"Fatty Liver Diseases: NASH and Related Disorders" is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease.

It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.

Clinical and Basic Neurogastroenterology and Motility is a state-of-the-art, lucidly written, generously illustrated, landmark publication that comprehensively addresses the underlying mechanisms and management of common adult and pediatric motility disorders. These problems affect 50% of the population and include conditions such as dysphagia, achalasia, gastroesophageal reflux disease, gastroparesis, irritable bowel syndrome (IBS), gas and bloating, SIBO, constipation and fecal incontinence. The book brings together international experts and clinician scientists, epitomizing their years of wisdom into a concise yet practical text that is delivered in two distinct sections, basic and clinical. It fulfills a large unmet need, and bridges a long-awaited knowledge gap among trainees, clinicians, scientists, nurses and technicians, earnestly engaged in this field.

Many nurses work as specialist practitioners within several areas of gastrointestinal medicine, including inflammatory bowel disease, stoma care, nutrition, endoscopy and counselling. There has been a steady increase in nurse-led services and gastrointestinal nursing is an expanding area. This comprehensive text lays the foundation by reviewing the anatomy and physiology underlying common conditions before covering the pathophysiology of clinical features, causes, investigation and management. Underlying this approach will be the specific nursing aspects of caring for patients with gastrointestinal conditions, covering psychosocial factors and issues such as the measurement of health related quality of life.

This practical text is indispensable to all clinicians working with dysphagia and is suitable for those involved in a range of settings and with a diversity of client groups. With its perspective on everyday working practice, "Working with Dysphagia" fills a gap in an area where practical and workable material is much sought after. This book is a useful resource for all therapists, ranging from students to specialist, as the practical assessment approach and comprehensive management strategies are supported throughout with references of recent relevant research.

Digestive Diseases in Sub-Saharan Africa: Changes and Challenges provides an in-depth examination into the rise of western digestive diseases in Sub-Saharan Africa (SSA). For those interested in the causes of the major diseases of the 'West', the patterns in Africa have always reflected on the emergence of western diseases and elucidated the pattern of these conditions and their clinical course. Coverage includes the present epidemiology of GI diseases in SSA, the trends that are occurring, and the context of other emerging diseases. Appropriate for researchers, gastroenterologists and internists, this book brings together the latest research in a single, complete volume.

This comprehensive manual discusses the many aspects of inflammatory bowel disease (IBD), providing relevant information along with practical guidance. The reader is also directed to additional resources for extra and current information. This book comes at a time when the number of people suffering from the two major forms of IBD, ulcerative colitis (UC) and Crohn's disease (CD), is rising around the globe. Despite their huge impact on daily life and health economics, these diseases are not fully understood, and diagnosis and treatment remains a significant challenge. IBD nurses are increasingly recognised as key clinicians within the multidisciplinary team caring for people with IBD. Through experience and specialist knowledge IBD nurses provide timely support, advice, and treatment for people living with this unpredictable condition. IBD nurses are also well placed to liaise with the wider team, developing patient centred services which best fit their local health framework. The combined international expertise and accessible guidance here will equip nurses, or any clinician wanting to increase their competence in IBD management. Thereby this manual aims to contribute to the optimisation of IBD care throughout the world.

This book reviews the latest advances in treating ulcerative colitis. Its structure is designed to reflect the natural presentation of the disease; accordingly, it starts with the symptoms and the clinical picture, before addressing the use of radiological and endoscopic studies that are performed to make a diagnosis, and the role of the pathological examination. The book also includes detailed information on the medical treatment of the disease, written by some of the most expert gastroenterologists in the field, while also paying considerable attention to the latest medical treatments and to expected future developments. The book describes various surgical techniques for ulcerative colitis in detail, providing readers with concrete guidelines on which is the most appropriate operation to perform in any given case. It also presents extensive information on the most important operation, the formation of the IPAA (ileal pouch-anal anastomosis), together with helpful tips and tricks. A closing chapter addresses the long-term complications that can occur after a pouch formation, and what to do for each case. As such, the book offers a unique and comprehensive guide for surgeons, gastroenterologists, researchers and students alike.

New Concepts in the Management of Septic Perianal Conditions provides a comprehensive review of the medically important basic and clinical aspects of perianal diseases in adults. This book presents current, medically important information in the rapidly changing field of anorectal diseases, including significant topics like perianal abscess and fistula. It provides an accurate source of clinically relevant information that is presented clearly and succinctly, making it perfect for the diagnosis, treatment and management of septic perianal conditions.

