Dr. Waxman has assembled global experts to provide comprehensive coverage of Barrett's Esophagus, including diagnosis, management, treatment, and beyond. Articles are devoted to photodynamic therapy, minimally invasive surgery, advanced imaging, endoscopic mucosal resection, cryotherapy, and radiofrequency ablation. The clinical information in these articles will give readers a true picture of the advances in this disease state as well as what the clinical picture will look like in the near future.

This comprehensive update on irritable bowel syndrome addresses both the state of art diagnosis and treatment as well as emerging therapies and future directions. Worldwide authority, Dr. Eammon Quigley, contributes an article on Therapies Aimed at the Gut Microflora and Inflammation. Other highlights include articles devoted to genetics, biomarkers, and symptom-based diagnostic criteria.

This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.

'The Year Book of Gastroenterology' brings you abstracts of the articles that reported the year's breakthrough developments in gastroenterology, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice.

This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system.? Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

Dr. Kiesslich secured authors who are at the top of their field in GI Imaging to write articles that will serve as an up-to-date source for all gastroenterologists.? The issue is divided into sections devoted to imaging of the esophagus, stomach, small bowel, liver& pancreas, and colon; two articles are devoted to molecular imaging.? Readers will be very interested in the articles devoted to Contrast Enhanced and 3D-Endosonography, High Definition and Filter Aided Colonoscopy, and Autofluorescence and NBI Imaging in Barrett's Esophagus.

This issue focuses on the latest cutting-edge research in GI diseases that have or may have an infectious origin, including gallbladder disease, gastric cancer, inflammatory bowel disease and others.

Dr. Hunt has assembled a group of top experts to discuss the newest and most successful medical therapies to treat gastrointestinal diseases.? The issue is divided into sections devoted to each of these diseases states or disorders: ? acid-related disorders, functional gastrointestinal disorders, inflammatory bowel disease, gastrointestinal oncology, and hepatitis; the last 2 articles address the future directions in gastrointestinal pharmacotherapy.? Articles of special interest include those on? Anti-TNFa Drugs and New Biological Drugs for IBD, 5-ASA Drugs and Modified Formulations, and Potential for Manipulation of the Microbiome in Gastrointestional Disease

Dr. Allen's issue focuses on how gastroenterologists can maximize the "value? of colonoscopy - where value is defined as quality/cost. Clinical issues are covered, like sedation issues, complications of colonoscopy, and infection risk, but the majority of the articles deal with the discussions that surround quality colonoscopy-articles like: Risk Management and Legal Issues for Colonoscopy; Cost effectiveness of Colonoscopy in Prevention of Colon Cancer; Efficacy and Effectiveness of Colonoscopy: How Do We Bridge the Gap?; Current State of Colonoscopy Performance Measures; Use of Databases and Registries to Enhance Quality; and Maximizing the Value of Colonoscopy in Community, to name a few. In preparation of the changing landscape of healthcare, this issue will be an important one for all practicing gastroenterologists.

Dr. Soetikno has organized a comprehensive issue devoted to the detection and diagnosis of non-polypoid colorectal neoplasms with special emphasis on sessile or flat colon adenoma.? Top experts in the field have supplied the latest clinical information in the following areas: Non-Polypoid Colorectal Neoplasms in Ulcerative Colitis; Detection and Diagnosis of Non-Polypoid Colorectal Neoplasms; Image-Enhanced Endoscopy to Detect and Diagnose Non-Polypoid Colorectal Neoplasms; CT Colonography and Non-Polypoid Colorectal Neoplasms, as well as Endoscopic Mucosal Resection of Non-Polypoid Colorectal Neoplasms.? This issue is an important one as there are not many references on the topics that are as comprehensive.

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

As the debate continues about who should perform CT Colonography, radiologists or endoscopists, this issue marks the first time that the debate is addressed in great detail by BOTH endoscopists AND radiologists. As a result, this issue will be of great interest to both groups. Both offer their point of view on this screening method in great detail. Articles include: Only Radiologists Should Read CT Colonography; Gastroenterologists Should Read CT Colonography; Small and Medium Sized Polyps Noted at CT Colonography Need Not Be Reported; Small and Medium Sized Polyps Noted at CT Colonography Should Be Reported; Role of CTC in a Colorectal Cancer Screening Program; and Establishing a CT Colonography Service, to name a few.

Given the prevalence of obesity, any physician providing clinical care will be involved in the care of obese patients. Gastroenterologists will play an active role in the evaluation and treatment of these patients. Thereby, it is essential to fully understand the scope of the problem and the opportunities for intervention. The expert authors assembled for this issue offer expanded insight which can enhance care plans provided to this patient population. Since Dr. Johnson's first issue published, there are several updates in this area, and the articles in this volume address those.? These updates are seen in the areas of medical therapy, surgical options, and endoscopic treatments for obese patients.

This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area. The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.

