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Drug-Induced Hepatotoxicity (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R3,052
Discovery Miles 30 520
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Drug-Induced Hepatotoxicity (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Handbook of Experimental Pharmacology, 121
Expected to ship within 10 - 15 working days
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The advances in science and medicine we are now experiencing are
unprec edented and exciting. Life expectancy is prolonged, and
quality of life is much improved. We learn of fabulous new
discoveries made at the bench or the bedside every week. Many
diseases have been totally eliminated, others can be significantly
improved by new therapeutic formulations. Much of the success can
be attributed to a better understanding of disease processes and
the specific targeting of new and more effective medications. As is
the case in many areas of successful human endeavour, there can be
a downside. In the case of drugs and chemicals it is their adverse
effects which are of concern. Of course, every effort is made to
devise medications that are safe, and the need to elucidate and
understand mechanisms are crucial, yet adverse effects remain a
problem. They can be unpredictable and diverse. Drugs have been
shown to induce virtually the whole gamut of human liver pathology
from acute fulminant hepatitis to chronic active hepatitis to
cirrho sis and even malignancy. Hence the possibility of adverse
drug effects must be considered in the differential diagnosis of
many patients with liver disease. This is well recognized and is
very important; indeed, removal of the offending agent can often
lead to reversal of the adverse effect. This is an area of
hepatology where we can really make a difference."
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