Diseases of the pancreas have been extremely difficult to study. Until relatively recently, the pancreas was viewed by surgeons as an organ to be avoided, given its deep retroperitoneal location and the sometimes severe consequences of manipulation. Similar difficulties have plagued careful study of the pancreas. In humans, only inf- quently have we had the opportunity to evaluate the evolution of d- eases of the pancreas; instead, we are confronted with end-stage chronic pancreatitis or acute pancreatitis with extensive necrosis of the gland. Within the past decade, revolutionary techniques in molecular biology, genetics, and animal models have begun to give us dramatic new insights into pancreatic disease. Coupled with these advances has been a slow but steady progress in the development of our clinical tools for diagnosing and treating pancreatic diseases. These advances place us on the threshold of a much more complete understanding of pancreatic diseases, opening up new opportunities for novel therapies and preventive measures. Pancreatitis and Its Complications brings together many of the world's experts in pancreatic diseases. These "pancreatologists" include basic scientists, endoscopists, gastroenterologists, and surgeons. The ch- ters have been organized to provide a comprehensive discussion of acute and chronic pancreatitis, with up-to-date discussions of pat- physiology, epidemiology, diagnostic strategies, treatment, and c- plications of disease. It is hoped that this text will serve as a useful reference for clinicians as well as provide a clinical background for scientists with an interest in pancreatic or related diseases.

Similar to the first edition, the goal of Mayo Clinic Gastrointestinal Imaging Review, 2nd Edition is to provide an atlas of common abnormalities that affect the gastrointestinal tract. This comprehensive review includes all imaging modalities used within GI radiology, as well as plain radiographs, fluoroscopy, ultrasound, CT, MR, angiography, and nuclear medicine. Focusing solely on adult conditions, the book is divided into 13 chapters covering a separate organ within the gastrointestinal system and a final exam chapter reviewing all chapter content. Each organ-focused chapter is subdivided into sections related to diseases or findings of that organ. Running headers allow the reader to rapidly identify the chapter and the section being viewed.
Large, high-quality images are presented in a format so that they can be reviewed as unknowns. A discussion of the cases is presented as if it were a consultation-- with a description of the findings, differential diagnosis, and final diagnosis. A brief discussion of the disease is included. Emphasis is placed on brevity of the text and a single-page layout for all but a few cases. Study guides at the end of each section are in the form of tables summarizing major radiographic findings into differential considerations with brief imaging clues to a specific diagnosis and case references within the book. The end of each chapter lists differential diagnoses for the chapter's specific organ. Full-color composite anatomical illustrations show the immediately obvious appearance of common conditions that correlate with major radiologic findings.

Gastroenterology and Hepatology Lecture Notes is a comprehensive yet easy-to-read overview of luminal gastroenterology and hepatology. Covering the epidemiology, causes, clinical features, investigation, treatment and prognosis of all the main gut and liver conditions, it is ideal for both exam preparation and fact finding. Key features include: A full range of new illustrations, including clinical photographs and scans, that clearly demonstrate signs and symptoms Sections on anatomy, physiology, pharmacology, and epidemiology written to enhance understanding of clinical features Essential information highlighted throughout the text Case-based self-assessment for each chapter helps retention of knowledge and puts it in its clinical context A new section of best answer MCQs New chapters on inflammatory bowel disease and different diagnosis of the upper GI tract Includes a companion website at www.lecturenoteseries.com/gastroenterology featuring 16 in-depth case studies Whether learning the basics of the gastrointestinal system, starting a general medical or gastroenterological placement, or looking for a quick-reference overview to revise key concepts, Gastroenterology and Hepatology Lecture Notes is an ideal resource for medical students, MRCP or FRACP candidates, and junior doctors.

Offering 171 unique cases, Gastrointestinal Imaging Cases features over 700 high-quality images. The clinically relevant cases cover both benign and malignant conditions and are grouped into 12 sections organized by the parts of the Gastrointestinal System including: the Pharynx and Esophagus, Stomach, Duodenum, Small Intestine, Appendix, Colon, Rectum, and Anus, Liver, Gallbladder, Bile Ducts, Pancreas, Spleen, and Mesentery and Peritoneum. Within each section, the cases appear in a random order to facilitate the self-assessment experience of reading cases as unknowns. Each case is complete with pertinent findings, differential diagnoses, management recommendations, teaching points, and suggested further reading. This comprehensive, yet easy-to-follow, casebook is an ideal tool for the resident preparing for the boards, the fellow for recertification exams, or the radiologist in need of a quick review.

International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.

There have been significant developments in the fields of gastroenterology and hepatology since the previous edition and this new edition has been entirely revised, updated and considerably expanded. The format and layout have also been updated to include key points at the start of each chapter, bulleted lists and text boxes for tips and warnings.

A new author team - which, for the first time, is international - has brought a new global perspective to this book.

This is still the leading book for trainees/fellows in gastroenterology and hepatology, as well as junior doctors and general medicine interns. The series title is 'Pocket Consultant' - and that's exactly what the reader gets - the advice and guidance of a consultant on hand when and where they need it.

