This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis, and related autoimmune disorders.

This volume provides a comprehensive guide to advanced endoscopic procedures and techniques. Primarily focused on Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS), the book also explores related topics such as cholangioscopy, pancreatoscopy, advanced pancreaticobiliary imaging, stenting, and endoscopic means to achieve pain control. The text also presents a plethora of tips and tricks on how to perform these procedures safely, emphasizes common mistakes and how to avoid them, and features high quality videos illustrating key procedural aspects for every chapter. Written by top experts in the field, Advanced Pancreaticobiliary Endoscopy is an invaluable resource for gastrointestinal endoscopists and fellows interested in advanced endoscopic procedures.

This book provides a concise, focused and clinically relevant summary of complications and emergencies related to bariatric surgery. The first section of the text addresses general complications related to anesthesia and the stress of surgery, including issues such as deep vein thrombosis, pulmonary embolism, hemorrhage, pneumonia and cardiac complications. Additionally, this section addresses the workup of the bariatric patient with abdominal pain. The second portion of the text focuses on gastric bypass and sleeve-specific complications, including staple line and anastomotic leaks, internal hernia, marginal ulceration, GI obstruction, hernia formation and gallstone disease. The third portion of the book examines metabolic, nutritional and psychological complications after bariatric surgery. The text also covers management of weight loss failure. Bariatric Surgery Complications and Emergencies serves as a very useful resource for physicians and surgeons who are involved in any parts of evaluation or management of bariatric patients suffering from postoperative complications or emergencies including bariatric surgeons who perform these operations on a regular basis, non-bariatric general surgeons who cover such patients when on-call, surgical trainees, and primary care physicians.

Postgraduate education courses taught by the leading hepato-gastroenterologists in Europe, members of the EAGE, are published each year as part of this collection.

* Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. "This is a well written text and should be a good reference book for those who see patients with HCC.." - Practical Gastroenterology "...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC." - Digestive and Liver Disease

This volume provides a concise overview of the most important and vital aspects of upper endoscopy. The text is specifically geared towards first-year GI fellows and novice endoscopists in order to help them rapidly assimilate the core concepts needed to perform upper endoscopy in the most important and most commonly encountered clinical situations. The book also covers the most important variations of normal anatomy and pathology and how to manage them. Key concepts covered include foreign body removal, diagnosis and management of upper GI bleeding, Barrett's Esophagus, evaluation and management of benign and malignant strictures of the esophagus, stomach, and duodenum, submucosal lesions, and evaluation of post operative upper GI anatomy. A plethora of high quality color illustrations and narrated online video clips illustrate major concepts in the book are also included. Written by experts in the field, Upper Endoscopy for GI Fellows is a valuable resource for new physicians just starting to perform upper endoscopy.

Each volume in this richly illustrated series, sponsored by the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytologic and histologic diagnosis of small tissue samples including fine-needle aspiration biopsy, cell block samples and core, pinch and forceps biopsies. This volume provides a practical approach to preparing and assessing pancreatic aspiration, core biopsy and brushing samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format supported with high-resolution color photomicrographs, tables, tabulated specific morphologic criteria and appropriate ancillary testing algorithms. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This unique series strengthens the bridge between surgical pathology and cytopathology, providing the pathologist with the ability to diagnose small tissue samples with confidence. The CD-ROM packaged with the printed book contains all the images in a downloadable format, making this a valuable resource for practicing and trainee pathologists.

This book provides a comprehensive, state-of-the art review of intestinal polyposis syndromes. The book reviews the most up-to-date clinical, management, and genetic information regarding the continually evolving colorectal condition that manifests as a polyposis condition. It provides a reference for clinicians and researchers in understanding the complexity of intestinal polyposis and the importance of utilizing multiple modalities for the diagnosis, management and control of these conditions. It also provides an overview of what should alert a care provider to the possibility of a polyposis syndrome. Written by experts in their fields, Intestinal Polyposis Syndromes: Diagnosis and Management is a valuable resource for physicians and researchers who deal with the challenges of diagnosing and managing colorectal cancer and intestinal polyposis syndromes.

This clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text. Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.

This book includes studies aimed at determining design interventions in which the composition of microbiota may be modulated to achieve a specific microbial profile beneficial to overall host behavior. In addition, this compilation summarises and critically discusses recent literature on the evaluation of changes in the microbiota associated with liver diseases, aiming to evaluate which alterations could be involved in the initiation and progression of liver disease. The authors emphasize the importance of promoting a balanced microbiome to maintain or improve oral health effectively. In order to fully understand the progression of oral diseases, it is essential to evaluate the microbiome together with genetic, immunological and environmental factors.

A rigorous and groundbreaking study. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. The author tackles a subject that has puzzled care professionals for decades: hypochondria. Martine Derzelle confronts all specialists (psychotherapists, psychiatrists, doctors, psychosomaticians) with the paradox of this pathology and the theoretical void on which the approach to those patients who express a suffering of various kinds has stood for more than a century. In the first part, the author highlights the lack of theoretical elaboration on hypochondria in the existent literature; in the second part, on the basis of clinical examples, she analyzes the nature of the disease, and then offers a completely innovative theoretical elaboration. Finally, in the third part, she proposes a new and specific approach to treating this pathology at both the theoretical and clinical levels within the framework of psychoanalysis and implementing key concepts from relational psychosomatics.

