This volume is the proceedings of the symposium 'Trends in Inflammatory Bowel Disease Therapy 1999' held in Vancouver, Canada, August 27-29, 1999, and sponsored by the Canadian Association of Gastroenterology, The Crohn's and Colitis Foundation of Canada and Axcan Pharma. It is the seventh international IBD symposium to be held in Canada and focuses on all areas of IBD therapy.Topics include: genetics; pathogenesis with reference to the role of autoimmunity, bacterial factors and neutrophil -- epithelial interactions; special clinical problems such as difficult diagnoses and challenges presented by children and the elderly; bone disease in IBD; an overview of current therapy; and a discussion of alternative therapy.

Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.

Our own experience shows that there is no simple, yet of good scientific and clinical quality guide for practitioners and patients on gastrointestinal diseases. In the proposed book we will cover a vast area in the field, from GI tract physiology to disease diagnosis and treatment, in a comprehensive and approachable manner. The guide will not replace online resources (often used by patients) or specialized editions addressing experienced medical doctors, but rather fill the gap between those two. Our aim is to design this book so that it appeals to a wider audience; yet - if needed - encourages to explore the field further.

As we approach the end of this millennium, enteric diseases remain impor tant public health problems. In many parts of the world, sanitary measures have advanced little over the last century, although some of the governments in those areas are striving to improve facilities for sanitation and to educate their people in proper handling of food, water, sewage, and other modes of transmission of pathogenic microbes. Even in highly developed countries, outbreaks of diarrheal diseases occur today. Globally, the annual morbidity from enteric infections is estimated at several billion and deaths at several million per year. In this volume, descriptions of some of these diseases, of immunity that results from them, of clinical studies that promote under standing of individual and community immunity, of molecular factors of pathogenesis, and/or of advances in vaccine development have been pro vided by leading researchers. At present, the application of molecular methods is enhancing the identification of protective antigens of many microorganisms. In addition, new methods for design and delivery of vac cines are being devised. Perhaps then more effective tools for reducing at least some of these diseases will be available within the next decade. Lois J. Paradise Herman Friedman Mauro Bendinelli vii Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv LOIS J. PARADISE 1. Indigenous Microorganisms as a Host Defense 1 KENNETH H. WILSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Composition of Intestinal Biota. . . . . . . . . . . . . . . . . . . . . . . . 2 3. Molecular Approaches to Determine Composition of the Biota . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4. Role of the Host in Determining the Composition of the Biota . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ."

Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this book describes one of the broad aspects of HDV from virology to molecular biology, and from diagnosis to therapy.

With all of the information available why do patients still have difficulty sticking to their diets? Nutritional Counseling for Lifestyle Change provides clinicians with easy-to-follow instructions on how to change dietary behavior. The book uses examples from work completed in actual patient settings and emphasizes why a strategy works and what may have happened when it is not successful. Using science-based predictors of behavior change, it focuses on the concept of "tailoring" for individuals and shows how to achieve it. The book also discusses exercise and stress reduction and covers organizational skills necessary to implement lifestyle change.

International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.

This book, the proceedings of Falk Symposium 100, Gut and the Liver', held in Freiburg, Germany, 29-31 May 1997, comprehensively reviews the physiological and pathophysiological interactions between the intestine and the liver as well as between intestinal and hepatic diseases. Apart from the basic aspects of the intestinal microflora and the immune system of the gut, gastrointestinal permeability and translocation as well as the contribution of the intestine and the intestinal bacteria to the metabolism of bile acids, amino acids and drugs are discussed. In addition, experimental as well as clinical data demonstrating the significance of gut-derived bacterial toxins for the development of liver diseases and the effect of liver diseases on gastrointestinal functions are discussed. The major aim of this book, therefore, is to highlight the interactions between gut and liver at the molecular level as well as in clinical disease.

