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Books > Medicine > Other branches of medicine > Pathology > Gross pathology
A historical review of the evolution of concepts, postulates and
guidelines concerning disease causation from early germ theory to
current work in the area of chronic noncontagious diseases.
Students and researchers in epidemiology, clinical medicine,
microbiology and related fields will value discussion of changing
criteria as these apply to speci
The Year Book of Pathology and Laboratory Medicine brings you
abstracts of the articles that reported the year's breakthrough
developments in pathology and laboratory medicine, carefully
selected from more than 300 journals worldwide. Expert commentaries
evaluate the clinical importance of each article and discuss its
application to your practice. There's no faster or easier way to
stay informed! Chapters in this annual cover the most current
information on all aspects of pathology and laboratory medicine
including: molecular diagnostics, dermatopathology, anatomic
pathology techniques, outcomes analysis, cytopathology, clinical
immunology, clinical microbiology, neuropathology and hematology.
Topics that are essential to the surgical pathologist in
cytopathology are included in this issue of Surgical Pathology
Clinics. Topics include cytopathology of the Thyroid; Pancreas,
Salivary glands; Lung; Urine; Gynecologic; Metastasis of unknown
origin; and Preparation techniques and Cell transfer. Expert
cytopathologist and prolific author and researcher and expert
clinician Tarik Elsheikh leads this issue as Guest Editor. "The
latest edition of this book is always in use by our trainees and
cytology staff. A most helpful up to date reference book" Reviewed
by: Dr David Poller, Consultant Pathologist & Reader in
Pathology on behalf of PathLab.org, Aug 2014 "The latest edition of
this book is always in use by our trainees and cytology staff. A
most helpful up to date reference book" Reviewed by: Dr David
Poller, Consultant Pathologist & Reader in Pathology on behalf
of PathLab.org, Aug 2014
Topics in Hematopoietic Neoplasms: Controversies in Diagnosis and
Classification include: ABC vs GC subtyping of diffuse large B cell
lymphoma-Does it matter?; Clonal link between malignant lymphoma
and histiocytic tumors; Diagnostic criteria for grey zone lymphoma:
Are there any?; Diagnostic criteria for primary cutaneous B cell
lymphoma; Distinguishing reactive and leukemic large granular
lymphocyte proliferations; Differential diagnosis of
erythroleukemia; Early pre-T ALL versus MPAL: Diagnostic criteria;
Myeloid neoplasms with inv(3) or t(3;3); Update on classification
and prognosis in myelodysplastic syndrome;?Approach to atypical
immunophenotypes in Hodgkin lymphoma; Blastic plasmacytoid
dendritic cell tumor: How do you distinguish it from acute myeloid
leukemia?; The differential diagnosis of eosinophilia in neoplastic
hematopathology; Transformation in myeloproliferative neoplasms;
and Challenges in consolidated reporting of hematopoietic
neoplasms. This publication is an extremely useful and practical
source for pathologists working with this spectrum of disorders. As
with all publications in this series, Differential Diagnosis is the
main focus of discussion. Staging, Diagnosis, Prognosis, and
summaries of Pitfalls in working with these pathologies are
presented along with ample figures.
Molecular pathology is based on the emergence of new techniques
that greatly enhance the diagnostic accuracy when facing with
challenging differential diagnoses. In addition, new molecular
techniques are entering the clinical arena for their value in
predicting therapy response and tumor prognosis. This book provides
a guide for the practicing pathologist and for both pathology
residents and fellows during the daily sign-out of challenging
cases. The book is organized by anatomical systems and provides a
detailed description of molecular tests that may help in the
diagnosis. Furthermore, a description of the current molecular
tests required to identify patients for treatment is offered. The
application of molecular pathology techniques to the clinical
practice has already shown its usefulness and the number of such
tests is growing exponentially as more molecular targets are
discovered. Molecular Pathology and Diagnostics of Cancer will give
practicing and training pathologists an up-to date resource to
guide the correct management of pathology cases requiring molecular
testing.
This issue of Neuroimaging Clinics focuses on the endovascular
treatment of pathology in adults and children. Topics include
cerebral aneurysms, cerebral vasospasms, dural fistulas, carotid
stenosis, acute ischemic stroke, vascular malformations, and more.
