Hepatologie konkret - komplett - kompakt Erfahrene Kliniker fuhren ubersichtlich, zusammenfassend und gewichtet durch das Gebiet der Leber- und Gallenwegserkrankungen. Komplexe Inhalte werden anschaulich, klar und gut verstandlich dargestellt. Differenzierte Diagnostik und Therapie: Was - Wann - Warum Neueste diagnostische und therapeutische Konzepte Rasche, prazise Information Konzentration auf krankheitsbezogene klinische Informationen Therapie individuell abgestimmt auf Ihre Patienten Standards Therapie fur multimorbide Patienten Loesungen fur typische und atypische Therapieprobleme Zur sofortigen sicheren Anwendung Entsprechend der neuesten Studien und Leitlinien aller wichtigen deutschen, europaischen und amerikanischen Fachgesellschaften

This innovative handbook bridges the gap between the colorectal surgeon, the stoma nurse and the dermatologist. It addresses the questions of what pathology is involved, what can be done by nurses, when to refer to a dermatologist, and what can be done by a dermatologist. Now in its second edition, the book has been revised throughout and contains new information on nutrition and child stoma patients.

Acute pancreatitis is a common cause of acute abdomen. Diagnoses is difficult as the symptoms mimic that of many other medical and surgical conditions. Patients with severe acute pancreatitis can develop multiple organ failure and need intensive care. As its management is multi-disciplinary involving gastroenterologists, radiologists and surgeons, this book shall appeal to every doctor, irrespective of the specialty. This focused book conveys the knowledge of the basic concepts of acute pancreatitis in an innovative way. Original photographs and figures are used for the better understanding of the readers. In this pocketbook, various aspects related to acute pancreatitis are covered in a unique, simple and easy-to-read A-to-Z format and will be useful to medical students, post-graduate trainees and practicing doctors as a ready reckoner for pancreatitis. Key Features: * Innovative and unique A - Z format. * focuses on signal knowledge and fast clinical management of various facets of different types of acute pancreatitis. * Comprehensive approach with interesting facts. * Lucid and self-explanatory text. * Can be used as a ready reckoner pocketbook .

A practical handbook on fecal microbiota transplantation (FMT) for physicians, nurses, physician assistants, students, residents, and fellows, The 6 Ds of FMT: A Primer for Clinicians from Decision to Discharge and Beyond provides a clinical framework to understand and administer this treatment as safely and effectively as possible. FMT has emerged as a promising treatment for C. difficile infection (CDI), and there is a major need for educational resources on the topic. Drs. Jessica Allegretti, Zain Kassam, and their expert contributors are leaders in the field and have collectively cared for thousands of patients suffering from recurrent CDI who have benefitted from FMT. This guide provides practical tools, clinical pearls, and answers to frequently asked questions. Beginning with introductory information on the microbiome and exploring the history of FMT, The 6 Ds of FMT outlines a step-by-step checklist for administering FMT: Decision: Who is the right CDI patient to receive FMT? What clinical questions should you ask patients in your FMT clinical assessment? Donor: How do you select and screen a donor for FMT? Discussion: What are the risks, benefits, and alternatives that need to be discussed with patients? Delivery: What is the best delivery method for FMT - colonoscopy, nasogastric tube, enema, or capsules? Discharge and follow-up: What is the ideal post-FMT care? How should you council patients following FMT? Discovery: What are the most promising emerging clinical applications for FMT? What is the evidence for FMT in obesity, autism, irritable bowel syndrome, inflammatory bowel disease, antibiotic resistant bacteria, and liver disease? Arming healthcare professionals with the ability to answer questions from patients regarding FMT and the microbiome, The 6 Ds of FMT provides a pragmatic guide for this exciting treatment.

