Stillbirth remains a sufficiently frequent outcome of pregnancy to pose great problems for clinicians, who have to treat extremely distressed patients. This concise but comprehensive book from an international team of contributors sets out clear guidelines for clinical procedures and patient management for the obstetrician, as well as the gynecologist and the gynecologic pathologist.

This superbly illustrated book is the most comprehensive available guide to adnexal neoplasms of the skin. More than 70 entities are described in individual chapters that follow a uniform structure: historical review, clinical features, histopathology, histogenesis, immunohistochemistry, molecular anomalies, and treatment. Readers will find state of the art knowledge on all aspects, including the cytogenetic and chromosomal abnormalities associated with each neoplasm. Without exception, the illustrations are high-quality, full-color, original digital pictures. The histopathology images are taken from perfectly cut and stained sections and the immunohistochemistry illustrations are of an unrivalled quality among textbooks of dermatology and dermatopathology. A complete list of references from original description to the present day is also supplied for each neoplasm. Cutaneous adnexal neoplasms are a large and heterogeneous group of benign and malignant lesions. This book will assist the reader in early and correct recognition, which is essential for appropriate choice of treatment and prognostic assessment.

The autopsy is a central component of postgraduate training in pathology and remains an important part of medical practice today. Pathologists are now expected to possess a higher level of knowledge and understanding of the autopsy, the law surrounding it, and its clinical value, in an increasingly scrutinized and legislated environment. Autopsy practice can no longer be viewed in the absence of external contextual issues: it is vital that pathologists have solid grounding not only in standard technique, but also in such matters as personal health and safety to obtaining informed family consent, before undertaking an autopsy procedure. This new and revised edition of The Hospital Autopsy presents a clear and systematic approach to safe and effective modern autopsy practice. Like the extremely popular second edition, it begins by discussing issues of consent and mortuary design before going on to comprehensively cover external examination, evisceration, dissection of internal organs, and report writing. In this edition, new chapters have been added on the radiological autopsy, religious attitudes to autopsy, and the implications of high-risk infections for autopsy practice. Specialist techniques are covered in depth, and chapters are devoted to complex issues including perinatal autopsies, maternal deaths, and neuropathological examinations. The Hospital Autopsy, Third Edition, is sure to be an indispensable resource for pathologists in training, as well as a useful refresher for practicing pathologists and autopsy technicians.

Microbiologists, medical mycologists, immunologists, and biochemists are increasingly working together to focus on the processes involved in the progression and treatment of fungal disease. Host-Fungus Interactions: Methods and Protocols is designed for research scientists who are involved in this work and interested in undertaking new or comparative studies of interactions between the mammalian host and clinically important fungal pathogens. Aiming to combine approaches for reverse genetics in pathogenic fungi with methods for their application in in vitro and in vivo models of disease, the book includes methods for the culture and genetic manipulation of the primary fungal pathogens and the opportunistic pathogens, as well as methods for investigating host-fungus interactions in model systems. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Host-Fungus Interactions: Methods and Protocols describes available molecular methods and fungal infection models in great detail in order to encourage researchers to try new approaches to investigating host-fungus interactions with added levels of confidence.

Once the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regulatory functions of ROS and RNS in physiological and pathophysiological states. An exploration of the main questions of signaling mechanisms of reactive oxygen and nitrogen species in enzymatic processes, this book draws attention to the chemical mechanisms of these reactions. It elucidates the differences between signaling functions and damaging effects of ROS and RNS in biological systems. The text also covers free radical signaling processes catalyzed by enzymes, producers of superoxide and nitric oxide that are able to use produced ROS and RNS as signaling species in their own catalytic processes. It then examines ROS and RNS signaling produced by mitochondrial enzymes. The author explores signaling functions of ROS and RNS in enzymatic heterolytic reactions, supplying important data on ROS and RNS signaling in the catalysis by the enzymes which do not produce free radicals by themselves. He provides information on signaling by reactive oxygen and nitrogen species in apoptosis and aging/senescence and concludes with coverage of mechanisms of free radical signaling in enzymatic processes. The book provides new understanding of signaling functions in living organisms related to cardiovascular processes, cancer, inflammation, hereditary diseases, and their regulation of physiological functions such as development, aging, and senescence. This information can support the development of new drugs and novel treatment methods.

A NEW EYE-OPENING ILLUSTRATED EDITION OF MEERA SENTHILINGAM'S TIMELY GUIDE For decades scientists have been warning of a global pandemic, and the Covid-19 coronavirus outbreak has realised their worst fears. Covid-19 and monkeypox make Outbreaks & Pandemics an essential guide to the future. It narrates a disquieting journey through the history, science, and politics of humankind's ongoing war against contagion; investigates modern responses; and assesses the chances of eradicating disease in the future. it also reveals how globalisation, mobile populations, climate change, vaccine hesitancy, and drug-resistant pathogens have combined to create the perfect conditions for pandemics to spread. This updated and illustrated edition is essential reading, combining extensive research with illuminating photographs and infographics to chart the pattern of outbreaks and reveal the microscopic world at their heart.

