This book has its roots in a monograph on cancer of the esophagus and gastric cardia edited by us in 1965 and published in Chinese on ly. Along with a number of colleagues in various fields, we summa rized our work in the epidemiology, pathology, diagnosis, radiother apy, and surgery of carcinoma of the esophagus and gastric cardia, carried out chiefly at Peking Union Medical College Hospital, Fu wai Hospital, and the Cancer Institute of the Chinese Academy of Medical Sciences during the 25 years from 1939 to 1964. In the 18 years since the publication of that monograph, further progress has been made in China in various aspects of research and surgical treatment. Abundant material has been accumulated on the long term results of surgery, and a number of newer principles and meth ods for diagnosis and management have been evolved. In order to meet the need for the exchange of scientific and technical informa tion, both domestically and internationally, we have invited a group of our current colleagues working on the different aspects of carci noma of the esophagus and gastric cardia to contribute to the pre sent volume, which is being printed in both Chinese and English. The Chinese edition, like the original monograph, is being publish ed by Shanghai Science and Technology Publishers. Through the kind invitation of Dr. Heinz Gotze, the English text is being publish ed for international circulation by Springer-Verlag.

This book is written to assist those who have responsibility for the nutritional and gastrointestinal care of children with neurodisability. The emphasis throughout is on the importance of multidisciplinary care. It is concerned with the problems surrounding the nutritional management of children with neurological impairment who have difficulty swallowing and feeding. Written from a multidisciplinary perspective by a group of authors with considerable clinical and research experience in this area, it covers: ?The epidemiology of feeding disorders in children with cerebral palsy ?Nutritional assessment?Evaluation of oral-motor function?Dietetic management?Nursing issues in the nutritional care of the disabled child?Tube feeding?Gastrointestinal problems and their investigatio

The development and improvement of new technologies have made pancreatic disease more accessible to diagnosis in the last decade. The cooperation and coordination of experts in the fields of gastro enterology, radiology, biochemistry, immunology, and pathology are necessary if the methods are to be made available and the progress made to be fully exploited. Each of the new methods requires special training, and extensive experience is needed to guarantee high standards in the diagnosis of pancreatic disease. New methods have to be tested carefully against established diagnostic procedures, though at the same time we must be ready to adopt a new approach to diagnosis. The aim of this book is to update the material already published and to focus on the various imaging methods and functional tests currently available, the features specific for each, and their integrative potential in the detection of pancreatic disease. The various pathologic findings are analyzed with reference to the clinical stages of pancreatic disease. As an introduction to the morphological and functional features of acute pancreatitis, chronic pancreatitis, and pancreatic cancer revealed by the different imaging methods and functional tests, basic knowledge of the patho-physiological and pathomorphological events is provided by research workers. This knowledge is essential for the understanding and interpretation of the diagnostic findings recorded in pancreatic diseases.

Albumin is the most abundant serum protein produced by the liver. In clinical practice the serum level of albumin continues to be used as an important marker of the presence, progress or ofthe improvement of many diseases, even though it is the complex end result of synthesis, degradation a. nd distribution between intra- and extravascular space. The clinical history of albumin began as early as in 1837, when Ancell first recognized "albumen" and noted that this protein is needed for trans port functions, for maintaining fluidity of the vascular system and for the prevention of edema. However, the important physiological properties of serum proteins and their role in the regulation ofthe oncotic pressure were demonstrated later by the physiologist E. H. Starling in 1895. In 1917 the clinician A. A. Epstein first described the edema in patients with the nephro tic syndrome as being a result of a very low level of serum albumin. Al though the determination of serum albumin concentration became more popular after Howe in 1921 introduced the technique of separation of serum globulins from albumin by sodium sulfate, the first preparations of human serum albumin were made available for clinical use in only 1941 by the development of plasma fractionation by Cohn and his coworkers at Harvard Medical School."

