Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

This easy to read, easy to use pocket guide has been written with the busy health care provider in mind. Patients with Crohn's disease and ulcerative colitis - collectively known as Inflammatory Bowel Disease (IBD) - present special challenges for practitioners, whether in the office, in the clinic, or on the telephone. IBD patients typically require lifetime care, and grapple with a wide range of changing intestinal symptoms and extraintestinal concerns that can be confusing for the nonspecialist who may not know what to ask or what to do next. This guide has been written by respected clinicians in the field of IBD to help anyone who cares for these patients identify the problems and make decisions about treatment. Each chapter is devoted to a particular symptom and follows the same format for rapid access. The book also contains a comprehensive table of IBD medications, and chapters on other management issues like long term complications, nutrition, and alternative therapies.

Diverticular disease first became recognised at the beginning of the 20th century and although the incidence of the disease is not known, it is considered to be a disease of the older person. This book looks at a disease that is known as a Western world disease, often called by surgeons a 'cinderella disease' as they often feel that there is little to offer the patient with uncomplicated diverticular disease.

The book endeavours to give the healthcare professional a holistic view of the care and pattern of diverticular disease, and chapters may be used as stand alone chapters for those wishing to know more about stoma care, alternative treatments or food management. This book is essential reading for healthcare professionals involved in the care of patients with this disease.

This book provides a state-of-the-art overview of dysphagia. The text reviews current evidence behind the diagnosis, evaluation, and management of esophageal disorders that cause dysphagia, including GERD, eosinophilic esophagitis, achalasia, and spastic motor disorders. The book also focuses on the different variants of dysphagia, from oropharyngeal dysphagia to functional dysphagia, highlights advances in testing for dysphagia, and features evidence-based algorithms. Written by experts in the field, Evaluation and Management of Dysphagia: An Evidence-Based Approach is a valuable resource for gastroenterologists, otolaryngologists, and other clinicians and practitioners who treat patients afflicted with dysphagia.

The first edition of this book was judged by many to be the best available atlas of upper gastrointestinal and hepato-pancreato-biliary surgery. The second edition builds upon this success by covering all of the significant intervening developments, including both new procedures and adaptations of established techniques. The atlas opens with an introductory section on the basic principles of operative surgery. All of the important surgical techniques are then presented in a series of sections devoted to the esophagus, stomach, and duodenum, the liver, the biliary system, portal hypertension, the pancreas, and the spleen. General, oncologic, and transplantation surgical procedures are described step by step with the aid of more than 900 superb illustrations drawn by a team of artists with extensive experience. The contributors were selected on the basis of their extensive experience in the procedures discussed and most are established educators.

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

This book shows the huge impact the gut microbiota has on the gastrointestinal health of humans with a particular focus on children. It also highlights the potential use of probiotic microorganisms to protect or improve children's gastrointestinal health. Humans are not single organisms: We are a multi-organism structure composed of ourselves and our microbiota, living in close symbiosis since birth and even before. The huge impact that the billons of microscopic cells living in our gut have on our gastrointestinal and systemic health cannot be overestimated. The enormous progress that has been made in the past decade in our still very incomplete understanding of the gut microbiota is opening the door to potential applications in human health that were simply unthinkable before. One of the most interesting aspects of this new scientific horizon is the fact that we may identify (or even create in the laboratory) and utilize many of these "friendly bacteria" to protect, or improve our health. Thus, strains of probiotic microorganisms are being identified and studied in a vast array of clinical scenarios. Among the most investigated areas for probiotics is the gastrointestinal health of children. The topics addressed in this book are spanning from the development of the gut microbiota in the fetus and newborn all the way to current and potential applications in disparate conditions such as necrotizing enterocolitis, or infectious, or inflammatory conditions affecting the child. The book is written in a rigorous, evidence based manner by an international group of outstanding experts in these fields and is aimed at pediatric gastroenterologists, pediatricians and physician scientists alike.

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Human illness attributed to foodborne pathogenic microorganisms has been prominent in the mass media in recent years. The Practical Food Microbiology Series has been devised to give practical and accurate information about specific organisms of concern to public health. The information is designed for use by those in the food industry working in manufacturing, retailing and quality assurance, those in associated professional sectors e.g. public health, and students in each of these areas.

The series is unique in its practical approach as it draws on real life situations to highlight practical means for controlling the organism in foods.

Salmonella species are arguably the most commonly reported food associated human pathogens in the developed world. They are zoonotic agents and many different animal reservoirs are known. They can be found widely in the environment and may also establish in food processing environments. Over 2000 serotypes of Salmonella have been identified to-date, some of which cause very serious illness in humans particularly in vulnerable populations such as the elderly. Although rare, illness may result in fatality or long term debility and sequelae. Salmonella spp. are so widespread in raw foods and food source environments that the food industry has to maintain constant vigilance regarding contamination in raw materials, effectiveness of food processing systems and control of finished product characteristics for assuring food safety with respect to this important pathogen.

