Offering 171 unique cases, Gastrointestinal Imaging Cases features over 700 high-quality images. The clinically relevant cases cover both benign and malignant conditions and are grouped into 12 sections organized by the parts of the Gastrointestinal System including: the Pharynx and Esophagus, Stomach, Duodenum, Small Intestine, Appendix, Colon, Rectum, and Anus, Liver, Gallbladder, Bile Ducts, Pancreas, Spleen, and Mesentery and Peritoneum. Within each section, the cases appear in a random order to facilitate the self-assessment experience of reading cases as unknowns. Each case is complete with pertinent findings, differential diagnoses, management recommendations, teaching points, and suggested further reading. This comprehensive, yet easy-to-follow, casebook is an ideal tool for the resident preparing for the boards, the fellow for recertification exams, or the radiologist in need of a quick review.

Gastroenterology and Hepatology Lecture Notes is a comprehensive yet easy-to-read overview of luminal gastroenterology and hepatology. Covering the epidemiology, causes, clinical features, investigation, treatment and prognosis of all the main gut and liver conditions, it is ideal for both exam preparation and fact finding. Key features include: A full range of new illustrations, including clinical photographs and scans, that clearly demonstrate signs and symptoms Sections on anatomy, physiology, pharmacology, and epidemiology written to enhance understanding of clinical features Essential information highlighted throughout the text Case-based self-assessment for each chapter helps retention of knowledge and puts it in its clinical context A new section of best answer MCQs New chapters on inflammatory bowel disease and different diagnosis of the upper GI tract Includes a companion website at www.lecturenoteseries.com/gastroenterology featuring 16 in-depth case studies Whether learning the basics of the gastrointestinal system, starting a general medical or gastroenterological placement, or looking for a quick-reference overview to revise key concepts, Gastroenterology and Hepatology Lecture Notes is an ideal resource for medical students, MRCP or FRACP candidates, and junior doctors.

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Childhood allergies are booming, but what if there was a way to prevent allergies in the first place? What if simple lifestyle changes in the critical first 1000 days could change your baby's life? For families across the world, eczema, asthma, hay fever and food allergies are constant anxieties, sometimes with devastating consequences. Leading gastroenterologist Dr Vincent Ho has taken a deep dive into the exploding medical field of gut health and explains that from conception to birth, and from breastfeeding to the introduction of solid foods, small steps go a long way in preventing allergies and fortifying your baby's immune system. Dr Ho cuts through the scientific jargon to provide strategies for allergy management and treatment, and shows you how to strengthen your child's gut health for the long term - all before they begin to walk. The Healthy Baby Gut Guide is packed with sensible advice, surprising scientific discoveries and even a nutritionist-approved nine-week infant meal plan to help parents navigate the introduction of common allergenic foods. Practical, easy-to-follow and utterly eye-opening, this book is essential reading for every parent and parent-to-be. 'Essential reading for every parent and parent-to-be.' - Dr Rupy Aujla, Author & Founder, The Doctor's Kitchen 'This is a really useful guide. Dr Vincent Ho has put together an easy to read and understand book on how to reduce allergies in children. I highly recommend this book in your list of baby books to read.' - Dr Sonny Chong, Consultant Paediatrician and Gastroenterologist, Queen Mary's Hospital for Children 'A terrific evidence-based guide to help parents foster the optimum gut health for their babies. As a mother and scientist, I will turn to this book time and time again. Dr Ho is clearly and expert in his field, navigating a tricky subject with admirable ease and dexterity.' - Dr Saliha Mahmood Ahmed

Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

Many gastroenterologists are presented with patients complaining of one or more of several anorectal symptoms. Patients expect that a gastroenterologist can treat their symptomatic hemorrhoids or anal fissures or diagnose accurately their rectal bleeding. Today the evaluation and treatment of these common ailments is not included within the core curriculum of most gastrointestinal fellowship training programs, and therefore has not been incorporated into a typical GI practice. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference looks to fill that void. Dr. Waqar Ahmed Qureshi states that most of these perianal and anorectal problems can be successfully treated non-surgically. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference reviews a number of diseases that gastroenterologists should be able to effectively manage in their office, which eliminates extra cost, inconvenience, and frustration for their patients. A few of the topics that can be found inside: Anatomy and Examination Anatomy and Physiology of the Pelvic Floor Benign Anorectal Conditions Hemorrhoids, Anal Fissures, and Anal Pruritus Benign Soft Tissue, Perianal, Perineal, and Complicated Conditions Pilonidal Disease, Aanorectal IBD Management, and Defecation Disorders Neoplasms Anal Carcinoma and screening high-risk groups The gastroenterologist occupies a unique position between conservative treatment offered by primary care physicians and the more invasive procedures offered by the surgeon. Diagnosis and Management Guide for Anorectal Disease: A Clinical Reference is designed to provide a comprehensive understanding of anorectal diseases that they can manage and, therefore, improve the care of their patients in one comprehensive volume.

Recent discoveries and clarifications of known information about the mesentery have now established that these complex structures function together as an individual organ within the human body. As such, conditions that affect the mesentery can now be grouped within a single area of study and clinical practice. The various aspects of mesenteric diseases have not been brought together in a single source and this book aims to bring them together for the first time. It will cover general areas such as anatomy, histology and physiology of the mesentery. A description of diagnostic procedures used to evaluate patients with mesenteric disorders will follow. A practical survey with detailed descriptions of medical, surgical, and neoplastic disorders of the mesentery is also be included. This book is intended to be a guide for clinical practitioners including gastroenterologists, general surgeons, colorectal surgeons, primary care physicians, nurse practitioners and physician assistants who manage patients with mesenteric disorders.

In 74 chapters, Gastrointestinal Oncology brings together a diverse group of specialists to provide the most authoritative, up-to-date and encyclopedic volume currently available on the subject. The first part of this text introduces a series of concepts and topics taht are important to gastrointestinal malignancies in general. These topics include epidemiologic principles, prevention, screening, familial GI cancers, developmental and molecular biology, pathobiology, general therapeutic principles, emerging therapies, and palliative care. The second part of the book covers each of the specific cancers affecting the human gastrointestinal tract. These chapters are introduced by state of the art discussions outlining our current understanding of the pathobiology and molecular biology relevant to each cancer. Subsequent sections describe the multidisciplinary management of specific clinical situations. By organizing the treatment-related chapters around clinical scenarios, the reader will readily find the information necessary to effectively manage the complex clinical situations encountered by patients with gastrointestinal malignancies.

The Handbook of Electrogastrography is the first textbook dedicated to reviewing the physiology of gastric myelectrical activity and the measurement of this electrical activity with electrodes placed on the abdominal surface - the electrogastrogram. The Handbook is divided into three major sections. The first section (Chapters 1-3) focuses on the history of electrogastrography, electrical activity of the interstitial cells of Cajal, the cells from which gastric electrical rhythmicity emanates. The cellular level of gastric electrical rhythmicity provides an understanding of the physiological basis of the electrogastrogram signal.

The second major section of the book (Chapters 4-6) incorporates the practical aspects of recording a high quality electrogastrogram and approaches to the analysis of the electrogastrogram using visual inspection and computer techniques. This section focuses on the authors' combined experience of examining EGG recordings for more than sixty years. From this rich research and clinical experience, the clinical application of EGG recordings in an approach to patients with unexplained nausea and vomiting is described. Neuromuscular disorders of the stomach involving gastric dysrhythmias are reviewed.

The third major section of the book (Chapters 7-9) comprises many examples of gastric dysrythmias ranging from bradygastrias to tachygastrias and mixed dysrythmias. Current understanding of the mechanisms of gastric dysrhythmias is reviewed. Artifacts in the EGG signal, which may be confused with gastric dysrhythmias, are also presented.

The Handbook of Electrogastrography will be a valuable reference for physicians interested in recording gastric electrical activity in clinical practices or in clinical research. Gastroenterologists, internists, psychologists and others with an interest in gastric myoelectrical events will also find extensive and relevant information for recording and interpreting EGGs in the Handbook.

