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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cellular Senescence in Disease (Paperback)
Loot Price: R3,089
Discovery Miles 30 890
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Cellular Senescence in Disease (Paperback)
Expected to ship within 12 - 17 working days
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Research in the field of senescence has boomed recently due to the
gradual realization that senescent cells are associated with a
significant number of diseases. The genetic or pharmacological
elimination of senescent cells can cause widespread benefits and
improves outcomes for most of those diseases. Cellular Senescence
in Diseases presents an updated review of the role of cellular
senescence in multiple pathologies. Focus is given to those
diseases where the implication of senescence has been more
extensively documented, such as (cancer, lung and liver diseases,
diabetes, Neurodegenerative diseases and others). The Editors
recruited a group of worldwide experts in each individual pathology
to review the role of cellular senescence in each one of them,
aiming at identifying potential therapeutic pathways. The first two
chapters provide an overview of the cellular senescence principles.
Next, the chapters are divided into specific diseases. Cancer,
including premalignant lesions (OIS), Advanced disease (TIS), and
Metastasis are covered. The following condition covered is Lund
diseases, including IPF, COPD, and Pulmonary Hypertension. Next
Liver Diseases are covered, including Fibrosis and Cirrhosis, and
Fatty liver disease. Next there is coverage for Kidney
implications, including fibrosis and transplantation. Vascular
diseases are covered next including infarction and hear fibrosis,
and atherosclerosis. Both diabetes types 1 and 2 are covered next.
Following chapters cover Obesity, Sarcopenia, and Bone and
Cartilage disorders, respectively. Neurodegenerative diseases are
covered next, focusing on Alzheimer and Parkinson. The next chapter
discusses accumulation of senescent cell in tissues during aging.
The two final chapters cover current developments and conclusions.
Cellular Senescence in Diseases is designed for researchers and
clinicians with a focus on the cellular mechanisms of diseases. All
chapters cover current experimental therapeutic approaches to
eliminate or cancel the pathological effects of senescent cells.
Pharmaceutical scientists may also benefit from the contents of the
book in the exploration of novel therapeutic opportunities.
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