The application of molecular techniques to gastroenterology continues to yield important advances in the development of drugs to treat gastrointestinal disorders. Important new drugs have emerged through the collaborative and complementary efforts of basic scientists, clinicians, and clinical researchers in academia and the pharmaceutical industry. The challenge has been exciting, with a few surprises along the way. Consider peptic ulcer disease as an example. The discovery of H receptors and the availability of potent and 2 selective H-receptor antagonists signaled the beginning of a new era 2 in the treatment of gastric hypersecretory states and peptic ulcers. Introduction of proton pump inhibitors offered another therapeutic option. Though H-receptor antagonists and proton pump inhibitors 2 are important and useful drugs, the discovery of the link between H. pylori infection and peptic ulcer disease has led to even more effective pharmacotherapeutic regimens. Our intent in Drug Development: Molecular Targets for GI Diseases is to bring together hands-on experts to review promising areas of gastrointestinal pharmacology. The contemporary topics covered, from a mechanistic viewpoint, are relevant to gastrointestinal inflammation and motility disorders. Authoritative opinions are offered on both future research directions and potential applications for new therapies.

In offering this book to what we hope will be interested readers, we have several aspirations. We have aspired to present to students and clinicians a rather narrow view of epidemiology concentrating on the causal factors and setting of the more usual gastroenterological problems and giving greater space to conditions of importance for which major knowledge of causation andcourse is available. Part of the rationale is thebelief that modern medicine lays excessive emphasis on therapy with increasingly expensive, and in many cases, dangerous drugs and too little emphasis on the causes and avoidance of disease. We are of the view that traditional views handed st down through generations of clinicians need scrutiny worthy of 21 century medicine whose currency includes topics like nanomoles, megabytes and logistic regression. We hope that clinicians will see that there is often a practical application to the findings of epidemiological exploration and that what passes for canonical knowledge is so often unsubstantiated myth and are fully aware of the reluctance of organized medicine to reject old paradigms in favor of the new, matched by an often uncritical enthusiasm for new therapies. Our researches have increased our belief in the major role of social factors especially diet, both in quantity and quality in many disorders and that clinicians have a responsibility to provide appropriate advice to policy makers as well as patients.

- 'Big' book has sold close to 1400 in just over a year and is maintaining high rate of sale.

- This practical handbook fully explains the essentials of this state-of-the-art technique to radiologists, gastroenterologists, radiology residents, and technologists.

- Makes the key chapters of the big book accessible and affordable to the resident.

Ulcerative Colitis: The Complete Guide to Medical Management serves as the definitive source for medical management of ulcerative colitis (UC). Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with ulcerative colitis. Sections Include: * General o The role of the FDA in drug development; pediatric considerations; disease modifiers; and more * Medications o Antibiotic use in treatment of UC; oral novel biological therapies for UC; calcineurin inhibitors use in UC; novel biologic and non-biologic therapy for UC; and more * Specific Clinical Presentations o Medical management of toxic megacolon; management of extraintestinal manifestations; medical therapy of left-sided UC; use of prebiotics and probiotics; maintenance of remission; and more Features: * Color images, graphs, and tables * Extensive index that includes cross-referencing to Crohn's Disease: The Complete Guide to Medical Management * Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Ulcerative Colitis: The Complete Guide to Medical Management threads theory into practice and provides gastroenterology professionals with the most comprehensive information available. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Crohn's Disease: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.

Crohn's Disease: The Complete Guide to Medical Management serves as the definitive source for medical management of Crohn's Disease (CD). Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with Crohn's disease. Sections Include: * General o The role of the FDA in drug development; pediatric considerations; disease modifiers; and more * Medications o Antibiotic use in treatment of CD; oral budesonide; infliximab; novel biological and non biologic therapies for CD; and more * Specific Clinical Scenarios o Management of steroid unresponsive CD; management of enteric fistulae; use of pre- and probiotics; medical management of short bowel syndrome; maintenance therapy of CD; and more Features: * Color images, graphs, and tables * Extensive index that includes cross-referencing to Ulcerative Colitis: The Complete Guide to Medical Management * An appendix on Infliximab treatment * Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Crohn's Disease: The Complete Guide to Medical Management threads theory into practice and provides Gastroenterology professionals with the most comprehensive information available on this disease state. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Ulcerative Colitis: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.

