Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. The field of gastrointestinal bleeding is rapidly evolving. The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. The initial management has rapidly evolved with new transfusion thresholds, the use of risk stratification scores and no more nasogastric tubes. There is new data and recommendations on optimal timing of endoscopy. Medical therapies have also evolved with changes in proton pump inhibitor administration and the use of prokinetics to improve endoscopic visualization. Many modifications in endoscopic therapy have recently been advanced including the use of endoscopic ultrasound guided angiotherapy, topical sprays (i.e. Hemospray) and over-the-scope clips. In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding.

This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon Cancer; Predictive and Prognostic Markers in the Treatment of Colorectal Cancer; Surgical Management of Hepatic Metastases of Colorectal Cancer; Combination Therapies in Colorectal Cancer Treatment; A Critical Look at Management of Peritoneal Metastases of Colorectal Cancer; Non-surgical Management of Rectal Cancer; and Ablative Therapies for Metastatic Colorectal Cancer.

The Guest Editors for this issue have assembled top experts to discuss only those most challenging aspects of diagnosis and treatment of inflammatory bowel disease.? Emphasis is on comparing treatment paradigms, current and future biologics agents, safety profile of therapeutics, and novel diagnostic and prognostic tools for IBD.? Articles are also devoted to pregnancy and IBD, IBD in children, and post-operative management of IBD.

Bestselling author of the Wheat Belly franchise brings his next big, game changing idea - the human microbiome and the silent epidemic of SIBO - to the mainstream.

Dr Davis has connected the dots between ''gut health'' and many common, modern ailments and complaints. 1 in 3 people have SIBO (small intestinal bacterial overgrowth), which causes a long list of health issues and illnesses; it is a silent and profound epidemic created by the absence of microbial species that our ancestors had even 50-100 years ago, which have been erased by the industrialisation of food and medicine.

Super Gut shares a four-week plan to reprogram your microbiome based on research and techniques that not only gets to the root of many diseases but improves levels of oxytocin (the bonding/happy hormone), brain health and promotes anti-aging and weight loss. Dr Davis provides not just the science and case studies but also more than 40 recipes and solutions. In Super Gut, he ensures readers understand the science, diagnose their gut issues, eradicate them and maintain their long-term health.

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

The last decade has seen enormous upheaval within all aspects of health care, and the gastrointestinal/ gastroenterology (GI) service has been no exception. Increasing demand for new and established diagnostic and interventional procedures has encouraged innovative models of service delivery, resulting in a range of health professionals crossing traditional practice boundaries. In particular, nurses and radiographers have seized the opportunity to develop their scope of practice, managing a range of procedures including colonoscopy, barium studies and CT colonography. This has, in many cases, freed both radiologists and gastroenterologists to take on new roles in the interventional service. The development of new procedures and new ways of working has promoted a renewed enthusiasm for critical evaluation of the GI service as a whole. As practitioners and clinicians learn new skills and extend their scope of practice it is essential that they have a thorough understanding of the basis of safe, effective and evidence based practice. This book offers the reader a detailed overview of the range of imaging procedures that may be employed in the investigation of gastrointestinal tract pathology, and explores current practice related to the subsequent patient care pathways and treatment options. It has been designed as a detailed reference guide for all health professionals who have a direct involvement in the GI tract and its imaging, including those who may be referring patients for GI radiological investigation, those professionals who are performing and subsequently reporting the procedures, and the clinicians responsible for the subsequent patient management. This book offers a unique insight into the rapidly changing radiology service, and offers introductory chapters which provide the fundamental underpinning knowledge required for safe and effective GI practice. Subsequent chapters discuss the evidence base related to a range of imaging procedures suitable for investigation of upper and lower GI symptoms, supported by key pathology chapters. The book also explores the range of treatments available for the more common GI tract pathology. Multi professional authorship. Detailed evidence-informed explanations of a range of individual GI procedures, including suggestions for problem solving and adaptation of technique. With extensive illustrations, medical images, boxes and tables. References and further reading. /ul>

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

In recent years, epidemiological studies have shown a significant increase of incidences regarding ulcerative colitis (UC) in most regions of the world. At present, a common therapeutic modality for inflammatory bowel disorders is the use of anti-inflammatory agents, including sulfasalazine and acetylsalicylic acid, steroid hormone, and other immunosuppressive agents. Most of these treatments are symptomatic and palliative because the etiology of the disease is not yet established. As a result of no proper drug available to treat UC, patients with UC are at a high risk of developing colitis-associated cancer (CAC). It is necessary to understand the genetic and molecular mechanisms involved in the pathogenesis of UC and CAC that lead to the path of new drug discoveries. Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer provides innovative insights that describe the fundamental understanding of UC and CAC and the molecular mechanisms behind the etiology as well as modern diagnostic methods that are employed in UC and CAC. Current prevention and therapeutic strategies practiced in the pre-clinical level are also discussed. The content within this publication examines alternative medicine and dietary intervention and drug delivery techniques. It is designed for healthcare professionals, physicians, academicians, researchers, R&D organizations, and medical students involved in drug discovery and clinical and therapeutic research.

Inflammatory bowel disease (IBD) is the term that includes Crohn's disease (which can affect any part of the gut) and ulcerative colitis (which affects the colon) - two chronic auto-immune conditions that cause gut pain, whole-body symptoms and poor digestion leading to nutritional deficiencies. Both are on the rise in the developed world and are newly affecting developing economies such as China (where the author was actually diagnosed). The link with the standard Western lifestyle is evident, yet what elements of that lifestyle can be modified to make a difference? And how can sufferers live with symptoms and 'flare ups' that do not respond to treatment and/or lifestyle changes? What is the real-life experience of IBD and what can be done to take back control? Jenna Farmer offers an holistic and positive guide to living with IBD, combining conventional, nutritional, stress reduction and other lifestyle approaches, drawing on her blogs, ebooks and website www.abalancedbelly.co.uk. Throughout, the book is 'illustrated' with case histories from Jenna's blog and other contacts, and from her own experience of delayed diagnosis and listening to her symptoms.