As a medical detective of the modern world, forensic pathologist Ryan Blumenthal’s chief goal is to bring perpetrators to justice. He has performed thousands of autopsies, which have helped bring numerous criminals to book. In Autopsy he covers the hard lessons learnt as a rookie pathologist, as well as some of the most unusual cases he’s encountered.

During his career, for example, he has dealt with high-profile deaths, mass disasters, death by lightning and people killed by African wildlife. Blumenthal takes the reader behind the scenes at the mortuary, describing a typical autopsy and the instruments of the trade. He also shares a few trade secrets, like how to establish when a suicide is more likely to be a homicide.

Even though they cannot speak, the dead have a lot to say – and Blumenthal is there to listen.

Lucy Easthope lives with disaster every day. When a plane crashes, a bomb explodes, a city floods or a pandemic begins, she's the one they call. As one of the world's leading experts on disaster she has been at the centre of the most seismic events of the last few decades - advising on everything from the 2004 Boxing Day tsunami to the 7/7 bombings, the Salisbury poisonings, the Grenfell fire and the Covid-19 pandemic.

She has travelled across the world in this unusual role, seeing the very worst that people have to face, and finding that even the most extreme of situations, we find the very best of humanity. In her moving memoir she reveals what happens in the aftermath. She takes us behind the police tape to scenes of destruction and chaos, introducing us to victims and their families, but also to the government briefing rooms and bunkers, where confusion and stale biscuits can reign supreme.

With wisdom, resilience and candour When the Dust Settles looks back at a life spent on the edges of disaster and shows us that where there is terrible tragedy there is also great hope and that humanity and humour can - and must - still be found on the darkest of days.

* PRE-ORDER YOUR COPY TODAY * The compelling and moving memoir of forensic psychiatrist Dr Duncan Harding

Provides important points of each topic in continuous manner not in parts as given in previous guides. This book consists of theory of each topic followed by its questions so theory portion helps you to solve new questions. This pattern of book allows you to revise whole infectious diseases very clearly and quickly. It provides sufficient matter which can be revised without any problem. Topic and chapter-wise arranged explanatory series. Synopsis of every chapter helps in solving new questions. The very important points given in single unit 'Revision at a Glance'. Thoroughly revised and edited by a group of microbiologists. Simple text and mnemonics, to make things easy. Provides detailed coverage of immunology and parasitology. Provides the most essential facts in flow diagrams and tabulation with an easy-to-remember format. The focus of the book is to enable everyone to solve forthcoming questions.

Authored by the originator of the standard nomenclature for this spectrum of disorders, Congenital Heart Disease: A Clinical, Pathological, Embryological, and Segmental Analysis discusses the history, anatomic features, and physiologic consequences of CHD-in one authoritative resource. The Van Praagh approach to the segmental classification of CHD, developed and implemented by Dr. Richard Van Praagh in the 1960s at Boston Children's Hospital, remains widely used today, facilitating communication among radiologists, cardiologists, surgeons, and pediatricians who are involved in the diagnosis, characterization, and management of this disease. This unique atlas offers complete coverage of the ubiquitous Van Praagh "language" of CHD, including the signs, symptoms, and clinical manifestations of malpositioned, malformed, or absent cardiovascular chambers, vessels, and valves using traditional as well as state-of-the-art technology. Based upon the systematic, widely accepted Van Praagh system of three-part notation used to succinctly describe the visceroatrial situs, the orientation of the ventricular loop, and the position and relation of the great vessels. Demonstrates how the Van Praagh approach facilitates interpreting and reporting findings through cardiac imaging with CT, MR, and ultrasonography, including fetal cardiac imaging. Presents the pathologic anatomy that pediatric and adult cardiologists, radiologists, and echocardiographers need to understand in order to make accurate diagnoses in complex congenital heart disease; as well as the pathologic anatomy that interventionists, pediatric cardiac surgeons, and adult congenital heart surgeons need to know in order to manage their patients successfully. Features more than 550 high-quality images to help you visualize and recognize malformations. Shares the knowledge and expertise of a world-renowned authority on congenital heart disease-a master teacher and the originator of the Van Praagh segmental classification system. Explores the synergy between the various disciplines who manage patient care, including surgeons, radiologists, cardiologists, pathologists, and pediatricians. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

An autopsy is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any disease or injury that may be present for research or educational purposes. This book is a practical guide to autopsy for trainees in pathology and forensic medicine. The second edition has been fully revised to provide the latest advances and guidelines in the field. Beginning with an introduction to autopsy, its utility and techniques for both external and in situ examination, the following chapters explain autopsy procedures for different organ systems of the body, with an emphasis on dissection methods. The final sections explain autopsies in special situations such as in maternal death and in children, autopsy and the law, design of the autopsy room, biosafety, audit, and embalming. The text is further enhanced by photographs of dissection procedures, diagrams and tables. Key points Practical guide to autopsy techniques for trainees in pathology Fully revised, second edition providing latest advances and guidelines Highly illustrated with photographs, diagrams and tables Previous edition (9789386056160) published in 2017

This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord. Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood. Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning. We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis. GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact. Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.

This book performs a distinct introduction to the pathology of the placenta and its membranes, abortion material included, with the aim to facilitate and protect the quality of the morphological placental diagnostics by the pathologists. Seven chapters with coloured figures illustrating gross anatomy, development and maturation of the placenta explain the functional morphology in its clinical correlation of single and multiple findings for the pathologists, obstetricians and neonatologists. Moreover, the book contributes to a better understanding of pre- and perinatal investigations, maternal diseases, fetal outcomes and follow up of the newborns, as well as to the prevention of worse outcome in further pregnancies. The atlas intends to stimulate the interest for perinatal pathology and to contribute to a better interdisciplinary understanding of pathologists and clinicians, midwives and nurses.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.