family. Among indole derivatives,
oxindoles have a structural complexity, which have stimulated
generations of synthetic chemists to design strategies for
assembling these structures, and their enantioselective synthesis
is still growing.This book proposes to describe the known
enantioselective syntheses of oxindole derivatives. It is divided
in six chapters each referring to a specific class of asymmetric
oxindole derivatives. After the introduction, Chapter 2 describes
all-carbon spirooxindoles; Chapter 3, open chain
3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles;
Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6,
3-hetero-3-substituted oxindoles. It will be a useful tool for
synthetic chemists, who assemble total synthesis of natural
products, as well as for drug discovery chemists either in academic
or in industry R&S laboratories.
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