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This book delineates how systems biology, pharmacogenomic, and
behavioral approaches, as applied to neurodevelopmental toxicology,
provide a structure to arrange information in a biological model.
The text reviews and discusses approaches that can be used as
effective tools to dissect mechanisms underlying pharmacological
and toxicological phenomena associated with the exposure to drugs
or environmental toxicants during development. The book intends to
elaborate functional outcomes of component-to-component
relationships using rodent and nonhuman primate in vitro and in
vivo models that allow for the directional and quantitative
description of the complete organism in response to environmental
perturbations. In addition, attention has also been directed to
some of the more recent methodologies, including genomics,
proteomics and metabolomics, applied in the evolutionary
neurobiological field.
Neurotoxicity of Drugs of Abuse, Volume Eight provides carefully
crafted reviews on the disruptive impact of drugs of abuse on the
central nervous system. The neurotoxicity potential of several
agents including marijuana, fentanyl, and ketamine are carefully
reviewed, and their short-term and chronic effects are categorized.
Pharmacokinetic profiles as well as mechanisms of action for these
and other drugs of abuse such as alcohol and nicotine are also
evaluated. The implications of short and long-term abuse for agents
such as PCP are also characterized. The reader will come away with
a fuller understanding of the adverse effects of drugs of abuse on
the nervous system.
Neurotoxicology: Approaches and Methods provides a unique and
comprehensive presentation of the current concepts and
state-of-the-art methods for the assessment of neurotoxicity. The
book analyzes various techniques available and discusses their
strengths and weaknesses. This volume will serve as an excellent
desk companion and laboratory guide for all investigators,
researchers, clinicians, and students interested in
neurotoxicology. The internationally knowngroup of editors divide
the book into seven sections: "Neuromorphological and
Neuropathological Approaches; Neurophysiological Approaches;
Neurobehavioral Toxicology; Neurochemical and Biomolecular
Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk
Assessment of Neurotoxicity." Each section yields the most
up-to-date information by experts in their fields. Meticulously
organized and edited, Neurotoxicology: Approaches and Methods is
the most authoritative and well-planned neurotoxicology book on the
market.
Key Features
* Discusses neurobehavioral testing methods for assessment of
neural dysfunctions
* Explains state-of-the-art diagnostic methods, such as
clinico-neuropsychological and neurophysiological methods, for
patients confronted by neurotoxic problems
* Discusses "In Vitro" methods, including aggregating brain cell
methods, organotypic cultures, and the use of human neuronal cell
lines for the assessment of neurotoxicity
* Presents step-by-step procedures for many methods
* Provides state-of-the-art neuromorphological and biomolecular
methods and approaches for neurotoxicity investigation
This book delineates how systems biology, pharmacogenomic, and
behavioral approaches, as applied to neurodevelopmental toxicology,
provide a structure to arrange information in a biological model.
The text reviews and discusses approaches that can be used as
effective tools to dissect mechanisms underlying pharmacological
and toxicological phenomena associated with the exposure to drugs
or environmental toxicants during development. The book intends to
elaborate functional outcomes of component-to-component
relationships using rodent and nonhuman primate in vitro and in
vivo models that allow for the directional and quantitative
description of the complete organism in response to environmental
perturbations. In addition, attention has also been directed to
some of the more recent methodologies, including genomics,
proteomics and metabolomics, applied in the evolutionary
neurobiological field.
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