Uropathology, a volume in the High Yield Pathology Series, makes it easy to recognize the classic manifestations of urologic diseases and quickly confirm your diagnoses. A templated format, excellent color photographs, authoritative content, and online access make Uropathology an ideal reference for busy pathologists. Provides in-depth, bulleted outlines for each entity covering definition, anatomy, and pathology: histology, immunohistochemistry, and differential diagnosis. Features 1,600 high-quality illustrations that include gross, radiographic imaging, microscopic, immunohistochemical, and special stains, providing a comprehensive visual summary of the typical features of each entity. Includes expanded information on tumor staging expertly provided by Dr. Ming Zhou, primary author of the College of American Pathologists cancer protocols. Reflects recent guidelines and protocols including: Restructured tumor classification and new entities New and modified grading systems for GU cancers New and modified staging criteria for all GU cancers New recommendations for reporting New IHC and molecular markers for diagnosis and prognosis for GU cancers Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices Your first line resource for genitourinary pathology

A benchmark survey of current clinical findings on the complex interactions between diet, stress, and mental health, and their impact on disease states. The authors give special attention to the influence of stress on physical health, mental health, and cognitive function, including the critical effects of maternal nutritional status and stress levels on fetal physical and mental development, the role of lipids in the development and treatment of depression, the role of fish oil in the development of aggressive behaviors, and the consequences of obesity on stress and the development of eating disorders. Additional chapters examine the effects of stress on chronic disorders, women, and cardiac function, and the influence of inflammation on diet, neurological functions, disease incidence, and cognitive functions.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of thoracic pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Thoracic, 3rd Edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of pulmonary, pleural, and mediastinal entities Features an updated chapter on severe acute respiratory syndrome (SARS) pneumonia with current knowledge, statistics, and pathophysiology on COVID-19, including new images that encompass the radiology, gross pathology, and histopathology of the disease Includes updated criteria, terminology, and classifications for a wide range of tumors from the 2021 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus and Heart, reflecting changes to currently used terminologies for adenocarcinoma, squamous cell carcinoma, neuroendocrine tumors, mesothelioma, soft tissue tumors, benign tumors, and more Covers the recent explosion of molecular genetic information, including new Molecular Pathology sections with new information on the genetic underpinnings of diseases Specifies genetic mutation types associated with each tumor and covers numerous types of molecular tests, including next-generation sequencing studies and how the specific genetic alterations are used to differentiate disease and aid in diagnosis Features over 3,900 high-quality images, including histologic images, gross pathology images, radiologic images, and full-color illustrations as well as more than 750 additional online-only images to help practicing and in-training pathologists reach a confident diagnosis Contains multiple recent consensus clinical practice guidelines for thoracic disease diagnosis, including those for molecular genetic testing and predictive biomarker testing from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

This issue of Clinics in Laboratory Medicine, Guest Edited by Mark Yazer, MD, on the topic of Blood Transfusion will include the following article topics: Xenotransfusion; FDA Perspective; Inflammatory Cytokines as Predictors of Alloimmunization; Cryopreservation of RBCs, PLT and Stem Cells; PLT Storage Lesion; Future of Blood Management; Future of Molecular Testing for RBC Antigens: ECO Cells; Farmed RBCs; Farming RBCs from Stem Cells; Politics and Blood Transfusion; and Fetal Blood Grouping from Maternal Plasma.

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life. Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURES Focuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signs Serves as a ready clinical compendium for trainees, fellows and ophthalmologists Explores various corneal pathologies through a wealth of accompanying illustrations and teaching videos

Anatomy and pathology are key areas in medical training, but the amount medical students have to learn within them can seem overwhelming. This book helps students gain a firm grasp of the facts they must know before they enter their clinical years. It encompasses the core basics of the major organ systems in the body and presents them in a memorable, easy-to-read form. The book covers the background and knowledge that are clinically relevant to, and commonly encountered in, end-of-semester exams and provides a solid preparation for clinical years. It is an excellent resource for all medical students wishing to gain and retain anatomy and pathology knowledge in a time-effective manner.