Get complete massage pathology information in one convenient text! Mosby's Pathology for Massage Professionals, 5th Edition provides concise pathology information, along with specific therapeutic recommendations. Coverage of more than 300 pathologies shows you how to appropriately tailor treatment, and more than 500 full-color photographs make it easier to recognize common pathologies. Written by massage therapy educator, researcher, and practitioner Dr. Susan Salvo, this resource provides the pathology knowledge you need to succeed in the classroom and in your career. Coverage of more than 300 pathologies provides students with ample information without being overwhelming. More than 500 full-color photographs help students recognize common diseases and conditions. Case studies in each chapter encourage students to apply their knowledge and develop clinical reasoning skills. UNIQUE! Hospital-Based Massage chapter covers different protocols needed for massage therapists working in institutionalized care settings and provides useful information about working with clients who are medically fragile or in hospice care. User-friendly, comprehensive format makes it easy to find key information with learning objectives, a systems overview that includes the aging process, and pathologies that feature descriptions, etiologies, signs and symptoms, current treatment measures including medications in bold-italics for easy identification, and massage modifications. UPDATED! Refreshed artwork throughout the book visually reinforces key concepts and techniques. UPDATED! Information on the biopsychosocial model, transmission-based precautions, and disinfection procedures for today's massage practice. UPDATED! Inclusion of sleep disorders, opioids, and CBD use by clients, and their massage considerations. UPDATED! Addition of evidence-based protocols for scar tissue, constipation, hypoglycemia, and more. UPDATED! Detailed information on how to work with clients after surgery, who have a colostomy, amputations, or who are on dialysis. UPDATED! Thoroughly reviewed and revised pathologies feature current research findings and reflect what students will encounter in today's massage therapy practice, with a focus on evidence-informed practice.

The dramatic and compelling account of how a serial killer was finally unmasked after evading justice for more than twenty years.

Soon to be a major TV series starring Luke Evans

1980s. In the beautiful, unspoiled landscape of Pembrokeshire, a serial killer is at large: two double murders; an assault; the rape and assault of two teenagers - all potentially the work of one man.

This is the fascinating true story of a brutal murderer and the detectives who worked the cold case for six years in order to bring him to justice. Combining cutting edge forensic techniques with old fashioned detective work, a team of detectives worked to build a case against their prime suspect. But it was a race against time: would he strike again?

No one could predict that the killer's appearance on a gameshow would provide bizarre but crucial evidence.

The operation is now recognised as one of the greatest cold case reviews ever undertaken in the UK.

The killer is now serving a "life means life" sentence.

Once students have learned the principles behind basic pathology and the mechanisms of disease, they must then consolidate their knowledge by putting those principles into clinical practice. Providing a practical learning experience, this volume presents fifty structured clinical scenarios. Each case is based on a clinical situation that pulls together the key pathological, radiological, and clinical aspects of a condition. Questions and answers highlight diagnostic avenues and provide an effective way of testing assimilation of the material. Students can set their own level of challenge and build their clinical understanding by delving into a cluster of cases covering related topics, or instead emphasize one of the five main themes: symptoms, signs, investigations, treatment, and overall management. Ample illustrations supplement the text, which blends typical clinical case presentations with narrative-style and imaging-based cases.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of bone pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Bone is a one-stop reference for accurate, complete surgical pathology reports, ideal as a day-to-day reference or as a reliable training resource. Includes a wide range of nonneoplastic and neoplastic entities in bone pathology that enhance diagnostic accuracy and provide the biological basis for optimal treatment of patients with bone tumors and nonneoplastic conditions Reflects updates from the 5th Edition of the WHO Classification of Tumors of Soft Tissue and Bone Brings you fully up to date with recent advances in nonneoplastic orthopaedic specimens, including osteoarthrosis, osteonecrosis, pathology of intervertebral discs and menisci, non-infectious inflammatory arthritis, crystal deposition diseases, and common metabolic disorders Features new chapters covering growth and development, radiologic approach to bone tumors, and synovial tumors Contains thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs, immunohistochemistry, FISH, correlative radiologic imaging, and full-color illustrations Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls, key facts in each chapter; and an extensive index for easy reference Provides an excellent resource at the point of care for physicians in pathology, radiology, and orthopaedics, as well as medical and radiation oncologists who treat bone tumors Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