In recent years there have been huge advances in the understanding of the genetic and molecular basis of the fibrocystic diseases. This volume provides a thorough review of fibrocyctic diseases that affect the liver. It contains in-depth discussions of the genetics, molecular biology, pathogenesis, histology, clinical presentations, complications of, treatment, and prognosis of the conditions affecting children and adults, and hence will be the gold-standard reference for these conditions. In addition, the histological features that distinguish these conditions from other potentially fibrosing hepatopathies are illustrated. Conditions with syndromic features involving the kidney or other organ systems are also reviewed. Thorough review of the clinical phenotypes, their presentations, treatment, potential complications of, and prognosis is discussed.

Fibrocystic Diseases of the Liver will be an invaluable resource for hepatologists, gastroenterologists, nephrologists, and hepatic surgeons who care for children and adults with liver disease, as well as basic scientists in molecular genetics, hepatobiliary pathophysiology, hepatology and nephrology.

Nausea is a complex sensation that results from the interaction of certain fixed biological factors, such as gender, with changeable psychological factors, such as anxiety. This is the first book to provide a complete, in-depth explanation of what we know about nausea, along with the latest research results on its causes and treatment. As it is the product of long-term collaboration between scientists from the three main approaches to studying and treating nausea-psychology, gastroenterology and physiology-the information this book provides in both comprehensive and well integrated.

In recent years functional gastrointestinal disorders have attracted much interest. These disorders are extremely common. They are characterized by symptoms and the lack of structural lesions that can be identified with clinically available routine diagnostic tests. Several functional abnormalities are now believed to play a role in the development of the symptoms. This book summarizes the presentations at the International Falk Symposium No. 99 `Functional Dyspepsia and Irritable Bowel Syndrome: Concepts and Controversies' that took place on May 27-28, 1997. This symposium brought together clinical and basic researchers and clinicians to improve interdisciplinary communication. The meeting comprehensively covered basic and clinical aspects of these disorders, and it not only summarized the current knowledge, but also identified scientific questions that need to be addressed in the future.

Most symposia on chronic inflammatory bowel disease during the last few years have focused on new aspects of aetiology and pathophysiology. However, based on such new aspects, changes in diagnosis and treatment have been developed over the last few years and some others are currently under investigation. This book, the proceedings of Falk Symposium 97, `Clinical Challenges in Inflammatory Bowel Diseases - Diagnosis, Prognosis and Treatment', held in Lugano, Switzerland, 18-19 April 1997, summarizes these changes and new developments, discusses their value and defines further new approaches. The topics include primary diagnosis, definition of different patient groups, special problems of these patients in daily life and very new therapeutic principles. This volume opens new possibilities of diagnosis and treatment of inflammatory bowel disease to physicians and provides stimulation for further development.

Tavistock Press was established as a co-operative venture between the Tavistock Institute and Routledge & Kegan Paul (RKP) in the 1950s to produce a series of major contributions across the social sciences. This volume is part of a 2001 reissue of a selection of those important works which have since gone out of print, or are difficult to locate. Published by Routledge, 112 volumes in total are being brought together under the name The International Behavioural and Social Sciences Library: Classics from the Tavistock Press. Reproduced here in facsimile, this volume was originally published in 1958 and is available individually. The collection is also available in a number of themed mini-sets of between 5 and 13 volumes, or as a complete collection.

Gastrointestinal motility has evolved from an esoteric laboratory tool into a sophisti cated diagnostic technique that is now widely used clinically to guide in management of complex gastrointestinal problems. Today, it is the most rapidly growing subspecialty within gastroenterology. Previously, many of the gastrointestinal motility problems were either ignored or attributed to a disturbance of "psyche." But with the growing knowledge and understanding of how a dysfunction of the gastrointestinal muscle and nerves can cause disease, we are at the threshold of a revolution in our approach to the diagnosis and treatment of gastrointestinal motility disorders. The purpose of this book is to serve as a useful, up-to-date reference manual and guide for the diagnostic and therapeutic approach towards common adult and pediatric gastrointestinal motility problems. In order to enhance the understanding of these disor ders, a problem-oriented approach has been chosen, and wherever possible the authors have provided clinical case scenarios to illustrate their message. The emphasis has been on how to diagnose and treat motility disorders rather than to provide an encyclopedic infor mation. The reference list at the end of each chapter should enable the enthusiast to seek further information. Some of the material presented in this book has been derived from the proceedings of the annual University ofIowa College of Medicine GI Motility Symposia."

