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Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease - From Basic Principles to Rational Therapy (Hardcover, 1996 ed.) Loot Price: R4,649
Discovery Miles 46 490
Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease - From Basic Principles to Rational Therapy (Hardcover, 1996 ed.):...

Glucocorticoid Therapy in Chronic Inflammatory Bowel Disease - From Basic Principles to Rational Therapy (Hardcover, 1996 ed.)

H.W. Mollmann, B. May

Series: Falk Symposium, 73b

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Loot Price R4,649 Discovery Miles 46 490 | Repayment Terms: R436 pm x 12*

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The clinical efficacy of glucocorticoids in the treatment of inflammatory bowel disease has been confirmed in a multitude of controlled monocentre and multicentre studies as well as from observations of the clinical course of the disease. Although, in the past, the treatment recommendations, dose regimen, substance selection and mode of administration were deduced principally from clinical trials, in recent years experimental research has yielded a mass of therapeutically significant new results. This seeks to optimize the clinical effects of the steroids and minimize their adverse events on a rational basis by the application of the knowledge obtained in pharmacokinetic and pharmacodynamic models, taking into account the different types of protein binding and the intrinsic activity of the various glucocorticoids. However, the transfer of this type of `disease-adapted differential glucocorticoid treatment' into a clinical context involves a critical examination of the `received' notions that have characterized steroid treatment in the past, such as strictly circadian administration or time-related dose reduction, as well as proof of the clinical superiority of the new therapeutic approaches. This book, the proceedings of a workshop on Glucocorticoid Treatment held in Strasbourg, France, identifies the current status of existing therapeutic concepts in inflammatory bowel disease, presents the pharmacokinetic and pharmacodynamic interactions in connection with the specific pharmacological properties of steroids with reference to substance differences and different modes of administration, and demonstrates their therapeutic significance.

General

Imprint: Springer
Country of origin: Netherlands
Series: Falk Symposium, 73b
Release date: 2001
First published: October 1996
Editors: H.W. Mollmann • B. May
Dimensions: 235 x 155 x 9mm (L x W x T)
Format: Hardcover
Pages: 128
Edition: 1996 ed.
ISBN-13: 978-0-7923-8708-4
Categories: Books > Medicine > Clinical & internal medicine > Gastroenterology
Books > Medicine > Clinical & internal medicine > Diseases & disorders > General
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LSN: 0-7923-8708-2
Barcode: 9780792387084

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