Through five well-regarded editions, Dr. David Dabbs' Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today's surgical pathologists. Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications. Contains current biomarker guidelines and up-to-date references throughout. Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Presenting all the information your students need in an accessible layout, Essentials of Pathophysiology for Pharmacy will give students a practical understanding of the pathophysiologic basis of selected diseases while providing a rationale for subsequent drug therapy.

Laboratory automation is an increasingly important part of the job description of many laboratory scientists. Although many laboratory scientists understand the methods and principles involved in automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. A step-by-step, how-to reference and guide, Practical Pharmaceutical Laboratory Automation explores the processes needed to automate the majority of tasks required in research today. The author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com) that contains all the sample code and examples contained within the text as well as other information related to laboratory automation. Providing a starting point for tackling automation problems, Practical Pharmaceutical Laboratory Automation helps you develop a strategy for automation that gets consistent results.

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS -assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans -presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters -examines the multidrug resistance protein P-glycoprotein as a natural transporter -analyzes current drug designs to known requirements for transport -looks at drug delivery systems for the brain -and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

The screech of rubber against asphalt. And then the crash: a violent two-car collision resulting in a twisted mass of metal, plastic, and glass-and worse, the deaths of both drivers.

Accident reconstruction is but one phase of road traffic fatality (RTF) cases. Even as police officers draw their last diagram, interview their last witness, and reconstruct their final scenario, a different team of investigators works diligently on solving another puzzle: determining how the victims actually died.

Investigation of Road Traffic Fatalities: An Atlas covers the issues that face medical examiners and coroners in determining the nature and extent of RTF injuries as well as the cause, manner, and circumstances of death. Also ideal for medicolegal death investigators and law enforcement personnel who work with medical examiners and coroners during RTF investigations, this Atlas covers everything from "Typical road traffic fatality injuries" to "Injuries caused by safety/restraint devices" and "Autopsy and toxicology testing."

For anyone involved in RTF probes, Investigation of Road Traffic Fatalities: An Atlas is essential reading.

This is the first critical edition and translation of the first Islamic medical work on fevers. Zad almusafir is perhaps the most influential handbook in the history of medical science, and Gerrit Bos's provides invaluable insight into the medical theory of Book Seven.

These practical books written by members of the British Association of Medical Managers (BAMM) help clinical directors tackle their role as medical managers. They provide information and guidance, to enable their readers to benefit from the sharing of learning, good ideas and best practice. 'What is innovative about this series is the focus. Focused training is the norm. Yet the clinician in management makes do with generic management texts which, excellent as they may be, do not recognise the enormous diversity of today's NHS. Managing a pathology service is just not the same as managing a cardiac surgery service. This series is about providing help with the context and practicalities of managing directorates.' Peter Lees and Jenny Simpson in the Series Foreword Clinical Director of Pathology is for consultants considering taking up the role of clinical director, and those actually doing the job. It is also useful for laboratory business managers as an induction to pathology. It summarises the key management issues within pathology and is based on practical case studies rather than theoretical management concepts. It highlights a number of key areas that clinical directors of pathology should be tackling in order to maintain the quality and cost effectiveness of their service.

This book shows how the discipline of pathology fits into society and interfaces with science and medicine. It focuses on anatomical pathology and covers the practice of laboratory medicine in the clinical setting. The book is helpful for health professionals, especially anatomical pathologist.

Key features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This "one-stop" guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader 'from the mouse to the microscope', it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.

Guide to Forensic Pathology provides a concise overview of forensic pathology to those who wish to know the basics but lack formal forensic training. Both fascinating and practical, this book explains everything from who the experts are in death investigation and what their roles are to how effective testimonies are presented in court. The importance of forensic DNA testing is emphasized with a separate section in this timely reference guide.

This volume begins with a summary of the classical genetic studies and molecular genetic studies of the most common diseases, and indicates what makes them amenable to analysis and treatment. A range of possible future therapeutic options are discussed, from conventional drug targets through to gene therapy. The final chapters assess the value of diagnosis and prediction of the inheritance of various diseases.

General Pathology covers the study of pathological or disease processes in general with particular reference to morphological changes. The book is designed for second- and third-year pathology students in the medical and paramedical fields. Topics covered include cell injury, death and necrosis, pigmentation, calcification, haemorrhage, shock and oedema.

The realization that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology.;This volume adopts a step-by-step approach whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive, but integrated, treatise of piethelial function and its immunopharmacology, which aims to scrve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immununopharmacology as they are currently understood.

