Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community since its first publication in 1988, the book shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in the book are still important and informative. Shortly after its publication, the genomics revolution turned Mathematical Biology into a prominent area of interdisciplinary research. In this new millennium, biologists have discovered that mathematics is not only useful, but indispensable! As a result, there has been much resurgent interest in, and a huge expansion of, the fields collectively called mathematical biology. This book serves as a basic introduction to concepts in deterministic biological modeling.

Provides a mathematically rigorous introduction to the fundamental ideas of modern statistics for readers without a calculus background. It is the only book at this level to introduce readers to modern concepts of hypothesis testing and estimation, covering basic concepts of finite, discrete models of probability and elementary statistical methods. Although published in 1970, it maintains a modern outlook, especially in its emphasis on models and model building and also by its coverage of topics such as simple random and stratified survey sampling, experimental design, and nonparametric tests and its discussion of power. The book covers a wide range of applications in manufacturing, biology, and social science, including demographics, political science, and sociology. Each section offers extensive problem sets, with selected answers provided at the back of the book. Among the topics covered that readers may not expect in an elementary text are optimal design and a statement and proof of the fundamental (Neyman-Pearson) lemma for hypothesis testing.

This unique book addresses advanced linear algebra from a perspective in which invariant subspaces are the central notion and main tool. It contains comprehensive coverage of geometrical, algebraic, topological, and analytic properties of invariant subspaces. The text lays clear mathematical foundations for linear systems theory and contains a thorough treatment of analytic perturbation theory for matrix functions.

Offers an alternative to the 'rote' approach of presenting standard categories of differential equations accompanied by routine problem sets. The exercises presented amplify and provide perspective for the material, often giving readers opportunity for ingenuity. Little or no previous acquaintance with the subject is required to learn usage of techniques for constructing solutions of differential equations in this reprint volume.

Functions of a complex variable are used to solve applications in various branches of mathematics, science, and engineering. Functions of a Complex Variable: Theory and Technique is a book in a special category of influential classics because it is based on the authors' extensive experience in modeling complicated situations and providing analytic solutions. The book makes available to readers a comprehensive range of these analytical techniques based upon complex variable theory. Proficiency in these techniques requires practice. The authors provide many exercises, incorporating them into the body of the text. By completing a substantial number of these exercises, the reader will more fully benefit from this book.

This book has become the standard for a complete, state-of-the-art description of the methods for unconstrained optimization and systems of nonlinear equations. Originally published in 1983, it provides information needed to understand both the theory and the practice of these methods and provides pseudocode for the problems. The algorithms covered are all based on Newton's method or "quasi-Newton" methods, and the heart of the book is the material on computational methods for multidimensional unconstrained optimization and nonlinear equation problems. The republication of this book by SIAM is driven by a continuing demand for specific and sound advice on how to solve real problems. The level of presentation is consistent throughout, with a good mix of examples and theory, making it a valuable text at both the graduate and undergraduate level. It has been praised as excellent for courses with approximately the same name as the book title and would also be useful as a supplemental text for a nonlinear programming or a numerical analysis course. Many exercises are provided to illustrate and develop the ideas in the text. A large appendix provides a mechanism for class projects and a reference for readers who want the details of the algorithms. Practitioners may use this book for self-study and reference. For complete understanding, readers should have a background in calculus and linear algebra. The book does contain background material in multivariable calculus and numerical linear algebra.

Provides a survey of the theoretical results on systems of nonlinear equations in finite dimension and the major iterative methods for their computational solution. Originally published in 1970, it offers a research-level presentation of the principal results known at that time. Although the field has developed since the book originally appeared, it remains a major background reference for the literature before 1970. In particular, Part II contains the only relatively complete introduction to the existence theory for finite-dimensional nonlinear equations from the viewpoint of computational mathematics. Over the years semilocal convergence results have been obtained for various methods, especially with an emphasis on error bounds for the iterates. The results and proof techniques introduced here still represent a solid basis for this topic.

