The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

"International Practices in Pancreatic Surgery" describes in great detail general and specific technical aspects of the standard resection procedures of the pancreas. Each surgical step during the pancreatic operation is precisely outlined and accompanied by drawings and photographs. The main chapters on pancreatic carcinoma, chronic and acute pancreatitis are written by the editors. An international faculty complements the texts by describing their own personal techniques. This concept offers the greatest possible overview of the techniques used by experienced surgeons.

Atlas of Dermatological Manifestations of Gastrointestinal Disease provides a comprehensive compendium of digestive tract diseases with dermatological manifestations. The work is arranged by digestive symptoms, with sections based on the specific digestive disease etiology. Each section contains paired chapters of text, one on gastrointestinal manifestations and the other on dermatological manifestations. The atlas includes clinical presentations, pathophysiology, differential diagnosis, diagnostic tests/procedures, pathology, and references presented with substantial numbers of images. Concise and easy to use, Atlas of Dermatological Manifestations of Gastrointestinal Disease is an important resource for gastroenterologists, dermatologists, and internists alike in the treatment of digestive tract diseases.

This book is based on the latest comprehensive data about molecular mechanism of acute pancreatitis, chronic pancreatitis and pancreatic cancer. The diagnostic techniques including histology, radiology, sonography etc. are based on the sensitivity and specificity of the respective methods. Special focus is given to the indication and contraindication to surgical techniques. The book contains specific treatment modality and results for the first time after long-term outcome evaluation. There is detailed description of diagnosis and treatment, and the book is abundantly illustrated with approximately 300 color illustrations.

The first edition of this book was judged by many to be the best available atlas of upper gastrointestinal and hepato-pancreato-biliary surgery. The second edition builds upon this success by covering all of the significant intervening developments, including both new procedures and adaptations of established techniques. The atlas opens with an introductory section on the basic principles of operative surgery. All of the important surgical techniques are then presented in a series of sections devoted to the esophagus, stomach, and duodenum, the liver, the biliary system, portal hypertension, the pancreas, and the spleen. General, oncologic, and transplantation surgical procedures are described step by step with the aid of more than 900 superb illustrations drawn by a team of artists with extensive experience. The contributors were selected on the basis of their extensive experience in the procedures discussed and most are established educators.

To date, diet programs and medical therapies for the treatment of obesity have had limited success. Bariatric surgery, however, provides a means of effective weight loss for many of those with morbid obesity. Most of these weight loss procedures are performed with a variety of techniques that continue to evolve. Each technique is associated with unique challenges and complications and it is important for the clinician to be knowledgeable about the endoscopic management of these patients. Additionally, as endoscopic technology evolves it may offer more than just the diagnosis and treatment of complications. Endoscopic therapy may soon allow less invasive bariatric revision procedures as well as a variety of primary obesity therapies for various patient populations. Bariatric Endoscopy reviews the management of obesity, normal post-surgical anatomy, endoscopic and medical management of post-surgical complications, and future endoscopic therapies for obesity management. Organized into five sections, the volume covers an obesity overview, traditional therapy, endoscopy and the bariatric patient, medical management of post-surgical complications, and the future role of endoscopy in obesity management. Detailed illustrations are also provided for surgical procedures, complications and obesity management chapters. Authored by authorities in the field, Bariatric Endoscopy is an indispensible tool for the gastroenterologist or surgical endoscopist as they care for patients with complicated bariatric issues.

This atlas provides sequential pictures for most existing reconstructive urology procedures. Though the use of technology is described, the book has been constructed in such a way that urologists from all countries will be able to pickup the technical tips to perform the laparoscopic procedures using simplified devices.

This book, based on the experience of a single large referral center, presents the characteristic findings obtained when using MR imaging and MR cholangiopancreatography (MRCP) to image the biliary tree and pancreatic ducts in a variety of disease settings. An introductory chapter is devoted to technical considerations, anatomy, and developmental anomalies. Subsequent chapters then present in detail the MR imaging and MRCP findings observed in choledocholithiasis, inflammatory and neoplastic disorders of the bile ducts, acute and chronic pancreatitis (according to etiology), and different pancreatic neoplasms. Dynamic MRCP with secretin stimulation is also illustrated, documenting both normal and abnormal responses of the pancreatic duct system to secretin. Readers will find this book to be an excellent aid to the interpretation of MR imaging and MRCP findings in patients with biliary and pancreatic disease.

