Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

This Recent Results in Cancer Research volume contains the majority of the invited expert contributions from the First St. Gallen EORTC Gastrointestinal Cancer Conference, held on 22-24 March 2012 in St. Gallen, Switzerland. Written by some of the world s leading experts in the field, the volume constitutes a comprehensive update on recent developments in the imaging, molecular biology, pathology, and multidisciplinary management of early cancer of the gastrointestinal tract. The latest recommendations regarding diagnosis and treatment are provided, and areas of consensus and controversy, identified. While the principal focus is on esophageal and gastric cancer, advances in the treatment of colorectal and pancreatic cancer are also discussed in some detail. This book will be of interest to every clinician involved in the care of patients with gastrointestinal malignancies. "

Do you want to feel happier, healthier, and younger? From impaired brain function to poor skin, weakened immunity to premature aging, your gut health affects more than just your digestive system. In fact, keeping it in balance can revolutionize your health and wellbeing. In this ground-breaking book, esteemed gastroenterologist Dr Roshini Raj outlines tried-and-tested methods to improve your gut health, and offers life-changing results. Sharing practical tips, developed over years of practice, Dr Raj covers everything from the food that we should be eating, to the probiotics, vitamins, and medicines that we should be taking. With Gut Renovation you can optimise your gut, renovate your body, and transform your health, for good.

The long tube that makes up the gastrointestinal tract is composed of a variety of tissue types and is the largest internal organ of the body. Its main function is to digest food and absorb the released nutrients. Furthermore, it is subdivided into functionally distinct regions that each mediate one of a variety of actions upon the food consumed, including ingestion, propulsion, secretion, digestion, absorption and expulsion. Autonomic neuronal circuitry is intimately involved in controlling many of these multiple functions of the gut, making it an appealing subject for the study of neuroscientists.
This book reviews the state of current knowledge on the innervation of the gut by the enteric nervous system, and its interface with the extrinsic innervation, from a number of different perspectives, with the aim of providing a comprehensive and accessible account of the subject.

eBook available with sample pages: 0203217012

Irritable bowel syndrome has emerged from relative obscurity to become widely recognised as the cause of considerable morbidity, reduction in quality of life and costs to patients and health services. This review of the current state of knowledge of the condition will act as a ready source of reference to both generalists and specialists and will also widen the reader's understanding of some of the patient's experience of functional somatic disorders.

The clinical efficacy of glucocorticoids in the treatment of inflammatory bowel disease has been confirmed in a multitude of controlled monocentre and multicentre studies as well as from observations of the clinical course of the disease. Although, in the past, the treatment recommendations, dose regimen, substance selection and mode of administration were deduced principally from clinical trials, in recent years experimental research has yielded a mass of therapeutically significant new results. This seeks to optimize the clinical effects of the steroids and minimize their adverse events on a rational basis by the application of the knowledge obtained in pharmacokinetic and pharmacodynamic models, taking into account the different types of protein binding and the intrinsic activity of the various glucocorticoids. However, the transfer of this type of `disease-adapted differential glucocorticoid treatment' into a clinical context involves a critical examination of the `received' notions that have characterized steroid treatment in the past, such as strictly circadian administration or time-related dose reduction, as well as proof of the clinical superiority of the new therapeutic approaches. This book, the proceedings of a workshop on Glucocorticoid Treatment held in Strasbourg, France, identifies the current status of existing therapeutic concepts in inflammatory bowel disease, presents the pharmacokinetic and pharmacodynamic interactions in connection with the specific pharmacological properties of steroids with reference to substance differences and different modes of administration, and demonstrates their therapeutic significance.

The human pancreas consists of two organs in one: the exocrine gland made up of pancreatic acinar cells and duct cells that produce digestive enzymes and sodium bicarbonate, respectively; the endocrine gland made up of four islet cells, namely alpha-, beta-, delta- and PP-cells that produce glucagon, insulin, somatostatin and pancreatic polypeptide, respectively. While the physiological role of exocrine p- creas is to secrete digestive enzyme responsible for our normal digestion, absorption and assimilation of nutrients, the endocrine pancreas is to secrete islet peptide h- mones maintaining our glucose homeostasis. The pancreatic functions are nely regulated by neurocrine, endocrine, paracrine and/or intracrine mechanisms. Thus, dysregulation of these pathways should have signi cant impacts on our health and disease. Nevertheless, the underlying mechanisms by which pancreatic functions are regulated remain poorly understood. Recent basic science and clinical studies con rm myriad physiological and pathophysiological roles of the tissue renin-angiotensin systems (RAS). Of parti- lar interest is the recent identi cation of a local and functional RAS in the pancreas, which in uences both its exocrine and endocrine function. Its role in the pat- genesis of pancreatic diseases including diabetes and pancreatitis is increasingly recognized, as is the therapeutic potential of RAS antagonism: RAS blockade l- its disease progression of type 2 diabetes mellitus and impaired glucose tolerance, and may also protect against pancreatic in ammation.

This series of pocketbooks sets out to provide easily-assimilable, essential information on the diagnosis and treatment of the most common medical conditions. This volume deals with reflux and oesophageal problems.

The second edition of "Clinical Dilemmas in Inflammatory Bowel Disease: New Challenges," is a practical, up-to-date handbook providing expert guidance on specific clinical dilemmas and areas of difficulty that the gastroenterologist regularly faces in day-to-day practice.

In this new edition, 75% of the "dilemmas" are brand new dilemmas facing the IBD specialist concerning emerging treatment therapies, such as the use of cannbinoids and Viagra for Crohn's disease. The remaining 25% of the dilemmas are fully updated from the previous edition, incorporating the latest clinical thinking.

Each of the 57 evidence-based chapters contains clear learning points, addresses different topics, and provides sound guidance on subjects ranging from optimizing current management through to special management problems and novel treatments.

This book is suitable for all medical professionals involved in the care of patients with IBD: established and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, specialist nurses, pharmacists, dieticians and counselors.

Single Incision Laparoscopic and Transanal Colorectal Surgery provide a comprehensive and state-of-the art review of single incision laparoscopic and transanal colorectal surgery. The text concentrates on surgical techniques and tricks in single incision laparoscopic and transanal surgery with detailed descriptions of the techniques, as well as indications and limitations of the procedures. The newly available evidence on these procedures is emphasized and all procedures are richly illustrated with diagrams and photos. Written by experts in their fields, Single Incision Laparoscopic and Transanal Colorectal Surgery is valuable resource for general surgeons, colon and rectal surgeons, laparoscopic GI surgeons, surgical residents and fellows in training interested in these two rapidly developing fields in colorectal surgery.

A comprehensive guide, Women's Health in IBD: The Spectrum of Care From Birth to Adulthood will help providers approach the specific issues that women with inflammatory bowel disease (IBD) face throughout their lifetimes. This book will better equip providers to counsel and support women of all ages with IBD. In Women's Health in IBD, Drs. Bincy P. Abraham, Sunanda V. Kane, and Kerri L. Glassner focus on the unique aspects of care for women with IBD. Half of the IBD patient population is female. As we understand more about gender and sex differences in terms of genetics, physiology, and medical care, it is important to consider these factors between men and women to personalize their care. This book encompasses the entire life span of the female IBD patient through birth, adolescence, pregnancy, menopause, and older adult years. Each chapter includes discussions of medications, treatment plans, and common questions or controversies on important topics in IBD such as: Transitioning from pediatric to adult care Diet and nutrition Mental health Health maintenance Family planning Pregnancy and breastfeeding Menopause Concomitant irritable bowel syndrome Women's Health in IBD: The Spectrum of Care From Birth to Adulthood is an essential text that will help anyone who treats women with IBD, offering practical tools and takeaways for point of care and beyond.

This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.

Reduce IBS symptoms with a 4-week meal plan and simple, delicious recipes! The Low-FODMAP IBS Solution Plan and Cookbook is your guide to successfully navigating the low-FODMAP diet and reducing IBS symptoms, including a 4-week meal plan and more than 100 low-FODMAP, gluten-free recipes that can be easily prepared in less than 30 minutes. If you are one of the 45 million Americans suffering from Irritable Bowel Syndrome (IBS), eating food may be the start of a vicious cycle. The Low-FODMAP IBS Solution Plan and Cookbook will provide everything you need to stop this cycle and heal your gut, using the medically proven low-FODMAP diet. Reduce symptoms of IBS and other digestive conditions with an easy-to-understand introduction to the low-FODMAP diet, a 4-week meal plan to guide you through the first phases, and more than 100 delicious low-FODMAP, gluten-free recipes that can be easily prepared in less than 30 minutes. You will receive sound, results-based advice from internationally recognized physician, surgeon and researcher Dr. Rachel Pauls, who uses the low-FODMAP diet to successfully treat her own IBS symptoms. Inside, you'll find guidance and straightforward low-FODMAP recipes that put you back in control, plus numerous vegan and vegetarian options. Enjoy mealtime once again with recipes such as: Lemon Blueberry Mug Muffins Make-Ahead Breakfast Burritos Flat-Tummy Chicken Corn Chowder Summertime Salad with Toasted Pecans Lemon Chicken with Rotini and Vegetables Tangy Turkey Sloppy Joes Peanut Pad Thai Hummus Pizza with Greek Salad Banana Chocolate Chip Oat Bars Chewy Brownie Cookies with Walnuts Scrumptious Pumpkin Pie Energy Bites Make this book the start of a healthier and happier lifestyle and a healthier and happier you!

Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic. Derivative organs esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. Chapters detailing the use of model organisms Drosophila, sea urchin, zebrafish, C. elegans, Xenopus for basic discovery studies are included. Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.

Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments.

Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.