Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.

Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

The Understanding GERD chart presents a detailed overview of the symptoms and causes of Gastroesophageal Reflux Disease (GERD). Several views show normal esophagus and stomach anatomy, as well as GERD, esophagitis and Barrett's esophagus. Heavy cover stock with protective varnish for durability.

This volume provides a comprehensive overview of quality metrics and methods used to improve quality for all major modalities of CRC screening. It introduces the readers to the evidence of effectiveness behind various CRC screening modalities: stool-based tests (Fecal Occult Blood, Fecal Immunochemical and Fecal DNA tests), flexible sigmoidoscopy, colonoscopy and CT colonography. In-depth chapters review the latest guidelines for CRC screening, compare differences among the five major national guidelines, and highlight the need for valid quality and cost indicators. While the main focus of this volume is on colonoscopy, since most quality indicators and analyses have focused on this modality of screening and surveillance, one chapter is devoted to quality indicators of other screening modalities. Differences between process and outcome measures are also highlighted and a small but valid set of recommended national measures are listed. Written by experts in the field, Colorectal Cancer Screening: Quality and Benchmarks is an important and useful resource written for gastroenterologists, primary care physicians, general and colorectal surgeons, family physicians, and investigators with research focus in screening and quality metrics.

This issue of Hematology/Oncology Clinics will focus on Upper Gastrointestinal Malignancies; specifically, articles on the following: Epidemiology / Genetics, H. pylori and the gastric microbiome in gastric cancer carcinogenesis; Barrett's esophagus and esophageal cancer; Tumor Staging; Localized disease; Metastatic Disease; Immunotherapy Antiangiogenic therapy; and many more!

The Guest Editors have tapped top key opinion leaders to provide current reviews on the clinical diagnosis and treatment of gastrointestinal disease in children. They have focused on topics related to GERD; Celiac Disease and Gluten Sensitivity; IBD; Motility Disorders; GI Bleeding and Management; Pancreatic Disorders; Hepatitis B and C; Liver Transplant; Abdominal Pain; Complications from Obesity; and Neonatal Cholestasis.These articles will provide a state-of-the-art overview of diagnosis and treatment of GI diseases that are impactful for the general pediatrician.

This issue of Surgical Clinics of North America focuses on Advances in Colorectal Neoplasia, and is edited by Dr. Sean J. Langenfeld. Articles will include: Colorectal cancer screening; Imaging for colon and rectal cancer; The difficult colorectal polyp; Emergency presentations of colorectal cancer; Advances in laparoscopic colorectal surgery; Robotic colorectal surgery; Local excision of rectal cancer; New strategies in rectal cancer; Hereditary colorectal cancer syndromes; Dysplasia and cancer in inflammatory bowel disease; Atypical colorectal neoplasms; Resection of the primary tumor in stage IV colorectal cancer: when is it necessary?; Cytoreduction and HIPEC for colorectal cancer; Molecular markers for colorectal cancer, and more!

Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs. The authors in this book comprehensively discuss the different biomarkers for early diagnosis, and current therapeutic treatments for these diseases. All of these would allow us to better understand the pathogenesis of both diseases. As such, this book provides comprehensive information concerning the interrelationship between inflammation and cancer in a cohesive manner, and the information derived would benefit not only basic scientists but also clinicians who are working in these fields.

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. David Ilson, is devoted to Topics in Esophageal and Gastric Cancers. Dr. Ilson has assembled expert authors to review the following topics: Minimally Invasive Surgery: The Emerging Role in Esophageal and Gastric Cancer; Novel Targeted Therapies in Esophagogastric Cancer; The Role of Nutritional Support in Esophagogastric Cancer; Screening and Preventive Strategies in Esophagogastric Cancer; Current Progress in HER2 Targeted Therapies in Esophagogastric Cancer; The Role of Radiotherapy in Esophagogastric Cancer; Endoscopic Management of Early Esophagogastric Cancer; Current Progress in the Adjuvant Treatment of Gastric Cancer; Controversies and Consensus in Preoperative Therapy of Esophageal and GE Junction Cancers; Issues in the Management of Esophagogastric Cancer in Geriatric Patients; East versus West: The Asian Perspective on the Surgical and Adjuvant Management of Esophagogastric Cancer; The Current Status of Immunotherapies in Esophagogastric Cancer; and more!

