This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. *Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology *Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence *Supplies quick access to information via tables, algorithms, and composite figures

This book fills the gap in understanding of pathology of the female genital tract that is often understated during training. Normal histology and pathology of abnormal conditions are covered for the lower and upper genital tract, in a concise manner with over 200 color illustrations. Topics include this covers inflammatory diseases, iatrogenic conditions, changes associated with menopause, and benign and malignant neoplasms. This text also address adjunctive testing such as molecular diagnostics and immunohistochemistry staining. The text is concise and practical with a liberal use of bullet points, and it includes clinicopathologic correlations. Breakout tables in each chapter cover information the clinician should provide the pathologist to get the most useful report, as well as pathology issues and challenges that may result in a report less specific than the clinician is expecting. Written by board certified experts, this book is the ultimate resource for gynecological pathologists, obstetrics, OB/GYN physicians, and gynecology practitioners.

Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical students are engaged in fewer autopsies and are not reaping the rich educational rewards that accompany these examinations. The purpose of the autopsy is not only to establish the cause of death, but also to determine the nature and course of the disease process. Our goal with this book is to emphasize the importance of the post-mortem exam and the correlation between pathologic material and clinical data by analyzing actual cases with problem-based methodology. The focus of this handbook is on cardiovascular disease, and when appropriate, other disease categories are included if they have an impact on cardiovascular function. The approach is more than the usual clinico-pathological correlation. Rather, we attempt to present the material from the perspective of the autopsy table. We use the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition.

A Companion to Paleopathology offers a comprehensive overview of this rapidly growing sub- field of physical anthropology. * Presents a broad overview of the field of paleopathology, integrating theoretical and methodological approaches to understand biological and disease processes throughout human history * Demonstrates how paleopathology sheds light on the past through the analysis of human and non-human skeletal materials, mummified remains and preserved tissue * Integrates scientific advances in multiple fields that contribute to the understanding of ancient and historic diseases, such as epidemiology, histology, radiology, parasitology, dentistry, and molecular biology, as well as archaeological, archival and historical research. * Highlights cultural processes that have an impact on the evolution of illness, death and dying in human populations, including subsistence strategies, human environmental adaptations, the effects of malnutrition, differential access to resources, and interpersonal and intercultural violence

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life. Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURES Focuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signs Serves as a ready clinical compendium for trainees, fellows and ophthalmologists Explores various corneal pathologies through a wealth of accompanying illustrations and teaching videos

A large variety of organisms - from bacteria to man - form minerals. Skeletons, teeth, spicules, spines, shells, darts, and granules are all mineral-containing tissues. Why, where, and how these minerals form are the central questions addressed in this book. These questions have become important in many fields. Preserved fossils are used to interpret ancient climates, changes in chemical composition of the oceans, or to date geological and archaeological deposits and artefacts. Materials scientists investigate mineralized tissues to try to determine the design principles used by organisms to form strong materials, and many medical problems are associated with normal and pathological mineralization. Heinz Lowenstam, the pioneering researcher in biomineralization, and his former student Stephen Weiner discuss the basic principles of mineral formation by organisms, and compare the various mineralization processes. Reference tables list all known cases in which organisms form minerals.

Uropathology, a volume in the High Yield Pathology Series, makes it easy to recognize the classic manifestations of urologic diseases and quickly confirm your diagnoses. A templated format, excellent color photographs, authoritative content, and online access make Uropathology an ideal reference for busy pathologists. Provides in-depth, bulleted outlines for each entity covering definition, anatomy, and pathology: histology, immunohistochemistry, and differential diagnosis. Features 1,600 high-quality illustrations that include gross, radiographic imaging, microscopic, immunohistochemical, and special stains, providing a comprehensive visual summary of the typical features of each entity. Includes expanded information on tumor staging expertly provided by Dr. Ming Zhou, primary author of the College of American Pathologists cancer protocols. Reflects recent guidelines and protocols including: Restructured tumor classification and new entities New and modified grading systems for GU cancers New and modified staging criteria for all GU cancers New recommendations for reporting New IHC and molecular markers for diagnosis and prognosis for GU cancers Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices Your first line resource for genitourinary pathology

Written in the same accessible manner as previous editions, the fifth edition of Karch's Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch's Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Mycotic keratitis, also known asfungal keratitis, is commonly defined as an inflammation of the cornea. Globally, mycotic keratitis is more common as compared to others eye disorders. Though it occurs in all parts of the world it is more prevalent in tropical and subtropical areas. Mycotic Keratitis emphasizes novel perspectives on mycotic keratitis treatments and addresses different therapies used in treatment. The book is designed to be immensely useful for the students and teachers of microbiology, medicine, mycology, ophthalmology, biotechnology and nanotechnology. Medical microbiology researchers in general and medical mycology in particular will find it a valuable user-friendly book.

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

Dr. Lefkowitch is one the most well known experts on liver pathology and has updated the topic since it last published over 5 years ago. Important topics updated include benign liver tumor, vascular disorders of the liver, autoimmune hepatitis, and non-alcoholic fatty liver disease. Special emphasis is given to articles devoted to immunochemistry in liver tumors, hepatic granulomas, and diagnostic pitfalls in liver transplantation.

