Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions.

Handbook of Autopsy Practice, Fourth Edition is divided into three parts. Part I contains six new chapters in which the reader will find an assortment of tools that will increase the value of the autopsy. Included in the section are valuable resources and tools such as a sample next-of-kin letter, a quality assurance worksheet, new discourse on the dissection procedure which is accompanied by a worksheet and template for the gross description. There is also a new, detailed discussion of the safe handling of sharps, complete with photographs and the reader will also find the updated requirements of the Eye Bank of America and the U.S. Food and Drug Administration for ocular tissue transplantation. Part II has been updated with new diseases and recent references added. Practicing autopsy pathologists, residents and students are invited to review this alphabetical listing of disorders before each autopsy in order to re-acquaint themselves with what they might encounter. Part III provides a series of tables providing organ weights and body measurements for fetuses, children and adults. Handbook of Autopsy Practice Fourth Edition is an essential resource for clinicians, pathologists, residents and students who strive to hone their trade and increase the value of the autopsies they perform.

New technologies and medical treatments have complicated questions such as how to determine the moment when someone has died. The result is a failure to establish consensus on the definition of death and the criteria by which the moment of death is determined. This creates confusion and disagreement not only among medical, legal, and insurance professionals but also within families faced with difficult decisions concerning their loved ones. Distinguished bioethicists Robert M. Veatch and Lainie F. Ross argue that the definition of death is not a scientific question but a social one rooted in religious, philosophical, or social beliefs. Drawing on history and recent court cases, the authors detail three potential definitions of death--the whole-brain concept; the circulatory, or somatic, concept; and the higher-brain concept. Because no one definition of death commands majority support, it creates a major public policy problem. The authors cede that society needs a default definition to proceed in certain cases, like those involving organ transplantation. But they also argue the decision-making process must give individuals the space to choose among plausible definitions of death according to personal beliefs. Taken in part from the authors' latest edition of their groundbreaking work on transplantation ethics, Defining Death is an indispensable guide for professionals in medicine, law, insurance, public policy, theology, and philosophy as well as lay people trying to decide when they want to be treated as dead.

This issue of the Clinics in Laboratory Medicine, edited by Dr. Anil Parwani, is a special issue is devoted to topics in Pathology Informatics. Topics include but are not limited to: Basics of Information Systems (Hardware, Software); Networks, Interfaces and Communications; Databases; Data Representation, Coding and Communication Standards; Laboratory Information Systems; Enhancing and Customizing Laboratory Information Systems; Laboratory Management and Operations; Specialized Laboratory Information Systems; Middleware and Laboratory Automation; Bar Coding and Tracking; Molecular Pathology Informatics; Pathology Informatics and Project Management; Digital Imaging; Telepathology; Healthcare Information Systems; Data Security and Reliability; Role of Informatics in Patient Safety and Quality Assurance; Role of Pathology Informatics in IT Leadership; Selection and Implementation of New Information Systems; Biomedical Informatics and Research Informatics; Training in Pathology Informatics; and more.

This book serves as a quick study guide during the stages of examination preparation for the pediatric pathology boards. The material covers most of the major topics in pediatric pathology including the fetal, perinatal, infant, child, and organ system pathology. It includes a short quiz containing 115 questions with photomicrographs for each, and an answer key inserted at the end of the book.

