The aim of this Atlas is to present the three-dimensional arrangement of the liver structures, which should be familiar to those who diagnose and treat diseases of the liver, particularly in an era when the methods of diagnostic imaging and surgical treatment are becoming increasingly sophisticated. For this purpose a series of corrosive preparations of the blood vessels and bile ducts of the liver was made and photographed. In addition to the normal situations, many frequent and rare variations are shown. The Atlas also shows some blood vessels that have not been adequately described or are not well-known in the reference literature, but are nevertheless of great importance in performing segmental liver resections.This Atlas takes a fresh approach to the subject. The method used allows the size, three-dimensional arrangement and structure of the blood vessels and bile ducts of the liver to be preserved. The majority of photographs were taken from the direction from which surgeons see the liver during an operation. This, together with the schematic presentations complementing most of the photographs, gives a further instructional value to the work. With colour photographs and explanatory text, the Atlas forms a basic guide to orientation inside the liver parenchyma, to understanding and diagnosing certain pathological processes and to planning surgcial procedures.

Presenting patient- and problem-oriented review articles, this series is designed to keep the internist, general surgeon, and specialist in gastroenterology and hepatology abreast of the latest advances in the field.

Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states. This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to treat a diversity of inflammatory and degenerative conditions.

This book, Mechanisms in the Pathogenesis of Enteric Diseases 2, is an out come of the Second International Rushmore Conference on Mechanisms in the Pathogenesis of Enteric Diseases, held September 3D-October 3, 1998 in Rapid City, South Dakota, USA. Its chapters represent many of the reviews and papers presented at the conference. The meeting was organized by members of the North-Central Regional Research Committee "NC-62", a consortium of researchers of bovine and swine enteric diseases from land-grant institutions supported by the United States Department of Agriculture. The Rushmore Conferences were conceived as a forum for an interdiscipli nary discussion of mechanisms of infectious enteric diseases. It was intended that such a discussion would stimulate cross-pollination of ideas, and nurture synergistic collabora tions among scientists who might otherwise not interact. Enteric diseases are caused by widely divergent pathogens and parasites in broadly different settings, and affect multi ple organ systems. Some enteric diseases affect a single species, while others may affect multiple species, perhaps including human beings. Some enteric diseases were present in antiquity, while others have recently emerged. Knowledge regarding a particular disease or pathogen has frequently proven useful in understanding another disease or pathogen, because common themes in pathogenesis exist. As this knowledge base grows,strategies in the prevention and control of various enteric diseases often converge. Cross-discipli nary discussions and collaborations facilitate growth of this knowledge base, as well as development of tools for disease interdiction.

Hepatitis viruses research started more than fifty years ago. The names of hepatitis A and hepatitis B were introduced in 1947 when it became clear that there were two types of hepatitis that were transmitted either enterically or parenterally. It became apparent in the 1970's that there were additional hepatitis viruses distinct from hepatitis A and hepatitis B, and thus, the term non-A, non-B hepatitis was introduced. The non-A, non-B hepatitis was further divided into post-transfusion non-A, non-B hepatitis and enterically-transmitted non-A, non-B hepatitis in the 1980's. By the end of the 1980's, both post-transfusion non-A, non-B virus and enterically-transmitted non-A, non-B virus had been identified and renamed hepatitis C virus and hepatitis E virus, respectively. Hepatitis delta antigen was first recognized as an antigen associated with hepatitis B virus infection in the 1970's. In the early 1980's, a virus was isolated and named hepatitis delta virus. These five different hepatitis viruses have distinct replication pathways and are major health concerns. They have become an important topic for teaching to graduate-level and medical students.Hepatitis Viruses provides a comprehensive, up-to-date review of these viruses to readers. Each chapter is written by one of the top researchers in the field, and topics include: * the epidemiology and the natural history of infection of these viruses, * the molecular biology and the replication cycle of individual hepatitis viruses, * host-virus interactions and the pathogenesis of hepatitis viruses, * the immunology of hepatitis viruses, * the relationship between hepatitis viruses and hepatocellular carcinoma, * the viral vaccines and antiviral drugs. This book can serve as a supplemental reading material to graduate students and medical students, and to any researcher who would like to learn more about hepatitis viruses.

Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

Pancreatic Disease: Basic Science and Clinical Management summarises the state of the art in basic science and clinical management of pancreatic disease. This book provides a clear and up-to-date review of the advancing areas in clinical pancreatology and clinical research related to the pancreas. Written by leading experts in the field, this comprehensive review directs the interested reader towards important and current published source material. Covering all aspects of pancreatic disease, contributions are included from pancreatic surgeons and medical pancreatologists on pancreatic cancer, acute pancreatitis and chronic pancreatitis. Special features include a systematic review of the evidence for the use of gemcitabine in pancreatic cancer prepared for the National Institute of Clinical Excellence (NICE), the UK body charged with evaluating new drug treatment. Gemcitabine has FDA approval. There are several contributions dealing with the management of pancreatic neuroendocrine tumours. This book will be useful to gastroenterologists, internists and surgeons, and specialist clinicians with an interest in pancreatic disease. Trainees in medical and surgical pancreatology will find it a companion to supplement standard textbooks.

Now that Helicobacter pylori is generally accepted as a key aetiological agent in gastric cancer as well as the main agent in peptic ulcer, it can claim to be the most important new discovery in clinical gastroenterology of the last decade, and yet there is no up-to-date book available on the subject that is designed primarily for the clinical gastroenterologist. This book aims to fill that niche. It should also be of interest to the basic scientist, to those providing a clinical laboratory service (microbiologists and histopathologists), and to epidemiologists and others involved in clinical research.

The past 20 years have seen a surge of research into colorectal cancer, which is a reflection of the need to improve our methods of treating patients suffering from this increasingly common form of cancer. Greater knowledge of the basic mechanisms involved in colorectal carcinogenesis is an essential prerequisite to improvements in cancer prevention. In this volume the editors have brought together an impressive list of experts to cover the epidemiology, pathophysiology, morphology and basis for new diagnostic and therapeutic approaches to early detection and prevention. This broad scientific approach provides the reader with up-to-date review of our current state of knowl edge of colorectal carcinogenesis and indicates how this information can be used to generate more research and create new opportunities for diagnosis and treatment. This is a book of knowledge and ideas, some of them still at the stage of theoretical interest, but others with practical potential for the care of patients. I recommend it to those who have a research interest in colorectal carcinogenesis, as well as to readers who wish to know just how far medical scientists have progressed in their efforts to achieve the ideal of cancer prevention."

Clinical experts synthesize for the practicing physician all the important developments that have occurred recently in the diagnosis and treatment of acid-related diseases. They address the evaluation of patients suspected of harboring both peptic ulcers and ulcers from other causes, with emphasis on novel aspects of H. pylori infection. New information is also provided to assist clinicians in efficiently managing patients with dyspepsia and in the diagnosis and treatment of gastroesophageal reflux disease (GERD), including its extraesophageal manifestations and upper gastrointestinal bleeding. Authoritative and highly readable, Diseases of the Gastroesophageal Mucosa: The Acid-Related Disorders distills a wealth of cutting-edge clinical practice into one readable volume that will help every clinician manage patients with today's best diagnostic and treatment practice.

Leading experts in the fields of gastroenterology, surgery, and radiology comprehensively review the pathophysiology, diagnosis, management, and treatment of acute bleeding disorders of the GI tract. The authors break down acute bleeding into upper and lower GI tract sources and provide a differential diagnosis for each disease, evidence-based algorithms for clinical practice, treatment modalities for its management, and standards of care. The authors outline the many dilemmas faced by physicians in their approach to their patients, such as localization of the bleeding source (upper vs lower), the need and timing for emergency endoscopy, and the timing for radiologic intervention and/or surgery.

- Unlike previous atlases that deal with overall surgical techniques, this book goes into greater detail and focuses on individual cases.

- Lavishally illustrated with 534 illustrations, 133 of which are in color.