Learn all you need to know about gastrointestinal drugs and their clinical use with this one-stop, rapid reference pocket guide. Brought to you by many of the world's leading GI drug experts, Pocket Guide to Gastrointestinal Drugs provides comprehensive guidance to the pharmacological properties of drugs used to treat gastrointestinal conditions, including mechanisms of action, appropriate administration, and potential adverse effects associated with their use. Organized by class of drug and ranging from PPIs to immunosupressants, each chapter first examines the specific agents within that class and then their appropriate and judicious use across a range of specific GI disorders. Key features include: * Introduction of drug class * Basic pharmacology, including mechanism of action, bioavailability, metabolism, interactions, adverse effects, toxicity, and special considerations * Dosing information for each GI condition and on- and off-label use * Consistent use of both generic and trade names throughout * Specific reference to drug use in pediatric patients and during pregnancy Perfect for quick consultation on the wards and in the office, Pocket Guide to Gastrointestinal Drugs is the ideal tool for all those managing patients with GI conditions, including gastroenterologists, GI trainees, emergency physicians, GI specialist nurses, primary care physicians and residents, intensivists and pharmacists.

"Fatty Liver Diseases: NASH and Related Disorders" is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease.

It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.

The latest guidance on challenging and controversial aspects of colorectal cancer

Colorectal cancer is one of the most common forms of cancer in the US and Europe. Thousands of people are diagnosed with the disease every year and nearly half of these die as a result. As colorectal cancer is curable when detected early, a significant proportion of these deaths could be prevented by earlier diagnosis.

Much has changed since the publication of the first edition of this book in 2001: introduction of screening programs, improved diagnosis and surgery for rectal cancer, and advances in adjuvant and palliative medical therapy to name but a few.

"Challenges in Colorectal Cancer" provides the most up-to-date information on the new and emerging treatments. The second edition looks at the total patient management of this condition and is aimed at the entire medical team caring for those with colorectal cancer. It also contains the latest guidelines on epidemiology and prevention of colorectal cancer, and the application of molecular genetics.

The expanded international editor team present advice on surgical management, including new laparoscopic and endoscopic techniques and the role of the pathologist. They also review hot topics in colorectal cancer treatment, including the role of radiotherapy, options for chemotherapy and new developments in vaccines and immunotherapy.

Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world's leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

This book covers all aspects of small intestinal disease with the aim of providing an up-to-date reference of the highest quality that will assist in everyday clinical practice. After introductory chapters on anatomy, pathophysiology, epidemiology, and signs and symptoms, the roles of different imaging modalities in the diagnosis of small intestinal disease are clearly explained, focusing particularly on capsule endoscopy, device-assisted enteroscopy, CT and MR enterography, and nuclear medicine techniques. A series of chapters then address each of the diseases and conditions that may be encountered. The coverage is wide ranging, including, for example, obscure gastrointestinal bleeding, Crohn's disease and other inflammatory conditions, celiac disease, Behcet's disease, Meckel's diverticulum, intestinal tuberculosis, and various malignancies. Numerous informative clinical cases are presented to identify characteristic imaging findings and assist in treatment decision making. Small intestinal disease continues to represent a significant challenge. The scope and detail of this book will make it an invaluable asset for gastroenterologists and other clinicians.

Clostridium difficile and its toxin-producing strains are the most common causative agents of Clostridium difficile infections. It is an inflammatory bowel disease predominantly caused by prior antibiotic treatment. The use of broad-spectrum antibiotics suppresses bacterial intestinal microflora and causes overgrowth of the Clostridium difficile, and often occurs in immunocompromised, older and polymorbid patients. Following this, the authors discuss inflammatory bowel disease (including ulcerative colitis), a complex, multifactorial disease of unknown aetiology. Intestinal sulphate-reducing bacteria, especially Desuflovibrio, are often found in the intestines and faeces of people and animals with inflammatory bowel disease. Of late, the incidence of autoimmune colitis both in adults and children has been progressively increasing globally. The efficacy of conventional therapeutic measures is questionably limited due to short-term immunosuppressive effect along with possible serious side effects. As such, the authors present evidence from epidemiological studies that has demonstrated an inverse relationship between the occurrence of parasitic diseases and various autoimmune pathologies.

This practical text is indispensable to all clinicians working with dysphagia and is suitable for those involved in a range of settings and with a diversity of client groups. With its perspective on everyday working practice, "Working with Dysphagia" fills a gap in an area where practical and workable material is much sought after. This book is a useful resource for all therapists, ranging from students to specialist, as the practical assessment approach and comprehensive management strategies are supported throughout with references of recent relevant research.