The latest in a series of books from the International Hypoxia
Symposia, this volume spans reviews on key topics in hypoxia, and
abstracts from poster and oral presentations. The biannual
International Hypoxia Symposia are dedicated to hosting the best
basic scientific and clinical minds to focus on the integrative and
translational biology of hypoxia. Long before 'translational
medicine' was a catchphrase, the founders of the International
Hypoxia Symposia brought together basic scientists, clinicians and
physiologists to live, eat, ski, innovate and collaborate in the
Canadian Rockies. This collection of reviews and abstracts is
divided into six sections, each covering new and important work
relevant to a broad range of researchers interested in how humans
adjust to hypoxia, whether on the top of Mt. Everest or in the
pulmonary or cardiology clinic at low altitude. The sections
include: Epigenetic Variations in Hypoxia High Altitude Adaptation
Hypoxia and Sleep Hypoxia and the Brain Molecular Oxygen Sensing
Physiological Responses to Hypoxia
Use this set of colorful cards to learn and remember
pathophysiology! With 96 full-color cartoons covering
pathophysiologic concepts, Mosby's (R) Pathophysiology Memory
NoteCards uses humor and mnemonics to make review easier and more
fun. These durable, detachable cards are useful in preparing for
the NCLEX (R) or classroom exams, as a clinical reference, for
writing care plans, or for patient teaching information. This
convenient study tool may be used as either a spiral-bound notebook
or as individual flashcards. UNIQUE! 96 full-color, illustrated
mnemonics cover key pathophysiology concepts. Concise What You Need
to Know monographs on each card provide more detailed information
and specific nursing implications. UNIQUE! Color highlights
emphasize four central topics - serious/life-threatening
implications in pink, common clinical findings in blue, important
nursing implications in yellow, and patient teaching in green.
Colored tabs make it easy to find specific topics. Sturdy,
spiral-bound cards offer durability as well as portability. NEW!
All-new cartoons cover contemporary and timely pathophysiology
topics, including epigenetics and pulmonary immunology.
This is the first book to assemble the leading researchers in the
field of LRRK2 biology and neurology and provide a snapshot of the
current state of knowledge, encompassing all major aspects of its
function and dysfunction. The contributors are experts in cell
biology and physiology, neurobiology, and medicinal chemistry,
bringing a multidisciplinary perspective on the gene and its role
in disease. The book covers the identification of LRRK2 as a major
contributor to the pathogenesis of Parkinson's Disease. It also
discusses the current state of the field after a decade of
research, putative normal physiological roles of LRRK2, and the
various pathways that have been identified in the search for the
mechanism(s) of its induction of neurodegeneration.
Molecular pathology has significantly matured over the past decade
to establish itself as a discipline in its own right. Patient
diagnosis, prognosis, management and care have been influenced by
molecular pathology testing algorithms on a global scale. Whether
it pertains to carrier status of deleterious genes, diagnosis by
molecular techniques, assessment of appropriate remission post
treatment, parentage or forensics testing - molecular pathology
continues to increase its presence and influence in the diagnostic
laboratory armamentarium. Furthermore, intellectualization and
proprietization of molecular pathology with respect to the
discovery of new genes and or new techniques continues to pose new
challenges of test ownership, legalities, liabilities, widespread
acceptance and utility. This issue of Laboratory Clinics seeks to
provide selective state of the art understanding of molecular
pathology with respect to its relationship to key pathology
disciplines as well as the current challenges and promise for the
future
Written to satisfy a wide audience, from basic scientist to
clinical researcher, this volume explores such varied concepts as:
the influence of CBF in the pathotrajectory of TBI, modeling TBI as
a means to understand underlying pathological states associated
with brain injury victims, disrupted vasculature following head
trauma and advanced imaging techniques, vasoreactive substances
underlying disrupted blood flow, the role of age and sex on injury
outcome, and the latest pre-clinical rationale for focusing on CBF
and strategies to improve blood flow as a means to improve outcome
in patients suffering the effects of TBI.
This issue focuses on three disease sections: Diabetes, Hematology
and Coagulation, and covers diagnostic and management issues during
pregnancy of selected topics in each section. The chapters cover
new concepts, evolving management and important impacts on the
mother and unborn child.
Dating Neurological Injury: A Forensic Guide for Radiologists,
Other Expert Medical Witnesses, and Attorneys presents a unique way
to approach the dating of neurological injury as imaged by modern
computed tomography (CT), magnetic resonance (MR) and ultrasound
(US). Chapters are presented in a logical progression beginning
with the general appearance of normal brain and progressing to the
way abnormalities manifest themselves. The emphasis in these
discussions is on the appearance of edema and of hemorrhage, as
these two findings are the brain's most common response to injury.
