This book delineates how systems biology, pharmacogenomic, and
behavioral approaches, as applied to neurodevelopmental toxicology,
provide a structure to arrange information in a biological model.
The text reviews and discusses approaches that can be used as
effective tools to dissect mechanisms underlying pharmacological
and toxicological phenomena associated with the exposure to drugs
or environmental toxicants during development. The book intends to
elaborate functional outcomes of component-to-component
relationships using rodent and nonhuman primate in vitro and in
vivo models that allow for the directional and quantitative
description of the complete organism in response to environmental
perturbations. In addition, attention has also been directed to
some of the more recent methodologies, including genomics,
proteomics and metabolomics, applied in the evolutionary
neurobiological field.
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