This book details the causes of selected outbreaks and assesses the lessons that can be learnt from them. It examines the characteristics of Salmonella spp. and identifies factors that make foods susceptible to contamination and growth of these organisms. Specific product sectors are used to indicate practical measures that can be applied to control Salmonella spp. in foods and minimise their potential to cause harm to the consumer. It also provides guidance in selecting effective sampling plans and test methods to monitor and detect the organism and offers pragmatic advice on action to be taken when the organism is detected during monitoring programmes.

Perfect for residents, generalists, medical students, nurses, and other healthcare professionals who need a practical, working knowledge of gastroenterology, Netter's Gastroenterology, 3rd Edition, provides a concise overview highlighted by unique, memorable Netter illustrations. This superb visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a physician who has created clear, full-color illustrations in the Netter tradition. Up-to-date coverage of the full range of digestive diseases-including gastroenterology, hepatology, and nutrition- keeps you current with the latest information in the field. Offers a quick and memorable summary of nearly 200 of the most commonly encountered clinical conditions, from classic to contemporary. Concise text is presented in a templated format for fast, easy access to information. Features over 300 Netter and Netter-style images that highlight key aspects of patient presentation, pathophysiology, and relevant anatomy to provide a rich visual understanding of the most important concepts. Includes access to 25 printable patient education brochures in the enhanced eBook version. Provides complete guidance on all major GI diseases and conditions through sections on normal structure and function, the clinical picture, diagnosis, treatment and management, course and progress, and prevention and control. Offers dependable clinical advice from Drs. Martin H. Floch, Neil R. Floch, Joseph K. Lim, C. S. Pitchumoni, Raul J. Rosenthal, and James S. Scolapio, as well as many world-renowned chapter contributors. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance.

This book highlights treatment strategies for bacterial biofilms in connection with a variety of human diseases. In particular, it reviews bacterial biofilm formation and its mechanism. Topics covered include biofilms in human health, the role of biofilms in mediating human diseases, and methods for testing bacterial biofilms. Further sections concentrate on biofilm-mediated diseases in different parts of the human gastrointestinal tract, while therapeutic strategies for biofilm control and natural agents that disrupt bacterial biofilms are also covered. Readers will also find the latest advances in probiotics and biofilms, as well as the use of probiotics to counteract biofilm-associated infections. Biofilms and antimicrobial resistance are discussed. Subsequent chapters address the management of inflammatory bowel disease via probiotics biofilms, as well as the role of probiotics bacteria in the treatment of human diseases associated with bacterial biofilms. The book is chiefly intended for clinicians/scientists in the fields of medical microbiology, applied microbiology, biochemistry, and biotechnology.

This book provides a state-of-the-art overview of dysphagia. The text reviews current evidence behind the diagnosis, evaluation, and management of esophageal disorders that cause dysphagia, including GERD, eosinophilic esophagitis, achalasia, and spastic motor disorders. The book also focuses on the different variants of dysphagia, from oropharyngeal dysphagia to functional dysphagia, highlights advances in testing for dysphagia, and features evidence-based algorithms. Written by experts in the field, Evaluation and Management of Dysphagia: An Evidence-Based Approach is a valuable resource for gastroenterologists, otolaryngologists, and other clinicians and practitioners who treat patients afflicted with dysphagia.

Dr. Natasha Campbell-McBride created the term GAPS (Gut and Psychology Syndrome or Gut and Physiology Syndrome) in 2004 to describe the plethora of health problems that stem from an unhealthy gut. Since developing the GAPS nutritional protocol, Dr. McBride has received letters from GAPS sufferers all over the world: stories written by real people who have overcome their real health problems. Every one of these people has learned valuable lessons on their healing journey: lessons they are keen to pass to others who may be struggling through the same difficulties. These stories can be utilized as case studies for how to progress through personal healing and how to deal with problems that one may have to face along the way. There is nothing more valuable than real life experience! Those who have lived through something, fought the battle and won, know what is true and what is false, what works and what doesn't. Many of these stories are humbling--the kinds of horrific problems that people have had to deal with are hard to imagine for the majority of us--yet told with humor and grace!

Cleveland Children's Clinic developed this handbook for conducting a nutrition-focused physical exam (NFPE) of pediatric patients. Fully illustrated, this handbook assists bedside clinicians in nutrition assessment, helping discern the presence and degree of malnutrition. Most healthcare disciplines perform a physical exam and a NFPE should be part of the nutrition clinician's skill set. Techniques and tips that can be used in daily practice when examining patients, as well as charts and references, are provided. Chapters include: Overview of Physical Exam Techniques Physical Exam of Subcutaneous Fat and Muscle Assessment of Fluid Status Assessment of Functional Status Physical Exam of Hair, Eyes, Oral Cavity, Nails and Skin Birth to 3 Years of Age Ages 3 to < 11 Years Ages 11 - 20 Years Nutrition Issues in Specialty Populations (Critical Care, Obesity, Developmental Delay and Neurological Impairments)

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Colorectal cancer is a common cause of morbidity and mortality in which prevention, screening and early detection are vital. Beginning with the patient perspective and following the patient pathway, this new second edition covers epidemiology and prevention, screening programmes, decision support networks, the role of primary care, and supportive care for patients with colorectal cancer. The ABC of Colorectal Cancer provides the core knowledge on clinical genetics, diagnosis, imaging, therapy and surgery options and the latest evidence based guidelines for treating and managing colorectal cancer patients within the multidisciplinary team. Highly illustrated and accessible, it covers the full spectrum of the disease to provide the basis to make a real difference to clinical management. This is an invaluable practical guide for the non-specialist on all aspects of colorectal cancer, and is ideal for general practitioners, junior doctors, nurses and allied health professionals.

