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Dravet Syndrome (Paperback)
Charlotte Dravet, Renzo Guerrini
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R1,062
R803
Discovery Miles 8 030
Save R259 (24%)
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Ships in 12 - 17 working days
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Clinical case studies have long been recognized as a useful adjunct
to problem-based learning and continuing professional development.
They emphasize the need for clinical reasoning, integrative
thinking, problem-solving, communication, teamwork and
self-directed learning - all desirable generic skills for health
care professionals. Epilepsy is amongst the most frequently
encountered of neurological disorders. There are important emerging
clinical management issues (e.g., first seizure, therapy-resistant
seizures, ICU, pregnancy) but also differential diagnosis of
non-epileptic seizures (syncopy, pseudo-seizure, paroxysmal
dystonic syndromes, sleep disorders, psychosis, inborn errors of
metabolism, etc.). This selection of epilepsy case studies will
inform and challenge clinicians at all stages in their careers.
Including both common and uncommon cases, Case Studies in Epilepsy
reinforces the diagnostic skills and treatment decision-making
processes necessary to treat epilepsy and other seizures
confidently. Written by leading experts, the cases and discussions
work through differential diagnoses, treatments and social
consequences in pediatric and adult patients.
The identification of the cause of an epileptic seizure is a key
element in the clinical management of all patients. In recent
decades, advances in theory, neuroimaging, molecular genetics and
molecular chemistry have revolutionized our ability to investigate
and identify the underlying cause. The definitive and unrivalled
textbook on the causes of epilepsy, this second edition is
extensively revised and expanded. It provides concise descriptions
of all the major genetic and acquired conditions that cause
epilepsy in adults and children, and the provoking factors for
epileptic seizures and of the causes of status epilepticus. A new
section considers clinical approaches to diagnosing causes, to
guide and assist clinicians in investigations. With 128 chapters
written by leading figures from around the world, this
comprehensive and authoritative resource is indispensable to senior
and junior clinicians and trainees working in the field of
epilepsy, including specialists in neurology, paediatrics,
neurophysiology, psychiatry and neurosurgery.
Since its first description (1841) the identity of West syndrome
was deeply investigated and is now recognized as an epileptic
syndrome in infancy (ILAE Task Force, 1989). West syndrome has
become a paradigmatic model of an epileptic syndrome causing
neurological deterioration (epileptic encephalopathy) and the
object of a number of studies aimed at understanding the complex
relationships between an epileptic disorder and neurodevelopment.
Although the symptomatic triad (peculiar electrographic findings
named hypsarrhythmia, brief tonic spasms, and arrest of psychomotor
development) that characterizes the syndrome suggests a unique
pathogenetic mechanism, causal heterogeneity heavily influences
syndrome variability in terms of neurodevelopment, treatment
choices, management and, possibly, electroclinical semiology.
Important insights may arise for that might help developing models
of epileptic encephalopathies in the basic sciences. However, a
more immediate benefit may arise for clinicians in everyday
practice. A group of clinical researchers recently met in Rome to
discuss hot points concerning infantile spasms and West syndrome.
Their contributions were collected and are presented in this book
that we hope will contribute to the progress of knowledge of this
paradigmatic epileptic disorder.
Epilepsy is the most common serious neurological condition,
affecting children and adults, and can occur in a variety of
medical settings. It has many causes and many forms, and a variable
prognosis. Mortality and morbidity are high, social and legal
consequences can stretch well beyond the purely medical, and its
management is often poor. Part of the Oxford Textbooks in Clinical
Neurology (OTCN) series, this volume covers the scientific basis,
clinical diagnosis, and treatment of epilepsy and epileptic
seizures. Written by internationally-renowned specialists, each
chapter comprehensively covers the current knowledge and evidence
base related to each aspect of the disorder, with an emphasis on
the personal experience of the authors. The print edition of the
Oxford Textbook of Epilepsy and Epileptic Seizures is complemented
by an online version, which allows access to the full content of
the textbook, contains links from the references to primary
research journal articles, enables full text searches, and provides
access to figures and tables that can be downloaded to PowerPoint
(R). This textbook will prove a useful clinical reference for
neurologists and senior trainees in neurology, an educational
manual for trainees, and will offer practical assistance to all
physicians advising people with epilepsy.
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