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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Protein folding and misfolding: neurodegenerative diseases (Hardcover, 2009 ed.)
Loot Price: R4,390
Discovery Miles 43 900
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Protein folding and misfolding: neurodegenerative diseases (Hardcover, 2009 ed.)
Series: Focus on Structural Biology, 7
Expected to ship within 10 - 15 working days
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The worldwide increasing age of populations brought the
neurodegenerative diseases into the focus of interest. A number of
the diverse human neurodegenerative diseases are now recognized as
conformational diseases frequently caused by aggregations of
unfolded or misfolded proteins. Knowledge on the intrinsically
unstructured proteins, a new family of gene products as well as on
the misfolded proteins produced by genetic mutation or
environmental effects has been extensively accumulated in the past
years. These proteins frequently cause proteolytic stress and/ or
enter into aberrant, non-physiological protein-protein interactions
leading to sequestration of protein aggregates which are assemblies
of many not-yet-identified components in addition to the deposition
of well-characterized misfolded peptides and proteins such as
b-amyloid, tau, a-synuclein and polyglutamine containing proteins.
These protein assemblies display diverse ultrastructures such
aggresomes, fibers, oligomers or amorphous structures, however, the
nature of these species concerning their cytoprotective or
cytotoxic effects has not been clarified yet. The main focus of
this volume is to review the molecular events initiated by unfolded
or misfolded proteins leading to conformational human diseases,
with special emphasis on the macromolecular homo- and
heteroassociations of the malfolded proteins into characteristic
ultrastructures found primarily in Parkinson's and Alzheimer's
diseases. This book reviews the structural knowledge accumulated
for well-studied and for newly discovered proteins involved in
paradigmatic conformational disorders with the aim to broaden our
understanding of the pathomechanisms of neurodegeneration, which is
crucial for finding effective therapeutic interventions that could
prevent or circumvent the development of neurodegenerative
disorders in humans.
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