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****VERKAUFSKATEGORIE*** 0 e

"Neuropeptides and Stress" presents a comprehensive survey by leading pioneers in the field of the knowledge and concepts implicating neuropeptides in the regulations of responses to stress. Topics covered include: recent advances on the regulation and modulation of the behavioral, endocrine, autonomic, gastrointestinal, immune and analgesic responses to stress by neuropeptides. Neuroanatomical and biological data are considered. Special emphasis is given to corticotropin-releasing factor (CRF) and opioid peptides.

by Mario Banche, M.D. IX The neologism "coloscopy" (colonscopy, colonoscopy) is the latest addition to the vocabulary of endoscopy of the large intestine. just as the term "duodenoscopy" was in endoscopy of the upper digestive tract a few years ago. With the advent of the coloscope it is now possible to examine the large bowel more extensively and effectively than was formerly possible with the use of its rigid forerunner, the rectosigmoidoscope. The earliest rectoscopes, 11 endoscopes" introduced during the 19th century by Segales and Desormeaux (1826, 1853), were conceived for many uses-inspection of the urethra, bladder, uterus, rectum. Successive improvements eventually led to the construction of an instrument designed exclusively for endoscopy of the rectum and sigmoid colon (Bensaude, 1907). Over the following years the rectoscope underwent no substantial change and thus an abundant and homogeneous literature accrued in which the available instruments and their use were described while the endoscopic pathologic nosography and corresponding endoscopic pictures of the rectum and sigmoid colon were codified, illustrated first by simple sketches and later by still and motion photography. The literature contains many excellent publications, some in monograph form.

This volume reviews the most recent knowledge in the field of gastrointestinal motility in health and disease. The topics addressed include basic as well as clinical data concerning the motor functions of the entire gut: the lower oesophageal sphincter and the gastro-oesophageal reflux; the gastric emptying and the role of the pylorus; the motility of the biliary tract and its disorders; the cyclic motor activity of the gut and intestinal transit; the colonic and ano-rectal motility. There are also impOltant contributions in physiology and pharmacology relating to the neurohumoral regulation of the gut, and the function of digestive smooth muscle. Several papers explore the nature of the linkage between brain and gut. a link which has long been deduced by clinicians but not, until recently, systematically explored by scientists. The individual papers, selected from a large number of submissions, have been subject to 'peer-review' by an inter national committee which includes both cliniCians and basic scientists. Therefore this book should serve as an up to date source of information for researchers concerned with basic sciences as well as for clinicians in gastroenterology, medicine and surgery. C. Roman v This volume is dedicated to the memory of two friends and colleagues: Professor Dr J. HELLEMANS Professor Dr H. MONGES Acknowledgments This was the 9th of this series of symposia held alternatively in Europe and North America, and the first to be held in France."

International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.

This volume provides a history of Eosinophilic Esophagitis (EoE), a basic understanding of the physiology of the eosinophil, and a current understanding of the pathophysiology and genetics of EoE. The emphasis is on clinical applications including presenting symptoms, diagnosis and treatment options for patients with EoE. Written by both pediatric and adult experts in the fields of gastroenterology, allergy and pathology, this volume includes the most up to date information. Providing practical information useful in the treatment of patients, this book will be of great value to gastroenterologists, allergists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with eosinophilic esophagitis.

A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selection of the subjects discussed. The comparison between the two volumes tells something about the advancement in the time interval in knowledge about liver and biliary tract diseases, about the turnover of researchers interested in the liver and its diseases, and also about the present philosophy in biologic science. For this com parison, this volume is particularly suited because, in contrast to many other recent conferences, the more leisurely pace of the NATO Institutes permits more comprehensive but still scholarly reviews of the problems. The foreword of the first volume, written by my colleague, the late Harry Sobotka, expresses his, now dated, astonishment about the progress of knowledge of biology of the bile, so much less accessible to study than urine."

