This volume provides current protocols that can be used in various experimental settings involving bifidobacteria. Chapters guide readers through experimental protocols on procedures to isolate and cultivate bifidobacteria, taxonomic identification of bifidobacterial isolates, sequencing and annotate genomes, physiologically characterize bifidobacteria, and methods on the genetic manipulation of bifidobacterial strains. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bifidobacteria: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

This extensive and yet easy-to-read book covers technical aspects of the management of difficult acute cholecystitis. It discusses diagnostic evaluation, treatment, and strategies for avoiding and managing complications based on both evidence-based data and the experiences of the editor and the international contributors. Further, it analyses the latest guidelines to find the best clinical applications. Each chapter describes the current diagnostic and management strategies, focusing on a possible risk stratification by scores proposed in literature. Lastly, the book describes the relevant technical considerations and tips and tricks, explaining them in full. Illustrated throughout and including line graphs depicting fundamental anatomic and technical principles, making it easy-to understand, it is a useful toolkit for all residents, fellows and general surgeons needing a guide to the treatment of difficult acute cholecystits.

Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system

This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract.

It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits.

This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.

This book provides a comprehensive overview of the diagnosis and management of diseases of the biliary tree. Topics covered include: congenital biliary abnormalities, genetic cholangiopathies, autoimmune cholangiopathies, inflammatory and drug-related cholangiopathies, and cholangiocarcinoma. Given their particular importance (even for clinicians working with adults), pediatric conditions are also examined. In addition, a special section is devoted to pregnancy and diseases of the biliary tree, and to transplants and diseases of the biliary tree. Each chapter offers up-to-date information on the management of the diseases discussed. Moreover, the book addresses new treatments for autoimmune cholestatic liver diseases, reflecting the new therapeutic targets that have recently been discovered. Examples include farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)-agonists, together with new drugs that affect the composition of bile flow. Given its scope, the book offers a valuable guide for a broad range of practitioners.

This book addresses practical issues that reflect the current landscape of GI pathology practice and is organized in such a way that fits the fast-pacing daily life of practicing pathologists. It contains more than 540 questions that address difficult, prevailing and controversial issues in GI pathology that are frequently encountered in daily practice and consult service. For most questions, answers are straightforward with ample literature support. However, true diagnostic controversies and clinical dilemma cannot be easily resolved with current knowledge and available information. To such challenges, an expert approach regarding how to synthesize complicated topics and clearly communicate the thinking process is valuable to readers and can help guide clinicians making optimal treatment plans for their patients. The latter types of answers are highly enriched throughout the book. Distinct from other existing GI pathology textbooks, this book is primarily organized according to disease entities and pathological processes instead of specific organs and anatomic locations. Guided by chapter titles and listed questions, readers should be able to look up a disease or a pathological feature and find the most important and relevant diagnostic criteria and pertinent differential diagnoses. Written by experts in the field, Practical Gastrointestinal Pathology provides easy and quick access to concise, evidence-based and up-to-date information to aid accurate diagnosis and serves as a useful resource for practicing pathologists, pathology trainees and GI clinicians as well as allied health professionals who frequently deal with GI pathology.

This book provides a thorough overview of the radiologic and pathologic findings of neoplastic diseases of the biliary tract, a sound knowledge of which is essential for appropriate patient management. A key feature is the correlation of imaging findings with both gross pathologic and histopathologic findings for each disease. This is of the utmost importance in understanding true pathologic abnormalities, bearing in mind, for example, the difficulty in ascertaining disease spread and extent on the basis of pathology alone. Since the first edition of the book, conceptual understanding of neoplastic disease of the bile ducts and cholangiocarcinogenesis has evolved significantly, and in the new edition the classification of diseases is based on the most recent edition of the WHO Classification of Tumors of the Digestive System. In addition, some newly recognized pathologies are covered. The book will enhance understanding of the pathology of neoplastic diseases of the biliary tract and aid imaging interpretation. It will be a great asset for pathologists, radiologists, biliary surgeons, and gastroenterologists.

This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.

This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers' understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special "clinical correlates" sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals.

Advocate For Your Care It's expected that you will have questions about biliary cancer upon diagnosis. Whether it's your own diagnosis or a diagnosis of a loved one, this easy-to-read guide provides invaluable practical knowledge such as help for preparing to meet with an oncologist, seeking a second opinion, and understanding clinical trials. 100 Questions & Answers About Cholangiocarcinoma, Gallbladder, and Bile Duct Cancers is a resource that empowers patients and caregivers with the information needed to navigate their treatment with realistic goals for a good quality of life and targeted long-term survivorship. The perspective of patients and doctors is provided in this book with comprehensive answers to the most asked questions with added guidance for support and access to support services. You are the best solution to your cancer care.

This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.

This volume provides a comprehensive guide to advanced endoscopic procedures and techniques. Primarily focused on Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS), the book also explores related topics such as cholangioscopy, pancreatoscopy, advanced pancreaticobiliary imaging, stenting, and endoscopic means to achieve pain control. The text also presents a plethora of tips and tricks on how to perform these procedures safely, emphasizes common mistakes and how to avoid them, and features high quality videos illustrating key procedural aspects for every chapter. Written by top experts in the field, Advanced Pancreaticobiliary Endoscopy is an invaluable resource for gastrointestinal endoscopists and fellows interested in advanced endoscopic procedures.