This beautifully illustrated monograph provides an up-to-date and comprehensive overview about all fields of liver and biliary tract surgery and liver transplantation. It consists of four sections with 48 chapters: Section I: Anatomy, physiology, imaging and general principles, Section II: Biliary tract surgery, Section III: Liver surgery and Section IV: Liver transplantation. The book includes more than 500 figures and illustrations mostly in color. Some of the topics such as computer assisted surgery planning are treated comprehensively for the first time. The book is written in a concise and well conceived way.

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

Integrative Weight Management: A Guide for Clinicians intends to educate physicians and nutritionists about the wide ranges of approaches to weight control from non-traditional sources. The options for weight management in conventional practices are limited to a small number of medications, a confusing array of dietary approaches and surgical procedures with their inherent risks and complications. Unfortunately medical practitioners are not exposed to nutrition and weight control principles during training and thus are reluctant to manage their patients weight control issues. This volume is structured into 4 sections: Introduction to Weight Management Disorders; Morbidity and Mortality of Obesity; Therapy of Obesity; and Integrative Medicine and Obesity. Integrative Weight Management: A Guide for Clinicians represents a powerful collaboration of dozens of leading experts in the fields of nutrition, weight management and integrative medicine who have managed countless numbers of patients and summarized the research from thousands of articles to create an up-to- date state of the art guide for healthcare practitioners, allied health professionals and public health authorities who manage those who are overweight/obese along with the associated metabolic consequences.

To date, diet programs and medical therapies for the treatment of obesity have had limited success. Bariatric surgery, however, provides a means of effective weight loss for many of those with morbid obesity. Most of these weight loss procedures are performed with a variety of techniques that continue to evolve. Each technique is associated with unique challenges and complications and it is important for the clinician to be knowledgeable about the endoscopic management of these patients. Additionally, as endoscopic technology evolves it may offer more than just the diagnosis and treatment of complications. Endoscopic therapy may soon allow less invasive bariatric revision procedures as well as a variety of primary obesity therapies for various patient populations. Bariatric Endoscopy reviews the management of obesity, normal post-surgical anatomy, endoscopic and medical management of post-surgical complications, and future endoscopic therapies for obesity management. Organized into five sections, the volume covers an obesity overview, traditional therapy, endoscopy and the bariatric patient, medical management of post-surgical complications, and the future role of endoscopy in obesity management. Detailed illustrations are also provided for surgical procedures, complications and obesity management chapters. Authored by authorities in the field, Bariatric Endoscopy is an indispensible tool for the gastroenterologist or surgical endoscopist as they care for patients with complicated bariatric issues.

Colorectal Cancer Screening and Computerized Tomographic Colonography: A Comprehensive Overview is an authoritative volume on CT colonography. Structured in a manner that will allow the reader to understand the practical and larger public health issues surrounding both CT colonography and CRC screening in general, the text is designed to reach a broad audience of specialist clinicians and primary care physicians. The book provides an overview of the disease and risk factors of colorectal cancer, as well as the history and development of CTC as both a colorectal imaging and screening modality. The text also reviews the controversies, potential pitfalls, and exciting new directions and capabilities inherent in the practice of CTC. Filled with high quality images and authored by experts in the field, Colorectal Cancer Screening and Computerized Tomographic Colonography: A Comprehensive Overview is the definitive reference for clinicians interested in computerized tomographic colonography and CRC screening.

Atlas of Dermatological Manifestations of Gastrointestinal Disease provides a comprehensive compendium of digestive tract diseases with dermatological manifestations. The work is arranged by digestive symptoms, with sections based on the specific digestive disease etiology. Each section contains paired chapters of text, one on gastrointestinal manifestations and the other on dermatological manifestations. The atlas includes clinical presentations, pathophysiology, differential diagnosis, diagnostic tests/procedures, pathology, and references presented with substantial numbers of images. Concise and easy to use, Atlas of Dermatological Manifestations of Gastrointestinal Disease is an important resource for gastroenterologists, dermatologists, and internists alike in the treatment of digestive tract diseases.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

"Pediatric Surgery, Diagnosis and Management" features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields. The text provides detailed practical advice on the diagnosis and management of congenital and acquired conditions in infants and children.

"International Practices in Pancreatic Surgery" describes in great detail general and specific technical aspects of the standard resection procedures of the pancreas. Each surgical step during the pancreatic operation is precisely outlined and accompanied by drawings and photographs. The main chapters on pancreatic carcinoma, chronic and acute pancreatitis are written by the editors. An international faculty complements the texts by describing their own personal techniques. This concept offers the greatest possible overview of the techniques used by experienced surgeons.

While a surgeon many decades agotreated diseases from headtotoe, this concept has evolved, and today some degree of specialization is the rule worldwide. In many countries various boards for sub-specializations are designed, and after a broad training in general surgery, many young surgeons move on further into a specific field. Knowledge of anatomy and precise surgical technique remain the foundation of high quality surgery. A knowledgeable surgeon, equipped with excellent theore- cal and clinical skills, will only be accomplished when he or she masters the - erative techniques of the practice of surgery. The legacy of an academic surgeon or a surgical teacher relies in great part onthe transmission of his or her surgical abilities. Significant influence on the development in esophageal surgery arises from the surgical understanding of the anatomical and functional structures of the esophagus as well as the ongoing developments in the multidisciplinary m- agement in this challenging field of surgery. In bringing forth this atlas, we were motivated by the desire to create a comp- hensive and educational atlas on esophageal diseases, emphasizing all details of pathophysiologies, diagnostic strategies, pre- and postoperative management, and operative techniques covering minimally invasive and open procedures ranging fromstraightforward tomore complex procedures.