Despi te a slow decrease in the incidence of peptic ulcer in the Western world during the past decade, general practitioners, physicians, gastroenterologists, and surgeons deal with patients suffering from peptic ulcer and its complications almost daily. It has been estimated that some 10% of the population in the Western world becomes af flicted by peptic ulcer at least once and many of them have chronic relapsing disease. This lays a heavy burden on the amount of money which is spent in general health care. In recent years our understanding of peptic ulcer disease has in creased tremendously, but considerable gaps in our knowledge remain. Originally the increase in our knowledge has been stimulated by the development of fibre-optic endoscopy in the sixties, and later by the development of new surgical techniques and drugs in the seventies. New insights into the pathophysiology of the disease resulted from these developments and revived the scientific interest in peptic ulcer disease. However, the field remains complicated and the studies are be devilled by the large number of variables which can affect the results. In the symposium 'PEPTIC ULCER TODAY' we have attemp ted to bring together recent knowledge on basic and clinical aspects of peptic ulcer disease."

The most complete presentation of basic and advanced laparoscopic techniques available, due to its integration of procedures from general surgery and other subspecialities. Enhanced by over 750 illustrations (113 of them in full colour) and written by no less than 132 international, interdisciplinary experts, this definitive reference covers all aspects of this still new and expanding technique. Four main sections deal with: basic laparoscopy; laparoscopy and thoracoscopy in general surgery; laparoscopy in surgical subspecialities (gynaecology, urology, angioscopy); plus the technological aspects of laparoscopy. Throughout this authoritative volume, the surgeon will find in-depth reviews of the literature and extensive clinical and scientific data on the rationale for using laparoscopic procedures.
Certain to become a standard in the field.

The inflammatory bowel diseases, of unknown etiology and for which there are no cures, continue to attract the attention and interest of gastroenterologists, internists and surgeons. International symposia are common and it is safe to say that there is at least one major symposium held somewhere in the world each year. This book encompasses the proceedings of two recent symposia held in Victoria, British Columbia, Canada. The symposia were the fifth and sixth international meetings focused on inflammatory bowel disease in Canada in the last eight years. Once again they were sponsored by Axcan Pharma, Inc. (formerly Interfalk Canada, Inc.) and endorsed by the Canadian Association of Gastroenterology. As has become traditional at such meetings the faculty was drawn from an international roster ofleaders in the field of inflammatory bowel disease and gastroenterology. The chapters of the proceedings provide a timely, up-to-date review of the major issues, including those within the realm of basic science and others dealing with clinical problems. The first symposium, 'Basic Research and Clinical Implications', was co-ordinated by John Wallace in association with Stephen Collins and Stephan Targan. The themes of this section were organized under the general topics of predisposing factors (genetics, animal models, infection, permeability, and immune deficits) and the pathophysiology of intestinal inflammation. The second symposium, Trends in Therapy' was organized by Lloyd Sutherland along with Franc; ois Martin, Robin McLeod and Noel Williams.

The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renaL cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series, AdvancesinEicosanoidResearch, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the Series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr. Michael Brewis and the staff at MTP Press

Pancreatic Disease: Towards the Year 2000 provides a clear picture of the current research activity in pancreatic disease and its related basic science. Experts currently contributing to advances in understanding and treatment have provided concise and clear reviews of their subject. Each contribution summarises the relevant literature and describes recent advances whilst highlighting those areas where current research will impinge on clinical practice in the next few years. The reader will find in this book all the latest material related to pancreatic disease, cancer, acute and chronic pancreatitis and a number of other topics including transplantation and the relationship between endocrine and exocrine disease and cystic fibrosis. The book will supplement existing texts and will be of value to practising specialists who deal with pancreatic disease as well as specialist trainees in surgery and medical gastroenterology.

This book is a gift from the international community of amyloid friends, presented to Professor Dr. Enno Mandema on the occasion of his retirement from the University of Groningen, the Netherlands. It is the "precipitation" of up to date knowledge of amyloidosis, as presented at the International Course on Amyloidosis in Groningen, on the 10th and 11th of October 1986. Twenty years ago, Professor Mandema invited a group of scientists, who were studying the various aspects of amyloidosis from different points of view, to discuss their mutual interest in the subject. This "First International Symposium" was held for five days in September 1967. It was a wonderful experience for the participants, as most of them had until then only read each others work in the literature. The proceedings of that symposium, which contained the "lively" dis cussions, became a text-book for the following years. Research continued, and while the book was still in preparation, the revolutionary method of "water-soluble amyloid" was published. In the following years, different amyloid proteins were discovered and the mo lecular basis of the different amyloid syndromes was elucidated. The increase in knowledge parallelled the availability of modern, ingenious and also rapid methods in the biomedical sciences."