This volume presents in a systematic fashion the principles
involved in the interpretation of images of the central nervous
system specifically in a medical-legal setting where concern exists
about the occurrence and timing of an injury. Dating Neurological
Injury: A Forensic Guide for Radiologists, Other Expert Medical
Witnesses, and Attorneys is a welcome addition to institutional,
medical, and legal libraries, and to the personal libraries of
malpractice defense and plaintiff lawyers and physicians in the
neurosciences (neurosurgery, neurology, neuropathology, and
neuroradiology) involved in medical-legal issues.
The Year Book of Pathology and Laboratory Medicine brings you
abstracts of the articles that reported the year's breakthrough
developments in pathology and laboratory medicine, carefully
selected from more than 300 journals worldwide. Expert commentaries
evaluate the clinical importance of each article and discuss its
application to your practice. There's no faster or easier way to
stay informed! Chapters in this annual cover the most current
information on all aspects of pathology and laboratory medicine
including: molecular diagnostics, dermatopathology, anatomic
pathology techniques, outcomes analysis, cytopathology, clinical
immunology, clinical microbiology, neuropathology and hematology.
Obstetricical care and the growing number of pregnancies in older
women or medically challenged women creates an expanding need for
placental pathology that can provide information on neonatal care,
risk assessment, and infant and mother outcomes. In the Surgical
Pathology Clinics, Essential Gross Examination of the Placenta is
presented with an abundance of images along with clear steps in the
examination. Also presented are Placenta Accreta and Percreta;
Ascending Infection - Acute Chorioamnionitis; Maternal Floor
Infarction and Massive Perivillous Fibrin Deposition. Additionally,
Umbilical Cord Pathology, Monozygotic Twinning, and Fetal
Thrombotic Vasculopathy, Neonatal Stroke and other sequelae are
discussed. Each of the topics presents abundant clinical photos and
histology slides supporting diagnosis. Editor Rebecca Baergen,
whose specialty areas are fetal pathology, placental pathology,
gynecology and perinatal pathology, leads a group of authors who
are experts in placental pathology, including her mentor and one of
the pioneers in placental and perinatal pathology, Dr. Kurt
Benirschke.
For the surgical pathologist, this coverage of Liver Pathology
presents practical information with ample discussion of
differential diagnosis and use of special studies, where relevant,
to engage pathologists in what you can do daily in practice. Topics
include: Steatohepatitis: Histopathologic diagnosis; Regression and
subclassification of cirrhosis; Autoimmune hepatitis and overlap
syndrome; Liver transplant pathology: challenging diagnostic
situations; Hepatocellular adenoma; Immunohistochemistry for the
diagnosis of hepatocellular carcinoma; Histologic subtypes of
hepatocellular carcinoma: diagnostics and clinical significance;
Pediatric cholestatic disorders. Sanjay Kakar and Dhanpat Jain
bring their expertise in liver pathology and lead a group of
authors whose focus is on liver and GI pathology. The surgical
pathologist has at hand in this issue the essential and most
current aspects of liver pathology required for daily practice.
In October of 2011, CLSI published a new guideline EP23A on
"Laboratory Quality Control Based on Risk Management.? In March,
2012, CMS announced its intention to incorporate key concepts from
EP23A into its Interpretative Guidelines and QC policy for
"Individualized Quality Control Plans.? Thus begins a new era of
Quality Control in the Age of Risk Management. This issue is
intended to help laboratories with the transition between
traditional QC practices and the new risk management approach.
Laboratories face a steep learning curve to apply risk analysis for
identifying and prioritizing failure-modes, developing and
implementing control mechanisms to detect those failure-modes, and
assessing the acceptability of the residual risks that exist after
implementation of a QC Plan. One of the main benefits of the new
risk analysis based QC Plans should be an integration of all the
control mechanisms that are needed to monitor the total testing
process, including pre-analytic, analytic, and post-analytic
controls.? One of the main risks of the new approach is an
expectation that Statistical QC is no longer important, even though
SQC still remains the most useful and flexible approach for
monitoring the quality of the analytic process. The key to the
future is the successful integration of all these control
mechanisms to provide a cost-effective quality system that monitors
all phases of the total testing process. This issue should help
laboratories understand the evolution of QC practices to include
risk management, but also to recognize the need to maintain
traditional techniques such as Statistical QC, especially during
the transition to well-designed and carefully-validated QC Plans.
Risk analysis may be risky business unless laboratories proceed
carefully and cautiously.
This issue of Clinics in Laboratory Medicine titled, "Conceptual
Advances in Pathology" addresses the key factors impacting
pathology and details the technology surrounding the field. The
Guest Editor, Zoltan Oltvai, MD., splits the issue into three
sections; Technological Advances, Process Advances, Educational and
Practice Needs, and the Business of Pathology.
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