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Hepatic Transport of Organic Substances (Paperback, Softcover reprint of the original 1st ed. 1989)
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Hepatic Transport of Organic Substances (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Proceedings in Life Sciences
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Hepatic cells are involved in the metabolization and elimination of
a variety of endogenous and exogenous substances. They mediate the
uptake, processing and subsequent secretion of biliary compounds,
such as various drugs or hormones, and the passage of metabolites
to be released into different blood compartments. To perform
vectorial passages hepatocytes show a strong polarity with sites
for endocytotic processes or specific carrier molecules, and a
specified system of organelles for intracellular transport and
sorting, metabolization and secretion of compounds. Several
aspects, e.g. regulation, control and mechanisms of hepatic traffic
are reported in detail - complemented by methodological approaches
to analyse and monitor these processes.
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