The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain's ATP is derived from mitochondrial oxidative phosphorylation. Since that organ' s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there fore, to disruption of neuronal signaling within seconds. It seems that mamma lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning)."

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of head and neck pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Head and Neck is a one-stop reference for accurate, complete pathology reports-ideal as a day-to-day reference or as a reliable teaching resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 325 new or evolving entities of the head and neck and endocrine organs Features updates on recent changes in the field and current information from the AJCC Cancer Staging Manual, 8th Edition, and the World Health Organization Classification of Head and Neck Tumours, 5th Edition Covers numerous new diagnostic entities, including intraductal carcinoma, sclerosing polycystic adenoma, microsecretory adenocarcinoma, adamantinoma-like Ewing sarcoma, SMARCB1- and SMARCA4-deficient carcinomas, and HPV-related multiphenotypic sinonasal carcinoma Contains major updates on sinonasal tract, salivary gland, and odontogenic tumors; oropharyngeal squamous cell carcinoma and its correct classification and staging; the recent significant reclassification of neuroendocrine tumors; and changes in terminology and identification for head and neck soft tissue tumors Suggests supporting studies in a realistic clinical context, with tables and immunohistochemical charts that assist with management decisions and prognostic outcome predictions Features more than 3,200 images, including full-color drawings of head and neck anatomy, development pathway drawings, staging protocol illustrations, and genetic pathway graphics; radiologic images, clinical photographs, and gross images; and histology, histochemistry, immunohistochemistry, in situ hybridization, and molecular images; as well as more than 2,600 additional online-only images Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

A benchmark survey of current clinical findings on the complex interactions between diet, stress, and mental health, and their impact on disease states. The authors give special attention to the influence of stress on physical health, mental health, and cognitive function, including the critical effects of maternal nutritional status and stress levels on fetal physical and mental development, the role of lipids in the development and treatment of depression, the role of fish oil in the development of aggressive behaviors, and the consequences of obesity on stress and the development of eating disorders. Additional chapters examine the effects of stress on chronic disorders, women, and cardiac function, and the influence of inflammation on diet, neurological functions, disease incidence, and cognitive functions.

This issue of Clinics in Laboratory Medicine, Guest Edited by Mark Yazer, MD, on the topic of Blood Transfusion will include the following article topics: Xenotransfusion; FDA Perspective; Inflammatory Cytokines as Predictors of Alloimmunization; Cryopreservation of RBCs, PLT and Stem Cells; PLT Storage Lesion; Future of Blood Management; Future of Molecular Testing for RBC Antigens: ECO Cells; Farmed RBCs; Farming RBCs from Stem Cells; Politics and Blood Transfusion; and Fetal Blood Grouping from Maternal Plasma.

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of thoracic pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Thoracic, 3rd Edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of pulmonary, pleural, and mediastinal entities Features an updated chapter on severe acute respiratory syndrome (SARS) pneumonia with current knowledge, statistics, and pathophysiology on COVID-19, including new images that encompass the radiology, gross pathology, and histopathology of the disease Includes updated criteria, terminology, and classifications for a wide range of tumors from the 2021 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus and Heart, reflecting changes to currently used terminologies for adenocarcinoma, squamous cell carcinoma, neuroendocrine tumors, mesothelioma, soft tissue tumors, benign tumors, and more Covers the recent explosion of molecular genetic information, including new Molecular Pathology sections with new information on the genetic underpinnings of diseases Specifies genetic mutation types associated with each tumor and covers numerous types of molecular tests, including next-generation sequencing studies and how the specific genetic alterations are used to differentiate disease and aid in diagnosis Features over 3,900 high-quality images, including histologic images, gross pathology images, radiologic images, and full-color illustrations as well as more than 750 additional online-only images to help practicing and in-training pathologists reach a confident diagnosis Contains multiple recent consensus clinical practice guidelines for thoracic disease diagnosis, including those for molecular genetic testing and predictive biomarker testing from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Anatomy and pathology are key areas in medical training, but the amount medical students have to learn within them can seem overwhelming. This book helps students gain a firm grasp of the facts they must know before they enter their clinical years. It encompasses the core basics of the major organ systems in the body and presents them in a memorable, easy-to-read form. The book covers the background and knowledge that are clinically relevant to, and commonly encountered in, end-of-semester exams and provides a solid preparation for clinical years. It is an excellent resource for all medical students wishing to gain and retain anatomy and pathology knowledge in a time-effective manner.

This issue of Clinics in Laboratory Medicine, entitled Respiratory Viruses in Pediatric and adult Populations, is Guest Edited by Alexander J. McAdam MD, PhD, and includes: Developments in Specimen Collection and Tissue Culture for Respiratory Viruses; Nucleic acid amplification assays for respiratory viruses; Emerging molecular assays for respiratory viruses; Drug Resistance in Influenza Virus; Quantitative assays for adenovirus; RSV vaccine development; Human Metapneumovirus; and Recently discovered coronaviruses.