No one working in duality should be without a copy of Convex Analysis and Variational Problems. This book contains different developments of infinite dimensional convex programming in the context of convex analysis, including duality, minmax and Lagrangians, and convexification of nonconvex optimization problems in the calculus of variations (infinite dimension). It also includes the theory of convex duality applied to partial differential equations; no other reference presents this in a systematic way. The minmax theorems contained in this book have many useful applications, in particular the robust control of partial differential equations in finite time horizon. First published in English in 1976, this SIAM Classics in Applied Mathematics edition contains the original text along with a new preface and some additional references.

This is the only book available that analyzes in depth the mathematical foundations of the finite element method. It is a valuable reference and introduction to current research on the numerical analysis of the finite element method, as well as a working textbook for graduate courses in numerical analysis. It includes many useful figures, and there are many exercises of varying difficulty. Although nearly 25 years have passed since this book was first published, the majority of its content remains up-to-date. Chapters 1 through 6, which cover the basic error estimates for elliptic problems, are still the best available sources for material on this topic. The material covered in Chapters 7 and 8, however, has undergone considerable progress in terms of new applications of the finite element method; therefore, the author provides, in the Preface to the Classics Edition, a bibliography of recent texts that complement the classic material in these chapters.

This book provides a unified view of tomographic techniques, a common mathematical framework, and an in-depth treatment of reconstruction algorithms. It focuses on the reconstruction of a function from line or plane integrals, with special emphasis on applications in radiology, science, and engineering. The Mathematics of Computerized Tomography covers the relevant mathematical theory of the Radon transform and related transforms and also studies more practical questions such as stability, sampling, resolution, and accuracy. Quite a bit of attention is given to the derivation, analysis, and practical examination of reconstruction algorithms, for both standard problems and problems with incomplete data.

This reprint of the 1969 book of the same name is a concise, rigorous, yet accessible, account of the fundamentals of constrained optimization theory. Many problems arising in diverse fields such as machine learning, medicine, chemical engineering, structural design, and airline scheduling can be reduced to a constrained optimization problem. This book provides readers with the fundamentals needed to study and solve such problems. Beginning with a chapter on linear inequalities and theorems of the alternative, basics of convex sets and separation theorems are then derived based on these theorems. This is followed by a chapter on convex functions that includes theorems of the alternative for such functions. These results are used in obtaining the saddlepoint optimality conditions of nonlinear programming without differentiability assumptions.

This book is the most comprehensive, up-to-date account of the popular numerical methods for solving boundary value problems in ordinary differential equations. It aims at a thorough understanding of the field by giving an in-depth analysis of the numerical methods by using decoupling principles. Numerous exercises and real-world examples are used throughout to demonstrate the methods and the theory. Although first published in 1988, this republication remains the most comprehensive theoretical coverage of the subject matter, not available elsewhere in one volume. Many problems, arising in a wide variety of application areas, give rise to mathematical models which form boundary value problems for ordinary differential equations. These problems rarely have a closed form solution, and computer simulation is typically used to obtain their approximate solution. This book discusses methods to carry out such computer simulations in a robust, efficient, and reliable manner.

This unabridged republication of the 1980 text, an established classic in the field, is a resource for many important topics in elliptic equations and systems and is the first modern treatment of free boundary problems. Variational inequalities (equilibrium or evolution problems typically with convex constraints) are carefully explained in An Introduction to Variational Inequalities and Their Applications. They are shown to be extremely useful across a wide variety of subjects, ranging from linear programming to free boundary problems in partial differential equations. Exciting new areas like finance and phase transformations along with more historical ones like contact problems have begun to rely on variational inequalities, making this book a necessity once again.

Many advances have taken place in the field of combinatorial algorithms since this book first appeared two decades ago. Despite these advances and the development of new computing methods, several basic theories and methods remain important today for understanding mathematical programming and fixed-point theorems. In this easy-to-read classic, readers learn Wolfe's method, which remains useful for quadratic programming, and the Kuhn-Tucker theory, which underlies quadratic programming and most other nonlinear programming methods. In addition, the author presents multiobjective linear programming, which is being applied in environmental engineering and the social sciences. The book presents many useful applications to other branches of mathematics and to economics, and it contains many exercises and examples. The advanced mathematical results are proved clearly and completely. By providing the necessary proofs and presenting the material in a conversational style, Franklin made Methods of Mathematical Economics extremely popular among students. The addition of a list of errata, new to this edition, should add to the book's popularity as well as its usefulness both in the classroom and for individual study.