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hoekfelt and V.C. Jordan.

Biopsy Interpretation of the Gastrointestinal Tract Mucosa is your definitive bench reference for the diagnosis of these challenging specimens. One of the best-selling titles in the Biopsy Interpretation Series, its practical, richly illustrative coverage encompasses the most common mucosal biopsies from the esophagus, stomach, small intestine, large intestine, and anus, helping you to evaluate the full range of samples and recognize their distinguishing features. This volume focuses on non-neoplastic entities; Volume Two, also available, is your complete source on neoplastic gastrointestinal lesions. Key Features Successfully navigate both common and unusual issues that arise in the day-to-day interpretation of gastrointestinal biopsies. Entities covered in this volume include: Autoimmune gastritis, sexually transmitted infectious proctitis, inflammatory bowel disease and mimics, medication induced injury, and many others. Enhance your interpretation skills with valuable pearls and pitfalls at the beginning of each chapter. Compare your samples to hundreds of full-color illustrations that capture the characteristic appearance of most mucosal biopsies of the gastrointestinal tract. Access additional illustrations plus 50 multiple-choice review questions in the companion VitalSource eBook! Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click

The book offers a comprehensive review of the relations between volumes and outcomes in oncological surgery especially in Italian hospitals, based on national and regional data. After illustrating the quality-control methodology and the determinants of surgical outcomes, it discusses the volume-outcome relationship in different fields of surgical oncology (cancers of the upper and lower gastrointestinal tract, hepatopancreatobiliary system, breast, sarcomas etc.) and suggests possible solutions. The latest findings from Europe and the USA are also presented.

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

This fully revised and updated third edition of the Oxford Handbook of Gastroenterology and Hepatology provides up-to-date, pragmatic advice on the management of common conditions and emergencies. An essential resource for all those involved in the care of patients with gastroenterological and hepatological disease, both for specialists and trainees in gastroenterology and hepatology, and also clinicians from other specialties. The handbook includes a problems-based approach, a unique A to Z compendium of conditions, and sections on therapeutic drugs, and emergencies. Thoroughly revised and updated, it now includes such updates as new approaches for the management of eating disorders, and post-liver transplant patients, the latest advances in endoscopy, new therapies, refined advice on how to select between therapeutic options, as well as additional emergency topics on abdominal trauma, bowel obstructions, and major haemorrhage.

This issue details the latest knowledge of early diagnosis, risk factors, limited surgical treatments, and novel therapies for pancreatic diseases. Clinicians will learn the most prognostic scoring systems for acute pancreatitis, review the basics for early management of the disease, and see how current practice guidelines have evolved. Advances in radiological imaging when applied to the pancreas have resulted in enhanced staging and improved selection for surgical intervention. Endoscopy of the pancreas via both ERCP and endoscopic ultrasound has led to unprecedented access and potential for non-operative intervention. Pancreatic surgery now takes advantage of both minimally invasive approaches and techniques learned from organ transplantation. These latest advances are addressed in this issue by key opinion leaders.

The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.

Advocate For Your Care It's expected that you will have questions about biliary cancer upon diagnosis. Whether it's your own diagnosis or a diagnosis of a loved one, this easy-to-read guide provides invaluable practical knowledge such as help for preparing to meet with an oncologist, seeking a second opinion, and understanding clinical trials. 100 Questions & Answers About Cholangiocarcinoma, Gallbladder, and Bile Duct Cancers is a resource that empowers patients and caregivers with the information needed to navigate their treatment with realistic goals for a good quality of life and targeted long-term survivorship. The perspective of patients and doctors is provided in this book with comprehensive answers to the most asked questions with added guidance for support and access to support services. You are the best solution to your cancer care.

Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. The field of gastrointestinal bleeding is rapidly evolving. The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. The initial management has rapidly evolved with new transfusion thresholds, the use of risk stratification scores and no more nasogastric tubes. There is new data and recommendations on optimal timing of endoscopy. Medical therapies have also evolved with changes in proton pump inhibitor administration and the use of prokinetics to improve endoscopic visualization. Many modifications in endoscopic therapy have recently been advanced including the use of endoscopic ultrasound guided angiotherapy, topical sprays (i.e. Hemospray) and over-the-scope clips. In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding.

