This book shows the huge impact the gut microbiota has on the gastrointestinal health of humans with a particular focus on children. It also highlights the potential use of probiotic microorganisms to protect or improve children's gastrointestinal health. Humans are not single organisms: We are a multi-organism structure composed of ourselves and our microbiota, living in close symbiosis since birth and even before. The huge impact that the billons of microscopic cells living in our gut have on our gastrointestinal and systemic health cannot be overestimated. The enormous progress that has been made in the past decade in our still very incomplete understanding of the gut microbiota is opening the door to potential applications in human health that were simply unthinkable before. One of the most interesting aspects of this new scientific horizon is the fact that we may identify (or even create in the laboratory) and utilize many of these "friendly bacteria" to protect, or improve our health. Thus, strains of probiotic microorganisms are being identified and studied in a vast array of clinical scenarios. Among the most investigated areas for probiotics is the gastrointestinal health of children. The topics addressed in this book are spanning from the development of the gut microbiota in the fetus and newborn all the way to current and potential applications in disparate conditions such as necrotizing enterocolitis, or infectious, or inflammatory conditions affecting the child. The book is written in a rigorous, evidence based manner by an international group of outstanding experts in these fields and is aimed at pediatric gastroenterologists, pediatricians and physician scientists alike.

This book provides a state-of-the-art overview of dysphagia. The text reviews current evidence behind the diagnosis, evaluation, and management of esophageal disorders that cause dysphagia, including GERD, eosinophilic esophagitis, achalasia, and spastic motor disorders. The book also focuses on the different variants of dysphagia, from oropharyngeal dysphagia to functional dysphagia, highlights advances in testing for dysphagia, and features evidence-based algorithms. Written by experts in the field, Evaluation and Management of Dysphagia: An Evidence-Based Approach is a valuable resource for gastroenterologists, otolaryngologists, and other clinicians and practitioners who treat patients afflicted with dysphagia.

A Guide to Alternative Medicine and the Digestive System is unique in that it provides answers to many practical clinical questions, all in one comprehensive resource. This single-authored handbook by Dr. Anil Minocha contains content supported by close to a 1,000 scientific citations. A Guide to Alternative Medicine and the Digestive System discusses the supportive evidence, and addresses safety issues, side-effects, and drug interactions. Dr. Anil Minocha is Board-certified in gastroenterology, internal medicine, nutrition as well as fellowship trained in clinical pharmacology and medical toxicology. This extensive background brings a systematic approach to evaluating, treating, and managing patients with alternative medicine options when treating conditions related to the digestive system. Gastroenterologists, primary care physicians, and internists will find more than 70 chapters of succinct information written in a user-friendly format inside A Guide to Alternative Medicine and the Digestive System.

This book provides specialist and general nurses with a comprehensive guide to the art and science of stoma care nursing, from the Association of Stoma Care Nurses UK, the only association for SCNs in UK. The chapters follow a schematic outline of knowledge required for nurses caring for patients who are undergoing stoma surgery; from the essence of nursing to the management of patients living with a long term condition. It also presents and discusses the issues surrounding the clinical picture such as prescription and community issues as well as sources of support available for patients. This text serves as an excellent resource for all disciplines of health care staff caring for individuals living with a stoma.

Now with full-color illustrations throughout, dozens of new review questions, and state-of-the-art coverage of this fast-changing area, Pediatric Gastrointestinal and Liver Disease, 6th Edition, remains the leading text in the field. You'll find definitive guidance on diagnosis and treatment from experienced editors Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay, as well as globally renowned contributors who share their knowledge and expertise on complex issues. Features an enhanced art program with full-color anatomical figures, clinical photos, and other illustrations throughout the text. Includes a new chapter on fecal transplantation (FCT), covering donor and recipient screening, preparation, delivery, follow-up, and safety considerations, as well as investigative uses for FCT for disorders such as IBD, IBS, and D-lactic acidosis. Prepares you for certification and recertification with more than 400 board review-style questions, answers, and rationales - 30% new to this edition. Includes detailed diagrams that accurately illustrate complex concepts and provide at-a-glance recognition of disease processes. Contains numerous algorithms that provide quick and easy retrieval of diagnostic, screening, and treatment information. Provides up-to-date information on indigenous flora and the gut microbiome and clinical correlations to treatment, as well as advancements in liver transplantation including split liver transplantation (SLT) and living donor liver transplantation (LDLT). Details key procedures such as esophagogastroduodenoscopy and related techniques; colonoscopy and polypectomy; endoscopic retrograde cholangiopancreatography; capsule endoscopy and small bowel enteroscopy; gastrointestinal pathology; and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Medical students and junior doctors are an integral part of the healthcare system. On an academic gastroenterology service, they often initially evaluate the patients that are then staffed by the consulting physician. Like all clinical specialties, the acquisition of medical knowledge is required to gain expertise. There are several resources such as textbooks and evidence-based articles that are available for this purpose. Inspired from patient care, this book offers a fresh approach to clinical teaching. This is a different kind of book. It encompasses a gamut of cases for which gastroenterologists are commonly consulted for in the hospital and outpatient setting. Each case is presented from initial history and work-up including imaging (various modalities including endoscopy), followed by a brief discussion on management. Questions are presented to the reader in each case followed by an answer. Since each case is unique, the pertinent teaching points are tested in a question format within the case narrative. Similar to real-life scenarios, this helps the reader to retain the most important information. Why buy this book? Unlike listing facts as most review books do, teaching points are integrated into realistic clinical cases. Medical students to residents/registrars in internal medicine, emergency medicine, GI medicine, radiology and surgery would benefit from this book alike. Secondary audiences will include nurses and general practitioners who want to understand the presentation of common GI cases and associated imaging. Moreover, it could also be potentially used as a training tool a valuable educational resource for senior colleagues who enjoy teaching. Finally, this book would make an excellent prerequisite prior to starting any gastroenterology rotation.