Integrative Weight Management: A Guide for Clinicians intends to educate physicians and nutritionists about the wide ranges of approaches to weight control from non-traditional sources. The options for weight management in conventional practices are limited to a small number of medications, a confusing array of dietary approaches and surgical procedures with their inherent risks and complications. Unfortunately medical practitioners are not exposed to nutrition and weight control principles during training and thus are reluctant to manage their patients weight control issues. This volume is structured into 4 sections: Introduction to Weight Management Disorders; Morbidity and Mortality of Obesity; Therapy of Obesity; and Integrative Medicine and Obesity. Integrative Weight Management: A Guide for Clinicians represents a powerful collaboration of dozens of leading experts in the fields of nutrition, weight management and integrative medicine who have managed countless numbers of patients and summarized the research from thousands of articles to create an up-to- date state of the art guide for healthcare practitioners, allied health professionals and public health authorities who manage those who are overweight/obese along with the associated metabolic consequences.

There is an increase in specialisation within general surgery and now even within its sub specialties. Colorectal surgery is probably the largest of the subspecialties of general surgery, and one of the areas where trainees and consultant general /colorectal surgeons are least confident is in their understanding of the anatomy, physiological pathology and management of the anal canal and pelvis. Currently available there are books on the market centred around the general management of colorectal disease, but the time is now right for a definitive text on the anal canal and pelvis specifically.

While a surgeon many decades agotreated diseases from headtotoe, this concept has evolved, and today some degree of specialization is the rule worldwide. In many countries various boards for sub-specializations are designed, and after a broad training in general surgery, many young surgeons move on further into a specific field. Knowledge of anatomy and precise surgical technique remain the foundation of high quality surgery. A knowledgeable surgeon, equipped with excellent theore- cal and clinical skills, will only be accomplished when he or she masters the - erative techniques of the practice of surgery. The legacy of an academic surgeon or a surgical teacher relies in great part onthe transmission of his or her surgical abilities. Significant influence on the development in esophageal surgery arises from the surgical understanding of the anatomical and functional structures of the esophagus as well as the ongoing developments in the multidisciplinary m- agement in this challenging field of surgery. In bringing forth this atlas, we were motivated by the desire to create a comp- hensive and educational atlas on esophageal diseases, emphasizing all details of pathophysiologies, diagnostic strategies, pre- and postoperative management, and operative techniques covering minimally invasive and open procedures ranging fromstraightforward tomore complex procedures.

2-D and 3-D anal ultrasound are among the most recent and advanced tools available for both the diagnosis and the management of anorectal diseases. They are neither expensive nor harmful for the patients and progressively replaced anal mapping with EMG electrodes for the diagnosis of sphincter's defects and anismus, which represents nearly 50% of the cases of chronic constipation. Anal US may provide the clinician with useful information for both classification, diagnosis and management of anorectal sepsis, anal incontinence and anorectal-perineal chronic pain. Almost any case presented in this Atlas shows both imaging and clinical pictures, thus allowing both the radiologist and the clinician to assess the reliability of the exam and the outcome of the selected treatment.

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational science including the viral life cycle, the immunopathogenesis of virus induced chronic hepatitis, the mechanism of virus induced liver cancer, and their potential applications for the clinical management of patients. The clinical aspects of this chronic viral infection are reviewed in detail with important chapters on the global epidemiology, the natural history of the disease, co-infections with its satellite virus HDV or HIV, and management of special patient populations. A major emphasis is made on the management of antiviral therapy and the recent international guidelines for the treatment of hepatitis B. Finally, the book reviews the current state of the art regarding immunoprophylaxis to prevent the spread of the virus and its major clinical consequences. The new advances and perspectives in the development of improved antiviral treatments are also discussed. Hepatitis B Virus in Human Diseases will serve as a very useful resource for students, physicians and researchers dealing with, and interested in, this challenging chronic viral infection. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

Fecal incontinence is a common and embarrassing condition with a devastating impact on patients' lives. Since it may result from a variety of pathophysiological situations, an accurate diagnostic work-up is crucial. A range of therapies is available, but choosing the correct option is pivotal to successful management. This book reviews the latest advances in the epidemiologic, socio-economic, psychological, diagnostic, and therapeutic aspects of fecal incontinence, helping to establish effective treatment guidelines.