Providing an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain. Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits. The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.

In offering this book to what we hope will be interested readers, we have several aspirations. We have aspired to present to students and clinicians a rather narrow view of epidemiology concentrating on the causal factors and setting of the more usual gastroenterological problems and giving greater space to conditions of importance for which major knowledge of causation andcourse is available. Part of the rationale is thebelief that modern medicine lays excessive emphasis on therapy with increasingly expensive, and in many cases, dangerous drugs and too little emphasis on the causes and avoidance of disease. We are of the view that traditional views handed st down through generations of clinicians need scrutiny worthy of 21 century medicine whose currency includes topics like nanomoles, megabytes and logistic regression. We hope that clinicians will see that there is often a practical application to the findings of epidemiological exploration and that what passes for canonical knowledge is so often unsubstantiated myth and are fully aware of the reluctance of organized medicine to reject old paradigms in favor of the new, matched by an often uncritical enthusiasm for new therapies. Our researches have increased our belief in the major role of social factors especially diet, both in quantity and quality in many disorders and that clinicians have a responsibility to provide appropriate advice to policy makers as well as patients.

Discover a unique toolkit of science, self-compassion and intuitive eating practices to help you understand, love and heal your gut. Living with gut problems means it can feel like our insides are working against us, but have you ever taken a moment to really listen to your gut? Inspired by her own healing journey, expert patient Cara Wheatley-McGrain has developed a revolutionary approach to thriving with IBS and IBD through understanding, loving and listening to your gut. As Cara shares her tried-and-tested methods, you'll be empowered to create your own unique gut-led journey based on science, self-compassion and intuitive eating. You'll discover an extensive toolkit of exercises and strategies designed to calm your gut and support you wellbeing at every level. Cara shares how to: * get to know your unique gut microbiome and microbes * cultivate compassion, self-care and greater connection with your gut * use simple techniques for a calmer and more mindful lifestyle * develop intuitive eating practices and a diet that suits you * create fresh, healthy and delicious recipes for every mealtime When you start to truly listen to your gut - in a deeply powerful, gut-loving way - it will change your life.

- 'Big' book has sold close to 1400 in just over a year and is maintaining high rate of sale.

- This practical handbook fully explains the essentials of this state-of-the-art technique to radiologists, gastroenterologists, radiology residents, and technologists.

- Makes the key chapters of the big book accessible and affordable to the resident.

A complex disease entity, intestinal failure (IF) has only recently become accepted as a distinct clinical syndrome. Improvements across a wide range of disciplines-including critical care and organ transplantation as well as surgical, medical, and nutritional therapies-have led to a steady rise in survival and quality of life for patients with IF. Taking a current, multidisciplinary approach to their care, Clinical Management of Intestinal Failure offers intensive discussion of medical and nutritional issues in adults and children with intestinal failure. It addresses all facets of IF, including epidemiology, clinical presentation, intestinal rehabilitation, and transplantation. Topics covered include: Etiology and epidemiology Pathophysiology and clinical assessment Medical and surgical management Prevention and treatment of complications Nursing management Emerging diagnostic and therapeutic methods Long-term care Reflecting the diverse nature of IF clinical care and research, this book is written by a group of expert clinician scientists that includes gastroenterologists, surgeons, nurses, pharmacists, dietitians, social workers, and patients. They show how a multidisciplinary approach to patient care is instrumental in achieving optimal patient outcomes through more efficient lines of communication, improved monitoring of medications and their effects, detailed evaluation of growth parameters, and facilitation of the creative process that can lead to research breakthroughs. Advancing the discipline of IF, this book summarizes the current state of the art of patient management as well as new developments in the science of tissue engineering, medical and surgical therapy, and transplantation.

