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Endorphins and Opiate Antagonists in Psychiatric Research - Clinical Implications (Paperback, Softcover reprint of the original 1st ed. 1982)
Loot Price: R1,578
Discovery Miles 15 780
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Endorphins and Opiate Antagonists in Psychiatric Research - Clinical Implications (Paperback, Softcover reprint of the original 1st ed. 1982)
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The discovery of new molecules that function in neuronal
communication can be viewed as a progression of steps beginning
with the identification of the molecular structure, moving to the
understanding of the mecha nisms mediating the synaptic action, and
to the appraisal of the involve ment of the new molecules in
various neuronal mechanisms, and finally reaching the evaluation of
this molecule's role in brain function and the consequences that
are triggered by its abnormalities. Enkephalins have followed such
a pattern, and the present publication expresses the salient points
of the last two phases in this succession. Enkephalins were
discovered in December 1975; in addition to pain threshold
regulation, their participation in other brain functions was soon
ascertained. Perhaps, there are multiple recognition sites for
multiple molecular forms of endogenous enkephalins; similarly to
other transmitter recognition sites, these are coupled with ionic
and nucleotide amplifying systems; thus, when activated, they can
modify membrane funtion and ionic permeability of membranes. The
present publication probes the current status of our knowledge
concerning the consequences related to abnormalities in enkephalin
storage, release, and synthesis. However, since our basic
understanding of enkephalins is incomplete, the views reported
should be considered to be in a state of flux.
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