This book provides a practical guide for all those working in or with Medical Examiner Services in England and Wales. It is an adjunct to the e-learning and face-to-face training required to fulfil the Medical Examiner and Medical Examiner Officer roles. Medical Examiner Services also work closely with a wide range of stakeholders including bereavement and mortuary teams, Coroners and their Officers, Registrars, Funeral Directors and those working in clinical governance and patient safety. This book provides an essential overview of all aspects of the Medical Examiner system for anyone working in these areas, or in any aspect of the support and management of the deceased and bereaved. A concise guide including the knowledge base required to develop and run a Medical Examiner Service Content is completely aligned with required training Written by those with direct experience of establishing and working with Medical Examiner Services Relevant to a wide range of stakeholders who work with patients and the bereaved

Covering all aspects of neuropathology, this updated volume in the Diagnostic Pathology series is an excellent point-of-care resource for pathologists at all levels of experience and training-both as a quick reference and as an efficient review to improve knowledge and skills. The third edition is an easy-to-use, one-stop reference for the most recent clinical, pathological, histological, and molecular knowledge in the field. It offers complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions, enabling you to arrive at the correct diagnosis and prepare actionable, useful reports. Incorporates new WHO Classification of Tumors of the Central Nervous System, 5th Edition Offers information on neoplasms of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, and vascular lesions, aiding you in arriving at the correct diagnosis Emphasizes surgical pathology but also provides significant content on nonneoplastic diseases that present with focal lesions, especially those that are potentially misinterpreted as neoplasms Features new and updated chapters detailing several types of tumors that have been reclassified due to recent molecular driver information, cIMPACT-NOW recommendations, and the WHO Classification, 5th Edition Features nearly 1,700 annotated images throughout, including neuroimaging studies, histology and immunohistochemical stains, and high-quality medical illustrations Incorporates time-saving features such as a templated, highly formatted design; concise, bulleted text; a variety of test data tables; key facts in each chapter; and an extensive index Includes the enhanced eBook version, which allows you to access all text, figures, and references on a variety of devices

Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It 's aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in cells and tissues of the immune system. It describes their general molecular and biological characteristics and examines how they participate in the evolution, organization, function, and regulation of leukocytes, as well as their interaction with other tissues. The next section examines immunologically related disease scenarios where gap junctions and connexins have been shown to play a fundamental role. The contributors explain how gap junctional communication participates in the establishment and maintenance of immunological properties such as antibody and cytokine production, as well as lymphocyte immune surveillance in both physiological and pathological conditions. The book explores the most important technical approaches used and how they have been specially adapted to answer key biological questions particular to the mobile nature of leukocytes. It also describes the most recent understanding of how gap junctions and connexins participate in antigen recognition, cross-presentation, lymphocyte activation, and in the assembly and function of the immunological synapse. Finally, the book focuses on the latest progress made on translating the knowledge gained to specific treatment modalities. Topics in this section include approaches for reducing scarring and cardiac arrhythmia, combating inflammation in the central nervous system, and enhancing epithelial tissue repair. A comprehensive view of achievements in this promising field, the book will inform and update specialists, clinical practitioners, and those studying the potential for commercial applications.

This work presents the results of a comprehensive study of literature on patents, patent applications and other literature, such as journal articles. The survey covers literature published from the United States, Japan and Western Europe between January 1980 and April 1991. The authors have made a selection of many hundreds of documents on immunoassay procedures and systemized them according to entries listed in the contents. The book covers many basic procedures which may form a foothold to new interesting methods, kits and devices. It should be of interest to chemists, pharmacologists and bioengineers.

This book demonstrates that nutrients play a direct role as co-factors and regulators of the immune system. The book also shows that modulating the immune response with nutrients can provide a fundamental approach to preventive medicine.;Containing nearly 2300 bibliographic citations as well as illustrative figures, tables, and micrographs, this book is designed to be of interest to clinical immunologists, immunology and vitamin researchers, nutrition specialists, paediatricians, neonatologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Addressing the early clinical diagnosis of Alzheimer disease, this book was written to evaluate the relevance of current research on the subject. It uncovers the present lack of clinical utility in research methodologies such as neuro-imaging, drug challenges, electro-encephalographic studies and brain biopsy. The essays addressing each of these issues will provide the reader with a perspective on the role of each technology in clinical practice and an in-depth introduction to the technologies and research findings in each of the areas reviewed.

Understanding Human Anatomy and Pathology: An Evolutionary and Developmental Guide for Medical Students provides medical students with a much easier and more comprehensive way to learn and understand human gross anatomy by combining state-of-the-art knowledge about human anatomy, evolution, development, and pathology in one book. The book adds evolutionary, pathological, and developmental information in a way that reduces the difficulty and total time spent learning gross anatomy by making learning more logical and systematic. It also synthesizes data that would normally be available for students only by consulting several books at a time. Anatomical illustrations are carefully selected to follow the style of those seen in human anatomical atlases but are simpler in their overall configuration, making them easier to understand without overwhelming students with visual information. The book's organization is also more versatile than most human anatomy texts so that students can refer to different sections according to their own learning styles. Because it is relatively short in length and easily transportable, students can take this invaluable book anywhere and use it to understand most of the structures they need to learn for any gross anatomy course.

Estimation of the Time Since Death remains the foremost authoritative book on scientifically calculating the estimated time of death postmortem. Building on the success of previous editions which covered both the early and later postmortem periods this edition includes a new chapter on DNA/RNA degradation and further new content on drug testing in hair, thus widening the scope of the material. Chapters have been improved, updated and expanded, and include new and additional images to enhance the text. A unique work of synthesis combining rigorous science with practical guidance, this update reinforces the book's reputation as an invaluable resource - and also the standard - for the estimation of the time since death.