The autobiography of one of America's most important gastroenterologists. Michael Lepore [1910-2000] was a pioneer in the field of gastroenterology. He was a member of one of the first graduating classes of the University of Rochester Medical School, and went on to a distinguished career at Columbia University, New York University, and St. Vincent's Hospital and Medical Center of New York. This autobiography tells of his experiences as an Italian-American who overcame prejudices to become the personal physician to such notablesas Greta Garbo and President Herbert Hoover. His story is witty and cleverly written, and details the way the medical profession changed from the Great Depression to the late 1990s. Michael Lepore was an alumnus of Duke University Medical School and the University of Rochester School of Medicine, and was the Director, Gastroenterology Section, Departments of Medicine and Surgery Emeritus, St. Vincent's Hospital and Medical Center of New York.

Die Forschung zu Diagnostik und Behandlung von Dysphagien verschiedenster Stoerungsbilder bei Erwachsenen und Kindern hat in Deutschland in den letzten zwanzig Jahren deutlich an Bedeutung gewonnen. Der Arbeitskreis Dysphagie Ostwestfalen-Lippe in Kooperation mit dem Studiengang der Klinischen Linguistik an der Universitat Bielefeld befasst sich im Rahmen einer zweijahrig stattfindenden Tagung speziell mit aktuellen Fragen dieser Thematik. Der vorliegende Band diskutiert aktuelle Forschungsfragen und Ergebnisse aus Diagnostik und Therapie.

This book concisely summarises non-neoplastic gastrointestinal (GI) pathology and provides histopathologists aiming to refresh or expand their knowledge with a practical approach to the interpretation of biopsies. It focuses on GI biopsies, but also covers the pathology of resections and other organs where appropriate. The editor and contributors bring their expertise as practicing diagnostic pathologists across Europe and the US. Examples of topics include inflammatory bowel disease, infections, vascular disorders, and inflammatory conditions specific to various anatomical sites. Fact sheets, practice points and tables facilitate rapid assimilation of information and enhance the reader's experience, and with additional access to the full online version, including expandable images on Cambridge Core; achieve accuracy every time. High-quality illustrations are also numerous, and references are relevant and reliable. This book is a practical, readable and up-to-date asset for any pathologist encountering GI biopsies.

Jordan Rubin, junto con el D.M. Joseph Brasco, muestran a los lectores como aplicar las 7 claves para la salud y el bienestar y combatir en forma natural el sindrome de irritabilidad intestinal, una enfermedad dolorosa y debilitante.

This volume provides the most comprehensive coverage of clinical management of borderline resectable pancreatic cancer available. Authored by leaders in the field, the book focuses on current clinical management of this disease stage, the importance of multimodality treatment algorithms, and an interdisciplinary approach to care. Surgical chapters are well-illustrated to provide surgeons and surgical trainees with important technical pearls. Clinical trials and trial design are also discussed. Multimodality Management of Borderline Resectable Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, radiation oncologists, surgical oncologists, general surgeons, and trainees interested in the treatment of pancreatic cancer.

Probiotics are live microorganisms that, when consumed, can provide health benefits, generally by improving or restoring the gut flora. As probiotics have become increasingly popular in recent years, it is important for consumers and clinicians to understand the details of the potential health effects of these supplements. Chapter 1 focuses on the relationship between different types of milk, the growth of probiotics, and relevant characteristics regarding viability, the quality of the dairy product, and the production of undesirable components. Chapter 2 summarizes studies on the probiotic impact of functional foods on the immune system and analyzes the future of the probiotic functional food market. Chapter 3 describes pathways and mechanisms through which probiotics may improve hypothyroidism and its complications. Chapter 4 presents a literature review of intestinal microbiota and bone health and discusses the effectiveness of probiotics in the treatment and prevention of osteoporosis. Chapter 5 presents an FTIR analysis of protein/peptide-based biopolymers used for probiotic encapsulation. Lastly, Chapter 6 collates experimental studies on probiotics with ameliorative effects on arsenic toxicity.