Thanks to new tools of research and the heightened scientific rigor with which they are applied, medical science has reached a far more heightened understanding of nutrition s complex relation with digestive disease.
Nutritional Management of Digestive Disorders bring together the contributions of leading experts in nutrition and digestion to provide readers with a concise yet thorough record of the advances made in this area of research. In addition to discussing traditional areas of nutrition, it presents essential findings on more recent and novel therapies.

Specific Therapeutic Approaches to Specific Digestive Concerns

Among the specific topics, it describes celiac disease and eosinophilic esophagitis and their management through diet. It considers the role of nutrition in treating acute pancreatitis and liver disease, the role of macro- and micronutrients in preventing colon cancer, and the role of nutrition and dietary supplements in inflammatory bowel disease. Among emerging topics, it considers

• Guidelines for the use of probiotics to ease irritable bowel syndrome and antibiotic-associated diarrhea
• Bariatric surgery for the treatment of obesity
• Short bowel syndrome and small intestinal transplantation
• Expanding metal stents used to overcome malignant obstructions of the upper gastrointestinal (GI) tract
• Nutrition s role in treating acute pancreatitis and liver disease

Chapters in the book are dedicated to modern approaches to nutritional assessment, parenteral nutrition, and home nutritional support. Putting those recent developments into perspective, the book begins with a chapter that recounts the history of nutritional therapy in gastrointestinal disorders. Offering a cutting edge look at the field, Nutritional Management of Digestive Disorders provides researchers with critical data needed to conduct further research, while also providing clinicians with a look at new approaches to effective treatment.

Are you looking for concise, practical answers to questions that are often left unanswered by traditional cancer references that are not designed for gastroenterologists? Are you seeking brief, evidence-based advice for complicated cases or patients with complications that need management? Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a "curbside consultation" between colleagues. Dr. Douglas G. Adler has designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with GI cancer. The unique Q&A format provides quick access to current information related to GI cancer with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate the treatment of GI cancer patients. Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions provides information basic enough for residents while also incorporating expert advice that even high-volume clinicians will appreciate. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: * An 81-year-old man is found to have unresectable esophageal cancer and malignant dysphagia. Should he have a stent? A nasogastric feeding tube? A PEG tube? * How is tumor-related bleeding from gastric cancers best approached? * Do patients with pancreatic cancer and jaundice need to have an ERCP preoperatively? * What is the role of ERCP and EUS in patients with suspected cholangiocarcinoma? * Why are rectal cancers so different from colon cancers with regards to medical and surgical management? Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions illustrates how patients at different points in their treatment may go back and forth between specialists to receive coordination of care, and incorporates input from gastroenterologists, surgeons, radiologists, and oncologists. While providing up-to-date information, this book will help gastroenterologists to manage complex cancer-related issues and guide physicians through the maze of cancer-related treatments available. Ideal for practicing gastroenterologists, gastroenterology fellows, surgeons, oncologists, residents, and medical students, Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions is sure to benefit anyone caring for patients with gastrointestinal cancers.

Diseases of the pancreas have been extremely difficult to study. Until relatively recently, the pancreas was viewed by surgeons as an organ to be avoided, given its deep retroperitoneal location and the sometimes severe consequences of manipulation. Similar difficulties have plagued careful study of the pancreas. In humans, only inf- quently have we had the opportunity to evaluate the evolution of d- eases of the pancreas; instead, we are confronted with end-stage chronic pancreatitis or acute pancreatitis with extensive necrosis of the gland. Within the past decade, revolutionary techniques in molecular biology, genetics, and animal models have begun to give us dramatic new insights into pancreatic disease. Coupled with these advances has been a slow but steady progress in the development of our clinical tools for diagnosing and treating pancreatic diseases. These advances place us on the threshold of a much more complete understanding of pancreatic diseases, opening up new opportunities for novel therapies and preventive measures. Pancreatitis and Its Complications brings together many of the world's experts in pancreatic diseases. These "pancreatologists" include basic scientists, endoscopists, gastroenterologists, and surgeons. The ch- ters have been organized to provide a comprehensive discussion of acute and chronic pancreatitis, with up-to-date discussions of pat- physiology, epidemiology, diagnostic strategies, treatment, and c- plications of disease. It is hoped that this text will serve as a useful reference for clinicians as well as provide a clinical background for scientists with an interest in pancreatic or related diseases.