Gallstone disease has afflicted man since antiquity, but only in the past decade has it been recognized as a major health problem and been the subject of widespread investigation. This investiga tion, initiated by the definition of the limits of cholesterol solubility in bile, has led to our current understanding of the pathogenesis of gallstone formation and has provided the hasis for a rational approach to the in situ dissolution and prevention of cholesterol gallstones. This volume comprises the papers and discussion which formed the Fourth International Syrnposium of the Canadian Foundation for Diseases of the Liver. The Syrnposiurn, held in Montreal on May 12 and 13, 1978, was designed to bring together investigators from various disciplines and to review the current status of cholesterol gallstone disease. The Editors wish to thank these experts for their lucid and important contributions. We also wish to thank Valerie M. Price and Dianne McFee, of the Canadian Foundation for Diseases of the Liver, for their considerable and expert help in organizing the meeting, and preparing this volume for publication."

Experts from Europe, Japan and the United States have contributed to this in-depth volume on digestive disease pathology. Each chapter contains numerous electron micrographs, often supplemented byline drawings, and extensive references to the literature.The clear illustrations and text are an excellent aid for the diagnosis of pathological entities in the gastrointestinal tract.

Gastrointestinal Surgery: Pathophysiology and Management is an invaluable reference text for surgeons and surgical trainees. Written entirely by Dr. Haile T. Debas, Dean of School of Medicine and former Professor and Chairman, Department of Surgery, at the University of California, San Francisco, this book provides the unified approach only found in a single-authored text. Based on the three pillars of understanding particular disease processes -- fundamental anatomy and physiology, pathopysiology, and clinical correlations -- surgical treatment of GI disease is presented as the means to correct abnormal physiology and restore health. Using an integrated approach of basic science and clinical practice, Dr. Debas allows the student of surgery to gain a solid understanding of disease processes that minimizes the need for rote memorization. Thirteen lavishly illustrated chapters cover the GI system as well as gastrointestinal peptides and peptide-secreting tumors, abdominal trauma, the abdominal wall, surgery for morbid obesity, the liver, spleen, retroperitoneum, and perioperative care. Dozens of summary tables throughout each chapter condense "essentials" for quick reference. Comprehensive discussions of clinical disorders review the surgical treatment options. With 400 illustrations and tables, including hundreds of anatomical line drawings commissioned exclusively for this textbook, Gastrointestinal Surgery provides a clinical and therapeutic approach to surgical diseases which will prove invaluable to the surgical trainee and the practitioner preparing for recertification.

In the spring of 1987, nearly 350 individuals gathered in a hotel in Bethesda, Maryland, just outside of Washington, D. C. , to participate in a two-day medical symposium devoted to the topic of liver diseases. A small minority of this group had been attracted by what promised to be an outstanding Continuing Medical Education course. The remainder, however, although obviously interested in the content of the symposium, had come primarily to honor a man who, over the years, had profoundly touched them, personally or professionally, for the course had been conceived as a tribute to an exceptional man of medicine, a man with remarkable scholarly and personal attributes: Hyman J. Zimmerman. Dr. Zimmerman, referred to affectionately by all as Hy, was born in 1914 in Rochester, New York, the city in which he received both his early schooling and his undergraduate education. In the late 1930s, he moved to Palo Alto to begin his medical education at Stanford University, from which he graduated cum laude in 1942, having spent an additional year acquiring a masters degree and as World War II in bacteriology. Almost immediately thereafter, he entered military service, was in progress, was assigned to duty in France. Soon after his arrival, he was made chief of an Army field hospital. A major medical problem plaguing U. S. troops at the time was viral hepatitis, which resulted in a deluge of patients admitted to his hospital.

Liver surgery has made extraordinary progress over the past 40 years, evolving from the first, timid partial resections in the 1950s to today's major resections and organ transplants. Examining the rea- sons for this progress, one cannot but be impressed by the substan- tial role that has been played by radiology. Formerly, preoperative planning was based on only nebulous scintigraphic scans. Today, surgeons have at their disposal a wide variety of radiological modalities for diagnosis and topography which are precise enough to exclude most operative surprises. Fur- thermore, the radiologist is becoming increasingly involved in ther- apy: prior to operation for tumor reduction by embolization and after resection for treatment of local complications - which could otherwise necessitate difficult and occasionally dangerous reoper- ations. As the author writes in his preface, it is not really astonishing that a radiologist is publishing a book on this topic, and he must be congratulated for his work-up, which combines important personal experience with a complete analysis of published papers on this topic.