Barrett's oesophagus refers to an abnormal change or metaplasia in
the cells of the lower portion of the oesophagus. When the normal
squamous epithelium lining of the oesophagus is replaced by goblet
cells, Barrett's oesophagus is diagnosed. The medical significance
of Barrett's oesophagus is its strong association with oesophageal
adenocarcinoma, a particularly lethal cancer. In this book, the
authors discuss the risk factors, diagnosis and management of
Barrett's oesophagus. Topics include chemoprevention strategies
including aspirin and non-steriodal inflammatory agents in treating
Barrett's oesophagus; an endoscopic ablative technique used in the
management of Barrett's oesophagus and early oesophageal cancer; a
histopathological analysis of protease activated receptor-2 (PAR-2)
and cyclooxygenase-2 (COX-2) immunoexpression in oesophageal
glandular metaplasia; and the impact of
inflammation-metaplasia-adenocarcinoma sequence and inflammatory
microenvironment in oesophageal carcinogenesis using surgical rat
models.
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