"Biomedical Science in Professional and Clinical Practice" is essential reading for all trainee biomedical scientists looking for an introduction to the biomedical science profession whether they are undergraduates following an accredited biomedical sciences BSc, graduate trainees or experienced staff with overseas qualifications. This book guides trainees through the subjects, which they need to understand to meet the standards required by the Health Professions Council for state registration. These include professional topics, laws and guidelines governing clinical pathology, basic laboratory techniques and an overview of each pathology discipline. It helps trainees at any stage of training and in any pathology discipline(s) to think creatively about how to gather evidence of their understanding and professional competence. By referring to specialist sources of information in each area, it helps students to explore particular topics in more depth and to keep up to date with professional and legal changes. It is also of value to any Training Officers who are looking for ideas while planning a programme of training for a trainee biomedical scientist.

The book includes basic principles of working in the pathology laboratory including laws and regulations, which must be observed, such as health and safety, data protection and equal opportunities laws and guidelines. Practical exercises are included throughout the book with examples of coursework, suggestions for further exercises and self -assessment. Summary boxes of key facts are clearly set out in each chapter and ideas for group/tutorial discussions are also provided to enhance student understanding.

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.
Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.
The second section focuses on the therapeutic applicationsof immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.
The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.
Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

Key features: Succinct case studies presented in an easy-to-read format, listing patient history, examination and investigations Questions at the end of each case prompt readers to consider their options for diagnosis, investigation and management Answer pages then guide readers through the clinician's sequence of thoughts and actions Subsections include histopathology, laboratory medicine (chemical pathology and immunology), haematology and microbiology Illustrations, information boxes and key points summaries reinforce learning, ideal during exam revision A broad range of common conditions is covered, from acidosis to urinary tract infection, together with more unusual cases

This authoritative reference work and practical bench book provides a thorough clinico-pathologic analysis of melanocytic disorders, as well as effective practical guidance in the diagnosis of problem lesions. The authors, both renowned experts in surgical pathology of tumors, expansively discuss clinical and microscopic characteristics of a very wide spectrum of melanocytic lesions. Key diagnostic features as well as potential pitfalls are highlighted in reader-friendly tables, facilitating quick reference in a busy diagnostic pathology practice. Pertinent up-to-date references are included and the index has been meticulously compiled.From reviews of the previous edition: 'I strongly recommend this book to everyone interested in benign or malignant melanocytic disorders'. "The New England Journal of Medicine"'Any histopathologist or histopathology department with skin biopsies to report should have a copy of this book.' "Histopathology"'This book is undoubtedly a real advance for the diagnostic pathologist and I would recommend it to all departments: it will probably become the standard text on pigmented lesions' "The Bulletin of the Royal College of Pathologists"'I found the book a pleasure to read. It is to be highly recommended for all routine pathological departments; those dealing with only occasional cases will easily find guidance and reassurance; those departments dealing with large numbers will find it helpful in the more unusual case.' "The Journal of Pathology"""

The Postmaster looked over my shoulder. As I turned to look I saw a flicker of movement from across the street. I felt unseen eyes peer at me. He walked away without another word. I watched as he climbed onto his bicycle and sped away down the street. I turned back and looked over my shoulder. Someone had been watching us. 1904. Thomas Bexley, one of the first forensic photographers, is called to the sleepy and remote Welsh village of Dinas Powys, several miles down the coast from the thriving port of Cardiff. A young girl by the name of Betsan Tilny has been found murdered in the woodland - her body bound and horribly burnt. But the crime scene appears to have been staged, and worse still: the locals are reluctant to help. As the strange case unfolds, Thomas senses a growing presence watching him, and try as he may, the villagers seem intent on keeping their secret. Then one night, in the grip of a fever, he develops the photographic plates from the crime scene in a makeshift darkroom in the cellar of his lodgings. There, he finds a face dimly visible in the photographs; a face hovering around the body of the dead girl - the face of Betsan Tilny.

