This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

A comprehensive guide to Apple's entry-level editing software from a passionate iMovie fan, this book features a full introduction to the editing process that will help you create professional, unique videos Key Features * Understand the core principles of editing * Leverage cross-platform insights and master iMovie for iOS and iPadOS; and the fully-featured macOS version * Use Keynote to create unique and engaging titles Book Description Complete with step-by-step tutorials for essential tools and concepts - and guides as why you should use them - this is a practical guide to iMovie that will prepare you well for the world of post-production, and the creative process at large. It's not about having the shiniest tools; it's about what you do with them. With this in mind, this book is written to help Apple users get more out of iMovie than you may think possible with free editing software as well as helping you avoid common gotchas. You can then apply the principles of editing, and understanding of common edits, effects, and keyframing - to other editing software. This book begins with an introduction to the principles of editing, and how to apply them to Apple's Magic Movie and Storyboard frameworks. Then you will learn how to navigate iMovie for iOS and iPadOS as well as for macOS, mastering simple editing tools to deliver effective videos from import to export. The final section brings in Keynote to create custom titles and animations, helping you to create a creative brand that makes your video uniquely yours. By the end of this book, you will understand the important principles behind the post-production process. You will also be able to combine iMovie and Keynote for macOS to create high-quality, engaging video projects for different formats. What you will learn * Learn the principles of editing: create, refine and add meaning * Use iMovie's Magic Movie and Storyboard tools to create simple, themed videos * Learn iMovie's 'Magic Timeline' and navigate macOS iMovie with keyboard shortcuts * Create a basic video using the iMovie timeline, using overlays and keyframing effects * Create custom titles and animations for your iMovie project using Keynote * Understand the best export settings for each project; convert videos for alternative aspect ratios * Learn how to solve and common problems with iMovie, and avoid them in future Who This Book Is For If you have an Apple device and have been asked to make a video for your professional environment, this book is the place to turn. Simple, progressive guides will help you master editing principles; using iMovie to create simple but effective videos to inform, educate and entertain your colleagues, friends, and family. This book also provides more advanced users such as YouTubers and other online content creators with valuable tips on how to stamp their unique identity and brand USPs into their videos.

Science of Synthesis Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series, Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008. Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. Science of Synthesis is designed to be the first point of reference when searching for a synthesis strategy. - Contains the expertise of presently 250 leading chemists worldwide. - Critically evaluates the preparative applicability and significance of the synthetic methods. - Discusses relevant background information and provides detailed experimental procedures