This book focuses on the management of children with fecal incontinence and constipation. Despite accurate anatomic reconstruction, many children still suffer from a variety of functional bowel problems. These include not only children with congenital anatomic problems such as anorectal malformations and Hirschsprung disease, but also includes the huge population of children who suffer from constipation, with or without soiling, and a large spinal population (spina bifida) who have bowel problems.

The Liver in Systemic Disease A practical guide for non-hepatologists who encounter abnormal liver test results in patients The Liver in Systemic Disease is an easy-to-use and authoritative guide for non-hepatologist health care professionals who need guidance on the management of patients with abnormal liver tests. The book provides definitive advice for when further investigation, or changes in management, are indicated. With a practical focus throughout the text, the editors explore when and how to investigate and manage patients whose primary disease is non-hepatic, but whose liver tests are unexpectedly abnormal. The Liver in Systemic Disease provides substantial flow diagrams and advice on the process, together with updates on the liver diseases non-hepatologists are most likely to encounter. Take-home primers included in the book shine a light on best practice and recommended procedures when dealing with abnormal liver test results. The book also provides: A thorough introduction to evaluate the liver, including serum liver tests, liver imaging, and liver biopsy Comprehensive discussions of practical issues in patients with liver abnormalities, including the diagnosis of drug induced liver injury, prescribing in patients with abnormal liver tests, and more Practical discussions of the management of patients with unexplained abnormal liver tests in primary care In-depth examinations of secondary care management of patients with unexplained abnormal liver tests, including intensive care, and the care of infectious and immunosuppressed patients The Liver in Systemic Disease is an indispensable resource for non-hepatologist medical practitioners seeking to understand the implications of abnormal liver tests and who wish to know when further investigation or alteration of management is indicated.

Acute appendicitis is one of the most common surgical abdominal emergencies worldwide, with a lifetime risk of 8.6% for males and 6.7% for females. This compilation discusses how while non-operative treatment of appendicitis has been proposed as an alternative to surgery, appendicectomy remains the mainstay of treatment in most cases and techniques have shifted from open to laparoscopic methods. The current knowledge in pathogenesis, diagnosis, and clinical management of acute appendicitis is also discussed. Next, the authors present an updated review chapter of appendicitis regarding its prevalence and risk factors, particularly how the diagnosis of appendicitis is based on a history of diffuse abdominal pain, which usually starts in the central region of the abdomen and migrates to the lower right quadrant of the abdomen. The residual remnant or "stump" of the appendix after an initial appendectomy may become inflamed causing what is commonly referred to as stump appendicitis. Treatment with antibiotics may be attempted as an alternative to surgery; however, the vast majority of cases require definitive surgical excision of the remnant appendix. The authors propose that keeping this disease in the differential is important in reducing complications associated with delayed diagnosis.

For Kathleen Nicholls, life with Crohn's disease has been a constant battle against her bowels. But life has also been about David Bowie, dancing, and laughter. Go Your Crohn Way follows the highs and lows of Kathleen's experiences, and is full of useful advice for maintaining self-confidence and positivity while navigating the world of work, relationships, and those conversations. Warm and inspiring, this book demonstrates how Crohn's can be life-changing, but not just for the worse. Kathleen gives advice and tips on adapting and thriving through Crohn's, including a specially created phrasebook, which proves that so long as you know how to ask for the nearest bathroom, globe-trotting is still firmly on the agenda. Full of fun and humour, Kathleen's journey through life with Crohn's disease will leave you - like her - in stitches.

