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Arrestins - Structure and Function in Vision and Beyond (Paperback): Vsevolod  V. Gurevich Arrestins - Structure and Function in Vision and Beyond (Paperback)
Vsevolod V. Gurevich
R4,054 Discovery Miles 40 540 Ships in 12 - 17 working days

Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

G Protein-Coupled Receptor Kinases (Hardcover, 1st ed. 2016): Vsevolod  V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer G Protein-Coupled Receptor Kinases (Hardcover, 1st ed. 2016)
Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer
R3,982 R3,688 Discovery Miles 36 880 Save R294 (7%) Ships in 12 - 17 working days

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Arrestins - Pharmacology and Therapeutic Potential (Hardcover, 2014 ed.): Vsevolod  V. Gurevich Arrestins - Pharmacology and Therapeutic Potential (Hardcover, 2014 ed.)
Vsevolod V. Gurevich
R9,973 R9,141 Discovery Miles 91 410 Save R832 (8%) Ships in 12 - 17 working days

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

G Protein-Coupled Receptor Kinases (Paperback, Softcover reprint of the original 1st ed. 2016): Vsevolod  V. Gurevich, Eugenia... G Protein-Coupled Receptor Kinases (Paperback, Softcover reprint of the original 1st ed. 2016)
Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer
R4,140 Discovery Miles 41 400 Ships in 10 - 15 working days

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Arrestins - Pharmacology and Therapeutic Potential (Paperback, Softcover reprint of the original 1st ed. 2014): Vsevolod  V.... Arrestins - Pharmacology and Therapeutic Potential (Paperback, Softcover reprint of the original 1st ed. 2014)
Vsevolod V. Gurevich
R9,767 Discovery Miles 97 670 Ships in 10 - 15 working days

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

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