In this issue of Hematology/Oncology Clinics, guest editors Drs. Caron A. Jacobson and Parth S. Shah bring their considerable expertise to the topic of CAR T-Cell Therapy. Top experts in the field discuss the multiple ways CAR T-cell therapy can be used to help fight a variety of cancers, such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, mantle cell lymphoma, multiple myeloma, and B-cell acute lymphoblastic leukemia (ALL). Contains 12 practice-oriented topics including CAR T-cells in aggressive B-cell lymphomas; CAR T-cells in multiple myeloma; CAR T-cells in AML; mechanisms of resistance of CAR T-cell therapy; the role of CAR T-cell therapy in the era of bispecific antibodies; and more.  Provides in-depth clinical reviews on CAR T-cell therapy, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

This book forms the Proceedings of a RILEM workshop in Barcelona in November 1994. It is structured as a series of presentations/reviews by some of the leading international researchers and technical experts of the concrete world. Coverage ranges from developments in materials science, through performance and behaviour of concrete, to manufacturing and construction. Contributors include C. Audrade (Spain), H. Bache (Denmark), Z.P. Bazant (USA), H.W. Reinhardt (Germany), S. Rostam (Denmark), S.P. Shah (USA), J.P. Skalny (USA), A. Skarendahl (Sweden), M. Sugita (Japan) and J.F. Young (USA). This book should be of interest to RILEM members; concrete technologists in construction companies, materials supliers (cement, admixtures, fibres, aggregates, steel); research departments in universities and government labs; and consulting engineers.

This guide to green 'retro-fitting' for corporate real estate, facility managers and occupiers struggling to reduce their building's carbon footprint will help in the planning and management of a sustainable refurbishment programme.

Facilities managers have a key role in improving and maintaining a building's sustainability credentials over its whole life - through benchmarking and developing improvement strategies, energy efficiency measures and installation of low carbon technologies, as well as through waste minimisation and appropriate material use.

The first part of the book gives the context, providing the structure and linkage between the other chapters, together with an overview on sustainable development and refurbishment projects separately and the value gained from a sustainable refurbishment.

Part 2 details the regulatory and financial drivers, together with market pressures, and provides an overview of where this is leading together with the implications for sustainable refurbishment.

Part 3 provides technical support on carbon measures, helping to determine the feasibility of good practices as part of the refurbishment. Included is a review of energy efficiency, renewable and low carbon technologies and embodied carbon to enable lifecycle carbon calculations, together with the necessary behavioural change aspects needed to embed the changes. Linkages and benefits between the technologies will be highlighted.

Part 4 reviews refurbishment from a wider environmental perspective, understanding the challenges and opportunities that exist for particular developments from a materials, water, biodiversity and transport perspective.

Throughout the book, checklists are provided on typical activities and good practice that should be performed. These are expanded through relevant case studies and examples to show-case previous good practices and lessons learnt.

The book is structured to allow a matrix approach, with Parts 3 and 4 providing the technical information necessary to deliver a sustainable refurbishment; with sector relevance and best practice with case studies throughout the book.

sectors including offices, retail and manufacturing. It explains the facilities manager's role in incorporating sustainability into the whole life-cycle of a building - from initial briefing to final disposal.

The book takes a structured approach:
- masterplanning and real estate (acquisitions and disposals)
- design
- construction and commissioning
- refurbishment, fit-out and project management
- maintenance
- operation
- occupant satisfaction.

Sustainable Practice for the Facilities Manager fills a the gap between the policy-level sustainability books and the detailed technical documents by focusing on the 'what' and 'how' of planning and implementing sound environmental management practices in the context of FM operations.

It covers policy and trends on global, European and UK levels affecting businesses; compliance requirements for organisations - including some sector-specific areas; and best practice, with good and bad case studies showing the business benefits of incorporating sustainable practice into day-to-day activities.

The book is for:
- facilities management professionals
- public and private organisations owning properties
- property companies
- institutional investors
- building services or supplier organisations
and will help you deliver an improved operationally performing facility.

Sunil Shah - Technical Director and Head of Sustainability, Jacobs
Sunil has over eight years consultancy experience within the built environment, reviewing lifecycle environmental and social impacts from facilities. He has experience in a number of sectors, providing strategic consultancy support for clients including GlaxoSmithKline, BP, BAA, HM Prison Service, Pfizer and London Fire Brigade.

Sunil has most recently been involved in supporting the inclusion of facilities management within the DTI's Sustainable Construction Strategy.

There is no area in medicine that has affected biological psychiatry more pro 15 years in en foundly than the developments that have occurred in the last docrinology and more specifically in neuroendocrinology. In the 1960s, the regulation of endocrine function was considered to rest primarily in the feed back system between the pituitary and the secretions of various target organs. In R. H. Williams' Fourth Edition of the Textbook of Endocrinology published in 1968, the chapter on neuroendocrinology did refer to the median eminence gland with a relatively brief mention of various releasing factors that were the subject of ongoing studies. Only six years later, in the Fifth Edition published in 1974, Seymour Reichlin's chapter on neuroendocrinology listed nine specific hypothalamic releasing factors of which three had already been isolated and purified and thus were referred to as hormones. Most recently in the current Sixth Edition, published in 1981, the chapter on neuroendocrinology contains a detailed description of the physiology of the various hypothalamic releasing factors and hormones, but also significant emphasis is given to the various neurotransmitters that have been shown to regulate the synthesis and release of these important hypothalamic hormones. In addition, there appeared for the first time in this classic textbook a chapter on psychoendocrinology. One may wonder why there is so much interest not only in endocrinology but more recently in psychology and psychiatry about psychoneuroendocrine It has been known for some time function. Several reasons may be suggested.