Modern biological understanding is the basis for a multimodality treatment of a tumor. 'Anatomic Basis of Tumor Surgery' is the only book that provides an anatomic basis and description of tumor surgery based on an understanding of both the anatomy and biology of tumor progression. It presents the regional anatomy to allow tailoring of the operation as demanded.

The first laparoscopic cholecystectomy, performed by Prof. Philippe Mouret in 1987 and described by himself in the first chapter of this book, was an event that revolutionized surgery in the past few decades. Although the majority of surgeons today are unfamiliar with the his- ry of early minimally invasive surgery developments, it is important to realize that the advent of laparoscopy led not only to new surgical te- niques, but also to a change in the doctrine of medical care, by streng- ening the concept of minimal invasiveness. This is particularly the case for biliary lithiasis, for which laparoscopy has provided major benefits in terms of both diagnosis and surgical tre- ment. However, our understanding of the etiology of this disease, as well as the availability of effective medical therapies, have remained subst- tially unchanged over time. The application of the innovative approach has not been, in routine practice, without problems: between 1990 and 2000, the rate of serious complications from laparoscopic cholecystectomy were four times higher than those observed with open surgery. Even initial attempts at lapa- scopic treatment of biliary common bile duct stones resulted in excessive complications and associated medico-legal problems. Nonetheless, today, most indications have been stated, techniques have been standardized, and a new aspect to the treatment of biliary lithiasis has appeared.

This atlas provides a comprehensive, state-of-the-art review of all interventions that pertain to the esophagus. It includes a review of the current staging modalities, ablation technologies, resection and reconstruction techniques, and disease classification. Evidence-based guidelines regarding how each intervention is chosen are also included. With color illustrations and photographs for each surgery, the atlas details specific anatomic topics such as micro-anatomy of Barrett's and Dysplasia, EMR pathology, endoscopic ultrasound, and conventional surgical anatomy. Each intervention is presented in task format as a task list to be checked-off as each step is completed. Written by experts in the field, Atlas of Esophageal Disease and Intervention: A Multidisciplinary Approach serves as a valuable resource for any practitioner who performs esophageal intervention and will guide new surgeons and gastroenterologists into the hybrid multidisciplinary approach to this disease.

Endoscopic Therapy is emerging as the preferred therapy for early neoplasia in Barrett's Esophagus. This volume provides the key decision making factors in determining endoscopic therapy for an individual patient. All current techniques and complications of ET are provided including, photodynamic therapy (PDT), APC, multipolar electrocoagulation (MPEC), RF, ER, and cryotherapy. Each technique includes "how to highlights", high quality color endoscopic images, line drawings and diagrams. Endoscopic imaging modalities to detect dysplasia, decision making in the clinical arena and cost-effectiveness of ablation are some of the additional topics discussed in this highly practical volume. Written by experts in the field of endoscopic therapy, this text educates GI practitioners and researchers about this under-utilized approach to the treatment of Barrett's Esophagus.

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

This volume provides a comprehensive, state-of-the art review of inflammatory bowel disease and its management through the use of telemedicine applications. The book reviews barriers to successful outcomes in patients with IBD and offers a rationale for how self-management and telemedicine approaches can improve care in chronic illnesses such as IBD. This volume also includes a summary of the burden of telephone encounters in patients with IBD, characteristics of frequent callers to the office, outcomes associated with high telephone use, and strategies to provide education via telephone to patients with IBD. Prior literature on implementation of teleconsultation in research and clinical practice, as well as mobile applications used to track symptoms, quality of life, diet, and medication use in IBD are also explored in the book. Written by experts in the field, Telemanagement of Inflammatory Bowel Disease is a valuable resource for gastroenterologists, surgeons, a nd other clinicians dealing with, and interested in, this novel adjunct to routine care for inflammatory bowel disease.

