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Showing 1 - 4 of 4 matches in All Departments
This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.
Neurotoxicity of Drugs of Abuse, Volume Eight provides carefully crafted reviews on the disruptive impact of drugs of abuse on the central nervous system. The neurotoxicity potential of several agents including marijuana, fentanyl, and ketamine are carefully reviewed, and their short-term and chronic effects are categorized. Pharmacokinetic profiles as well as mechanisms of action for these and other drugs of abuse such as alcohol and nicotine are also evaluated. The implications of short and long-term abuse for agents such as PCP are also characterized. The reader will come away with a fuller understanding of the adverse effects of drugs of abuse on the nervous system.
Neurotoxicology: Approaches and Methods provides a unique and
comprehensive presentation of the current concepts and
state-of-the-art methods for the assessment of neurotoxicity. The
book analyzes various techniques available and discusses their
strengths and weaknesses. This volume will serve as an excellent
desk companion and laboratory guide for all investigators,
researchers, clinicians, and students interested in
neurotoxicology. The internationally knowngroup of editors divide
the book into seven sections: "Neuromorphological and
Neuropathological Approaches; Neurophysiological Approaches;
Neurobehavioral Toxicology; Neurochemical and Biomolecular
Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk
Assessment of Neurotoxicity." Each section yields the most
up-to-date information by experts in their fields. Meticulously
organized and edited, Neurotoxicology: Approaches and Methods is
the most authoritative and well-planned neurotoxicology book on the
market.
This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.
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