This book reviews recent knowledge of the role of stem cells in the gastrointestinal system. It covers extensive topics for each organ, including the pancreas, esophagus, liver, and colon, while also discussing the contributions of stem cells to therapeutic approaches toward gastrointestinal diseases, including inflammatory bowel diseases. Comprehensive and cutting-edge, Digestive System Diseases: Stem Cell Mechanisms and Therapies deepens a reader's theoretical expertise in gastrointestinal stem cell biology. It furthers scientists' understanding of gastrointestinal stem cells and, most importantly, the development of novel therapeutic targets. Graduate and postdoctoral students, medical doctors (including gastroenterologists and surgeons), and principal investigators in both academia and industry will benefit from this book. In particular, it is a valuable resource for professionals within the fields of gastrointestinal research, pharmaceutical science, molecular biology, regenerative medicine, and genetics.

This volume provides the most comprehensive coverage of clinical management of borderline resectable pancreatic cancer available. Authored by leaders in the field, the book focuses on current clinical management of this disease stage, the importance of multimodality treatment algorithms, and an interdisciplinary approach to care. Surgical chapters are well-illustrated to provide surgeons and surgical trainees with important technical pearls. Clinical trials and trial design are also discussed. Multimodality Management of Borderline Resectable Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, radiation oncologists, surgical oncologists, general surgeons, and trainees interested in the treatment of pancreatic cancer.

Jordan Rubin, junto con el D.M. Joseph Brasco, muestran a los lectores como aplicar las 7 claves para la salud y el bienestar y combatir en forma natural el sindrome de irritabilidad intestinal, una enfermedad dolorosa y debilitante.

Dirk Haller und Gabriele Hörmannsperger geben einen Überblick über die zentrale Rolle des Darms und seiner Bewohner für die Gesundheit und vermitteln zusätzlich einen ersten Eindruck von den komplexen und dynamischen Interaktionen zwischen D+armbakterien und Wirt. Denn Forschungsergebnisse der letzten Jahre weisen darauf hin, dass die lange unbeachteten Darmbakterien (intestinale Mikrobiota) eine unerwartet zentrale Rolle für die Aufrechterhaltung der Gesundheit einnehmen. Die Forschung beschäftigt sich aktuell intensiv damit, die Grundlagen für ein funktionierendes und gesundheitsförderndes mikrobielles Ökosystem zu identifizieren. Dieses Wissen kann zukünftig für die Entwicklung gezielter Maßnahmen zur Prävention und Therapie Mikrobiota-assoziierter Erkrankungen eingesetzt werden.

Inflammatory Bowel Diseases: A Clinician s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterology trainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use. Written by the experts, Inflammatory Bowel Diseases: A Clinician s Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease.

"Contemporary Coloproctology" covers colorectal surgery, as practiced today, in an easily accessible format with emphasis on bringing key facts rapidly into focus. It is ideal reading both for the medical trainee and the practicing colorectal surgeon.

As well as a succinct presentation of the current colorectal knowledge base, each chapter contains practical advice and pearls of wisdom from established practicing clinicians. A unique feature of the format is the identification of key references and questions and scenarios that present real life decisions in colorectal surgery.

Edited and authored by outstanding surgeons in their fields, this book brings the reader expertise in surgery and management across the various conditions encountered in coloproctology.""

Intestinal failure is a challenging, emerging field that has been the subject of much research and debate in recent years and has only recently become widely accepted as a distinct clinical syndrome.
This comprehensive book provides an in-depth review of scientific theory and clinical practice relating to intestinal failure with specific emphasis on assessment and management as part of a multidisciplinary team. Compiled by an internationally recognised editorial team, the book provides a practical how-to guide to the management of adult and pediatric patients with intestinal failure, focusing on quality-of-life issues that are at the heart of patient care.
* World experts from centers of excellence share their clinical experience and expertise, offering the first ever authoritative resource on intestinal failure
* All aspects of patient management are covered, from diagnosis and medical and surgical management (including transplantation) to nutritional consideration and psychosocial aspects of care
* Numerous illustrations, flow diagrams and summary boxes complement the text and emphasize important concepts, providing an accessible approach to this complex field
This landmark book is essential reading for any gastroenterologists, surgeons, transplant teams or clinical nutritionists involved in the care of patients with intestinal failure.