The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.

This book forms the Proceedings of an RILEM workshop in Barcelona in November 1994. It is structured as a series of presentations/reviews by some of the leading international researchers and technical experts of the concrete world. Coverage ranges from developments in materials science, through performance and behaviour of concrete, to manufacturing and construction.

Ideal for both neurosurgical residents and recertifying neurosurgeons, Neurosurgery Self-Assessment: Questions and Answers offers the most comprehensive, up to date coverage available. Over 1,000 clinically relevant multiple-choice questions across 46 topic areas test the candidate's knowledge of basic neuroscience and neurosurgical subspecialties to an unparalleled degree and provide detailed answer explanations to facilitate learning and assessment. Over 700 histology, pathology, radiology, clinical and anatomical images serve as an index of routinely tested-on images in neurosurgical examinations with high-yield summaries of each pathology to reinforce and simplify key concepts. Includes only multiple choice questions in both single-best-answer and extended matching item (10-20 options) format increasingly adopted by neurosurgery certification boards worldwide. Questions are organized by topic and classified by degree of difficulty through a highly visual "traffic light system" which codes each question in green, amber, or red. Includes coverage of the landmark studies in areas such as vascular, stroke, spine and neurooncology. Practical tips facilitate study with test-taking strategies and things to consider before sitting for an exam. Utilizes Imperial and SI units throughout. Expert Consult eBook version included with purchase. This enhanced eBook experience acts an interactive question bank which automatically scores and provides immediate answer feedback, as well as allowing you to search all of the text, figures, and references from the book.

This new edition of the Oxford Handbook in Geriatric Medicine has been expanded and updated to reflect the substantial changes in clinical practice since the previous edition, including the Francis report and the impact on care for the older patient, the National Dementia Strategy and screening, and the evolution of the role of Geriatricians in other specialities. It includes new material on risk scoring management of TIA, and a new chapter on the older surgical patient. With an ageing population, geriatric medicine is increasingly central to emergency and internal medicine in hospital settings and in general practice. Diseases are more common in the older person, and can be particularly difficult to assess and to treat effectively in a field that has limited evidence, yet makes up a substantial proportion of the work of most clinicians. Using clinical vignettes and how-to boxes to provide practical advice on common problems, this is a practical, accessible, and essential handbook for all medical staff who manage older patients.

America has been struggling to come out of a crisis of confidence in our financial system. The country has not become poor, but its government is paralyzed, people have lost their jobs, houses, and their faith in themselves and their elected officials. They have seen their health insurance recede out of reach, or have lost it all together. The country's infrastructure, education, environment, and its bicameral, two party system of democracy have deteriorated, as if it has been made a colony by some invaders. It is being subjected to exploitation by the invisible and ill defined conquistadors on its own soil. These victors are collecting their trophies, without even acknowledging any responsibility towards their subjugated brethren. America has become a colony again. Capitalism has turned upon the very people it was supposed to benefit and has encouraged a small segment of the populace to cannibalize the rest, resembling the mating ritual of the praying mantis. Dr. Shah calls up on his medical skills to diagnose this complex financial morass that has baffled the greatest brains of our time. He believes that defining the problem clearly in itself may guide us towards its solution, preferably a nonviolent one, since we have contacted the enemy, and it is us

"Questions, Answers, and Exclamations" is an invaluable treasure chest of creative and practical ideas at various stages of development and execution to further the medical basic science and to help patients live longer and better. It presents original and innovative approaches to medicine's age old questions, provides some answers, questions some accepted answers, while stressing the wonder of search for the truth all along. Written for innovative and inquisitive minds in search for ideas to pursue, and for sharing the mystique of medical research with the enlightened lay person, in "Questions, Answers, and Exclamations" Dr. Bharat Shah offers the contents of his garage--the modern innovator's den, in its entirety just for volunteering to take them. Dr. Shah's vision encompasses an extremely wide spectrum of doctors' daunting challenges in the areas of vital signs-- body temperature, heart rate, and respiration; issues of smoking cessation, craving, and weight gain; problems of failure of surgical wounds to heal; psychiatric issues like depression, suicide, anxiety, panic, and violence; and finally, developing artificial lungs system to treat respiratory failure. Even as the book is interesting to read, it is the author's final will and testament to bequeath his work of lifetime to future generations. He has carried the ball as far as he could. Now he passes it to more able hands to carry it further. To borrow from the field of organ donation and transplantation, he says, "Don't take your ideas to heaven. Heaven knows, how badly they are needed here " Bharat S. Shah, M.D. is a retired Pulmonary Internist, and he lives in the metropolitan New York area.

This is a real life story of Usha, who is waiting to get a liver transplant, and her physician husband Bharat. It provides the inside look at the world of transplants, in a succinct and interesting manner, with anecdotes and stories from their personal life. It is a story of contradictory elements, like pathos and humor, despair and elation, optimism and disappointment, friendship and competition. It also presents the human side of medical and nursing staff.

A stepwise simple introduction to this delightful ancient and very much alive language of Indian scriptures, classic literature, and philosophy. Nothing to memorize, but you would want to

Second U.S. edition of a highly acclaimed, simple introduction to Jainism, an ancient (more than 2600 years old) but currently relevant religion from India. Written in a clear and friendly style, full of explanations, and a gradual, stepwise presentation of its fundamental principles. For personal or classroom study. Equally interesting for non-Jains of either Indian, non-Indian, or Western origin, and for students and scholars of non-violence, vegetarianism, and ecology.