Dr. Rothstein has assembled top experts to present the current status of the role of endoscopy in managing the obese patient. Authors present current clinical information on the following topics: Small Bowel Target Devices and Techniques; Reimbursement Issues for Endoscopic Devices Used for Metabolic Endoscopy; the Physiologic Alteractions of Bariatric Surgery; Non-Balloon Gastric and Pyloric Therapies for Obesity; Aspiration Therapy for Obesity; Endoscopic Therapies after Surgery; Duodenal Mucosal Resurfacing: Role for Diabetes Treatment; Gastric Plication; and Gastric Balloons. Readers should come away with the information they need to utilize endoscopic techniques to improve outcomes in their patients.

This issue of Surgical Pathology Clinics, edited by Drs. Laura Wood and Lodewijk Brosens, will cover the current research and concepts on Pancreatic Pathology. Topics discussed will include dissection of pancreatic resection specimens; pancreatic ductal adenocarcinoma; pancreatic neuroendocrine tumors; chronic pancreatitis; pancreatic cytopathology; and molecular genetics of pancreatic neoplasms, among others.

Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components.

Fluids and Electrolytes: Essentials for Healthcare Practice is designed to give a solid understanding of fluid and electrolyte physiology and its implications for practice, including acid-base balance and intravenous (IV) therapy, in a concise and easily understandable format. Chapters incorporate physiological, developmental and practical aspects, highlighting some of the key issues that arise from childhood to old age. This accessible text is presented with clear graphical representations of key processes, numerous tables and contains interesting facts to explore some common myths about human fluid and electrolyte physiology. A valuable resource for healthcare students, this book also provides a strong comprehensive overview for practitioners, nurses, physiotherapists and paramedics.

In the Western world around 360 in every 100,000 individuals have inflammatory bowel disease (IBD), a relapsing-remitting autoimmune disease that affects the gastrointestinal tract. Its impact on individual functioning across physical and psychosocial domains is significant and psychological distress is a common feature, with research suggesting that active IBD is associated with one of the highest rates of depression and anxiety of all chronic illnesses. Despite the high prevalence of mental health co-morbidities in IBD, psychological illness remains largely undertreated, with studies showing that 60% of IBD patients experiencing mental health problems do not receive adequate help. In this book, Knowles and Mikocka-Walus bring together world experts who practice integrated and holistic approach in their care for IBD patients, to provide an overview of research across a range of topics associated with the biopsychosocial treatment of IBD. Each chapter provides an up-to-date comprehensive consolidation and evaluation of the current literature alongside recommendations for practice. Key themes include: current understanding of the interrelationship of the neurological and biological aspects of IBD common concerns and issues individuals with IBD face exploring challenges across individual life-stages current evidence for psychosocial interventions recommendations for future directions of biopsychosocial work. Psychological Aspects of Inflammatory Bowel Disease: A biopsychosocial approach is a key resource for researchers, practitioners and academics considering psychosocial aspects of the disease and psychological interventions. It will also appeal to health psychologists and mental health practitioners working with clients with IBD, as well as gastroenterologists interested in a comprehensive and holistic approach to IBD management.

Dr. Quigley has created a must-have reference on the gut microbiome for the practicing gastroenterologist. A leader in the field of human physiology and digestive disorders, he has laid out the basics on this increasingly important topic, devoting articles to the organization and biology of the human gut microbiome as well as its diagnostic potential. Top international authors have presented articles that discuss the intersection of the gut microbiome and diet and the gut-brain axis. Clinical implications of the gut microbiome are discussed with disease states like IBD, GI cancer, and liver diseases. Finally, the issue ends with the cutting-edge clinical innovation of fecal microbial transplantation. This issue bridges the gap between science and clinical practice and should be an important reference to practicing gastroenterologists.

In the last three decades, the prevalence of obesity has doubled with over 600 million obese adults worldwide. The gastrointestinal complications of obesity are well publicized; however, the role of the gastrointestinal tract in the development and treatment of obesity is often understated. From the pathophysiologic role of gut hormones and the microbiota, to the purposeful, anatomic derangement of the gastrointestinal tract that is utilized as a treatment for obesity, it is imperative that gastroenterologists understand the full scope of obesity in relation to the gastrointestinal system. Studies suggest that in the U.S. obesity is underrecognized and undertreated by health care providers. Given its complex sociology, pathophysiology, and treatment, obesity, like many other diseases, requires a multidisciplinary approach. Therefore, gastroenterologists must be equipped with the relevant knowledge of obesity that will empower them to properly manage their patients.