This book provides a concise, state-of-the-art overview of occult GI bleeding. The text reviews the epidemiology, screening and detection methods for localization, and prominent treatment strategies for occult GI bleeding. It also features a dedicated section on special patient populations including children, premenopausal women, older adults, and patients with other predisposing, and complicating medical conditions. This volume is supplemented with numerous color illustrations, photographs, and table, and is one of the few dedicated resources on occult GI bleeding. Written by experts in the field, Management of Occult GI Bleeding: A Clinical Guide is a valuable resource for clinicians, practitioners, and students who are involved in the treatment of patients with occult GI bleeding.

This book provides a comprehensive state-of-the art overview on the main trends in the newest endoscopic, robotic, and minimal invasive surgical innovations. It also aims to give insight on some of the innovative ideas around Gastro-intestinal Surgery and Endoscopy to stimulate further activities. It contains established knowledge in the field of endoscopic and surgical techniques, and the integration of these new findings in updated therapeutic decision making are demonstrated. The text reviews the latest literature on the subjects and describes the decision making to establish new therapeutic options in the management of diseases applying new technologies. These new techniques are described in detail, which provide excellent back-up information for clinicians in daily practice. Written by experts in the field, Innovative Endoscopic and Surgical Technology in the GI Tract is a valuable resource of knowledge for clinicians, surgeons, nurses, technicians, students and researchers with an interest in GI- disease.

This volume provides current protocols that can be used in various experimental settings involving bifidobacteria. Chapters guide readers through experimental protocols on procedures to isolate and cultivate bifidobacteria, taxonomic identification of bifidobacterial isolates, sequencing and annotate genomes, physiologically characterize bifidobacteria, and methods on the genetic manipulation of bifidobacterial strains. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bifidobacteria: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

This book provides a comprehensive overview of the diagnosis and management of diseases of the biliary tree. Topics covered include: congenital biliary abnormalities, genetic cholangiopathies, autoimmune cholangiopathies, inflammatory and drug-related cholangiopathies, and cholangiocarcinoma. Given their particular importance (even for clinicians working with adults), pediatric conditions are also examined. In addition, a special section is devoted to pregnancy and diseases of the biliary tree, and to transplants and diseases of the biliary tree. Each chapter offers up-to-date information on the management of the diseases discussed. Moreover, the book addresses new treatments for autoimmune cholestatic liver diseases, reflecting the new therapeutic targets that have recently been discovered. Examples include farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)-agonists, together with new drugs that affect the composition of bile flow. Given its scope, the book offers a valuable guide for a broad range of practitioners.

This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.

This book discusses the community of microbial species (the microbiota, microbiome), which inhabits the large bowel of humans. Written from the perspective of an academic who has been familiar with the topic for 40 years, it provides a long-term perspective of knowledge about this high profile and fast-moving topic. Building on general ecological principles, the book aims to help the reader to understand how the microbiota is formed, how it works, and what the consequences are to humans. Understanding the Gut Microbiota focuses on conceptual progress made from studies of the human bowel microbiota. Where appropriate, it draws on knowledge obtained from other animal species to provide conceptual enlightenment, but this is essentially a book about humans and their bowel microbes. Particular research approaches are recommended to fill knowledge gaps so that fundamental ecological theory and information about the microbiota can be translated into benefits for human health. The relationship between food for humans and resulting food for bowel bacteria emerges as an important topic for consideration. This concise scholarly treatise of the microbiota of the human bowel will be of great interest and use as a text and reference work for professionals, teachers and students across a wide range of disciplines, including the health sciences, general biology, and food science and technology. The provision of handy explanation of terms means that those with a general interest in science can also read the book with enjoyment.

Constipation and incontinence are of considerable importance to a great number of patients but many put it under taboo. Both functional disturbances comprise a wide spectrum of pathophysiological findings of neuro-muscular changes of the colon or the pelvic floor, but psychological factors may play an important role as well. In recent years much progress has been made in several disciplines which are important for the understanding and handling of constipation and incontinence. This volume, the proceedings of Falk Symposium No. 95 held in Freiburg, Germany, October 28-30, 1996, concentrates on clinically relevant and open questions rather than trying to cover the whole field in all details.