Although dyspepsia has been investigated for a long period of time, there is no international agreement on what constitutes this condition nor any standardized guidelines. National guidelines followed by practitioners in different countries vary in diagnostic and therapeutic approach, underlining the necessity for a unique definition worldwide. Dyspepsia in Clinical Practice summarizes the current guidelines while offering a unified, practical definition of dyspepsia, and a diagnostic algorithm with an emphasis on the upper gastrointestinal endoscopy and rational first-line therapeutic approach based on epidemiology, pathophysiology, clinical presentation, diagnostic workup and response to previous therapy. Up-to-date scientific information about dyspepsia is presented from a practical, clinician's point of view. Written by experts in the field, this volume addresses dyspepsia in childhood and in the elderly, a very important issue often insufficiently emphasized in the literature. Guidelines are provided that can be easily followed in clinical practice, leading to a reduction in costs and increased patient safety. Dyspepsia in Clinical Practice will be of great value to gastroenterologists, internists, primary care physicians, pediatricians, infectious disease specialists, residents and fellows in training.

1 2 MARCEL B. ROBERFROID AND GLENN R. GIBSON 1 Universite Catholique de Louvain, Department of Pharmaceutical Sciences, Avenue Mounier 73, B-1200 Brussels, BELGIUM 2 Food Microbial Sciences Unit, Department of Food Science and Technology, The University of Reading, Reading, UK It is clear that diet fulfils a number of important human requirements. These include the provision of sufficient nutrients to meet the requirements of essential metabolic pathways, as well as the sensory (and social) values associated with eating. It is also evident that diet may control and modulate various body functions in a manner that can reduce the risk of certain diseases. This very broad view of nutrition has led to the development of foodstuffs with added "functionality." Many different definitions of functional foods have arisen. Most of these complicate the simple issue that a functional food is merely a dietary ingredient(s) that can have positive properties above its normal nutritional value. Other terms used to describe such foods include vitafoods, nutraceuticals, pharmafoods, foods for specified health use, health foods, designer foods, etc. Despite some trepidation, the concept has recently attracted much interest through a vast number of articles in both the popular and scientific media.

Managing the Complications of Cirrhosis: A Practical Approach is a simple pocket guide for the community gastroenterologist and primary care provider who manages liver disease. While there are other books on the market available on the management of cirrhosis, this reference includes information geared toward the busy practitioner, allowing the reader to reference a chapter that easily addresses the clinical issue at hand. Dr. Atif Zaman provides essential and current information on the management of cirrhosis for the non-hepatologist. Each chapter in Managing the Complications of Cirrhosis: A Practical Approach is broken down into four sections, including a summary of the issue at hand, diagnosing the problem, treating algorithm in a figure, and what to do if the treatment algorithm is ineffective. In addition, each chapter highlights complex cases that have no standard treatment, but have emerging concepts or data. Chapter Topics Include: * Preventative health issues in patients with cirrhosis * Nutrition in patients with cirrhosis * Management of heptocellular carcinoma * Pulmonary issues in patients with cirrhosis * Timing for referral for liver transplant With algorithms, tables, and tabbed chapters for easy access to information, Managing the Complications of Cirrhosis: A Practical Approach is the perfect book for all community gastroenterologists, primary care practitioners, medical residents and fellows, physician assistants, and nurse practitioners who provide care in the area of liver disease.

While the gastrointestinal tract ingests, digests, and absorbs nutrients, the liver transforms nutrients, synthesizes plasma proteins, and detoxifies bacteria and toxins absorbed from the gut. It is therefore not surprising that gastrointestinal and hepatic diseases have a major impact on the nutritional state of the individual. Integrating nutrition and the gastrointestinal system, the Gastrointestinal and Liver Disease Nutrition Desk Reference brings together experts in the field of nutrition, gastroenterology, and hepatology to offer dietary, nutritional, and natural therapies for gastrointestinal and hepatic ailments in order to improve overall health. Providing a review of the digestive tract, liver, and core concepts, this important reference presents the nutritional consequences and considerations of digestive disorders. Contributors examine the role of nutrition in gastrointestinal and liver disease, including alcoholic and nonalcoholic liver disease, viral hepatitis, cirrhosis, malabsorption, colorectal disease, transplantation, pancreatitis, and inflammatory bowel disease. Of special interest to the practitioner are chapters on food allergy and intolerance, the effects of medicinal plants, and the role of fiber in the gastrointestinal tract. The reference also addresses the challenges of managing nutritional issues for hospitalized patients and covers eating disorders and ethical issues. Other key topics include: Obesity Clinical applications of probiotics The impact of micronutrient deficiencies Genomic applications for gastrointestinal care Drug-drug and drug-nutrient interactions Guidelines for performing a nutrition assessment This comprehensive reference offers a toolbox of key concepts, charts, tables, algorithms, and practical therapeutic strategies for practitioners involved in gastrointestinal and hepatic nutrition care. Dr. Mullin maintains a website discussing the integration of both Eastern and Western (conventional) medicines to help patients overcome their digestive illnesses.

