Inflammatory bowel disease - i.e. ulcerative colitis and Crohn's
disease - not only creates significant patient morbidity but also
imposes a diagnostic and therapeutic challenge to the physician in
charge of these patients. Since the development of sulphasalazine
by Dr Nanna Svartz in Sweden half a century ago, important
improvements in the prognosis of ulcerative colitis and Crohn's
disease have been achieved. This book makes an attempt to present
and discuss some of the most recent advances in diagnostic
procedures and therapeutic approaches to inflammatory bowel disease
with special respect to Crohn's disease. Although the fmal
diagnosis of ulcerative colitis and Crohn's disease is generally
based on endoscopic, histological or X-ray examinations, nuclear
medicine and its imaging procedures have established their place in
certain aspects of inflammatory bowel disease. One chapter of this
book is dedicated accordingly to the indications of nuclear
diagnostic procedures in the clinical setting. Sulphasalazine has
been the mainstay of medical therapy in ulcerative colitis and
Crohn's disease of the colon. Recently 5-aminosalicylic acid has
been discovered to be its active compound and sulphapyridine was
found to be the component responsible for most of the adverse
effects of sulpha salazine. It is not surprising that many studies
have investigated 5-amino salicylic acid as a single therapeutic
agent in inflammatory bowel disease."
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