With the rapid development of Chinese urbanization in the 21st century, "urban diseases" become more serious, mainly manifested in water environmental pollution, urban flooding, water shortage, and deterioration of water ecology. It is necessary to establish a modern rainwater management system, scientifically solve the problem of excess urban rainwater and to improve water environment quality. Improvement of water environment quality is conducive to the ecological function of a sponge city. Sponge city construction has contributed to control non-point source pollution. Sponge systems cause the stagnation and purification of rainwater runoff, which is an important guarantee for water environment quality. This monograph summarizes theories and practices of the integrated water environment treatment in Chongqing, a typical representative mountainous city in the Three Gorges Reservoir Region. Based on the mountainous terrain and unique water environment characteristics in the Three Gorges Reservoir Region, the monograph analyzes measures and difficulties in the basin water environment integrated treatment. Moreover, the monograph makes suggestions for risk management amid drainage systems during the COVID-19 epidemic.

With the rapid development of Chinese urbanization in the 21st century, "urban diseases" become more serious, mainly manifested in water environmental pollution, urban flooding, water shortage, and deterioration of water ecology. It is necessary to establish a modern rainwater management system, scientifically solve the problem of excess urban rainwater and to improve water environment quality. Improvement of water environment quality is conducive to the ecological function of a sponge city. Sponge city construction has contributed to control non-point source pollution. Sponge systems cause the stagnation and purification of rainwater runoff, which is an important guarantee for water environment quality. This monograph summarizes theories and practices of the integrated water environment treatment in Chongqing, a typical representative mountainous city in the Three Gorges Reservoir Region. Based on the mountainous terrain and unique water environment characteristics in the Three Gorges Reservoir Region, the monograph analyzes measures and difficulties in the basin water environment integrated treatment. Moreover, the monograph makes suggestions for risk management amid drainage systems during the COVID-19 epidemic.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A RIGOROUS EXPLORATION OF THE STATE OF THE ART IN CONTROLLED RELEASE DRUG DELIVERY Written by an International team of experts, this comprehensive text offers pharmaceutical scientists and engineers working in the field, state-of-the-art design principles for the development and bioengineering of drug delivery systems/technology. Readers will find drug delivery systems presented with a particular emphasis on the design principles and their physiological/pathological basis. For each specific design principle, the contributors briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome. This in-depth text features detailed coverage of: Physiological and biochemical barriers to drug delivery Pharmacokinetics and pharmacodynamics of drug delivery Diffusion and dissolution strategies Prodrugs Bioadhesive and gastric retentive systems Physiological and biochemical barriers to drug delivery Targeted drug delivery Device controlled and programmable drug delivery And more A COMPREHENSIVE REFERENCE ON THE BIOCHEMICAL, PHYSICAL, AND TECHNICAL ASPECTS OF DRUG DELIVERY SYSTEMS * Pharmacokinetics and Pharmacodynamics: Applications in the Design of Controlled Release Drug Delivery Systems * Barriers to Drug Delivery: Physiological and Biochemical Aspects * Prodrugs as Delivery Systems * Diffusion Controlled Systems * Dissolution Controlled Systems * Osmotic Controlled Systems * Biodegradable Polymeric Delivery Systems * Gastric Retention Retentive Dosage Forms * Device Controlled Delivery of Powders * Physical Targeting of Approaches for Drug Delivery * Ligand Based Drug Targeting Approaches for Drug Delivery * Programmable Drug Delivery Systems * Carrier and Vector Mediated Delivery Systems for Biological Macromolecules

Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive introduction to this subject as well as its drug development applications. Beginning with foundations and basic terminology, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The result is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehension Detailed discussion of topics including dissolution, absorption, metabolism, and more Real-world examples of methods in actions throughout Oral Bioavailability and Drug Delivery is ideal for pharmaceutical scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, and other related fields; and graduate courses in drug development and delivery.