This issue presents topics of importance in current point-of-care testing for laboratory medicine professionals. Topics such as POCT: An overview and look to the future; Fine needle aspiration biopsy: POCT in cytopathology; Drugs of abuse; POCT and disaster response; POCT regulatory affairs; Fecal occult blood testing; Tight Glycemic control;Molecular POCT; Information management and connectivity; Alternate QC and EQC; Managing POCT; and Coagulation and D-dimer

New technologies in urology involves minimal invasion, less recovery time, and organ-sparing techniques. This issue addresses those cutting-edge technologies that are currently being researched and are just entering clinical practice. Therefore, a main goal of this issue is to bring the information about these technologies to all practicing urologists so that they are knowledgeable and equipped to master them. Focus is given to new imaging modalities, like virtual endoscopy, molecular imaging, and image fusion. The issue also presents articles on robotics, laparoscopic surgery and endoscopy, and nanotechnology.

Topics include: Development and Validation of Reverse Phase Protein Microarrays for Personalized Therapy, Imaging Mass Spectrometry for Predictive and Prognostic Medicine, Immunomic Based Profiling for Early Cancer Detection, Antibody Arrays for Clinical Applications, Autoantibody profiling for Cancer Detection, Development and validation of a protein based signature for ovarian cancer detection, Analytical considerations for Mass Spectrometry Profiling in Serum Biomarker Discovery, Salivary Biomarkers for Clinical Applications, Proteomics of Caveolea: Clinical Applications, Clinical opportunities for renal cell cancer managment using proteomics, Cardiovascular Proteomics: implications for clinical applications, Clinical Proteomic Applications from FFPE, Development of high throughput mass spectrometry- based approaches for cancer biomarker discovery and implementation, Proteomics and Diabetic Retinopathy.

In this unique issue, the content is devoted to the socioeconomics of healthcare. Healthcare economics provide the underpinning of urologic practice for today and tomorrow. All of our clinical endeavors are dependent on the economic realties of the twenty-first century. This issue elucidates some of the challenges that are facing patients, physicians, and society. There are two major sections, The Healthcare Landscape: The Big Picture and Urologic Practice: Current Issues and Future Prospects. In the first section, articles address the history and demographics of healthcare and following this, several authors provide different proposals for healthcare reform. These proposals are followed by more parochial urologic issues which include residency training, certification and recertification, urologic research, practice management, and the impact of medical malpractice.

Get complete massage pathology information in one convenient text! Mosby's Pathology for Massage Professionals, 5th Edition provides concise pathology information, along with specific therapeutic recommendations. Coverage of more than 300 pathologies shows you how to appropriately tailor treatment, and more than 500 full-color photographs make it easier to recognize common pathologies. Written by massage therapy educator, researcher, and practitioner Dr. Susan Salvo, this resource provides the pathology knowledge you need to succeed in the classroom and in your career. Coverage of more than 300 pathologies provides students with ample information without being overwhelming. More than 500 full-color photographs help students recognize common diseases and conditions. Case studies in each chapter encourage students to apply their knowledge and develop clinical reasoning skills. UNIQUE! Hospital-Based Massage chapter covers different protocols needed for massage therapists working in institutionalized care settings and provides useful information about working with clients who are medically fragile or in hospice care. User-friendly, comprehensive format makes it easy to find key information with learning objectives, a systems overview that includes the aging process, and pathologies that feature descriptions, etiologies, signs and symptoms, current treatment measures including medications in bold-italics for easy identification, and massage modifications. UPDATED! Refreshed artwork throughout the book visually reinforces key concepts and techniques. UPDATED! Information on the biopsychosocial model, transmission-based precautions, and disinfection procedures for today's massage practice. UPDATED! Inclusion of sleep disorders, opioids, and CBD use by clients, and their massage considerations. UPDATED! Addition of evidence-based protocols for scar tissue, constipation, hypoglycemia, and more. UPDATED! Detailed information on how to work with clients after surgery, who have a colostomy, amputations, or who are on dialysis. UPDATED! Thoroughly reviewed and revised pathologies feature current research findings and reflect what students will encounter in today's massage therapy practice, with a focus on evidence-informed practice.

Combining theory and practice, this book is a comprehensive analysis of suffocation, asphyxiation, and neck pressure deaths. It includes important developments in the field such as lung histomorphology in fatal strangulation, systematic dissection of the larynx, biochemical findings, and postmortem imaging. Significant challenges arise in accurately diagnosing these deaths when compared to other forms of external violence. International experts explain the pitfalls and subtleties of identifying such cases making this an important resource for readers involved in such investigations. Tables, statistics, scientific and historical evidence throughout further validate the value of this book. Provides a comprehensive introduction to every major topic of asphyxia and neck pressure death Features more than 300 figures to aid understanding and facilitate accurate diagnosis of these death types Includes the important topic of postmortem radiology findings Navigates the reader through the potential pitfalls and misdiagnoses of asphyxia and neck pressure deaths with expert guidance About the Editor Professor Burkhard Madea MD, Director, Instiute of Forensic Medicine, University of Bonn, Germany, is a world-renowned forensic pathologist and the author of more than a dozen books and 600 papers.