Each volume in this richly illustrated series, sponsored by the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytologic and histologic diagnosis of small tissue samples including fine-needle aspiration biopsy, cell block samples and core, pinch and forceps biopsies. This volume provides a practical approach to preparing and assessing pancreatic aspiration, core biopsy and brushing samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format supported with high-resolution color photomicrographs, tables, tabulated specific morphologic criteria and appropriate ancillary testing algorithms. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This unique series strengthens the bridge between surgical pathology and cytopathology, providing the pathologist with the ability to diagnose small tissue samples with confidence. The CD-ROM packaged with the printed book contains all the images in a downloadable format, making this a valuable resource for practicing and trainee pathologists.

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hoekfelt and V.C. Jordan.

The Guest Editors for this issue have assembled top experts to discuss only those most challenging aspects of diagnosis and treatment of inflammatory bowel disease.? Emphasis is on comparing treatment paradigms, current and future biologics agents, safety profile of therapeutics, and novel diagnostic and prognostic tools for IBD.? Articles are also devoted to pregnancy and IBD, IBD in children, and post-operative management of IBD.

IBS, which affects almost one in six Americans, is characterized by abdominal pain, bloating, gas, and diarrhea or constipation. Today more than ever before, physicians are able to diagnose this complex disorder, understand and explain its origins, and develop a treatment plan that effectively meets the individual needs of a patient. Drawing on his many years of experience treating people who have symptoms of IBS, Dr. Brian E. Lacy explains normal digestion, the causes of IBS, how IBS is diagnosed, and what to expect with treatment. He also explores special topics such as IBS in children and psychological, hypnotherapeutic, and psychiatric therapies. Important new information in the second edition includes: the roles of fiber, gluten, lactose, and fructose in the development and treatment of IBS; the use of probiotics and antibiotics to treat IBS; similarities and differences between IBS and inflammatory bowel disease (IBD); the relationship between small intestine bacterial overgrowth and IBS; how to make the most of your visits to a gastroenterologist; and lifestyle modifications that can improve symptoms of IBS. Making Sense of IBS is an essential resource for anyone who has symptoms or a diagnosis of IBS as well as for health professionals who treat people with this complex disorder.

Esophageal Cancer and Barrett s Esophagus, 3E, focuses on these two common and key conditions that affect the esophagus, providing expert guidance to their pathogenesis, cause, prevention, diagnosis and clinical management. Top international names in the field examine each of the many issues involved, using the very latest evidence-based research, and clear, didactic advice allows the reader to understand the best methods of diagnosis and clinical management of each condition whether early or late stage. Well-illustrated and fully revised to include the latest in ACG/ASG/UEGW guidelines, it is the perfect consultation tool for gastroenterologists and oncologists managing patients with cancer of the esophagus. It is also ideal for teaching residents and fellows optimum patient management, and for identifying areas requiring future research.

Many gastroenterologists are presented with patients complaining of one or more of several anorectal symptoms. Patients expect that a gastroenterologist can treat their symptomatic hemorrhoids or anal fissures or diagnose accurately their rectal bleeding. Today the evaluation and treatment of these common ailments is not included within the core curriculum of most gastrointestinal fellowship training programs, and therefore has not been incorporated into a typical GI practice. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference looks to fill that void. Dr. Waqar Ahmed Qureshi states that most of these perianal and anorectal problems can be successfully treated non-surgically. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference reviews a number of diseases that gastroenterologists should be able to effectively manage in their office, which eliminates extra cost, inconvenience, and frustration for their patients. A few of the topics that can be found inside: Anatomy and Examination Anatomy and Physiology of the Pelvic Floor Benign Anorectal Conditions Hemorrhoids, Anal Fissures, and Anal Pruritus Benign Soft Tissue, Perianal, Perineal, and Complicated Conditions Pilonidal Disease, Aanorectal IBD Management, and Defecation Disorders Neoplasms Anal Carcinoma and screening high-risk groups The gastroenterologist occupies a unique position between conservative treatment offered by primary care physicians and the more invasive procedures offered by the surgeon. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference is designed to provide a comprehensive understanding of anorectal diseases that they can manage and, therefore, improve the care of their patients in one comprehensive volume.

Gastroenteritis viruses are a major cause of morbidity and mortality in humans. Many hundreds of thousands of children die annually from rotavirus diarrhoea in the developing world, and although in industrialized countries rotavieus infection is rarely fatal, the economic burden of the disease is substantial. Human caliciviruses have emerged as a significant cause of viral gastroenteritis globally. This book contains presentations and discussions by internationally recognized experts on virus structure, replication, pathogenesis, immune response and correlates of protection, molecular-epidemiological surveillance, advances in treatment, and efforts to develop vaccines, particularly against rotavirus disease. The spectrum of viruses covered comprises rotaviruses, human caliciviruses, astroviruses, coronaviruses and viruses causing gut disease in the immunocompromized host. The book not only conveys facts but also gives ample room to lively discussions on many issues at the forefront of research and development.

