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Fertility preservation has become one of the most important and
fast growing fields of reproductive medicine. Although there are
several strategies for fertility preservation in female, most of
them are still considered experimental. It is important to perfect
the existing technologies, but also developing new strategies
should be actively sought. The future development of fertility
preservation strategies should be based on the sound scientific
knowledge and principles. One of the main objectives of fertility
preservation in females is prevention of oocyte depletion. The
mechanisms of oocyte loss and survival in the ovary are complex,
which include genetic control both in germ cells and in somatic
cells, DNA damage and repair mechanism, apoptosis and autophagy,
and other poorly understood molecular mechanisms. To develop
clinically effective and safe strategies for fertility
preservation, it is essential to know and understand the
fundamentals of oocyte and ovarian biology at the molecular level.
Thus, the purpose of this edition is to review the current progress
in research related to molecular and genetic control of oocyte
development that can be applied to fertility preservation. The main
topics that are discussed in this publication include molecular
signaling mechanisms of oocyte activation and loss, genomic
integrity of oocytes, and epigenetics.
Fertility preservation has become one of the most important and
fast growing fields of reproductive medicine. Although there are
several strategies for fertility preservation in female, most of
them are still considered experimental. It is important to perfect
the existing technologies, but also developing new strategies
should be actively sought. The future development of fertility
preservation strategies should be based on the sound scientific
knowledge and principles. One of the main objectives of fertility
preservation in females is prevention of oocyte depletion. The
mechanisms of oocyte loss and survival in the ovary are complex,
which include genetic control both in germ cells and in somatic
cells, DNA damage and repair mechanism, apoptosis and autophagy,
and other poorly understood molecular mechanisms. To develop
clinically effective and safe strategies for fertility
preservation, it is essential to know and understand the
fundamentals of oocyte and ovarian biology at the molecular level.
Thus, the purpose of this edition is to review the current progress
in research related to molecular and genetic control of oocyte
development that can be applied to fertility preservation. The main
topics that are discussed in this publication include molecular
signaling mechanisms of oocyte activation and loss, genomic
integrity of oocytes, and epigenetics. "
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