A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

The second edition of this distinguished textbook introduces undergraduates to the concepts, terminology and representations needed for an understanding of how English is pronounced around the world. Assuming no prior knowledge, this textbook guides the reader through the vocal tract and explains how the sounds of speech are made, offering an accessible and expanded introduction to areas including transcription, vowels and acoustic analysis. As far as possible, it uses naturally-occurring conversational speech so that readers are familiar with the details of everyday talk (and not just the careful pronunciations presented in dictionaries.) The book also includes a new concluding chapter that works through a piece of spoken data to show the reader how a more complete phonetic analysis can be conducted. Examples are taken from around the English-speaking world, including North America, Australia, New Zealand and varieties of British English. The book takes an open-minded approach to what sounds of English might be significant for making meaning, and highlights the significance of word meaning, morphology, sociolinguistics and conversational interaction in phonetic analysis.

First published in 2003, Phonetic Interpretation presents innovative work from four core areas: phonological representations and the lexicon, phonetic interpretation and phrasal structure, phonetic interpretation and syllable structure, and phonology and natural speech production. Written by major figures in the fields of phonetics, phonology and speech perception, the chapters in this volume use a wide range of laboratory and instrumental techniques to analyse the production and perception of speech, their aim being to explore the relationship between the sounds of speech and the linguistic organisation that lies behind that. The chapters present evidence of the lively intellectual engagement of laboratory phonology practitioners with the complexities and richness of human language. The book continues the tradition of the series, Papers in Laboratory Phonology, by bringing linguistic theory to bear on an essential problem of linguistics: the relationship between mental models and the physical nature of speech.

This study presents innovative work from four core areas: phonological representations and the lexicon; phonetic interpretation and phrasal structure; phonetic interpretation and syllable structure; and phonology and natural speech production. Written by experts in the fields of phonetics, phonology and speech perception, the chapters in this volume use a wide range of laboratory and instrumental techniques to analyze the production and perception of speech. They explore the relationship between the sounds of speech and the linguistic organization that lies behind them.

In the third edition of this bestselling introductory textbook, Richard Ogden presents the concepts, terminology and representations needed for understanding how English is pronounced globally. He guides you through the vocal tract, explains clearly how the sounds of speech are made, and introduces phonetic transcription and acoustic analysis. This textbook uses naturally-occurring conversational speech throughout so you can get to know the details of everyday talk (and not just the careful pronunciations presented in dictionaries.) Written in a user-friendly style with plenty of examples, this textbook is a great starting point for your first university course on English phonetics.

In the third edition of this bestselling introductory textbook, Richard Ogden presents the concepts, terminology and representations needed for understanding how English is pronounced globally. He guides you through the vocal tract, explains clearly how the sounds of speech are made, and introduces phonetic transcription and acoustic analysis. This textbook uses naturally-occurring conversational speech throughout so you can get to know the details of everyday talk (and not just the careful pronunciations presented in dictionaries.) Written in a user-friendly style with plenty of examples, this textbook is a great starting point for your first university course on English phonetics.

The second edition of this best selling textbook introduces undergraduates to the concepts, terminology and representations needed for an understanding of how English is pronounced around the world. Assuming no prior knowledge, it guides the reader through the vocal tract and explains how the sounds of speech are made, offering an accessible and expanded introduction to areas including transcription, vowels and acoustic analysis. As far as possible, it uses naturally-occurring conversational speech so that readers are familiar with the details of everyday talk (and not just the careful pronunciations presented in dictionaries). The book also includes a new concluding chapter that works through a piece of spoken data to show the reader how a more complete phonetic analysis can be conducted.

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.