This book provides a comprehensive, state-of-the art review of intestinal polyposis syndromes. The book reviews the most up-to-date clinical, management, and genetic information regarding the continually evolving colorectal condition that manifests as a polyposis condition. It provides a reference for clinicians and researchers in understanding the complexity of intestinal polyposis and the importance of utilizing multiple modalities for the diagnosis, management and control of these conditions. It also provides an overview of what should alert a care provider to the possibility of a polyposis syndrome. Written by experts in their fields, Intestinal Polyposis Syndromes: Diagnosis and Management is a valuable resource for physicians and researchers who deal with the challenges of diagnosing and managing colorectal cancer and intestinal polyposis syndromes.

Taking the problem-based approach, this text helps clinicians improve their diagnostic and therapeutic skills in a focused and practical manner. The cases included demonstrate the diversity of clinical practice in the specialty worldwide, and are divided into five major sections: Upper GI, Pancreato-Biliary, Liver, Small and Large Bowel, and Miscellaneous.

A Guide to Alternative Medicine and the Digestive System is unique in that it provides answers to many practical clinical questions, all in one comprehensive resource. This single-authored handbook by Dr. Anil Minocha contains content supported by close to a 1,000 scientific citations. A Guide to Alternative Medicine and the Digestive System discusses the supportive evidence, and addresses safety issues, side-effects, and drug interactions. Dr. Anil Minocha is Board-certified in gastroenterology, internal medicine, nutrition as well as fellowship trained in clinical pharmacology and medical toxicology. This extensive background brings a systematic approach to evaluating, treating, and managing patients with alternative medicine options when treating conditions related to the digestive system. Gastroenterologists, primary care physicians, and internists will find more than 70 chapters of succinct information written in a user-friendly format inside A Guide to Alternative Medicine and the Digestive System.

The autobiography of one of America's most important gastroenterologists. Michael Lepore [1910-2000] was a pioneer in the field of gastroenterology. He was a member of one of the first graduating classes of the University of Rochester Medical School, and went on to a distinguished career at Columbia University, New York University, and St. Vincent's Hospital and Medical Center of New York. This autobiography tells of his experiences as an Italian-American who overcame prejudices to become the personal physician to such notablesas Greta Garbo and President Herbert Hoover. His story is witty and cleverly written, and details the way the medical profession changed from the Great Depression to the late 1990s. Michael Lepore was an alumnus of Duke University Medical School and the University of Rochester School of Medicine, and was the Director, Gastroenterology Section, Departments of Medicine and Surgery Emeritus, St. Vincent's Hospital and Medical Center of New York.

This book provides specialist and general nurses with a comprehensive guide to the art and science of stoma care nursing, from the Association of Stoma Care Nurses UK, the only association for SCNs in UK. The chapters follow a schematic outline of knowledge required for nurses caring for patients who are undergoing stoma surgery; from the essence of nursing to the management of patients living with a long term condition. It also presents and discusses the issues surrounding the clinical picture such as prescription and community issues as well as sources of support available for patients. This text serves as an excellent resource for all disciplines of health care staff caring for individuals living with a stoma.

This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.

The Liver in Systemic Disease A practical guide for non-hepatologists who encounter abnormal liver test results in patients The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated. With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter. Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides: A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more Practical discussions of the management of patients with unexplained abnormal liver tests in primary care In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.

This book provides a state-of-the-art overview of dysphagia. The text reviews current evidence behind the diagnosis, evaluation, and management of esophageal disorders that cause dysphagia, including GERD, eosinophilic esophagitis, achalasia, and spastic motor disorders. The book also focuses on the different variants of dysphagia, from oropharyngeal dysphagia to functional dysphagia, highlights advances in testing for dysphagia, and features evidence-based algorithms. Written by experts in the field, Evaluation and Management of Dysphagia: An Evidence-Based Approach is a valuable resource for gastroenterologists, otolaryngologists, and other clinicians and practitioners who treat patients afflicted with dysphagia.

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

This atlas provides a comprehensive, state-of-the-art review of all interventions that pertain to the esophagus. It includes a review of the current staging modalities, ablation technologies, resection and reconstruction techniques, and disease classification. Evidence-based guidelines regarding how each intervention is chosen are also included. With color illustrations and photographs for each surgery, the atlas details specific anatomic topics such as micro-anatomy of Barrett's and Dysplasia, EMR pathology, endoscopic ultrasound, and conventional surgical anatomy. Each intervention is presented in task format as a task list to be checked-off as each step is completed. Written by experts in the field, Atlas of Esophageal Disease and Intervention: A Multidisciplinary Approach serves as a valuable resource for any practitioner who performs esophageal intervention and will guide new surgeons and gastroenterologists into the hybrid multidisciplinary approach to this disease.

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Die Forschung zu Diagnostik und Behandlung von Dysphagien verschiedenster Stoerungsbilder bei Erwachsenen und Kindern hat in Deutschland in den letzten zwanzig Jahren deutlich an Bedeutung gewonnen. Der Arbeitskreis Dysphagie Ostwestfalen-Lippe in Kooperation mit dem Studiengang der Klinischen Linguistik an der Universitat Bielefeld befasst sich im Rahmen einer zweijahrig stattfindenden Tagung speziell mit aktuellen Fragen dieser Thematik. Der vorliegende Band diskutiert aktuelle Forschungsfragen und Ergebnisse aus Diagnostik und Therapie.