Short bowel syndrome (SBS) is a pathologic condition which is characterised by reduced intestinal length and diminished intestinal absorptive capacity mainly due to extensive surgical resection, congenital defect, or pathological process affecting the small bowel. In recent decades, a better understanding of the underlying pathophysiology, new and modified surgical techniques and improvements in enteral and parenteral nutritional support improved the results of therapy of patients with SBS. This book provides research on the etiology, symptoms, surgical options and outcomes, and complications of SBS.

Master the evaluation and treatment of swallowing disorders! Dysphagia: Clinical Management in Adults and Children, 3rd Edition provides the information you need to diagnose and manage dysphagia in patients of all ages. Emphasizing evidence-based practice, this complete resource covers topics from esophageal disorders to respiratory and iatrogenic disorders. This edition adds a new Aging and Dysphagia chapter and is updated with the latest research and advances in dysphagia management. Written by speech-language pathology educators Michael E. Groher and Michael A. Crary, this guide helps you develop clinical reasoning skills and learn today's best practices in dysphagia management. Learning features include chapter outlines, learning objectives, and bullet-point summaries in each chapter, helping you focus on and master key content. Emphasis on evidence-based practice prepares you to make and then properly support your diagnostic and treatment decisions. Case histories promote critical thinking in realistic clinical situations. Critical thinking questions help you assess your knowledge and reinforce understanding of the material. Video clips on the Evolve companion website depict a range of swallowing disorders. NEW! Aging and Dysphagia chapter examines the increasing evidence that older persons living at home may be at risk for dysphagia without any overt underlying disease. UPDATED! Treatment for Adults chapter is thoroughly revised. NEW! Clinical Pearls highlight key information that you need to know to prepare for the clinical setting. UPDATED content and references throughout reflect the latest research in the field.

This book provides a comprehensive overview of the epidemiology, clinical features, radiology, classification, molecular genetics, diagnosis and treatment of gastrointestinal stromal tumors in both adults and children. Various chapters of the book summarise all the important research findings and provide an updated text for all those involved in the research and clinical management of this tumor. This book is written by experts in the field from all over the world who have considerable research, clinical interest and experience in the management of this tumor. The book is a concise review of the relevant basic and clinical research on gastrointestinal stromal tumors, and provides a summary of their current classification, diagnosis and treatment strategies in both adults and children. It intends to provide a deep insight into the current knowledge on the subject and summarises all the important relevant data. It contains numerous radiologic and pathologic images, research illustrations and data that is valuable in the overall understanding of all aspects of this important tumor. This book is intended for researchers, students, paramedical staff, patients and doctors involved in the management of patients with this tumor, including gastrointestinal physicians, pediatricians, oncologists, surgeons, radiologists and pathologists. By reading this book, patients gain insight into the management of their own tumors, students find a platform on which they can build their research projects, and nurses and doctors maintain an overall understanding of the subject.

Probiotics, a word of Greek origin composed of "pro" (promoting) and "biotic "(life), have been defined by the Food and Agriculture Organization of the United Nations (FAO) as "live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host". Over 500 different types of bacteria reside in the human digestive system. In recent years, the study of intestinal microbiota and therefore the use of probiotics have been extensively studied in promoting health, as well as in treating several diseases and not solely regarding the gastrointestinal system. This book summarises the more recent knowledge about intestinal microbiota, its pathological correlations and the use of probiotics in children for the maintenance, recovery, and strengthening of healthy strains at the expense of bad ones.

Intestinal transplantation remains on the cutting edge of solid organ transplantation. Each potential recipient provides a unique case of intestinal failure with individual intricacies requiring the combined efforts of a complex multidisciplinary team in order to achieve success. Contemporary Small Bowel Transplantation covers all aspects of intestinal transplantation in a manner accessible to all providers and provides specific guidance for those that may come in contact with this field and these patients. The text provides an understanding of the critical pre-operative evaluation, thorough descriptions of each surgical procedure and postoperative management. Areas such as infectious disease, nutrition and graft versus host disease will be addressed in detail. Key controversies and administrative issues unique to intestinal transplantation are covered. Contemporary Small Bowel Transplantation provides critical guidance for the new transplant surgeon, gastroenterologist or administrator as they navigate the challenging field of intestinal transplantation.