* Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. "This is a well written text and should be a good reference book for those who see patients with HCC.." - Practical Gastroenterology "...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC." - Digestive and Liver Disease

This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

This volume provides a comprehensive guide to advanced endoscopic procedures and techniques. Primarily focused on Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS), the book also explores related topics such as cholangioscopy, pancreatoscopy, advanced pancreaticobiliary imaging, stenting, and endoscopic means to achieve pain control. The text also presents a plethora of tips and tricks on how to perform these procedures safely, emphasizes common mistakes and how to avoid them, and features high quality videos illustrating key procedural aspects for every chapter. Written by top experts in the field, Advanced Pancreaticobiliary Endoscopy is an invaluable resource for gastrointestinal endoscopists and fellows interested in advanced endoscopic procedures.

This book is part of a series covering surgical specialties. The volumes are multi-authored, containing brief chapters, each of which are devoted to one or two specific questions or decisions within that specialty that are difficult or controversial. The volumes are intended as a current and timely reference source for practicing surgeons, surgeons in training, and educators that describe the recommended ideal approach, rather than customary care, in selected clinical situations.

This volume provides a concise overview of the most important and vital aspects of upper endoscopy. The text is specifically geared towards first-year GI fellows and novice endoscopists in order to help them rapidly assimilate the core concepts needed to perform upper endoscopy in the most important and most commonly encountered clinical situations. The book also covers the most important variations of normal anatomy and pathology and how to manage them. Key concepts covered include foreign body removal, diagnosis and management of upper GI bleeding, Barrett's Esophagus, evaluation and management of benign and malignant strictures of the esophagus, stomach, and duodenum, submucosal lesions, and evaluation of post operative upper GI anatomy. A plethora of high quality color illustrations and narrated online video clips illustrate major concepts in the book are also included. Written by experts in the field, Upper Endoscopy for GI Fellows is a valuable resource for new physicians just starting to perform upper endoscopy.

This book provides a comprehensive, state-of-the art review of intestinal polyposis syndromes. The book reviews the most up-to-date clinical, management, and genetic information regarding the continually evolving colorectal condition that manifests as a polyposis condition. It provides a reference for clinicians and researchers in understanding the complexity of intestinal polyposis and the importance of utilizing multiple modalities for the diagnosis, management and control of these conditions. It also provides an overview of what should alert a care provider to the possibility of a polyposis syndrome. Written by experts in their fields, Intestinal Polyposis Syndromes: Diagnosis and Management is a valuable resource for physicians and researchers who deal with the challenges of diagnosing and managing colorectal cancer and intestinal polyposis syndromes.

This book is a state-of-the art review for clinicians and dieticians with an interest in nutrition and inflammatory bowel diseases (Crohn's disease, ulcerative colitis). The volume covers new data about dietary risk factors for Crohn's disease and ulcerative colitis, examines the association between diet and microbiome, describes the various diets in the management of these diseases, and discusses macro- and micronutrient deficiency that occurs in such patients. The book also examines the management of patients on total parenteral nutrition, and management of the short gut syndrome with TPN and novel pharmacologic therapies. Written by experts in their fields, Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide is a valuable and uniquely specialized resource for gastroenterologists, nutritionists, primary care physicians, and other health care providers and researchers dealing with the management of these complex illnesses.

This book provides a concise, focused and clinically relevant summary of complications and emergencies related to bariatric surgery. The first section of the text addresses general complications related to anesthesia and the stress of surgery, including issues such as deep vein thrombosis, pulmonary embolism, hemorrhage, pneumonia and cardiac complications. Additionally, this section addresses the workup of the bariatric patient with abdominal pain. The second portion of the text focuses on gastric bypass and sleeve-specific complications, including staple line and anastomotic leaks, internal hernia, marginal ulceration, GI obstruction, hernia formation and gallstone disease. The third portion of the book examines metabolic, nutritional and psychological complications after bariatric surgery. The text also covers management of weight loss failure. Bariatric Surgery Complications and Emergencies serves as a very useful resource for physicians and surgeons who are involved in any parts of evaluation or management of bariatric patients suffering from postoperative complications or emergencies including bariatric surgeons who perform these operations on a regular basis, non-bariatric general surgeons who cover such patients when on-call, surgical trainees, and primary care physicians.

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Postgraduate education courses taught by the leading hepato-gastroenterologists in Europe, members of the EAGE, are published each year as part of this collection.

This guide focuses on the answers to patient questions that are frequently posed to providers who care for patients with GI motility disorders. Additionally, the text guides clinicians through the complicated diagnostic and therapeutic/management approaches to motility disorders, including common and specialized tests, drug initiation, medications side effects, and disease complications. Written by experts in the field, Gastrointestinal Motility Disorders: A Point of Care Clinical Guide is a valuable reference for busy clinicians who need the best evidence-based answers to patient questions at their fingertips.

The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases.

The latest edition of this text provides a comprehensive overview of the "natural flow of knowledge" regarding inflammatory bowel disease, with an emphasis on state-of-the art approaches that should be the basis for diagnosis and treatment of most patients. In addition to updated chapters, this volume includes new chapters on such topics as the impending biosimilar revolution, quality of care, and new challenges to previously held beliefs about IBD diagnosis, treatment, and pathogenesis. The book is also one of the first to have a chapter written specifically by and for physician extenders in the training of colleagues and the treatment of patients, which is of increasing importance moving forward in the medical profession. Written by experts in the field, Inflammatory Bowel Disease: Diagnosis and Therapeutics, Third Edition is a valuable resource for physicians, nurses, researchers, and other health care providers interested in the latest cutting-edge knowledge for treating patients with inflammatory bowel disease.

This clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text. Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

Gastrointestinal (GI) endoscopy has become indispensable in both diagnosis and treatment of GI disorders. It has been 10 years now since the first Endoscopy Forum Japan was held, and in that time, leading young endoscopists, including colleagues from Asia, Australia, Europe, and the United States, have participated in the forum, discussing issues at the forefront of the field. Through their efforts, GI endoscopy has advanced with many new methods for both diagnoses and treatments, and those achievements are included in this book. Contributing to the development of endoscopic medicine all over the world, this is a groundbreaking, edifying, and engrossing publication offering the most recent advances in the field, precisely presented and depicted with more than 250 color photographs. Novel technologies are described in detail and will be of interest to those in the field of medicine and in engineering as well.

Liver Transplantation: Challenging Controversies and Topics grew out of a need I perceived within the fields of transplant hepatology and liver transplantation. Liver transplantation has rightly gained recognition as an established therapy for end-stage liver disease. Few would argue that liver transplantation is one of the few truly lifesaving and life-altering treatments within medicine and surgery. Not many realize that 20 years passed from the time of the first human liver transplantation in 1963 to its acceptance as therapy by the 1983 NIH Consensus Conference on Liver Transplantation. In 2008, 25 years will have passed since the 1983 NIH conference-a mere 25 years for a field that has provided patients hope, doctors options, and to some the "gift of life. " Many issues in liver transplantation involve indications, patient selection, and outcomes after transplantation-these are standard topics, covered by textbooks of hepatology and transplantation. In contrast, the field of liver tra- plantation is young, evolving, dynamic, and issues and decisions are often controversial. Thus, Dr. Trotter and I, as well as our colleagues at the University of Colorado, felt that a text with a different focus was required, one that highlighted controversy and challenged dogma. Out of this perceived need emerged Liver Transplantation: Challenging Controversies and Topics. To meet the transplant community's need for emerging information about liver transplantation, Dr. Larry Chan, Dr. Igal Kam, and I initiated the Controversies in Transplantation Conference.

- Written by international contributors including specialists in surgery, hematology and oncology.

- The information is presented in an instructive manner, allowing the phycisian to utilize the content immediately.

- Discusses new techniques such as minimally invasive approaches to surgery and new cancer treatments.

This book describes the surgical bariatric procedures most frequently performed worldwide and examines their evolution in recent years both within Italy and internationally. For each operation, indications, the surgical technique, potential complications, and the outcomes with respect to weight and obesity-associated comorbidities are presented. In view of the significant failure rate revealed by studies on the long-term results of bariatric surgery, the problem of weight regain and revision surgery are also discussed in detail, covering the different types of revision, conversion to other procedures, and the main outcomes. In addition, individual chapters focus on selected topics of importance. The role of bariatric surgery in the cure of type 2 diabetes ("diabetes surgery") is discussed and the debate over the significance of gastroesophageal reflux disease and hiatal hernia for choice of procedure is summarized. Finally, the most common endoluminal procedures, which have been gaining in importance, are described and other bariatric operations, outlined.

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research.

This beautifully illustrated monograph provides an up-to-date and comprehensive overview about all fields of liver and biliary tract surgery and liver transplantation. It consists of four sections with 48 chapters: Section I: Anatomy, physiology, imaging and general principles, Section II: Biliary tract surgery, Section III: Liver surgery and Section IV: Liver transplantation. The book includes more than 500 figures and illustrations mostly in color. Some of the topics such as computer assisted surgery planning are treated comprehensively for the first time. The book is written in a concise and well conceived way.

A rigorous and groundbreaking study. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. The author tackles a subject that has puzzled care professionals for decades: hypochondria. Martine Derzelle confronts all specialists (psychotherapists, psychiatrists, doctors, psychosomaticians) with the paradox of this pathology and the theoretical void on which the approach to those patients who express a suffering of various kinds has stood for more than a century. In the first part, the author highlights the lack of theoretical elaboration on hypochondria in the existent literature; in the second part, on the basis of clinical examples, she analyzes the nature of the disease, and then offers a completely innovative theoretical elaboration. Finally, in the third part, she proposes a new and specific approach to treating this pathology at both the theoretical and clinical levels within the framework of psychoanalysis and implementing key concepts from relational psychosomatics.

Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides a unique diagnostic reference text for the pathologic diagnosis of infectious diseases of the gastrointestinal tract. Written for the practicing surgical pathologist, this text combines the superior illustrations of an atlas with carefully written prose to create a useful diagnostic companion. The text is divided into four sections covering bacterial, fungal, viral, and parasitic infections of the gastrointestinal tract. The descriptive sections of each chapter are organized into short paragraphs for easy reference and include the use of tables to compare and contrast organisms and summarize differential diagnoses. Each chapter is extensively illustrated, and contains prose discussions of diagnostic features, differential diagnoses, brief clinical descriptions, and ancillary tests that help confirm the diagnosis (i.e. immunohistochemistry, special histochemical stains, and molecular diagnostic techniques). Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist. This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.