This issue of Clinics in Laboratory Medicine, entitled Respiratory Viruses in Pediatric and adult Populations, is Guest Edited by Alexander J. McAdam MD, PhD, and includes: Developments in Specimen Collection and Tissue Culture for Respiratory Viruses; Nucleic acid amplification assays for respiratory viruses; Emerging molecular assays for respiratory viruses; Drug Resistance in Influenza Virus; Quantitative assays for adenovirus; RSV vaccine development; Human Metapneumovirus; and Recently discovered coronaviruses.

This issue presents topics of importance in current point-of-care testing for laboratory medicine professionals. Topics such as POCT: An overview and look to the future; Fine needle aspiration biopsy: POCT in cytopathology; Drugs of abuse; POCT and disaster response; POCT regulatory affairs; Fecal occult blood testing; Tight Glycemic control;Molecular POCT; Information management and connectivity; Alternate QC and EQC; Managing POCT; and Coagulation and D-dimer

New technologies in urology involves minimal invasion, less recovery time, and organ-sparing techniques. This issue addresses those cutting-edge technologies that are currently being researched and are just entering clinical practice. Therefore, a main goal of this issue is to bring the information about these technologies to all practicing urologists so that they are knowledgeable and equipped to master them. Focus is given to new imaging modalities, like virtual endoscopy, molecular imaging, and image fusion. The issue also presents articles on robotics, laparoscopic surgery and endoscopy, and nanotechnology.

Topics include: Development and Validation of Reverse Phase Protein Microarrays for Personalized Therapy, Imaging Mass Spectrometry for Predictive and Prognostic Medicine, Immunomic Based Profiling for Early Cancer Detection, Antibody Arrays for Clinical Applications, Autoantibody profiling for Cancer Detection, Development and validation of a protein based signature for ovarian cancer detection, Analytical considerations for Mass Spectrometry Profiling in Serum Biomarker Discovery, Salivary Biomarkers for Clinical Applications, Proteomics of Caveolea: Clinical Applications, Clinical opportunities for renal cell cancer managment using proteomics, Cardiovascular Proteomics: implications for clinical applications, Clinical Proteomic Applications from FFPE, Development of high throughput mass spectrometry- based approaches for cancer biomarker discovery and implementation, Proteomics and Diabetic Retinopathy.

In this unique issue, the content is devoted to the socioeconomics of healthcare. Healthcare economics provide the underpinning of urologic practice for today and tomorrow. All of our clinical endeavors are dependent on the economic realties of the twenty-first century. This issue elucidates some of the challenges that are facing patients, physicians, and society. There are two major sections, The Healthcare Landscape: The Big Picture and Urologic Practice: Current Issues and Future Prospects. In the first section, articles address the history and demographics of healthcare and following this, several authors provide different proposals for healthcare reform. These proposals are followed by more parochial urologic issues which include residency training, certification and recertification, urologic research, practice management, and the impact of medical malpractice.

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

A short, highly readable and well illustrated book on general and systematic pathology, approached from the point of view of what medical students need to know in order to understand the clinical work they will eventually be doing. Includes a great variety of self-assessment, to reinforce the messages and to test understanding - and to help students prepare for exams. Concise synoptic (not telegraphic text). Appropriate self-assessment material. Only covers core, so student knows the whole book is essential. Includes key objectives. Contains simple and memorable diagrams for reproduction in exams. Ideal for learning as well as examination review, specifically trying to stimulate the student into assessing his/her own knowledge. The books in the series both complement other available major texts, but also contain enough material to stand in the own right. Provides examination practice. Part of co-ordinated series. Now general and systematic pathology combined in one volume. Further refinement to contents to reflect evolution of what is regarded as core knowledge. Major revision of self-assessment material to match change in style of examination (mainly more EMQ- and OSCE-style questions). New cover design.