Pocket Guide to IBD, Second Edition is designed to provide quick clinical information for gastroenterologists, primary care physicians, physician assistants, and nurse practitioners who need to review symptoms, medications, and disease management, in order to decide effective diagnoses and treatments for their patients with IBD. Some of the topics covered are: * Special populations, including pregnancy and children * Vaccinations in the patient with IBD * Treatment of the infliximab refractory patient * Diagnosis and treatment of perianal disease * Care of the post operative patient Dr. Marla Dubinsky and Dr. Sonia Friedman have created this go-to reference for one of the most popular topics among practicing gastroenterologists and other GI and primary care providers. Features: * Comprehensive chapters in quick reference format * Symptom-based guide for diagnosis and treatment * Tables highlighting the full array of IBD medications * Charts and figures detailing complete treatment algorithms The Pocket Guide to IBD, Second Edition is unique in its size, accessibility of information, thoroughness, and clarity of content. This clinical guide will be the quick reference to turn to when treating patients with IBD.

This totally revised and enlarged new edition offers concise and well-structured chapters each focusing on the clinical, diagnostic, and therapeutic aspects of a condition commonly encountered by the coloproctologist and gastroenterological surgeon, who are faced with an increasing number of precise and specific treatment modalities. The comprehensive, yet easy-to-read, information in this practical guide on both common and rare anorectal and colonic diseases is particularly important for both the practitioner, who needs to know all the possible modalities of conservative and surgical treatment, and the surgeon, who needs to adapt his surgical procedure to the clinical and anatomical findings. Precise guidelines are given and surgical techniques illustrated. Each chapter is completed with up-to-date references and a self-assessment quiz, and a DVD is included.

about the book... Standing alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging chapters and spans basic concepts in pharmacology, neurobiology, physiology, and psychology to provide a practical approach to the treatment of chronic pain. Examining a condition that affects up to 25% of the general U.S. population, this source is the only book on the subject to cover both clinical syndromes and neurobiology...ranges from basic mechanisms to diagnosis and clinical treatment of specific syndromes including inflammatory bowel disease, functional abdominal pain, dyspepsia, non-cardiac chest pain, and pelvic pain syndromes...analyzes the latest scientific advances including the role of functional imaging in patient care...integrates fundamental scientific concepts with a practical clinical approach...and supplies 250 figures, and more than 16 color photographs. about the editors... PANKAJ JAY PASRICHA is Chief, Division of Gastroenterology and Hepatology; Bassel and Frances Blanton Distinguished Professor of Internal Medicine; and Professor of Neuroscience and Cell Biology and Biomedical Engineering; University of Texas Medical Branch (UTMB), Galveston. Dr. Pasricha also heads the Enteric Neuromuscular Disorders and Pain Center at UTMB and has performed pioneering research in pain and motility disorders. Dr. Pasricha has served on numerous national gastroenterological committees and on panels for the National Institutes of Health. He received the M.D. degree (1982) from the All-India Institute of Medical Sciences, New Delhi, India, and post-graduate training in gastroenterology at the Johns Hopkins University Medical School in Baltimore, Maryland. WILLIAM D. WILLIS is Director, Cecil H. and

Diverticular disease first became recognised at the beginning of the 20th century and although the incidence of the disease is not known, it is considered to be a disease of the older person. This book looks at a disease that is known as a Western world disease, often called by surgeons a 'cinderella disease' as they often feel that there is little to offer the patient with uncomplicated diverticular disease.

The book endeavours to give the healthcare professional a holistic view of the care and pattern of diverticular disease, and chapters may be used as stand alone chapters for those wishing to know more about stoma care, alternative treatments or food management. This book is essential reading for healthcare professionals involved in the care of patients with this disease.

This book, the proceedings of Falk Symposium 152 a oeEndoscopy 2006 a" Update and Live Demonstrationa, held in Berlin, Germany, 4--5 May 2006 as part of the Intestinal Disease Meeting, provides an update on the entire spectrum of gastrointestinal endoscopy and its interface with gastroenterology as well as other disciplines. Endoscopy plays a pivotal role in gastroenterology and, vice versa, is crucially dependent on new developments and inventions in gastroenterology and basic sciences as well as technical progress.

The first section deals with the most relevant new technologies including conventional and novel endoscopic imaging as well as new developments in therapeutic gastrointestinal endoscopy, pancreatobiliary endoscopy and ultrasound. The second part highlights the role of endoscopy in special areas, e.g. inflammatory bowel syndrome or pediatrics. Therapeutic endoscopy of biliary and pancreatic diseases is often difficult and involves risks. The third section contains papers on hilar tumors and chronic pancreatitis.