This comprehensive manual discusses the many aspects of inflammatory bowel disease (IBD), providing relevant information along with practical guidance. The reader is also directed to additional resources for extra and current information. This book comes at a time when the number of people suffering from the two major forms of IBD, ulcerative colitis (UC) and Crohn's disease (CD), is rising around the globe. Despite their huge impact on daily life and health economics, these diseases are not fully understood, and diagnosis and treatment remains a significant challenge. IBD nurses are increasingly recognised as key clinicians within the multidisciplinary team caring for people with IBD. Through experience and specialist knowledge IBD nurses provide timely support, advice, and treatment for people living with this unpredictable condition. IBD nurses are also well placed to liaise with the wider team, developing patient centred services which best fit their local health framework. The combined international expertise and accessible guidance here will equip nurses, or any clinician wanting to increase their competence in IBD management. Thereby this manual aims to contribute to the optimisation of IBD care throughout the world.

Flavonoids are plant secondary metabolites with a basic polyphenolic skeleton and anticancer properties have greatly attracted the interest of scientists already for several years. This structurally diverse group of phytochemicals can be found abundantly in various edible plant products, such as fruits and vegetables, tea and cocoa, nuts, spices, grains and medicinal herbs. In the past decades, numerous experimental studies have shown antiproliferative, proapoptotic, antiinflammatory, antiangiogenic, antiinvasive and antimetastatic activities of these compounds in different cancerous systems. Because of close contacts and interactions of ingested food components with the epithelial lining of organ sites of the upper gastrointestinal tract, flavonoids can directly affect the development and progression of malignant neoplasms in the oral cavity, esophagus and stomach. This book gives a comprehensive and contemporary survey about the different anticancer actions of various natural and semisynthetic flavonoids in experimental models of oral, pharyngeal, esophageal and gastric cancers, involving the data obtained from studies of both cell lines as well as laboratorial animals. Also, the effects of flavonoids on the therapeutic responses of conventional cancer treatment modalities, i.e., different chemotherapeutic drugs and irradiation, are presented and analyzed. Moreover, the current epidemiological knowledge about the role of dietary intake of flavonoids on the risk of carcinogenesis in the upper digestive tract in populations with different dietary and lifestyle habits is described. By virtue of the high topicality of the subject but also the thoroughness of its discussion, this book could be interesting and attractive to basic scientists working in the field of plant chemicals, molecular cancer research or design and development of novel anticancer drugs; synthetic chemists in different pharmaceutical companies; health workers and nutritional counselors; medical doctors working with cancer patients; people suffering from any type of upper digestive tract tumors and their family members; and anyone who is interested in the natural tools for the fight against malignant neoplasms and whose purpose is to consciously prevent carcinogenesis within the upper gastrointestinal tract.

To all readers of this book on pancreatitis: The idea of centering a book on pancreatitis came to the authors mind after working as a general surgeon at his hospital over a period of twenty-seven years after his return from Britain, where he finished his postgraduate training and received the fellowship from the Royal College of Surgeons of Edinburgh. This book covers topics of pancreatitis including pathology, clinical presentation, investigations and treatment; it is recommended for resident surgeons and will help them to attain knowledge on pancreatitis. The author would like to thank the staff of the HBP unit at Queen Elizabeth Hospital at Birmingham, particularly Professor J. Buckle and Mr. D. Mirza, who gave the author the chance to practice his skills when he was a visiting surgeon at their unit.

Cystic tumours of the pancreas today are diagnosed more frequently in clinical practice, mainly due to an increased use of the modern advanced imaging modalities. Bland cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. However, the current knowledge concerning the development of cystic neoplasias of the pancreas is still rudimentary. Histopathologically, 90% of pancreatic cystic neoplasias are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary mucinous (IPMN) and solid pseudopapillary (SPN) neoplasias. Surgical treatment of these lesions can be highly challenging and occasionally demands complex surgical approaches that should be put in the hands of skilled pancreatic surgeons in experienced high-volume centres. While some of the described cystic tumours are harmless, such as SCNs of the pancreas, others such as IPMN and MCN harbour relevant malignant potential. The differential diagnosis of these lesions is critical for the patient- but often difficult. In addition, surgical treatment, even in the hands of skilled surgeons in centres of pancreatic surgery, can be complicated and can result in relevant morbidity and mortality. Therefore, it is of great importance for all doctors treating and advising patients with cystic tumours of the pancreas, i.e. surgeons, gastroenterologists, radiologists and pathologists as well as for the general practitioner, to have funded knowledge in regard to epidemiology, pathology, diagnostics and prognosis of the various pancreatic lesions, regardless of the necessity for surgical treatment. Together with recognised specialists in this field from Europe, the United States, and Japan, the authors offer a broad and detailed overview over diagnosis and the current treatment strategies for patients with cystic tumours of the pancreas.

