![]() |
![]() |
Your cart is empty |
||
Showing 1 - 9 of 9 matches in All Departments
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.
The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
"Cancer Drug Design and Discovery, Second Edition" is an
important reference on the underlying principles for the design and
subsequent development of new anticancer small molecule agents. New
chapters have been added to this edition on areas of particular
interest and therapeutic promise, including cancer genomics and
personalized medicine, DNA-targeted agents and more. This book
includes several sections on the basic and applied science of
cancer drug discovery and features those drugs that are now
approved for human use and are in the marketplace, as well as those
that are still under development. By highlighting some of the
general principles involved in taking molecules through basic
science to clinical development, this book offers a complete and
authoritative reference on the design and discovery of anticancer
drugs for translational scientists and clinicians involved in
cancer research.
This unique and practical resource provides the most complete and
concise summary of underlying principles and approaches to studying
nucleic acid structure, including discussion of x-ray
crystallography, NMR, molecular modelling, and databases. Its focus
is on a survey of structures especially important for biomedical
research and pharmacological applications. To aid novices, the book
includes an introduction to technical lingo used to describe
nucleic acid structure and conformations (roll, slide, twist,
buckle, etc.). This completely updated edition features expanded
coverage of the latest advances relevant to recognition of DNA and
RNA by small molecules and proteins. In particular, the reader will
find extensive new discussions on: RNA folding, ribosome structure
and antibiotic interactions, DNA quadruplexes, DNA and RNA protein
complexes, and short interfering RNA (siRNA). This handy guide ends
with a complete list of resources, including relevant online
databases and software.
The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.
The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.
|
![]() ![]() You may like...
West Across the Pacific - American…
Hilary Conroy, F. Hilary Conroy, …
Hardcover
R2,852
Discovery Miles 28 520
A Rock in the Clouds - A Life Revisited
Us Army (Ret ) Col Joseph Tedeschi
Hardcover
R638
Discovery Miles 6 380
|