Combining theory and practice, this book is a comprehensive analysis of suffocation, asphyxiation, and neck pressure deaths. It includes important developments in the field such as lung histomorphology in fatal strangulation, systematic dissection of the larynx, biochemical findings, and postmortem imaging. Significant challenges arise in accurately diagnosing these deaths when compared to other forms of external violence. International experts explain the pitfalls and subtleties of identifying such cases making this an important resource for readers involved in such investigations. Tables, statistics, scientific and historical evidence throughout further validate the value of this book. Provides a comprehensive introduction to every major topic of asphyxia and neck pressure death Features more than 300 figures to aid understanding and facilitate accurate diagnosis of these death types Includes the important topic of postmortem radiology findings Navigates the reader through the potential pitfalls and misdiagnoses of asphyxia and neck pressure deaths with expert guidance About the Editor Professor Burkhard Madea MD, Director, Instiute of Forensic Medicine, University of Bonn, Germany, is a world-renowned forensic pathologist and the author of more than a dozen books and 600 papers.

The much awaited third edition of the leading reference book in dermoscopy has undergone comprehensive revisions to all chapters, with updates and expanded content providing the reader with a more comprehensive and in-depth coverage of skin conditions, ranging from skin neoplasia to hair, nails, infections and inflammatory diseases. This compilation of contemporary dermoscopy knowledge will benefit the novice in building expertise and benefit experienced practitioners also by providing nuanced insights. Prepare to embark on a journey of learning as leading international experts in the field of dermoscopy explain via text and annotated exemplar images the amazing world of subsurface cutaneous colors and structures visible through a dermatoscope!

With its many diagnostic categories, relevant variants, and rare tumors, soft tissue pathology is one of the most challenging areas of surgical pathology. Focusing on the cutaneous soft tissue specimens and reactive mimics most likely to be encountered by pathologists and dermatopathologists, Diagnostic Atlas of Cutaneous Mesenchymal Neoplasia is a superbly illustrated, easy-to-use atlas designed to be used beside the microscope for efficient diagnosis and classification of soft tissue tumors of the skin. Features high-quality histologic and clinical images of multiple examples of each tumor, with captions and bulleted text for quick reference. Uses a high-yield format that facilitates a rapid and accurate diagnosis, including: Characteristic clinical setting Key morphologic features Immunohistochemical properties Molecular diagnostic testing (where applicable) Offers the most complete presentation available of this complex family of tumors, authored by renowned experts in dermatopathology. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Sudden cardiac death represents a highly heterogeneous group of cardiovascular disorders. While some may initially think of sudden death as primarily an arrhythmogenic event, this actually represents the minority of cases of sudden cardiac death. In the vast majority of cases, there is an underlying anatomic disorder of the cardiovascular system responsible for the ultimate hemodynamic collapse known as sudden cardiac death. This book will provide an atlas type review of ischemic and non-ischemic etiologies of sudden cardiac death. Beyond the atlas, however, will be a "clinical pathologic correlation" for each described disorder providing practicing clinicians with practical information to facilitate proper diagnosis and treatment. While an increasing array of noninvasive diagnostic tools continue to develop, the sad fact remains that many of the physicians and operators of these new diagnostic modalities have never actually seen specimens which demonstrate the fundamental pathologic abnormalities. This ability to see first hand the underlying pathology creates an opportunity to advance the science and enhance ones understanding of these disease processes. There is not a comprehensive text on this subject on the market today which provides clinical and patholigical material in such a comprehensive manner.

