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Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease - From Basic Principles to Rational Therapy (Hardcover, 1996 ed.)
Loot Price: R4,078
Discovery Miles 40 780
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Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease - From Basic Principles to Rational Therapy (Hardcover, 1996 ed.)
Series: Falk Symposium, 73b
Expected to ship within 10 - 15 working days
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The clinical efficacy of glucocorticoids in the treatment of
inflammatory bowel disease has been confirmed in a multitude of
controlled monocentre and multicentre studies as well as from
observations of the clinical course of the disease. Although, in
the past, the treatment recommendations, dose regimen, substance
selection and mode of administration were deduced principally from
clinical trials, in recent years experimental research has yielded
a mass of therapeutically significant new results. This seeks to
optimize the clinical effects of the steroids and minimize their
adverse events on a rational basis by the application of the
knowledge obtained in pharmacokinetic and pharmacodynamic models,
taking into account the different types of protein binding and the
intrinsic activity of the various glucocorticoids. However, the
transfer of this type of `disease-adapted differential
glucocorticoid treatment' into a clinical context involves a
critical examination of the `received' notions that have
characterized steroid treatment in the past, such as strictly
circadian administration or time-related dose reduction, as well as
proof of the clinical superiority of the new therapeutic
approaches. This book, the proceedings of a workshop on
Glucocorticoid Treatment held in Strasbourg, France, identifies the
current status of existing therapeutic concepts in inflammatory
bowel disease, presents the pharmacokinetic and pharmacodynamic
interactions in connection with the specific pharmacological
properties of steroids with reference to substance differences and
different modes of administration, and demonstrates their
therapeutic significance.
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