This fully revised and updated third edition of the Oxford Handbook of Gastroenterology and Hepatology provides up-to-date, pragmatic advice on the management of common conditions and emergencies. An essential resource for all those involved in the care of patients with gastroenterological and hepatological disease, both for specialists and trainees in gastroenterology and hepatology, and also clinicians from other specialties. The handbook includes a problems-based approach, a unique A to Z compendium of conditions, and sections on therapeutic drugs, and emergencies. Thoroughly revised and updated, it now includes such updates as new approaches for the management of eating disorders, and post-liver transplant patients, the latest advances in endoscopy, new therapies, refined advice on how to select between therapeutic options, as well as additional emergency topics on abdominal trauma, bowel obstructions, and major haemorrhage.

This Atlas comprehensively covers minimally invasive operative techniques for benign and malignant cancer surgery of the esophagus and stomach. It provides easy-to-follow instructions accompanied by a range of pictures and illustrations, as well as a collection of interactive videos to aid the reader in developing a deeper understanding of each surgical procedure. Techniques covered include minimally invasive surgical treatment for esophageal and gastric cancer including different approaches such as thoracoscopic, transhiatal, laparoscopic, and robot-assisted resections. These chapters include different types of cervical and intrathoracic anastomoses after esophageal resections, and different anastomoses and reconstructions after gastrectomy. Moreover, the Atlas includes an extensive description of minimally invasive procedures in bariatric surgery including sleeve resection, gastric bypass, biliopancreatic diversion, and others. Minimally invasive approaches for other benign pathologies such as benign tumors and treatment of gastroduodenal ulcer complications are also depicted. All chapters, written by a renowned and experienced international group of surgeons and their teams, are focused on practical step-by-step description of the techniques. Atlas of Minimally Invasive Techniques in Upper Gastrointestinal Surgery systematically describes the most frequently performed surgical procedures of the esophagus and stomach and is a valuable resource for all practicing surgeons and trainee general surgeons dedicated to upper gastrointestinal surgery, such as bariatric and surgical oncologists.

This book provides a thorough overview of the radiologic and pathologic findings of neoplastic diseases of the biliary tract, a sound knowledge of which is essential for appropriate patient management. A key feature is the correlation of imaging findings with both gross pathologic and histopathologic findings for each disease. This is of the utmost importance in understanding true pathologic abnormalities, bearing in mind, for example, the difficulty in ascertaining disease spread and extent on the basis of pathology alone. Since the first edition of the book, conceptual understanding of neoplastic disease of the bile ducts and cholangiocarcinogenesis has evolved significantly, and in the new edition the classification of diseases is based on the most recent edition of the WHO Classification of Tumors of the Digestive System. In addition, some newly recognized pathologies are covered. The book will enhance understanding of the pathology of neoplastic diseases of the biliary tract and aid imaging interpretation. It will be a great asset for pathologists, radiologists, biliary surgeons, and gastroenterologists.

The discovery of new and previously unknown organisms that cause foodborne illness makes it essential for scientists, regulators, and those in the food industry to reconsider their traditional approaches to food preservation. A single source reference that can provide the latest practical information on how to deal with the range of probiotic health issues that have recently arisen would be invaluable to have. Probiotics in Food Safety and Human Health is that resource. It presents an in-depth characterization and diagnosis of probiotic strains and their mechanisms of action in humans, explains the role food applications have in the development of new products that guard against gastrointestinal diseases, and addresses the current regulatory environment. The material in each chapter is written in an accessible format by internationally renowned experts and includes citations from scientific literature. Highlights include a thorough discussion of probiotic issues such as pre- and postharvest food safety applications of probiotics, genetic engineering, and probiotic identification. The book also presents information on new regulations and emerging trends in the two major probiotics markets in the world, Europe and Japan. Unique in its depth and breadth of scope, Probiotics in Food Safety and Human Health provides vital information to those who need to be knowledgeable of the functional properties of foods aimed at improving human health.