Constipation: A Practical Approach to Diagnosis and Treatment serves as an unmet resource for physicians and other health care providers, including trainees and students, who see patients with constipation. The text reviews pathophysiologic mechanisms and details evaluation and management strategies. The volume also enables the reader to identify epidemiologic factors and quality of life parameters for patients with constipation, discuss differences in pathophysiologic mechanisms for different etiologies of constipation, recognize primary causes of constipation, and assess special considerations related to the symptom of constipation including presentations in the elderly, in pregnant women, in patients with systemic diseases, and patients with a history of abuse. Written by thought leaders and recognized experts in gastrointestinal motility and medical education, Constipation: A Practical Approach to Diagnosis and Treatment is of great value and utility for gastroenterologists, primary care physicians, gynecologists, nurse practitioners, physician's assistants, as well as fellows and residents.

Short Bowel Syndrome: Practical Approach to Management is the first reference exclusively about the issues experienced by patients with a short bowel. It covers all aspects of normal and abnormal physiology, the presenting features, and outcomes, including metabolic problems, gallstones, and renal stones. It discusses both medical and surgical treatments, including intestinal transplantation. The use of growth factors, which is likely in the future to become increasingly important in promoting intestinal structural adaptation, is extensively discussed. Special emphasis is given to the psychosocial aspects of the quality of life of patients, including support groups. Emphasis is also given to the importance of an experienced multidisciplinary team in caring for these patients. This book is particularly timely given the recent advances in the management of Short Bowel Syndrome, including the availability of pharmacologic agents to enhance intestinal absorption, refinements in parenteral nutrition, and surgical procedures designed to eliminate the need for parenteral nutrition support. The goal of this international, interdisciplinary book is to bring the subject of Short Bowel Syndrome to a wide audience. A wide range of specialists have contributed to this book to provide various viewpoints on the state-of-the-art care of those with this condition.

Inflammatory Bowel Disease, 2nd edition presents updated information about inflammatory bowel disease in health-care workers. The theoretical content is based on controlled and randomized clinical studies in the meta-analyzes, conducted appropriately and especially in global consensus and led by international experts. As such, the reader has access the important topics required to understand the ulcerative colitis and Crohn's disease.The editors and chapter authors, all established names within gastroenterology and coloproctology, and having extensive experience in assisting patients with inflammatory bowel disease, provide a concise book with quick and objective reference texts that complement the knowledge of students, doctors, nurses, nutritionists and psychologists of daily clinical practice.

IBS is an invisible disease - sufferers battle on pretending nothing is wrong and hiding their embarrassing symptoms. And it isn't life-threatening - so why would anyone take it seriously? Yet it can seriously restrict how we live, work and play. Based on their experience as both sufferers and health specialists, Dr Arroll and Professor Dancey provide the latest guidance on causes, diagnosis and treatment, including the hugely significant part played by stress.

This is the first exploration of the relationship between the abdomen and British society between 1800 and 1950. Miller demonstrates how the framework of ideas established in medicine related to gastric illness often reflected wider social issues including industrialization and the impact of wartime anxiety upon the inner body.

Nutritional management is an integral part of the management for virtually all gastrointestinal diseases. Nutritional Care of the Patient with Gastrointestinal Disease fills a current void in nutritional education by providing a reference for diagnosing and managing common nutritional issues related to gastrointestinal disease. Its separation into focused chapters allows it to be read cover to cover or in selections, making it useful on a need-to-know basis or for more diligent study. The book presents case studies in each chapter to illustrate the main topic. They include new landmark examinations on the role of nutrition and diet in the management of eosinophilic esophagitis, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). The book also addresses contemporary concerns with the use of probiotics, including their effectiveness (or ineffectiveness) either individually or in combinations in given clinical situations. This book identifies and satisfies a need for evidence-based clinical knowledge. It provides up-to-date information on nutrition that practitioners need and serves as a guide to recognizing and administering nutritional care and support to patients with gastrointestinal disease. The new and updated information combined with supporting material make this book a necessary resource for study, research, and practice in understanding nutrition's role in gastrointestinal health.

"Handbook of Capsule Endoscopy "is a concise guide to the clinical diagnostic use of capsule endoscopy, a non-invasive imaging technology of the gastrointestinal tract. This book is written by an international team with over 30 authors from 8 countries, mainly China, Britain, Israel, Italy, Germany, Korea, United Arab Emirates and the United States.

This book introduces nearly all aspects of capsule endoscopy, including the six devices currently in use, the set up procedures, indications and contraindications, its application in three organs, special use in pediatrics, safety issues and case presentations. This book is an ideal reference work for physicians and surgeons who wish to utilize this helpful imaging technology.

Prof. Zhaoshen Li and Associate Prof. Zhuan Liao are doctors in Changhai Hospital, the Second Military Medical University, Shanghai, China. Mark McAlindon is a consultant gastroenterologist and the directorate of gastroenterology in Royal Hallamshire Hospital, England, the United Kingdom.

Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students.