Death Investigation: A Field Guide, Second Edition is updated and expanded to include a chronological analysis of the death scene investigative process from the first notification to the autopsy and final report. This book is written for the standpoints of a forensic pathologist and a forensic toxicologist emphasizing essential elements of the death investigation and how the results impact the final cause and manner of death. Topics discussed include how to assess the body at the scene and how to properly investigate natural and unnatural deaths. The book discusses various means and causes of deaths, demonstrating how death manifests in various parts of the body. A section on traumatic injuries examines and illustrates with color photographs blunt force, sharp force, gunshot wounds, and a host of other injuries that the investigator is likely to confront. Natural death conditions and disease are discussed in a separate chapter devoted to the most common manner of death. The Second Edition is fully updated with new added sections which cover forensic toxicology, statutory responsibilities, documentation and photography of the scene, DNA identification and possible contamination issues, decomposition, managing and utilizing electronic medical records, anaphylaxis and allergic reactions, infectious diseases such as Covid-19, acute peritonitis, and more. Despite including over 200 full-color photos, the book retains a succinct, handy format that is invaluable to those facing, and tasked with investigating, the reality of death on a day-to-day basis. Death Investigation: A Field Guide, Second Edition continues to serve as an invaluable resource for Crime Scene Investigators (CSIs), coroners, Medical Death Investigators (MDI), and medical examiner professionals.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of the female genital tract, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Gynecological is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Covers all areas of gynecologic pathology, organized into six easy-to-reference anatomic Covers all areas of gynecologic pathology, organized into seven easy-to-reference anatomic sections: vulva, vagina, uterine cervix, uterine corpus, fallopian tube and broad ligament, ovary, and peritoneum Includes all frequently encountered conditions plus extensive coverage of uncommon entities, such as inflammatory diseases of the vulva, discussed by experts in dermatopathology Provides updated differential diagnoses and diagnostic pearls as well as extensive revisions based on the 2020 WHO Classification of Tumors: Female Genital Tumors, including staging issues and measurement standards Reflects important molecular updates in endometrial carcinoma classifications as well as updated classifications for squamous and glandular tumors for the lower genital tract, both in situ and invasive Updates ancillary techniques, newly encountered pitfalls, and advances in the molecular landscape of epithelial and mesenchymal tumors Features more than 2,500 superb images in print and online, including many new gross and microscopic images as well as diagnostically relevant immunohistochemical and molecular findings Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Guest edited by Drs Sarah Vossoughi and Brie Stotler, this issue of Clinics in Laboratory Medicine will cover several key areas of interest related to Pediatric Transfusion Medicine. This issue is one of four selected each year by our series Consulting Editor, Dr. Milenko Tanasijevic. Articles in this issue include but are not limited to: Transfusion in the Pediatric Patient: Review of Evidence Based Guidelines, Transfusion in the Neonatal Patient: Review of Evidence Based Guidelines, Massive Transfusion in the Pediatric Patient, Pediatric Hemovigilance and Adverse Transfusion Reactions, Inventory Management and Product Selection in Pediatric Blood Banking, Evaluation and Management of Coagulopathies and Thrombophilias in the Pediatric Patient, Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease, Cellular Therapy in Pediatric Hematologic Malignancies, Hemolytic Disease of the Fetus and Newborn: Historical and Current State, Novel Blood Component Therapies in the Pediatric Setting, and more.

Written in the same accessible manner as previous editions, the fifth edition of Karch's Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch's Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Clinical Diagnostic Tests is a convenient, quick-reference guide to common errors and pitfalls in test selection and result interpretation for practitioners and trainees in all areas of clinical medicine. Authored by recognized experts and educators in laboratory medicine, it provides timely, practical guidance about what to do?and what not to do?for practitioners ordering or interpreting clinical tests. Each topic features a concise overview and summary followed by a list of bulleted "standards of care" that will enable practitioners to quickly recognize and avert a potential problem.

Written by one of the very few pathologists who has real expertise in this field, this book is a comprehensive key for the identification of fungal infections in tissues. With updated terminology and presentation, all invasive mycoses-types are covered, detailing their epidemiology, pathology, histomorphology of fungal elements, and differential diagnoses. Each of the separate fungal groups has a good combination of text and high-quality illustrations which is a critical feature for clinicians to state the mycopathological diagnoses. Key Features: 1. Elaborates on the histological observations of both the pathological reaction and the histomorphology of fungal elements, guiding the reader in the right direction for obtaining a diagnosis of the infection. 2. Includes key observations that can be a game-changer for infectious diseases specialists and histopathologists studying the combination of fungal morphology and host response. 3. Follows a logical layout, structure, and organization with a wealth of high-quality illustrations of the various fungi in tissues elucidated by different stains.