Numerical continuation methods have provided important contributions toward the numerical solution of nonlinear systems of equations for many years. The methods may be used not only to compute solutions, which might otherwise be hard to obtain, but also to gain insight into qualitative properties of the solutions. Introduction to Numerical Continuation Methods, originally published in 1979, was the first book to provide easy access to the numerical aspects of predictor corrector continuation and piecewise linear continuation methods. Not only do these seemingly distinct methods share many common features and general principles, they can be numerically implemented in similar ways. Introduction to Numerical Continuation Methods also features the piecewise linear approximation of implicitly defined surfaces, the algorithms of which are frequently used in computer graphics, mesh generation, and the evaluation of surface integrals. To help potential users of numerical continuation methods create programs adapted to their particular needs, this book presents pseudo-codes and Fortran codes as illustrations. Since it first appeared, many specialized packages for treating such varied problems as bifurcation, polynomial systems, eigenvalues, economic equilibria, optimization, and the approximation of manifolds have been written. The original extensive bibliography has been updated in the SIAM Classics edition to include more recent references and several URLs so users can look for codes to suit their needs or write their own based on the models included in the book.

Singular perturbations and time-scale techniques were introduced to control engineering in the late 1960s and have since become common tools for the modeling, analysis, and design of control systems. In this SIAM Classics edition of the 1986 book, the original text is reprinted in its entirety (along with a new preface), providing once again the theoretical foundation for representative control applications. This book continues to be essential in many ways. It lays down the foundation of singular perturbation theory for linear and nonlinear systems, it presents the methodology in a pedagogical way that is not available anywhere else, and it illustrates the theory with many solved examples, including various physical examples and applications. So while new developments may go beyond the topics covered in this book, they are still based on the methodology described here, which continues to be their common starting point.

Initial-Boundary Value Problems and the Navier-Stokes Equations provides an introduction to the vast subject of initial and initial-boundary value problems for PDEs. Applications to parabolic and hyperbolic systems are emphasized in this text. The Navier-Stokes equations for compressible and incompressible flows are taken as an example to illustrate the results. Researchers and graduate students in applied mathematics and engineering will find Initial-Boundary Value Problems and the Navier-Stokes Equations invaluable. The subjects addressed in the book, such as the well-posedness of initial-boundary value problems, are of frequent interest when PDEs are used in modeling or when they are solved numerically. The book explains the principles of these subjects. The reader will learn what well-posedness or ill-posedness means and how it can be demonstrated for concrete problems. There are many new results, in particular on the Navier-Stokes equations. When the book was written, the main intent was to write a text on initial-boundary value problems that was accessible to a rather wide audience. Therefore, functional analytical prerequisites were kept to a minimum or were developed in the book. Boundary conditions are analyzed without first proving trace theorems, and similar simplications have been used throughout. The direct approach to the subject still gives a valuable introduction to an important area of applied analysis.

Intended for students and researchers, this text employs basic techniques of univariate and multivariate statistics for the analysis of time series and signals. It provides a broad collection of theorems, placing the techniques on firm theoretical ground. The techniques, which are illustrated by data analyses, are discussed in both a heuristic and a formal manner, making the book useful for both the applied and the theoretical worker. An extensive set of original exercises is included. Time Series: Data Analysis and Theory takes the Fourier transform of a stretch of time series data as the basic quantity to work with and shows the power of that approach. It considers second- and higher-order parameters and estimates them equally, thereby handling non-Gaussian series and nonlinear systems directly. The included proofs, which are generally short, are based on cumulants.