Prevention and adequate management of complications is the topic of the final section. It is important to maintain high standards in interventional endoscopy. Complications can arise when patients are sedated, which is mostly the routine in daily endoscopic practice; during dilatation of gastrointestinal strictures perforations can occur or endoscopic retrograde cholangiopancreatography may result in post-interventional pancreatitis.

Continuous technical developments of radiological imaging techniques have not only improved the potential of organ-based radiological diagnostics, but now also allow for dedicated whole-body exams which may be used in the field of screening and preventive diagnosis. The concept of this book is to provide clinicians with a broader understanding of screening and preventive diagnosis using radiological imaging. The first part of the book is dedicated to the fundamentals of screening and preventive diagnosis, and will comprise chapters on epidemiology and pathology, technical and organizational aspects of radiological screening, and chapters on legal issues and cost-risk analysis. The second part of the book will discuss the most important practical examples of radiological screening and surveillance, both for unselected populations, as well as for individual risk groups.

This book, written by leading experts from many countries, provides a comprehensive and up-to-date description of how to use 2D and 3D processing tools in clinical radiology. The opening section covers a wide range of technical aspects. In the main section, the principal clinical applications are described and discussed in depth. A third section focuses on a variety of special topics. This book will be invaluable to radiologists of any subspecialty.

Probiotics: A Clinical Guide is one of the first books on the market to present current and evidence-based recommendations for primary care providers and gastroenterologists on the use of probiotics as a way to treat specific diseases and disorders. Why you will want Probiotics: A Clinical Guide: * Unique focus on the clinical use of probiotics in a wide variety of diseases * Comprehensive review of the science behind probiotics and probiotic products * In-depth review of current literature for specific diseases or disorders * Recommendations of the use of probiotics is supported by evidence-based clinical trials * Each chapter includes a table that outlines the exact probiotic organisms and dosages that are the most efficacious. A glance at what is inside Probiotics: A Clinical Guide: * Basic Physiology o Intestinal microecology; stimulating the immune response, nutrients to nourish the organism, role in fermentation and metabolism, and much more... * Use in Clinical Medicine o Probiotics in children, adult infectious diarrhea, surgical infections, allergic disease, ulcerative colitis, crohn's disease, liver disease, and more... Probiotics: A Clinical Guide by Dr. Martin Floch & Dr. Adam Kim is a ground-breaking book that will serve as a valuable reference and clinical guide for gastroenterologists, internists, family practitioners, nurse practitioners, and physician assistants.

This book is based on the proceedings of the Enteric Nervous System conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility. The book focuses on methodological strategies and unresolved issues in the field and explores where the future is heading and what technological advances have been made to address current and future questions. The Enteric Nervous System II continues in the tradition of a popular earlier volume which covered the previous meeting. Many of the same authors are contributing to this new volume, presenting state-of-the-art updates on the many developments in the field since the earlier meeting. The coverage include a wide range of topics, from structure and function of the enteric nervous system through gut motility and visceral pain. The author team includes long-established authorities who significantly contributed to the advances in ENS research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.

Human illness attributed to foodborne pathogenic microorganisms has been prominent in the mass media in recent years. The Practical Food Microbiology Series has been devised to give practical and accurate information about specific organisms of concern to public health. The information is designed for use by those in the food industry working in manufacturing, retailing and quality assurance, those in associated professional sectors e.g. public health, and students in each of these areas.

The series is unique in its practical approach as it draws on real life situations to highlight practical means for controlling the organism in foods.

Salmonella species are arguably the most commonly reported food associated human pathogens in the developed world. They are zoonotic agents and many different animal reservoirs are known. They can be found widely in the environment and may also establish in food processing environments. Over 2000 serotypes of Salmonella have been identified to-date, some of which cause very serious illness in humans particularly in vulnerable populations such as the elderly. Although rare, illness may result in fatality or long term debility and sequelae. Salmonella spp. are so widespread in raw foods and food source environments that the food industry has to maintain constant vigilance regarding contamination in raw materials, effectiveness of food processing systems and control of finished product characteristics for assuring food safety with respect to this important pathogen.

This book details the causes of selected outbreaks and assesses the lessons that can be learnt from them. It examines the characteristics of Salmonella spp. and identifies factors that make foods susceptible to contamination and growth of these organisms. Specific product sectors are used to indicate practical measures that can be applied to control Salmonella spp. in foods and minimise their potential to cause harm to the consumer. It also provides guidance in selecting effective sampling plans and test methods to monitor and detect the organism and offers pragmatic advice on action to be taken when the organism is detected during monitoring programmes.

