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bacterial carbohydrate recognition are conveyed, covering
Gram-positive as well as Gram-negative bacteria, in Chapter 4
Streptococci and Staphylococci, and in Chapter 5, carbohydrate
binding specificities of Helicobacter pylori. In Chapter 6, "Bitter
sweetness of complexity," the collected reflections on mic- bial
adhesion are expanded by a perspective on a broader impact of
glycosylation on cellular adhesion, motility and regulatory
processes, paralleling the complexity of N-glycan structures on
cell surfaces. It highlights particularly how structural details of
N-glycans have been causally related to pathological scenarios,
with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the
final chapter, biofilm formation is reviewed, covering knowledge
about structure and biosynthesis of polysaccharide intercellular
adhesins (PIAs) which are central to biofilm formation. This
comprehensive chapter explains all PIA-related principles of
medical device-associated infections. It is our hope, that this
collection of expert articles, ranging from structural ch- istry
and structural biology to biochemistry and medicine, will be a
stimulation and motivation for our colleagues in the life sciences.
At the same time, we hope that these reflections on microbial
adhesion will awake interest in and promote und- standing of the
complex processes associated with the glycocalyx and the multif-
eted interactions between the host cell and its "guest," as well as
the biological consequences resulting from this mutual interplay.
bacterial carbohydrate recognition are conveyed, covering
Gram-positive as well as Gram-negative bacteria, in Chapter 4
Streptococci and Staphylococci, and in Chapter 5, carbohydrate
binding specificities of Helicobacter pylori. In Chapter 6, "Bitter
sweetness of complexity," the collected reflections on mic- bial
adhesion are expanded by a perspective on a broader impact of
glycosylation on cellular adhesion, motility and regulatory
processes, paralleling the complexity of N-glycan structures on
cell surfaces. It highlights particularly how structural details of
N-glycans have been causally related to pathological scenarios,
with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the
final chapter, biofilm formation is reviewed, covering knowledge
about structure and biosynthesis of polysaccharide intercellular
adhesins (PIAs) which are central to biofilm formation. This
comprehensive chapter explains all PIA-related principles of
medical device-associated infections. It is our hope, that this
collection of expert articles, ranging from structural ch- istry
and structural biology to biochemistry and medicine, will be a
stimulation and motivation for our colleagues in the life sciences.
At the same time, we hope that these reflections on microbial
adhesion will awake interest in and promote und- standing of the
complex processes associated with the glycocalyx and the multif-
eted interactions between the host cell and its "guest," as well as
the biological consequences resulting from this mutual interplay.
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