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

The field of gastrointestinal biology has been transformed by an explosion of knowledge for gastrointestinal motility, absorption, and secretion. The chapters in this book summarise the methods of molecular biology and the cell biology of gut enzymes, secreting cells and cells that respond to these enzymes. This book is a valuable reference for students, researchers and faculties of gastrointestinal motility, absorption and secretion. No other single source covers this field so comprehensively. It contains a considerable amount of detail on subjects such as gut hormones, gut malabsorption, alcohol toxicity on the stomach and methods used in physiologic study of the digestive tract. Disease conditions are discussed only to the extent that they illustrate physiologic mechanisms. It is difficult for such a comprehensive work to remain up to date for very long, considering how rapidly our knowledge of life sciences expands. This book, a comprehensive treatise on the causes, diagnosis, and management of gastrointestinal-motility disorders, consists of eighteen chapters with extensive references contained in slightly fewer than 300 pages. It achieves its goal through generally lucid writing and the overlap of information from chapter to chapter commonly observed in multi-authored works. Therefore, the reader is best advised to go through this book in a relaxed manner; this will allow them to finish it in a relatively short amount of time and appreciate the field of gastrointestinal motility, particularly current practices and research methods for solving its many riddles. All the chapters are clearly written, but the target audience seems to vary from medical students to practicing gastroenterologists. Despite these drawbacks, gastroenterologists, surgeons, and basic scientists wishing to bring their general knowledge of clinical motility disorders up to date will find this book useful.

Nurses must deliver up-to-date, clinically effective, evidence-based care across a range of settings and develop nursing services to meet changing demands. The thoroughly revised and restructured Oxford Handbook of Gastrointestinal Nursing 2nd edition is tailored to provide the essential knowledge nurses need; at their fingertips when they need it. This handbook will guide the reader through the care of patients with a wide range of conditions of the gastrointestinal tract. Each chapter is written in a consistent structure for ease-of-use, including symptoms, causes, investigations, and treatments. Key information is provided clearly and succinctly with tables and bullet points. Chapters cover everything from anatomy to the appropriate treatment or nursing care. It now includes new conditions including colorectal cancer, anal warts, cleft lip, and volvulus, as well as the enhanced recovery after surgery pathway. Providing key summaries of common problems and essential issues, it will provide both an invaluable reference for gastrointestinal nurses, as well as a precise, targeted guide for nurses from other specialties caring for patients with GI problems.

Short bowel syndrome (SBS) is a pathologic condition which is characterised by reduced intestinal length and diminished intestinal absorptive capacity mainly due to extensive surgical resection, congenital defect, or pathological process affecting the small bowel. In recent decades, a better understanding of the underlying pathophysiology, new and modified surgical techniques and improvements in enteral and parenteral nutritional support improved the results of therapy of patients with SBS. This book provides research on the etiology, symptoms, surgical options and outcomes, and complications of SBS.

Gastroesophageal reflux disease (GERD) is a common disorder affecting approximately more than 10% of the population. GERD is highly heterogeneous in terms of varied manifestations, test findings and treatment responsiveness. The invasive treatment options for GERD have now greatly expanded from just the Nissen Fundoplication to various other options such as other minimally invasive options like the Lower Esophageal augmentation with a magnetic device, and multiple endoscopic options like Radiofrequency ablation, Trans-oral incisionless fundoplication (TIF) etc. Treatment options require an understanding of the patho-physiology of GERD, which is discussed in chapter one of this book. Chapter two studies the clinical practices for extra-esophageal reflux and explores the outcomes. Chapter three reviews extraesophageal reflux and sleep microarchitecture disturbance and excessive daytime sleepiness. Chapter four discusses osteopathic manipulative therapy. The final chapter provides updated research on the surgical treatment options for GERD and their long-term outcomes.