Pathology of Sharp Force Trauma illustrates and details sharp force trauma as seen in forensic pathology case work as well as in the clinical setting, outlining how one informs the other in interpreting such trauma for medico-legal purposes. For the purposes of discussion, the author defines sharp force trauma as: "The application of force to produce an injury which results in a clear division or separation of the skin and underlying tissues". Sharp force trauma may be caused by all manner of implements with a sharp edge and/or pointed end, whether or not they have been produced for use as a weapon, and includes knives, broken glass, scissors and many others, to name but a few. Certain tools, such as axes or machetes, combine a sharp edge with heavy weight and produce injuries with both sharp and blunt impact elements. In many countries, with the exception of those where firearms are readily available, sharp force trauma-particularly the use of knives-is the most common method of homicide and a frequent source of morbidity seen in emergency departments. Also, there has recently been an alarming upsurge in the use of knives in gang-related assaults and in terrorist incidents. As such, the book takes a comprehensive approach in explaining the different aspects of such trauma, most importantly the manner in which the victim has died. This includes cases of homicide, suicide or accident, indicating the type of weapon responsible, explaining how it was used, and presenting other such information to the investigation of such cases. Features: * Includes over 400 full-color graphic and illustrative images throughout * Addresses all aspects of the investigation including trauma, crime scene findings, post-mortem examination, characteristics of injuries and categorization into homicide, suicide or accident * Covers the biomechanics of knife trauma and tool mark examination techniques to identify implements used * Illustrates penetrating injuries caused by pointed implements which have linear components, such as arrows, nails, spears, stakes and others * Details cutting, penetrating, and other sharp force injuries resulting from medical intervention in a healthcare environment, such as might occur during surgical procedures * Examines sharp injuries caused by domesticated and wild animals * Written by one of the premier forensic pathologists in the world with over 40 years of first-hand case experience Pathology of Sharp Force Trauma is the first substantive book published in English to look exclusively at this subject. Although primarily intended for pathologists and clinicians who are involved in the examination of such injuries in the post-mortem room or in a hospital environment, it will also be of interest to medical examiners, police and criminal investigators, attorneys and legal professionals, personnel in other forensic disciplines, and all doctors and medical students with an interested in trauma and its management.

This comprehensive yet practical text reviews the pathology of neoplastic and non-neoplastic conditions of the pleura and peritoneum, with a particular focus on mesothelioma. The anatomy and embryology of serous membranes are discussed, and the causes, epidemiology, and clinical and radiologic features of malignant mesothelioma are reviewed. A comprehensive review of immunostains used for diagnosing serous membrane lesions is given, current treatment options for patients are outlined. The markers of asbestos exposure and their significance are also assessed. The pathology of non-neoplastic conditions of serous membranes, from peritoneal cysts and endometriosis to deciduosis and gliomatosis peritonei are also covered, as are lymphomas and soft tissue tumors in serous membranes. This makes Practical Pathology of Serous Membranes an essential resource for effective diagnosis.

Careful evaluation of the placenta can often give much insight into disorders of pregnancy in the mother and fetus. The techniques of gross placental examination are not difficult, but a systematic approach is necessary to be complete. Color Atlas of Gross Placental Pathology, Second Edition is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology. This work features 186 illustrations, of which 154 are in color. Cynthia G. Kaplan, MD is Associate Professor of Pathology at the State University of New York at Stony Brook in Stony Brook, New York.

New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of science and clinical medicine. Written by a team of well-known experts, Lipidology: Translational Medical Science presents an authoritative overview of key advances in biomedical research and reviews the most important recent advances in lipidology, highlighting their relationship to cardiovascular disease.

This book reviews the pathophysiology and physical manifestations of acromegaly and discusses the multiple treatment options now available for the management of the patient with acromegaly. The book contains an ample number of illustrations that help to emphasize points of particular interest, including radiological, histopathological, and physical diagnosis images. Sections are devoted to detailing important topics including determinants of pathological effects of disease activity in acromegaly, individual therapeutic choices and criteria for diagnosis, and disease control.

The emergence of Optical Coherence Tomography (OCT) in recent years has revolutionized the way we see the retina. Providing, in real time, high-resolution cross-sectional images of the macula that are very similar to obtaining in vivo histopathological specimens, OCT represents a major advance in the diagnostics of retinal disease. The excitement of working with this new tool has been dampened by the non-availability of any standard textbook on the subject and meant that every new finding on the OCT saw us rushing to the library almost on a daily basis to locate any published reports on the subject. Until now. Containing nearly 900 scans of both normal and diseased appearances, most in full color, Atlas of Optical Coherence Tomography of Macular Diseases covers how to use Stratus OCT for diagnosing various macular disorders, identifying correct therapeutic approaches and monitoring the responses to therapies and interventions. The authors provide brief case summaries, fundus photographs, fluorescein angiography, and the OCT images and the follow up images. They discuss OCT applications for diagnosis, management, and follow-up in diabetic macular edema, macular hole, taut posterior hyaloid membrane, vitreofoveal traction, idiopathic central serous chorioretinoplasty, submacular pathology, and more.

Biotin and Other Interferences in Immunoassays: A Concise Guide is aimed at clinical laboratory scientists, medical technologists and pathologists who are often the first individuals contacted by a clinician when a laboratory test result does not correlate with clinical presentation. Research scientists working in diagnostics companies will also find this information essential. Sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratory are also discussed so readers can get all important information from one concise guide. This succinct, user-friendly reference provides the necessary information to address high levels of biotin in clinical laboratory results.