This book provides a practical overview of the treatment and management of celiac disease. It examines new data which can be merged with clinical aspects to provide a global perspective for the busy clinician. The disease represents 1% of the population and often goes unnoticed for a long time; however, this book aims to reduce the instance of misdiagnoses of symptoms by providing clear guidance in a single book, with contributions from esteemed experts in the field. Advances in Celiac Disease - Improving Paediatric and Adult Care addresses the clinical characterisation of the disease, in both paediatric and adult populations. The clinical symptoms are clearly defined as well as treatment options and follow-up. This book will be an essential resource for clinicians seeking a clear, concise resource to identifying, treating, and managing celiac disease in both adults and children.

This volume serves as a hands-on, practical reference in nutrition support for the clinical gastroenterologist and for other clinicians with similar interests. The book offers expert nutritional knowledge and management ideas. It also provides methodology for combating problems such as short bowel syndrome, inflammatory bowel disease, celiac disease and obesity.

Hepatology is an expanding field -- it's hard to keep up. The liver has been sitting there the whole time, but the knowledge surrounding this perplexing organ is exploding; this makes it hard to prepare for board and recertification exams, where 1 in every 4 questions pertains to hepatology. Until now, there has been no single, slim, but high-yield volume that summarizes the hepatology you need to know for the boards. This book has it nailed. The authors have collected every pearl of wisdom, high-yield factlet, liver "board buzzword," hepatic micrograph, and classic liver imaging study they could muster, all while keeping the book a manageable size - because who has time for more than manageable when you're busy? The answer to your study questions (and study time ) can be found inside: Acing the Hepatology Questions on the GI Board Exam: The Ultimate Crunch-Time Resource. Traditional textbooks usually feature long and detailed discussions that are not directly related to Board and recertification exams. On the flip side, many Board review manuals provide lists and bullet points lacking sufficient background and context. Inside Acing the Hepatology Questions on the GI Board Exam, Drs. Brennan Spiegel and Hetal Karsan present time-tested and high-yield information in a rational, useful, and contextually appealing format. Why You Will Need to Read Acing the Hepatology Questions on the GI Board Exam: * Focuses exclusively on Hepatology review -- an area that comprises 25% of the Board exam * Carefully vetted board-style vignettes with color images * Comprehensive yet succinct answers using a high-yield format * Emphasis on key clinical pearls and "board buzzwords" * Answers to classic board "threshold values" questions that you need to know but always seem to forget: If an echinococcal liver cyst exceeds XX cm, then the risk of rupture is clinically significant and surgery is warranted * Rapid fire crunch-time exam with 135 classic

Are you looking for concise, practical answers to questions that are often left unanswered by traditional liver references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation of the Liver: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a "curbside consultation" between colleagues. Dr. Mitchell Shiffman has designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with the liver. The unique Q&A format provides quick access to current information related to the liver with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate the treatment of the liver. Curbside Consultation of the Liver: 49 Clinical Questions provides information basic enough for residents while also incorporating expert advice that even high-volume clinicians will appreciate. Gastroenterologists, fellows, residents in training, and medical students will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: How often should I follow a patient who had chronic hepatitis C after they achieved a sustained virologic response? Should I stop the HIV medications in a patient who has developed an elevation in serum liver transaminases? What should I tell my patient who is a carrier for alpha-1-antitrypsin deficiency? Which patients with fatty liver disease on an ultrasound examination require a liver biopsy? Which patients with chronic liver disease should I screen for hepatocellular carcinoma? How much ascites is safe to remove at any time?

Are you looking for concise, practical answers to questions that are often left unanswered by traditional GERD references? Are you seeking brief, evidence-based advice for complicated cases or complications? "Curbside Consultation in GERD: 49 Clinical Questions" provides quick and direct answers to the thorny questions commonly posed during a "curbside consultation" between colleagues.
Dr. Philip Katz has designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with GERD. The unique Q&A format provides quick access to current information related to GERD with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate the treatment of GERD patients.
"Curbside Consultation in GERD: 49 Clinical Questions" provides information basic enough for residents while also incorporating expert advice that even high-volume clinicians will appreciate. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within.
Some of the questions that are answered:
- Can medical therapy alter the natural history of Barrett's esophagus?
- Can antireflux surgery alter the natural history of Barrett's esophagus?
- How does pregnancy affect GERD? Is GERD in pregnancy a risk for long-term reflux?
- What is the association of obesity and GERD?
- What are the so-called extraesophageal manifestations of GERD?
- Is there a gender difference in reflux disease? Does this affecttreatment?