This book, the first of three volumes, provides a thorough background to the emerging field of neurobehavioral toxicology by looking at current clinical approaches and tests, as well as assessing current clinical research. The analysis of the impact of toxins on the human nervous system is particularly pertinent given the ongoing expansion of pharmaceuticals, industrial hazards, biological warfare and global pollution. A comprehensive introduction to neurobehavioral toxicology, this work will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Covering all aspects of neuropathology, this updated volume in the Diagnostic Pathology series is an excellent point-of-care resource for pathologists at all levels of experience and training-both as a quick reference and as an efficient review to improve knowledge and skills. The third edition is an easy-to-use, one-stop reference for the most recent clinical, pathological, histological, and molecular knowledge in the field. It offers complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions, enabling you to arrive at the correct diagnosis and prepare actionable, useful reports. Incorporates new WHO Classification of Tumors of the Central Nervous System, 5th Edition Offers information on neoplasms of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, and vascular lesions, aiding you in arriving at the correct diagnosis Emphasizes surgical pathology but also provides significant content on nonneoplastic diseases that present with focal lesions, especially those that are potentially misinterpreted as neoplasms Features new and updated chapters detailing several types of tumors that have been reclassified due to recent molecular driver information, cIMPACT-NOW recommendations, and the WHO Classification, 5th Edition Features nearly 1,700 annotated images throughout, including neuroimaging studies, histology and immunohistochemical stains, and high-quality medical illustrations Incorporates time-saving features such as a templated, highly formatted design; concise, bulleted text; a variety of test data tables; key facts in each chapter; and an extensive index Includes the enhanced eBook version, which allows you to access all text, figures, and references on a variety of devices

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Linoj Samuel brings his considerable expertise to the topic of Point of Care Testing. Top experts discuss the challenges, techniques, and data collection for point of care and at-home testing options for COVID-19, fungal pathogens, and STDs in various demographics, among other key topics. Contains 10 practice-oriented topics including point of care testing during the COVID-19 pandemic: challenges and pitfalls; will antigen testing remain relevant in point of care testing; the role of point of care testing in specific populations; lab at home: is at-home testing the new normal; point of care testing for sexually transmitted diseases; and more. Provides in-depth clinical reviews on point of care testing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

1 Zur Geschichte der Gynakopathologie.- 2 Entwicklung des Uterus, der Scheide und des ausseren Genitales.- 3 Entwicklungsstoerungen.- 4 Vulva.- 5 Vagina.- 6 Uterus.- 7 Zervix: Physiologie und Anatomie.- 8 Zervizitis (und Zervikovaginitis).- 9 Proliferations- und Reifungsstoerung der Portio und Metaplasiezone.- 10 Proliferations- und Reifungsstoerung im Zervixdrusenfeld.- 11 Tumorartige Lasionen der Ektozervix und des Zervixdrusenfeldes.- 12 Benigne Tumoren der Zervix.- 13 Dysplasien und Neoplasien des Plattenepithels der Zervix.- 14 Zervixkarzinom.- 15 Zervixmetastasen.- 16 Lymphome.- 17 Granulozytare Sarkome.- 18 Spezielle Tumoren des Kindesalters und junger Frauen.- 19 Endokrinologie, Orthologie, Funktionsdiagnostik und funktionelle Stoerungen des Endometriums.- 20 Endometritis.- 21 Endometriummetaplasie.- 22 Endometriumpolyp.- 23 Endometriumhyperplasie.- 24 Endometriumkarzinom.- 25 Metastasen des Uteruskoerpers.- 26 Mesenchymale Tumoren und verwandte Lasionen.- 27 Funktionelle Morphologie und Pathologie des Myometriums.- 28 Gefasse: Anatomie und Pathologie.- 29 Parakolpium, Parametrium, pelviperitoneales Weichgewebe.