This monograph presents a survey of mathematical models useful in solving reliability problems. It includes a detailed discussion of life distributions corresponding to wearout and their use in determining maintenance policies, and covers important topics such as the theory of increasing (decreasing) failure rate distributions, optimum maintenance policies, and the theory of coherent systems. The emphasis throughout the book is on making minimal assumptions--and only those based on plausible physical considerations--so that the resulting mathematical deductions may be safely made about a large variety of commonly occurring reliability situations. The first part of the book is concerned with component reliability, while the second part covers system reliability, including problems that are as important today as they were in the 1960s. Mathematical reliability refers to a body of ideas, mathematical models, and methods directed toward the solution of problems in predicting, estimating, or optimizing the probability of survival, mean life, or, more generally, life distribution of components and systems. The enduring relevance of the subject of reliability and the continuing demand for a graduate-level book on this topic are the driving forces behind its republication. Mathematical Theory of Reliability now joins a growing list of volumes in SIAM's Classics series. Although contemporary reliability books are now available, few provide as mathematically rigorous a treatment of the required probability background as this one.

Long considered to be a classic in its field, this was the first book in English to include three basic fields of the analysis of matrices - symmetric matrices and quadratic forms, matrices and differential equations, and positive matrices and their use in probability theory and mathematical economics. Written in lucid, concise terms, this volume covers all the key aspects of matrix analysis and presents a variety of fundamental methods. Originally published in 1970, this book replaces the first edition previously published by SIAM in the Classics series. Here you will find a basic guide to operations with matrices and the theory of symmetric matrices, plus an understanding of general square matrices, origins of Markov matrices and non-negative matrices in general, minimum-maximum characterization of characteristic roots, Krnoecker products, functions of matrices, and much more. These ideas and methods will serve as powerful analytical tools. In addition, this volume includes exercises of all levels of difficulty and many references to original papers containing further results. The problem sections contain many useful and interesting results that are not easily found elsewhere. A discussion of the theoretical treatment of matrices in the computational solution of ordinary and partial differential equations, as well as important chapters on dynamic programming and stochastic matrices are also included.

Recent interest in biological games and mathematical finance make this classic 1982 text a necessity once again. Unlike other books in the field, this text provides an overview of the analysis of dynamic/differential zero-sum and nonzero-sum games and simultaneously stresses the role of different information patterns. The first edition was fully revised in 1995, adding new topics such as randomized strategies, finite games with integrated decisions, and refinements of Nash equilibrium. Readers can now look forward to even more recent results in this unabridged, revised SIAM Classics edition. Topics covered include static and dynamic noncooperative game theory, with an emphasis on the interplay between dynamic information patterns and structural properties of several different types of equilibria; Nash and Stackelberg solution concepts; multi-act games; Braess paradox; differential games; the relationship between the existence of solutions of Riccati equations and the existence of Nash equilibrium solutions; and infinite-horizon differential games.

A reprint of the original volume, which won the Lanchester Prize awarded by the Operations Research Society of America for the best work of 1968. Although out of print for nearly 15 years, it remains one of the most referenced volumes in the field of mathematical programming. Recent interest in interior point methods generated by Karmarkar's Projective Scaling Algorithm has created a new demand for this book because the methods that have followed from Karmarkar's bear a close resemblance to those described. There is no other source for the theoretical background of the logarithmic barrier function and other classical penalty functions. Analyzes in detail the 'central' or 'dual' trajectory used by modern path following and primal/dual methods for convex and general linear programming. As researchers begin to extend these methods to convex and general nonlinear programming problems, this book will become indispensable to them.

In order to emphasize the relationships and cohesion between analytical and numerical techniques, this book presents a comprehensive and integrated treatment of both aspects in combination with the modeling of relevant problem classes. This text is uniquely geared to provide enough insight into qualitative aspects of ordinary differential equations (ODEs) to offer a thorough account of quantitative methods for approximating solutions numerically and to acquaint the reader with mathematical modeling, where such ODEs often play a significant role. Originally published in 1995, the text remains timely and useful to a wide audience. It provides a thorough introduction to ODEs, since it treats not only standard aspects such as existence, uniqueness, stability, one-step methods, multistep methods, and singular perturbations, but also chaotic systems, differential-algebraic systems, and boundary value problems. The authors aim to show the use of ODEs in real life problems, so there is an extended chapter in which not only the general concepts of mathematical modeling but also illustrative examples from various fields are presented. A chapter on classical mechanics makes the book self-contained.