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication, and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.

This book provides specialist and general nurses with a comprehensive guide to the art and science of stoma care nursing, from the Association of Stoma Care Nurses UK, the only association for SCNs in UK. The chapters follow a schematic outline of knowledge required for nurses caring for patients who are undergoing stoma surgery; from the essence of nursing to the management of patients living with a long term condition. It also presents and discusses the issues surrounding the clinical picture such as prescription and community issues as well as sources of support available for patients. This text serves as an excellent resource for all disciplines of health care staff caring for individuals living with a stoma.

This book concisely summarises non-neoplastic gastrointestinal (GI) pathology and provides histopathologists aiming to refresh or expand their knowledge with a practical approach to the interpretation of biopsies. It focuses on GI biopsies, but also covers the pathology of resections and other organs where appropriate. The editor and contributors bring their expertise as practicing diagnostic pathologists across Europe and the US. Examples of topics include inflammatory bowel disease, infections, vascular disorders, and inflammatory conditions specific to various anatomical sites. Fact sheets, practice points and tables facilitate rapid assimilation of information and enhance the reader's experience, and with additional access to the full online version, including expandable images on Cambridge Core; achieve accuracy every time. High-quality illustrations are also numerous, and references are relevant and reliable. This book is a practical, readable and up-to-date asset for any pathologist encountering GI biopsies.

This book provides a comprehensive state-of-the art overview on the main trends in the newest endoscopic, robotic, and minimal invasive surgical innovations. It also aims to give insight on some of the innovative ideas around Gastro-intestinal Surgery and Endoscopy to stimulate further activities. It contains established knowledge in the field of endoscopic and surgical techniques, and the integration of these new findings in updated therapeutic decision making are demonstrated. The text reviews the latest literature on the subjects and describes the decision making to establish new therapeutic options in the management of diseases applying new technologies. These new techniques are described in detail, which provide excellent back-up information for clinicians in daily practice. Written by experts in the field, Innovative Endoscopic and Surgical Technology in the GI Tract is a valuable resource of knowledge for clinicians, surgeons, nurses, technicians, students and researchers with an interest in GI- disease.

Gastroesophageal Reflux Disease (GERD) is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers ("pepcid, zantac") and proton pump inhibitors ("nexium, prevacid") has given physicians an excellent method of treating the symptoms of acid reflux.
Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.
The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together a vast amount of disparate literature and presents the entire pathogenesis of reflux disease in one place. In addition to providing a new concept of how gastroesophageal reflux causes cellular changes in the esophagus, GERD also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information about reflux disease and its treatment are presented. GERD is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.
*Outlines how gastroesophageal reflux causes cellular changes in the esophagus
*Brings together the pathogenesis of the disease in one source and applies it toward clinical treatment
*Tom DeMeester is THE leading international expert on reflux disease; Parakrama Chandrasoma is one of the leading pathologists in the area
*Book contains approximately 350 illustrations
*Ancillary web site features color illustrations: www.chandrasoma.com

Recent discoveries and clarifications of known information about the mesentery have now established that these complex structures function together as an individual organ within the human body. As such, conditions that affect the mesentery can now be grouped within a single area of study and clinical practice. The various aspects of mesenteric diseases have not been brought together in a single source and this book aims to bring them together for the first time. It will cover general areas such as anatomy, histology and physiology of the mesentery. A description of diagnostic procedures used to evaluate patients with mesenteric disorders will follow. A practical survey with detailed descriptions of medical, surgical, and neoplastic disorders of the mesentery is also be included. This book is intended to be a guide for clinical practitioners including gastroenterologists, general surgeons, colorectal surgeons, primary care physicians, nurse practitioners and physician assistants who manage patients with mesenteric disorders.

Gastrointestinal function represents an important, and hitherto inappropriately neglected, aspect of diabetes management. Disordered gastrointestinal motor and sensory function occurs frequently in both type 1 and type 2 diabetes and may be associated with gastrointestinal symptoms that adversely affect quality of life. During the last two decades there has been a rapid expansion in knowledge in this area. It is now recognised that upper gastrointestinal motility is pivotal to the regulation of postprandial blood glucose concentrations in both health and patients with diabetes. This book is the first of its kind and was stimulated by the need to consolidate these recent advances, which dictate that a knowledge of gastroenterology as it relates to diabetes is now required of the clinician/diabetologist.

• Features an organ-specific overview of the epidemiology and pathophysiology of disordered gastrointestinal (including hepatobiliary and pancreatic) function in diabetes mellitus

• Contains guidelines for the clinician, diabetologist and gastroenterologist for both diagnosis and management.

• Includes a comprehensive description of the relation between gastrointestinal function, gastrointestinal hormones, autonomic nerve function and glycaemic control in animal models.

• Covers the development of new treatment options, particularly those targeted at the reduction of postprandial hyperglycaemia, to optimise glycaemic control.

Target audience: gastroenterologists, diabetologists, specialist nurses and clinical researchers.