This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives

As nations reel from the effects of poverty, inequality, climate change and the aftermath of the COVID-19 pandemic, it feels as though the world has entered a period characterized by pessimism, cynicism and anxiety. This edited collection challenges individualized understandings of emotion, revealing how they relate to cultural, economic and political realities in difficult times. Combining numerous empirical studies and theoretical developments from around the world, the diverse contributors explore how dystopian visions of the future influence, and are influenced by, the emotions of an anxious and precarious present. This is an original investigation into the changing landscape of emotion in dark and uncertain times.

This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives

Fluctuation Mechanism and Control on System Instantaneous Availability facilitates the development of modeling and identification skills for both theoretical research and applications. Supplying a systematic introduction to the basic results in fluctuation analysis of instantaneous availability, it covers the theory, methodology, and specific engineering implementation required to conduct equipment instantaneous availability research. Presenting practical methods and tools, the book describes how to control the matching transition of new equipment systems as a result of interactions among sub-systems. It will help readers further extend their research on steady-state availability analysis to the optimization and control over instantaneous availability that is more suitable for engineering practices. The book provides the in-depth research on system instantaneous availability models, solutions, methodology, and frameworks required to investigate system instantaneous availability fluctuations within a certain range. Its chapters are divided into "Basic" and "Applied" components. The Basic chapters introduce the relevant concepts about system availability, the general continuous availability model approximate solution algorithms and problems, the discrete-time systems instantaneous availability model under general probability distribution, and the system instantaneous availability model and stability proof constraint by limited time, respectively. The Applied chapters focus on system instantaneous availability fluctuation analysis and control methods, discrete-time instantaneous availability model comparison and analysis under exponential distribution, system instantaneous availability fluctuations analysis under truncated discrete Weibull distribution, and system instantaneous availability fluctuations optimal design under truncated discrete Weibull distribution. Presenting the material in an accessible manner, the book summarizes current research results and engineering practices. It includes many examples that illustrate the roles of the new modeling methods for instantaneous availability. It also supplies Matlab (R) code for all the calculations performed in the book.

Modelling and Precision Control of Systems with Hysteresis covers the piezoelectric and other smart materials that are increasingly employed as actuators in precision engineering, from scanning probe microscopes (SPMs) in life science and nano-manufacturing, to precision active optics in astronomy, including space laser communication, space imaging cameras, and the micro-electro-mechanical systems (MEMS). As smart materials are known for having hysteretic dynamics, it is necessary to overcome issues with a broadband range of frequencies. This book offers both the mathematical tools for modeling the systems and applications, including complete case studies and source code for the experiments to help both academics and researchers in the industry to achieve precision in the control of Smart Actuator systems.

Based on the author s academic and industrial experience and backed by a thorough review of the current literature, "Side Reactions in Peptide Synthesis" provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay of progress. This unique resource gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results.

Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the referred side reactions. To enable use and navigation, side reactions are categorized by their peptide sequences and/or synthetic routes. This comprehensive resource covers solid phase and solution phase methodologies, and includes abundant references for further exploration.

As the market share of peptides and peptidomimetics as active pharmaceutical ingredients (APIs) is steadily increasing, "Side Reactions in Peptide Synthesis" answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product.
Systematic examination of the most frequent side reactions in peptide synthesisOptimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists "

IEC 61850-Based Smart Substations: Principles, Testing, Operation and Maintenance systematically presents principles, testing approaches, and the operation and maintenance technologies of such substations from the perspective of real-world application. The book consists of chapters that cover a review of IEC 61850 based smart substations, substation configuration technology, principles and testing technologies for the smart substation, process bus, substation level, time setting and synchronization, and cybersecurity. It gives detailed information on testing processes and approaches, operation and maintenance technologies, and insights gained through practical experience. As IEC 61850 based smart substations have played a significant role in smart grids, realizing information sharing and device interoperation, this book provides a timely resource on the topics at hand.

Welcome to Beijing. Beijing is one of the oldest and most interesting capitals in the world. A trip to Beijing is a trip to the ancient past but it is also a trip into the future. In Beijing the ancient and the modern live side-by-side with the traditional Chinese culture blending with the new global Chinese outlook. There is much to see in Beijing but also much that can be missed. The Top Ten Guide to Beijing makes sure you see and experience the very best of the city. Authors Li Sun, Yi Yang and Serena Hao Pan know the city intimately; they have grown up, gone to school and worked in Beijing. These authors bring a broad perspective that covers not only the quite pleasures of Beijing but also the excitement of a major cosmopolitan city. Whether you are visiting for a few days or a few weeks, THE TOP TEN GUIDE TO BEIJING lets you focus on the best of everything so that your experience in Beijing is a rich and rewarding one. THE TOP TEN TRAVEL GUIDES are designed to meet the needs of today's sophisticated travelers. They highlight the best the world has to offer. They are available for other cities of the world. Best wishes for an exciting visit to Beijing.

This is a collection of some of the best Chinese tales and anecdotes from the third to the sixth century. Most of these stories deal with the supernatural, some are folk tales, yet others are pen-pictures of historical figures.These stories give us exciting and intimate glimpses of four troubled centuries in Chinese history. Frequent civil wars made the lot of the Chinese people a bitter one. Peasants were often goaded to revolt, intellectuals to turn hermit or to seek consolation in wine or religion and the spread of Buddhism heightened the interest in the world of spirits.These tales have a unique place in Chinese literature and their influence upon the subsequent development of Chinese fiction was immense. Their form was copied right down to the nineteenth century, and some of them were adapted by later dramatists, poets or prose-writers.The stories are plentifully illustrated with reproductions of works of art which reflect the spirit and social background of their age.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A concise introduction to the study of medication utilization and safety in large populations of people "I found this book useful and clear, and appropriate for beginners in the world of research and, specifically, pharmacoepidemiology. Students could easily learn from this book if used in a classroom setting, where the professor could use the discussion points and questions at the end of each chapter to evaluate student learning. While it reads like a textbook, it is far from boring or dry. 3 Stars."--Doody's Review Service Understanding Pharmacoepidemiology is a clear, engagingly written roadmap to mastering the important concepts and methods of pharmacoepidemiology. It explains what pharmacoepidemiology is, how pharmacoepidemiology studies are conducted, and how to interpret findings. You will learn the importance of pharmacoepidemiology, basic terminology used in research, and the data sources, study designs, and statistical analyses employed in pharmacoepidemiology research. Upon completing Understanding Pharmacoepidemiology you will have a better understanding of how to evaluate the associations between medication utilization and outcomes. Each chapter includes these valuable learning aids: A list of learning objectives Case studies or examples Discussion questions Tables and Figures You will also find a glossary of important words and terms. The content you need to understand the concepts and methods of pharmacoepidemiology: Introduction to Pharmacoepidemiology: Principles of Epidemiology Applied to the Study of Medication Use, Study Designs in Pharmacoepidemiology: Using Secondary Data in Pharmacoepidemiology; Biostatistics and Pharmacoepidemiology: Other Methodological Issues; Evaluation of Pharmacoepidemiology Literature; Medication Utilization Patterns; Medication Safety and Pharmacovigilance; and FDA Perspectives on Post-market Drug Safety.

This book focuses on the various functional properties and potential applications of one-dimensional ZnO nanostructures, from basic principles to our most recent discoveries. It comprises experimental analysis of various properties of ZnO nanostructures, preparation techniques, research methods, and some promising applications. The areas of focus include ZnO-based gas/biochemical sensing devices, field emitters, solar cells, light-emitting diodes, e-papers, and single-nanowire-based transistors.