First Published in 1999. This is Volume XXI of twenty-eight in the Psychoanalysis series. Written in 1927 this study looks as the problems of psychopathology with particular focus on Freud.

Session I: Left Ventricular Hypertrophy: Structural Aspects and Mechanisms.- 1. Relations of Left Ventricular Geometry and Function to Prognosis in Hypertension.- 2. Left Ventricular Hypertrophy, Arterial Compliance, and Aging.- 3. Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension.- 4. Regulation and Role of Myocardial Collagen Matrix Remodeling in Hypertensive Heart Disease.- 5. Ultrasonic Reflectivity of the Heart: A Measure of Fibrosis?.- 6. Local Angiotensin II and Myocardial Fibrosis.- 7. Left Ventricular Anatomy and Function in Primary Aldosteronism and Renovascular Hypertension.- Session II: Pathophysiological and Molecular Aspects.- 8. Hypertension Differentially Affects the Expression of the Gap Junction Protein Connexin43 in Cardiac Myocytes and Aortic Smooth Muscle Cells.- 9. Modulation of Cardiac Hypertrophy by Estrogens.- 10. Salt Sensitivity and Left Ventricular Hypertrophy.- 11. Volume Overload, Atrial Natriuretic Peptide, and Left Ventricular Hypertrophy.- 12. The Renin-Angiotensin System Gene Polymorphism and Left Ventricular Hypertrophy.- 13. Renin-Angiotensin System Gene Polymorphisms and Left Ventricular Hypertrophy: The Case against an Association.- Session III: Pathophysiological and Therapeutic Aspects.- 14. Left Ventricular Hypertrophy and Arterial Hypertrophy.- 15. Relationship between Cardiac Hypertrophy and Microalbuminuria.- 16. Physiological versus Pathological Hypertrophy: The Athlete and the Hypertensive.- 17. Bradykinin and Cardiac Protection.- 18. Left Ventricular Hypertrophy and Sympathetic Activity.- 19. Hypertension, Left Ventricular Hypertrophy, and Heart Rate Variability.- 20. Comparison of Meta-Analyses of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 21. Comparison of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 22. Prognostic Significance of Left Ventricular Hypertrophy Regression.- Session IV: Myocardial Ischemia.- 23. Hypertension and Coronary Microvascular Disease.- 24. Myocardial Perfusion in Hypertensive Patients with Normal Coronary Arteries.- 25. Endothelial Dysfunction in Hypertension.- 26. Endothelial Dysfunction in Hypertensives: An Uncertain Association.- 27. Hypertension, Left Ventricular Hypertrophy, and Coronary Flow Reserve.- 28. Hypertensive Heart Disease, Ventricular Dysrhythmias, and Sudden Death.- 29. Hypertension and Heart Failure.- Speakers.

An aberrant belief is extreme or unusual in nature. In the most serious cases these beliefs cause emotional distress in those who hold them, and typify the core symptoms of psychological disorders. Each of the chapters in this volume seeks to examine the role that biases in reasoning can play in the formation of aberrant beliefs. The chapters consider several conjectures about the role of reasoning in aberrant belief, including the role of the jumping to conclusion bias in delusional beliefs, the probabilistic bias in paranormal beliefs, the role of danger confirming reasoning in phobias, and the controversial notion that people with schizophrenia do not succumb to specific forms of reasoning bias. There are also chapters evaluating different theoretical perspectives, and suggestions for future research. Aberrant Beliefs and Reasoning is the first volume presenting an overview of contemporary research in this growing subject area. It will be essential reading for academics and students in the fields of human reasoning, cognitive psychology and philosophy, and will also be of great interest to clinicians and psychiatrists.

