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bacterial carbohydrate recognition are conveyed, covering
Gram-positive as well as Gram-negative bacteria, in Chapter 4
Streptococci and Staphylococci, and in Chapter 5, carbohydrate
binding specificities of Helicobacter pylori. In Chapter 6, "Bitter
sweetness of complexity," the collected reflections on mic- bial
adhesion are expanded by a perspective on a broader impact of
glycosylation on cellular adhesion, motility and regulatory
processes, paralleling the complexity of N-glycan structures on
cell surfaces. It highlights particularly how structural details of
N-glycans have been causally related to pathological scenarios,
with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the
final chapter, biofilm formation is reviewed, covering knowledge
about structure and biosynthesis of polysaccharide intercellular
adhesins (PIAs) which are central to biofilm formation. This
comprehensive chapter explains all PIA-related principles of
medical device-associated infections. It is our hope, that this
collection of expert articles, ranging from structural ch- istry
and structural biology to biochemistry and medicine, will be a
stimulation and motivation for our colleagues in the life sciences.
At the same time, we hope that these reflections on microbial
adhesion will awake interest in and promote und- standing of the
complex processes associated with the glycocalyx and the multif-
eted interactions between the host cell and its "guest," as well as
the biological consequences resulting from this mutual interplay.
bacterial carbohydrate recognition are conveyed, covering
Gram-positive as well as Gram-negative bacteria, in Chapter 4
Streptococci and Staphylococci, and in Chapter 5, carbohydrate
binding specificities of Helicobacter pylori. In Chapter 6, "Bitter
sweetness of complexity," the collected reflections on mic- bial
adhesion are expanded by a perspective on a broader impact of
glycosylation on cellular adhesion, motility and regulatory
processes, paralleling the complexity of N-glycan structures on
cell surfaces. It highlights particularly how structural details of
N-glycans have been causally related to pathological scenarios,
with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the
final chapter, biofilm formation is reviewed, covering knowledge
about structure and biosynthesis of polysaccharide intercellular
adhesins (PIAs) which are central to biofilm formation. This
comprehensive chapter explains all PIA-related principles of
medical device-associated infections. It is our hope, that this
collection of expert articles, ranging from structural ch- istry
and structural biology to biochemistry and medicine, will be a
stimulation and motivation for our colleagues in the life sciences.
At the same time, we hope that these reflections on microbial
adhesion will awake interest in and promote und- standing of the
complex processes associated with the glycocalyx and the multif-
eted interactions between the host cell and its "guest," as well as
the biological consequences resulting from this mutual interplay.
In many fields, most notably medicine and molecular biology, the
understanding of the structure and function of carbohydrates and
glycoconjugates remains vital. This new volume contains critical
reviews covering the latest findings in both chemical and
biological sciences, and demonstrates the interdisciplinary nature
of modern carbohydrate research. This book addresses diverse
applications that continue to be major challenges for carbohydrate
chemists. The book starts with a review of Gerard Descotes
contribution to the field as a pioneer of French modern
carbohydrate chemistry. Green nanocatalytic oxidation of free
sugars, photosensitive glycomacrocycles, the application of
disaccharides in supramolecular chemistry, recent advances in the
radiation chemistry of polysaccharides, and the cell wall pectic
rhamnogalacturonan II, an enigma in plant glycobiology are just
some of the diverse topics presented in Volume 45. This set of
reports will certainly benefit any researcher who wishes to learn
about the latest developments in the carbohydrate field.
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