This practical volume is intended for all radiologists, gastroenterologists, and surgeons who are responsible for, or interested in, the diagnosis and care of patients with diseases of the anal and perianal region. After an introductory section focusing on surgical, MRI, and US anatomy, up-to-date clinical and therapeutic information is provided on the full range of perianal inflammatory conditions, with special attention to Crohn's disease, ulcerative colitis, and sexually transmitted diseases. Physical and surgical examination is carefully discussed, with consideration of limitations, results, clinical needs, and the questions likely to be posed of imaging. The subsequent three sections provide detailed information on the different imaging modalities: transanal and transperineal ultrasound, contrast-enhanced MRI, and CT. Techniques, diagnostic accuracy, common and unusual disease patterns, artifacts, and pitfalls are clearly presented.

Due to the latest developments in magnetic resonance imaging for the evaluation of liver pathology, a second, completely revised and enlarged edition of this book was felt necessary - despite only three years having elapsed since the first edition. All chapters from the first edition have been revised and enriched with additional illustrations and information. New chapters have been added covering important and highly relevant topics, among which imaging of pseudolesions, imaging of neoplastic diseases in pediatric subjects, imaging of bile ducts, MR angiography and imaging pre and post liver transplantation. Particular attention has been paid to the differential use of contrast agents with emphasis placed on the authors' broad experience of MR imaging of focal liver lesions using different contrast agents. The diverse mechanisms of action of all MR contrast agents applicable for liver imaging are explained in detail and comparative examples are provided. As was the case with the first edition, this book will prove invaluable to radiologists wishing to further expand or consolidate their routine approach to MR imaging of the liver.

Principles of Deglutition is the first in class comprehensive multidisciplinary textbook to encompass the entire field of normal and disordered deglutition. It is designed as the definitive text for all those who desire to further their knowledge of the dynamic and expanding field of deglutology. The text is created to serve as a treasured reference for clinicians, educators and trainees from such diverse backgrounds as gastroenterology, speech language pathology, otolaryngology, rehabilitation medicine, radiology and others. Principles of Deglutition brings together the state-of-knowledge from 12 disciplines involved in dysphagia through contributions of over one hundred thought leaders and master clinicians for the benefit of patients and providers alike. It concisely organizes the wealth of knowledge that exists in each of the contributing disciplines into one comprehensive information platform. Principles of Deglutition provides a one-stop destination for members of all specialties to obtain state-of-the-art and critically reviewed information regarding deglutition physiology, pathophysiology, diagnosis and management. It delivers a comprehensive and in depth review of deglutition related cerebral cortical, brainstem, peripheral nerves, and neuromuscular mechanisms, advanced diagnostic modalities and standard of care and cutting edge medical, rehabilitative and surgical treatments. It is an essential reference for all deglutologists.

"Pediatric Surgery, Diagnosis and Management" features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields. The text provides detailed practical advice on the diagnosis and management of congenital and acquired conditions in infants and children.

Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides a unique diagnostic reference text for the pathologic diagnosis of infectious diseases of the gastrointestinal tract. Written for the practicing surgical pathologist, this text combines the superior illustrations of an atlas with carefully written prose to create a useful diagnostic companion. The text is divided into four sections covering bacterial, fungal, viral, and parasitic infections of the gastrointestinal tract. The descriptive sections of each chapter are organized into short paragraphs for easy reference and include the use of tables to compare and contrast organisms and summarize differential diagnoses. Each chapter is extensively illustrated, and contains prose discussions of diagnostic features, differential diagnoses, brief clinical descriptions, and ancillary tests that help confirm the diagnosis (i.e. immunohistochemistry, special histochemical stains, and molecular diagnostic techniques). Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist. This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.