Intestinal failure is a challenging, emerging field that has been the subject of much research and debate in recent years and has only recently become widely accepted as a distinct clinical syndrome.
This comprehensive book provides an in-depth review of scientific theory and clinical practice relating to intestinal failure with specific emphasis on assessment and management as part of a multidisciplinary team. Compiled by an internationally recognised editorial team, the book provides a practical how-to guide to the management of adult and pediatric patients with intestinal failure, focusing on quality-of-life issues that are at the heart of patient care.
* World experts from centers of excellence share their clinical experience and expertise, offering the first ever authoritative resource on intestinal failure
* All aspects of patient management are covered, from diagnosis and medical and surgical management (including transplantation) to nutritional consideration and psychosocial aspects of care
* Numerous illustrations, flow diagrams and summary boxes complement the text and emphasize important concepts, providing an accessible approach to this complex field
This landmark book is essential reading for any gastroenterologists, surgeons, transplant teams or clinical nutritionists involved in the care of patients with intestinal failure.

Our own experience shows that there is no simple, yet of good scientific and clinical quality guide for practitioners and patients on gastrointestinal diseases. In the proposed book we will cover a vast area in the field, from GI tract physiology to disease diagnosis and treatment, in a comprehensive and approachable manner. The guide will not replace online resources (often used by patients) or specialized editions addressing experienced medical doctors, but rather fill the gap between those two. Our aim is to design this book so that it appeals to a wider audience; yet - if needed - encourages to explore the field further.

This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.

This book is a state-of-the art review for clinicians and dieticians with an interest in nutrition and inflammatory bowel diseases (Crohn's disease, ulcerative colitis). The volume covers new data about dietary risk factors for Crohn's disease and ulcerative colitis, examines the association between diet and microbiome, describes the various diets in the management of these diseases, and discusses macro- and micronutrient deficiency that occurs in such patients. The book also examines the management of patients on total parenteral nutrition, and management of the short gut syndrome with TPN and novel pharmacologic therapies. Written by experts in their fields, Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide is a valuable and uniquely specialized resource for gastroenterologists, nutritionists, primary care physicians, and other health care providers and researchers dealing with the management of these complex illnesses.

This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

This book is part of a series covering surgical specialties. The volumes are multi-authored, containing brief chapters, each of which are devoted to one or two specific questions or decisions within that specialty that are difficult or controversial. The volumes are intended as a current and timely reference source for practicing surgeons, surgeons in training, and educators that describe the recommended ideal approach, rather than customary care, in selected clinical situations.

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

This volume provides a concise yet comprehensive overview on surgical procedures performed on the cirrhotic patient. The text explains the underlying pathophysiologic alterations in liver disease and cirrhosis, provides assessment of disease severity and risk factors, and helps to predict potential outcomes based on the nature of the operation. Operations discussed in detail include bariatric surgery, colorectal surgery, hepatic surgery, kidney transplantation, gynecological procedures, neurosurgical procedures, and ophthalmic surgery. The book is also supplemented with instructive color illustrations and tables. Written by experts in the field, Surgical Procedures on the Cirrhotic Patient is a valuable, multidisciplinary resource for clinicians who treat the cirrhotic patient. With a Foreword by Thomas E. Starzl, the father of liver transplantation.

This book describes the surgical bariatric procedures most frequently performed worldwide and examines their evolution in recent years both within Italy and internationally. For each operation, indications, the surgical technique, potential complications, and the outcomes with respect to weight and obesity-associated comorbidities are presented. In view of the significant failure rate revealed by studies on the long-term results of bariatric surgery, the problem of weight regain and revision surgery are also discussed in detail, covering the different types of revision, conversion to other procedures, and the main outcomes. In addition, individual chapters focus on selected topics of importance. The role of bariatric surgery in the cure of type 2 diabetes ("diabetes surgery") is discussed and the debate over the significance of gastroesophageal reflux disease and hiatal hernia for choice of procedure is summarized. Finally, the most common endoluminal procedures, which have been gaining in importance, are described and other bariatric operations, outlined.

This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis, and related autoimmune disorders.

This volume provides a comprehensive guide to advanced endoscopic procedures and techniques. Primarily focused on Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS), the book also explores related topics such as cholangioscopy, pancreatoscopy, advanced pancreaticobiliary imaging, stenting, and endoscopic means to achieve pain control. The text also presents a plethora of tips and tricks on how to perform these procedures safely, emphasizes common mistakes and how to avoid them, and features high quality videos illustrating key procedural aspects for every chapter. Written by top experts in the field, Advanced Pancreaticobiliary Endoscopy is an invaluable resource for gastrointestinal endoscopists and fellows interested in advanced endoscopic procedures.