Based on the author s academic and industrial experience and
backed by a thorough review of the current literature, "Side
Reactions in Peptide Synthesis" provides analysis of, and proposes
solutions to, the most frequently encountered side reactions during
peptide and peptidomimetic synthesis. This valuable handbook is
ideal for research and process chemists working with peptide
synthesis in diverse settings across academic, biotech, and
pharmaceutical research and development. While peptide chemistry is
increasingly prevalent, common side reactions and their causes are
often poorly understood or anticipated, causing unnecessary waste
of materials and delay of progress. This unique resource gives
chemists the background information and the practical tools they
need to successfully troubleshoot and improve results.
Each chapter discusses common side reactions through detailed
chemical equations, proposed mechanisms (if any), theoretical
background, and finally, a variety of possible solutions to avoid
or alleviate the referred side reactions. To enable use and
navigation, side reactions are categorized by their peptide
sequences and/or synthetic routes. This comprehensive resource
covers solid phase and solution phase methodologies, and includes
abundant references for further exploration.
As the market share of peptides and peptidomimetics as active
pharmaceutical ingredients (APIs) is steadily increasing, "Side
Reactions in Peptide Synthesis" answers the growing, global need
for improved, replicable processes to avoid impurities and maintain
the integrity of the end product.
Systematic examination of the most frequent side reactions in
peptide synthesisOptimization-oriented analysis of side reactions
in peptide synthesis for improved industrial process development in
peptidyl API (active pharmaceutical ingredient) production Thorough
discussion of critical factors in peptide synthesis which are often
neglected or underestimated by chemists "
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