Rapid evolution of technical advances in infrared sensor technology, image processing, "smart" algorithms, databases, and system integration paves the way for new methods of research and use in medical infrared imaging. These breakthroughs permit easy-to-use, high-sensitivity imaging that can address key issues of diagnostic specificity and engender a new level of diagnostic standardization, thus enabling the even wider use of infrared imaging as a viable, non-invasive, lower-cost, safe and accessible first-line detection modality. Edited by the inventor of the MedATR concept that leads to the first IR-CAD for the early detection of breast cancer, Medical Infrared Imaging presents many of the new ideas, concepts, and technologies that are key to the wider acceptance of infrared imaging as a revolutionary new standard. Beginning with the worldwide advances and their medical applications from a historical perspective, the book provides detailed and comprehensive information on the technology and hardware resulting from these innovative breakthroughs that will make currently contributory infrared information even more pertinent. The book covers the physics and physiological basis of thermal imaging, and such cutting-edge concepts as: dynamic thermal imaging, thermal tomography, the important role of infrared in a multi-modality imaging setting, and novel processing techniques for the early detection of breast cancer. A significant portion of the book introduces new applications such as biometric facial recognition and the clinical use and quantification of the TAU technique which uses functional imaging to determine the relevance, the stage, and the progression of diseases. Effective and reproducible results are crucial and the book emphasizes the importance of standardization, calibration, and protocols. Finally, the editor includes chapters on the use of databases for storage and retrieval of images and the ethical obligations of infrared research and clinical practice. As a comprehensive state-of-the-science and indication of future directions, Medical Infrared Imaging provides the medical and biomedical engineering communities with the tools to fully utilize and further advance the applications of infrared imaging.

This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Biopsy Pathology in Colorectal Disease shows how the practising pathologist can extract the maximum of diagnostic value from biopsies of the colon, rectum, and anus. With the advances in colonoscopic mucosal biopsy techniques these are amongst the most frequently encountered specimens in hospital histopathology departments. This new edition provides practising pathologists and those in allied disciplines with a thorough guide to the diagnosis of colorectal conditions, both common and rare, and offers expert guidance in the handling of biopsy specimens. The most valuable information for diagnositc interpretation of the variuos types of inflammatory disease is presented clearly and succinctly, minimizing the use of non-diagnostic terms such as 'non-specific colitis.' Optimal ways of handling and examining polyps, the assessment of biopsies in motility disorders and the interpretation of biopsies of anal lesions are described. A rationale classification and practical approach to dysplasia is presented. The early chapters describe how to recognize the many different features, both normal and abnormal, which can be regarded as signposts to diagnosis. The significance of these diagnostic signposts is briefly described and cross referenced to later chapters, in which the histological features of the specific diseases are covered in greater depth.

Selecting illustrative examples from the recent literature, this reference studies the underlying principles and physics of a wide range of spectroscopic techniques utilized in the pharmaceutical sciences and demonstrates various applications for each method analyzed in the text-showing how knowledge of the mechanisms of spectroscopic phenomena may facilitate more advanced technologies in the field.

Tissue stem cells and their medical applications have become a major focus of research over the past decade. With 16 full-color illustrations, this reference provides a thorough and up-to-date overview of the current and emerging technologies for stem cell research and transplantation. Divided into three sections covering general issues, adult stem cells within specific tissues, and clinical applications, this source studies advances in bone marrow transplantation, cancer development modeling, tumor analysis, and gene therapy.

Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic dermatopathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Neoplastic Dermatopathology is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Covers the broad array of cutaneous neoplasms and their differential diagnoses in a concise, practical, and richly illustrated format Analyzes hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls Features thorough updates throughout, including new information from molecular pathology studies that describe multiple mutations in different cutaneous tumors, and updated staging details for melanoma, cutaneous lymphoma, and other tumors Addresses recent advances in molecular pathology-new diagnostic, immunohistochemical, molecular, and genetic techniques used for diagnosis, as well as updated reportable staging details for several new diagnoses and identification of newly recognized tumors Details the expanded scope of knowledge available from the 2018 update to the World Health Organization and European Organization for Research and Treatment of Cancer (WHO-EORTC) Includes more than 2,900 carefully annotated photographs, images, and illustrations plus nearly 1,000 additional digital-only images to help practicing and in-training pathologists reach a confident diagnosis Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes-more than 150 diagnoses in all Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others Meticulously edited by Dr. Vania Nose with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices