New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of science and clinical medicine. Written by a team of well-known experts, Lipidology: Translational Medical Science presents an authoritative overview of key advances in biomedical research and reviews the most important recent advances in lipidology, highlighting their relationship to cardiovascular disease.

This book reviews the pathophysiology and physical manifestations of acromegaly and discusses the multiple treatment options now available for the management of the patient with acromegaly. The book contains an ample number of illustrations that help to emphasize points of particular interest, including radiological, histopathological, and physical diagnosis images. Sections are devoted to detailing important topics including determinants of pathological effects of disease activity in acromegaly, individual therapeutic choices and criteria for diagnosis, and disease control.

The emergence of Optical Coherence Tomography (OCT) in recent years has revolutionized the way we see the retina. Providing, in real time, high-resolution cross-sectional images of the macula that are very similar to obtaining in vivo histopathological specimens, OCT represents a major advance in the diagnostics of retinal disease. The excitement of working with this new tool has been dampened by the non-availability of any standard textbook on the subject and meant that every new finding on the OCT saw us rushing to the library almost on a daily basis to locate any published reports on the subject. Until now. Containing nearly 900 scans of both normal and diseased appearances, most in full color, Atlas of Optical Coherence Tomography of Macular Diseases covers how to use Stratus OCT for diagnosing various macular disorders, identifying correct therapeutic approaches and monitoring the responses to therapies and interventions. The authors provide brief case summaries, fundus photographs, fluorescein angiography, and the OCT images and the follow up images. They discuss OCT applications for diagnosis, management, and follow-up in diabetic macular edema, macular hole, taut posterior hyaloid membrane, vitreofoveal traction, idiopathic central serous chorioretinoplasty, submacular pathology, and more.

Written by one of the very few pathologists who has real expertise in this field, this book is a comprehensive key for the identification of fungal infections in tissues. With updated terminology and presentation, all invasive mycoses-types are covered, detailing their epidemiology, pathology, histomorphology of fungal elements, and differential diagnoses. Each of the separate fungal groups has a good combination of text and high-quality illustrations which is a critical feature for clinicians to state the mycopathological diagnoses. Key Features: 1. Elaborates on the histological observations of both the pathological reaction and the histomorphology of fungal elements, guiding the reader in the right direction for obtaining a diagnosis of the infection. 2. Includes key observations that can be a game-changer for infectious diseases specialists and histopathologists studying the combination of fungal morphology and host response. 3. Follows a logical layout, structure, and organization with a wealth of high-quality illustrations of the various fungi in tissues elucidated by different stains.

Diseases of the nail represent a surprisingly large section of most dermatologists' practice - and can present difficult, sometimes intractable, clinical problems. Co-authored by one of the world's foremost authorities in the field, An Atlas of Diseases of the Nail provides expert and authoritative guidance on all aspects of diagnosis and management.

A comprehensive guide to common nail diseases, the book includes anatomy and physiology of the nail unit, paronychia and onycholysis, nail fungal infections, nails in dermatologic diseases, nails in systemic disease, nail cosmetic chemistry, nail cosmetics, clinical aspects, plus the treatment of nail disorders and nail surgery. Examining the nail from every angle, An Atlas of Diseases of the Nail provides you with a visual reference to nail diseases supported by text covering diagnosis and treatment.

An autopsy is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any disease or injury that may be present for research or educational purposes. This book is a practical guide to autopsy for trainees in pathology and forensic medicine. The second edition has been fully revised to provide the latest advances and guidelines in the field. Beginning with an introduction to autopsy, its utility and techniques for both external and in situ examination, the following chapters explain autopsy procedures for different organ systems of the body, with an emphasis on dissection methods. The final sections explain autopsies in special situations such as in maternal death and in children, autopsy and the law, design of the autopsy room, biosafety, audit, and embalming. The text is further enhanced by photographs of dissection procedures, diagrams and tables. Key points Practical guide to autopsy techniques for trainees in pathology Fully revised, second edition providing latest advances and guidelines Highly illustrated with photographs, diagrams and tables Previous edition (9789386056160) published in 2017

This book is designed with a purpose of solving all problems of examinees which arise specifically at the moment of practical and oral examination in the subject of physiology and pathology. The book contains a large number of laboratory investigations and a number of solved critical questions.

Medicolegal Neuropathology: A Color Atlas uniquely demonstrates and explains many neuropathologic findings in a way that will aid investigators of sudden and unexpected death integrate their own findings into the total case context. With helpful tips and reminders, as well as over 500 bold, colorful photographs, this well-organized resource helps you quickly recognize, document, and understand the diverse realm of neuropathological findings waiting to be discovered at autopsy.

Organized in a case-oriented format, Medicolegal Neuropathology: A Color Atlas shows you:

· Many large external and internal color photographs

· Proper methods of documenting and interpreting pathologic findings

· Methods of performing specialized autopsy procedures

· Techniques for proper sampling and preparation of tissues for microscopic examination

· Important traumatic and nontraumatic findings and their significance

· A refresher course on normal anatomical structures

Now in its second edition, this book remains a vital reference manual for those pathologists whose work involves them in the interpretation of endometrial biopsies. A full account is given of the appearances of the endometrium during the menstrual cycle, of the effects of hormones, the changes induced by steroid contraceptives and intrauterine devices, of functional disorders and of inflammatory disease. Particular attention is given to the various forms of hyperplasia and neoplasia, with special emphasis being placed upon the differential diagnosis of these conditions. Other chapters deal with sampling techniques, the anatomy and histology of the normal endometrium, descriptions of the tissue in normal and abnormal pregnancy, and gestational trophoblastic disease. This fully revised second edition reflects the fact that numerous new entities have been defined, the classification of many disease states has altered and new understanding of many endometrial diseases has been gained. This edition also discusses the changing pattern of endometrial biopsies resulting from modified clinical practice. Biopsy Pathology of the Endometrium provides the pathologist and gynaecologist with a highly illustrated and practical manual whose high quality photomicrographs will be an indispensable reference during the interpretation of endometrial biopsies.

The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.
Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.

This handy reference demonstrates how to use blood, plasma, serum, instrumentation, bone marrow, lymph nodes, and splenic tissue to establish diagnosis, emphasizing practical information to aid in the operation of an efficient hematology laboratory and highlighting up-to-date investigative procedures. Supplies case studies to allow for self-testing in hematopathology and coagulation! Gathering contributions from nearly 40 experts in the field and including more than 1450 references, tables, drawings, micrographs, and photographs, the Handbook of Hematologic Pathology -highlights the need for peripheral blood smear (PBS) review to supplement the quantitative analysis of automated instruments -focuses on the importance of clinical correlation in bone marrow evaluation and interpretation -addresses leukemia and lymphoma -examines clonal stem cell disorders characterized by self-perpetuating and differentiating proliferation -considers common causes of a hypercoagulable state associated with intrinsic circulating plasma factors -details inherited and acquired reactive leukocyte disorders -describes assessing cell lineage and stage of differentiation with monoclonal antibodies -summarizes the results of immunologic and molecular studies of Hodgkin's disease -explores the mechanisms of action, dosage, therapeutic monitoring, and complications associated with anticoagulants -discusses mechanisms of surgical bleeding and laboratory assessment -differentiates between acquired and congenital bleeding disorders and emphasizes laboratory test selection for diagnosis and successful therapy -clarifies the complexity of coagulation instrumentation and offers insight into the recognition of proceduralor instrument errors and interfering medications -outlines blood and blood component therapy options used in the management of bleeding disorders -and more! Presenting brief illustrative examples that elucidate specific clinical problems, the Handbook of Hematologic Pathology is an exceptional reference for clinical and experimental hematologists; pathologists; hematopathologists; medical, surgical, radiation, and research oncologists; immunologists; molecular and cell biologists; and medical school and graduate students in these disciplines.

Like an army of millions ready to defend its territory, the human immune system acts as the body's primary line of defense-a complex network of interacting cells that protects us from pathogens and other foreign substances. But many components of the immune system exhibit change after prolonged, heavy exertion, indicating that it is suppressed and stressed, albeit transiently, following prolonged endurance exercise.

For marathon runners, distance swimmers and any other endurance athlete who undergoes repeated cycles of heavy exertion, a weakened immune system could lead to health complications such as respiratory infection. As a result, interest in various nutrient supplements with the potential to counter exercise-induced immunosuppression has grown.

Nutrition and Exercise Immunology reviews the link between nutrition and immune function, with special application to athletic endeavor. Written by respected researchers in sports medicine and exercise immunology, this text covers topics such as carbohydrates and the immune response to prolonged exertion; protein, exercise, and immunity; and vitamins, immunity, and infection risk in athletes. It also takes a look at future directions in nutrition and exercise immunology.

For sports medicine professionals, dietitians, nutritionists, exercise immunologists, as well as endurance athletes, Nutrition and Exercise Immunology provides an important and in-depth look into this exciting, new area of scientific research.

This fully updated edition explores the latest techniques to study the challenging, and at times dangerous, genus of bacteria known as mycobacteria with basic methods that are still required for mycobacteriology along with the newer or improved methods that have been developed. The volume features chapters on the basics of DNA isolation, protein isolation, and lipid isolation, as well as more sophisticated techniques for isolation of ribosomes, and continues with sections involving analyzing subcellular fractions, culture methods, sequencing technology, in vitro models, molecular methods, as well as drug discovery applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mycobacteria Protocols, Fourth Edition serves as an ideal guide for those starting out with their mycobacteria research and also for those who have worked with it for decades.

AS FEATURED IN HEAT MAGAZINE AND THE SUNDAY TIMES 'I LOVE THIS SERIES!' ELLY GRIFFITHS 'TIMELY, GRITTY AND DARK' PAULA HAWKINS When the dead are silent, she will be their voice . . . Goth-girl mortuary technician Cassie Raven has seen thousands of dead bodies but when a drowned man knocks against the hull of her canalboat, it's a bit too close to home. Cassie is grappling with the loss of her 'gift' - her conviction that she could sense the last thoughts of the dead - and at first the mystery man with the golden-green eyes isn't sharing his secrets. But the case gets under her skin and when Cassie joins forces with Detective Phyllida Flyte, together they start to dredge up secrets from the past . . . Yet someone is watching, someone who's ready to kill to stop those secrets coming to the surface. PRAISE FOR THE CASSIE RAVEN SERIES: 'Spellbinding storytelling' Val McDermid 'Like Silent Witness but more believable' Susi Holliday 'Blackly humorous, with a fabulously one-of-a-kind protagonist' Heat Magazine 'Ingenious and sardonically written' Financial Times '[A] gritty novel with an engaging heroine' Sunday Times 'A terrific, well-placed plot' Spectator 'Cassie Raven is a lot of fun to spend time with' Big Issue 'Excellent fun, compulsive and Cassie Raven is a protagonist I want to meet again soon' James Oswald 'Cassie Raven is a blast of fresh air, striding onto the crime scene like a punk superstar' Sarah Hilary 'Move over Silent Witness - Cassie Raven is an utterly compelling contemporary forensic heroine' Isabelle Grey 'A fresh and exciting new series' Claire McGowan 'One of the best series openers I've read in years' Jane Casey

This book shows how the discipline of pathology fits into society and interfaces with science and medicine. It focuses on anatomical pathology and covers the practice of laboratory medicine in the clinical setting. The book is helpful for health professionals, especially anatomical pathologist.

This book draws together important facts, in particular areas of vascular biology, and allows the generation of hypotheses and principles that unite an area and define newer horizons. It is designed for scientists and physicians interested in immunology, inflammation and cardiovascular diseases.

Offering expert guidance on the practical use of the frozen section in the management of clinical problems, Biopsy Interpretation: The Frozen Section, 3rd Edition, is a highly illustrated, authoritative reference on this intraoperative consultative option. New editor Dr. Nicole A. Cipriani, along with Drs. Aliya N. Husain, Jerome B. Taxy, and a team of expert contributing authors, focus not only on how to view and interpret a slide, but also when to do a frozen section. Fully up to date with extensive new content and images, this third edition emphasizes intraoperative consultation and patient management, explaining the role the general surgical pathologist can play in the treatment of patients. Focuses on the assets and limitations of the frozen section including the practical techniques of execution, interpretation, and the communication of results, with emphasis on the morphologic expertise of the surgical pathologist in standard hematoxylin and eosin sections and imprints. New or thoroughly updated content in multiple critical areas, including infectious disease, female genital tract, head and neck, bone and soft tissue, and CNS. Features more than 400 full-color illustrations (many of actual frozen sections, with artifacts), nearly 50 additional figures online, and bonus online videos. Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

This accessible book examines poisoning in various contexts of international conflict. It explores the modern-day use of poison in warfare, terrorism, assassination, mass suicide, serial poisoning within healthcare, and as capital punishment. It examines a broad range of international cases from the Americas, Europe, Japan, India and more in relation to Situational Crime Prevention and its theoretical precursors, in order to explore potential prevention strategies and the ways in which perpetrators circumvent them. Case studies include analysis of attempts on the lives of Sergei and Yulia Skripal, the Tokyo subway attacks, the crimes of Dr. Harold Shipman and the Heaven's Gate and Jonestown cults. For each, the means, motive, opportunity, location, and perpetrator-victim relationship is examined. This accessible book speaks to students of criminology and those interested in penology, careers in criminal justice, homicide detectives, anti-terrorism personnel, forensic pathologists and toxicologists.

This volume presents chapters by leading figures researching the various pathways by which stress may interfere with health maintenance and contribute to disease etiology and progression. Their work focuses on direct effects of stress on the immune and endocrine systems, on behavioral factors in diseases such as cancer and diabetes, and with the general role of stress in illness processes.