This totally revised and enlarged new edition offers concise and well-structured chapters each focusing on the clinical, diagnostic, and therapeutic aspects of a condition commonly encountered by the coloproctologist and gastroenterological surgeon, who are faced with an increasing number of precise and specific treatment modalities. The comprehensive, yet easy-to-read, information in this practical guide on both common and rare anorectal and colonic diseases is particularly important for both the practitioner, who needs to know all the possible modalities of conservative and surgical treatment, and the surgeon, who needs to adapt his surgical procedure to the clinical and anatomical findings. Precise guidelines are given and surgical techniques illustrated. Each chapter is completed with up-to-date references and a self-assessment quiz, and a DVD is included.

H. pylori infection, both in man and in the laboratory animal, has become a standard model to investigate fundamental problems in biology, such as microbial-host interactions, intracellular signalling, modulation of inflammation, mucosal atrophic metaplasia, and microbial resistance, to name just a few. The issues addressed in this book are grouped according to their leading theme. Topics include: the new Helicobacters, strain differences of H. pylori and their consequence on microbial-host interactions and the effects of H. pylori infection on the gastric mucosa. The role of H. pylori is explained in relation to: gastric carcinogenesis; gastroesophageal reflux disease; dyspepsia and long-term acid suppression. Eradication therapies are reviewed with respect to their global consequences and problems. The last two sections are devoted to a global update on therapeutic indications and finally on priorities for further research.
These proceedings accurately reflect the state-of-the-art presentations delivered by world experts. This latest volume will further enrich this top-class series on H. pylori infection.

Although pancreatic cancer is one of the most serious forms of cancers, the lack of clinical symptoms often limits curative treatment options. This book gives insight into the current understanding of the management of pancreatic cancer and considers recent findings in cancer research. It provides answers to questions of how to know when cancer is respectable, how to proceed when the diagnosis comes too late for a curative approach, and how to assess different study results.

Ulcerative Colitis: The Complete Guide to Medical Management serves as the definitive source for medical management of ulcerative colitis (UC). Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with ulcerative colitis. Sections Include: * General o The role of the FDA in drug development; pediatric considerations; disease modifiers; and more * Medications o Antibiotic use in treatment of UC; oral novel biological therapies for UC; calcineurin inhibitors use in UC; novel biologic and non-biologic therapy for UC; and more * Specific Clinical Presentations o Medical management of toxic megacolon; management of extraintestinal manifestations; medical therapy of left-sided UC; use of prebiotics and probiotics; maintenance of remission; and more Features: * Color images, graphs, and tables * Extensive index that includes cross-referencing to Crohn's Disease: The Complete Guide to Medical Management * Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Ulcerative Colitis: The Complete Guide to Medical Management threads theory into practice and provides gastroenterology professionals with the most comprehensive information available. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Crohn's Disease: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.

Crohn's Disease: The Complete Guide to Medical Management serves as the definitive source for medical management of Crohn's Disease (CD). Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with Crohn's disease. Sections Include: * General o The role of the FDA in drug development; pediatric considerations; disease modifiers; and more * Medications o Antibiotic use in treatment of CD; oral budesonide; infliximab; novel biological and non biologic therapies for CD; and more * Specific Clinical Scenarios o Management of steroid unresponsive CD; management of enteric fistulae; use of pre- and probiotics; medical management of short bowel syndrome; maintenance therapy of CD; and more Features: * Color images, graphs, and tables * Extensive index that includes cross-referencing to Ulcerative Colitis: The Complete Guide to Medical Management * An appendix on Infliximab treatment * Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Crohn's Disease: The Complete Guide to Medical Management threads theory into practice and provides Gastroenterology professionals with the most comprehensive information available on this disease state. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Ulcerative Colitis: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.