This extensive and yet easy-to-read book covers technical aspects of the management of difficult acute cholecystitis. It discusses diagnostic evaluation, treatment, and strategies for avoiding and managing complications based on both evidence-based data and the experiences of the editor and the international contributors. Further, it analyses the latest guidelines to find the best clinical applications. Each chapter describes the current diagnostic and management strategies, focusing on a possible risk stratification by scores proposed in literature. Lastly, the book describes the relevant technical considerations and tips and tricks, explaining them in full. Illustrated throughout and including line graphs depicting fundamental anatomic and technical principles, making it easy-to understand, it is a useful toolkit for all residents, fellows and general surgeons needing a guide to the treatment of difficult acute cholecystits.

There are many diagnostic imaging techniques for the radiological exarmna- tion of the abdomen. Noninvasive methods include supine and upright views of the abdomen (sometimes fluoroscopy and decubitus films); posteroanterior (PA) views of the chest; contrast studies of the alimentary tract; ultrasonogra- phy (US), scintigraphy, computed tomography (CT), and magnetic resonance imaging (MRI). Biopsy under fluoroscopic control and angiography are inva- sive techniques. Most of the errors described in this book are related to faulty interpretation; others are due to improper technique. For example, a patient with acute abdominal pain secondary to a perforated hollow viscus may be studied only by supine and upright views of the abdomen that do not include the subdi- aphragmatic regions. A complementary PA view of the chest or a left lateral decubitus film would, however, detect free air in the pentoneal cavity that the incomplete two-film study might have missed. Errors of techmque are due to under- or overexposure, long exammation times or an uncooperative patient (both of which can induce motion artIfacts), improper processing, and failure to perform the proper standard noninvasive or mvaSlVe modalitIes for examining the hollow viscus and the solid organs of the alimentary tract. In order to visualize the diaphragm and the supra- and mfradiaphragmatIc spaces, frontal and lateral chest roentgenograms complement the standard views of the abdomen. Fluoroscopy IS of great value m assessing diaphrag- matic motion as well as being essential when contrast media are utilized.

This is the first comprehensive book exclusively dedicated to anorectal physiology and the importance of diagnostic tools in guiding the evaluation and treatment of anorectal dysfunction. Functional disorders, and specifically fecal incontinence and evacuatory disorders, are prevalent in the general population, affecting up to 20% of individuals. As many of these conditions have extremely complex mechanisms, a thorough understanding of anorectal physiology is a crucial element in the surgeon's "arsenal" to ensure accurate evaluation and to inform treatment. At this time, there is no other title that specifically addresses all aspects of anorectal physiology, as well as anorectal and pelvic floor disorders, including fecal incontinence and defecation disorders. Specifically, the book provides detailed descriptions of diagnostic methods and treatment algorithms for a range of anorectal conditions, including modern treatment modalities such as sacral neuromodulation. A unique and comprehensive reference covering all aspects of the evaluation and treatment of anorectal disorders, Anorectal Physiology - A Clinical and Surgical Perspective will be of significant interest to proctologists and coloproctologists, gastroenterologists, colorectal surgeons, gynecologists and all other professionals interested in anorectal physiology.

This volume provides a concise yet comprehensive overview of advanced techniques in interventional endoscopy beyond ERCP and EUS. Comprised of sections on endoscopic resection (including EMR, ESD, STER and EFTR), bariatric endoscopy, endoscopic myotomy (POEM, GPOEM, ZPOEM and PREM), endoscopic anti-reflux therapies, endoscopic tissue apposition, and advances in interventional EUS, the text highlights indications and technical details, assesses safety and efficacy, and provides quality metrics and training pathways for these endoscopic procedures. The book is also accompanied by multiple photos and videos illustrating these endoscopic techniques. Written by world renowned experts in the field, Gastrointestinal Interventional Endoscopy: Advanced Techniques is a valuable resource for gastroenterologists and surgeons interested in the latest advances in interventional endoscopy.