Gastrointestinal (GI) physiology is a fundamental subject that is indispensable not only for undergraduate but also for graduate courses. The audience include, but are not limited to, medical, pharmacy, nursing, human biology, Chinese medicine, and science students, as well as other health-related subject students.The overall objectives of this textbook are to present basic concepts and principles of GI physiology and, more importantly, to convey an understanding of how to apply this knowledge to abnormal GI physiology in the clinical context. As such, the basic knowledge of GI physiology and its application in the form of clinical case studies should be grasped, which are critical for professional examinations and bedside, as well as for general practice in the future. In this handbook, we aim to achieve these elements by covering the breadth of GI, pancreatic, hepatobiliary, and nutritional physiology. Moreover, we include relevant scenario-based clinical case in each chapter so as to evaluate whether the students can apply the basic GI they learn to the clinical setting."

Dr. Wolfsen presents information in this issue about endoluminal techniques that have been developed for removing Barrett's esophagus. Emphasis is on circumferential balloon-based radiofrequency ablation, ALA and porfimer sodium photodynamic therapy (PDT), endoscopic mucosal resection, submucosal dissection, and liquid nitrogen and carbon dioxide cryotherapy. Dr. Wolfsen's assembled authors also provide insight into advances in esophageal surgery, NOTES, and advances in the use of stents. The reader will find that the whole issue addresses the goal of moving closer to ideal endoscopic treatment modalities for the safe, effective, reproducible, stable, and durable treatment for Barrett's disease in order to prevent the development of dysplasia or carcinoma.

Intraductal papillary mucinous neoplasms (IPMNs) represent an opportunity to treat pancreatic tumors before they develop into aggressive, hard-to-treat cancers. Beginning with morphological classification and its clinical significance, natural history, and malignant change of both main duct and branch duct IPMNs, this book covers the whole field of IPMNs of the pancreas. It reviews the various methods of investigation: imaging, diagnostic investigation of cyst fluid, and those using pancreatic juice; and also examines aspects ranging from the development of malignancy to the timing and method of resection, focusing on both main duct and branch duct IPMNs.

Aimed at residents, clinical fellows, and pancreatologists who treat patients with this common disease of the pancreas, this book is a landmark in the current understanding and future perspectives of IPMNs of the pancreas.

"

The Guest Editors for this issue have assembled top experts to discuss only those most challenging aspects of diagnosis and treatment of inflammatory bowel disease. Emphasis is on comparing treatment paradigms, current and future biologics agents, safety profile of therapeutics, and novel diagnostic and prognostic tools for IBD. Articles are also devoted to pregnancy and IBD, IBD in children, and post-operative management of IBD.

The use of interventional endoscopy of the biliary and pancreatic ducts has increased dramatically in recent years. Although choledocholithiasis is the most common reason for endoscopic treatment, other indications include pancreatolithiasis, cholangitis, biliary pancreatitis, papillary stenosis, sphincter of Oddi dysfunction, and benign or malignant ductal strictures. The Guest Editor has assembled an issue full of expert authors to present state-of-the art information biliary and pancreatic endoscopy procedures and techniques.

The small intestine has, until 2001, been an organ largely inaccessible to conventional endoscopy. Since that time a variety of endoscopic technologies have become available that have transformed small bowel diagnosis and therapy with a concomitant increase in interest in this organ and its disorders. This issue is divided into two sections; first, the new technologies are presented and include video capsule endoscopy, single and double balloon enteroscopy, and very recently the innovative Spirus screw technology. An article on comparison of these new technologies and the evolving techniques of CT and MRI is included. Indications, contraindications, complications and therapeutic adjunctive devices are discussed. The second section addresses the application of these technologies to specific diseases and discusses how these technological advances have changed their management. An article on intra-operative enteroscopy and its utilization in this new era is included.

Aging is associated with an increased prevalence of several GI disorders, including those induced by drugs (eg, gastrointestinal bleeding caused by nonsteroidal anti-inflammatory drugs), anorexia of aging, development of constipation, diarrhea or fecal incontinence, and postprandial hypotension. This issue addresses these disorders and discusses the current treatments for management of these patients. Specifically, articles focus on celiac disease, anorexia of aging, chronic constipation, fecal incontinence, neurogastrointestinal diseases, ischemic gut, and the pharmacology of commonly used GI drugs.

An ulcer is an open sore in the lining of the stomach or intestine. Peptic ulcers are eventually caused by acid and pepsin, a digestive stomach enzyme. These ulcers can occur in the stomach, where they are called gastric ulcers, or they can occur in the first portion of the intestine. These are called duodenal ulcers. Peptic ulcer is a term used to describe either or both of these two types of ulcers. H. pylori and certain drugs are the two major factors that cause ulcers. This issue provides a comprehensive overview of the causes, diagnosis, and treatments of peptic ulcers, including conditions like Zollinger -Ellison syndrome. Articles are devoted to NSAID ulcers and how to prevent them, stress ulcers, and antiplatelet therapy.