The Fourth International Symposium on Cell Injury and Protection in the Gastrointestinal Tract: From Basic Sciences to Clinical Perspectives was held on 8-11 October, 1995 in Pecs, Hungary, under the auspices of the Hungarian Academy of Sciences, Hungarian Society of Gastroenterology (Section of Nutrition and Metabolism, Research Forum), International Union of Pharmacology, International Brain-Gut Society, Standing Committee of Ulcer Research and Medical University of Pecs. The main scientific programmes of the Fourth International Symposium on Cell Injury and Protection in the Gastrointestinal Tract are: general mechanisms of gastrointestinal injury and protection; cell injury and protection in the stomach; cell injury and protection in the small intestine and in the large intestine; cell injury and protection in the liver and pancreas; and cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book.

The Gastrointestinal Section of the International Union of Pharmacology (IUPHAR) was established in 1994 in Montreal, Canada. The establishment of the GI Section recognizes the international progress of gastrointestinal pharmacology, including basic and human studies. The Gastrointestinal Section of IUPHAR organized the first symposium, Biochemical Pharmacology as an Approach to Gastrointestinal Diseases: Basic Science to Clinical Perspectives, on 10-12 October, 1995, in Pecs, Hungary. The main topics covered include: gastrointestinal secretory and excretory functions; gastrointestinal mobility - biochemical-pharmacological mechanisms in neural and hormonal actions involved in GI functions; main normal and pathological biochemical mechanisms in GI functions; GI mucosal injury and protection; molecular mechanisms of premalignant and malignant diseases in GI tract; and the use of isolated cells and cell cultures in biochemical-pharmacological studies to approach GI diseases.

The intestinal protozoan Giardia was first described over 300 years ago in 1681 by Leeuwenhoek, from his own stools. In his description of Giardia, he noted the size, movement, and morphology of the organism, and associated its presence with the diarrheic nature of his stools and his dietary habits. This truly remarkable account contains the first description of Giardia in morphologic, pathogenic, and epidemiologic terms. Our knowledge of the organisms in the genus Giardia has advanced tremendously in the past two decades. With the advent of new tech nologies, including techniques in electron microscopy, biochemistry, immunochemistry, tissue culture, and physiology, a tidal wave of information has appeared on the organization and function of this parasitic protozoan and its interaction with its host. The purpose of this book is to celebrate the tricentennial discovery of Giardia by Leeuwenhoek by presenting the above-mentioned advances in our knowledge of Giardia and giardiasis. In the first section of this book, the dominant theme is the biology of the organism and the correlation of structure-function relationships."

Gastrointestinal Imaging: Case Review, by Vincent Low, MD, FRANZCR, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this medical reference book in the popular Case Review Series features 200 cases organized by difficulty, making it ideal for quick reference and easy board review! Study effectively with content that mimics the new format of board exams as well as the everyday clinical experience - offering highly effective preparation for certification, recertification, and practice. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty and then by body part within each category. Stay current with the most recent findings and advancements in gastrointestinal radiology. Review 200 cases organized by level of difficulty, with multiple-choice questions, answers, and rationales that mimic the new format of certification and recertification exams. Effectively employ differential diagnosis procedures to distinguish among diseases and disorders with similar sonographic presentations. Alleviate exam anxiety and sharpen your clinical skills with visual guidance from entirely new high-quality, state-of-the-art images presenting a wide range of clinical situations. Challenge your knowledge of a full range of topics in gastrointestinal imaging with - 200 cases that mimic the new board format

This work presents an examination of Crohn's disease (CD), from an historical evaluation of the field to future developments of aetiopathogenesis, diagnostic evaluation and therapeutic management. It reviews possible aetiologic agents, the various ways in which CD progresses, novel diagnostic techniques and standard and innovative therapies. The application of recent advances in basic research to clinical management of the disease is emphasized.