An aberrant belief is extreme or unusual in nature. In the most serious cases these beliefs cause emotional distress in those who hold them, and typify the core symptoms of psychological disorders. Each of the chapters in this volume seeks to examine the role that biases in reasoning can play in the formation of aberrant beliefs. The chapters consider several conjectures about the role of reasoning in aberrant belief, including the role of the jumping to conclusion bias in delusional beliefs, the probabilistic bias in paranormal beliefs, the role of danger confirming reasoning in phobias, and the controversial notion that people with schizophrenia do not succumb to specific forms of reasoning bias. There are also chapters evaluating different theoretical perspectives, and suggestions for future research. Aberrant Beliefs and Reasoning is the first volume presenting an overview of contemporary research in this growing subject area. It will be essential reading for academics and students in the fields of human reasoning, cognitive psychology and philosophy, and will also be of great interest to clinicians and psychiatrists.

Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

Autoimmune Reactions tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itself and other "self" systems. The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms. They also discusses possible general mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their current limitations as unifying explanations of the diseases described. The book illustrates the type of thinking and research that should eventually permit development of palliatives and cures for autoimmune diseases.

Progress in Clinical and Biological Research, Volume 397
ENDOTOXIN AND SEPSIS
Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy
Proceedings of the Fourth Conference of the International Endotoxin Society Held in Nagoya, Japan, October 23-27, 1996
Jack Levin, Matthew Pollack, Takashi Yokochi, and Masayasu Nakano, Editors
Recent breakthroughs in our understanding of the molecular biology of the human immune response have lead to important advances in the recognition and treatment of sepsis. Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy compiles the latest basic and clinical research on many aspects of sepsis, including sepsis/SIRS. It provides researchers and clinicians with an up-to-date overview of the critical data and concepts in this rapidly progressing field of inquiry.
Featuring contributions by researchers and clinicians from around the world, this book presents papers covering a broad spectrum of specialized topics in the bacteriology, biochemistry, molecular and cellular interactions, pathophysiology, and pharmacodynamics of sepsis/SIRS. It also presents information on in vivo detection and potential new therapies that target sepsis and its cellular effects. Specific topics covered in Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy include:
* Enzymes essential to the biosynthesis of Lipid A and their importance in the design of a new generation of antibiotics
* Recent breakthroughs in the understanding of the role of CD-14 in cellular resistance to infection and its therapeutic implications
* The role of Interleukin 6 in endotoxin-induced inflammatory response
* The molecular mechanisms responsible for endotoxin tolerance
* Unique chemical and biological features of LPS, and natural and synthetic LPS control mechanisms.

Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy is must reading for laboratory and clinical microbiologists, immunologists, and other investigators studying bacterial endotoxins, and specialists in internal medicine. It will also be of interest to biotechnology and pharmaceutical researchers involved with the development of new drugs to combat sepsis.

This textbook covers all aspects of rhinosporidiosis known till date and puts forward the various aspects of the disease on which further research can be carried out. Detailed descriptions of varied presentations of rhinosporidiosis managed at our institute is provided, accompanied by numerous clinical and intraoperative photographs. This book will serve as a comprehensive source of information related to all aspects of rhinoporidiosis. Experts from multiple specialties have contributed about aspects pertaining to their specialties.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

This book fills the gap in understanding of pathology of the female genital tract that is often understated during training. Normal histology and pathology of abnormal conditions are covered for the lower and upper genital tract, in a concise manner with over 200 color illustrations. Topics include this covers inflammatory diseases, iatrogenic conditions, changes associated with menopause, and benign and malignant neoplasms. This text also address adjunctive testing such as molecular diagnostics and immunohistochemistry staining. The text is concise and practical with a liberal use of bullet points, and it includes clinicopathologic correlations. Breakout tables in each chapter cover information the clinician should provide the pathologist to get the most useful report, as well as pathology issues and challenges that may result in a report less specific than the clinician is expecting. Written by board certified experts, this book is the ultimate resource for gynecological pathologists, obstetrics, OB/GYN physicians, and gynecology practitioners.