Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

This issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. Publishing on an annual basis, the volume will be divided into 7 sections: Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid tumors, and Identity/HLA. Led by Dr. Gregory Tsongalis of Dartmouth University, a team of experienced pathologists from institutions across the country oversee annual topic and expert author selection.

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders.

It contains contributions from leading experts in the field on topics such as:
age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

This accessible book examines poisoning in various contexts of international conflict. It explores the modern-day use of poison in warfare, terrorism, assassination, mass suicide, serial poisoning within healthcare, and as capital punishment. It examines a broad range of international cases from the Americas, Europe, Japan, India and more in relation to Situational Crime Prevention and its theoretical precursors, in order to explore potential prevention strategies and the ways in which perpetrators circumvent them. Case studies include analysis of attempts on the lives of Sergei and Yulia Skripal, the Tokyo subway attacks, the crimes of Dr. Harold Shipman and the Heaven's Gate and Jonestown cults. For each, the means, motive, opportunity, location, and perpetrator-victim relationship is examined. This accessible book speaks to students of criminology and those interested in penology, careers in criminal justice, homicide detectives, anti-terrorism personnel, forensic pathologists and toxicologists.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

The books Molecular Diagnostics Part 1 and 2 provide a comprehensive and practical overview of the state-of-the-art molecular biological diagnostic strategies that are being used in a wide variety of disciplines. The editors and experts in their respective fields have combined their knowledge to write these two books. Many years of experience in the development, application and quality control of molecular diagnostic methods is reflected herewith. Molecular Diagnostics Part 1 is dedicated to the theoretical backgrounds of the technologies often applied in molecular diagnostics, in which nucleic acid amplification methods (such as real-time PCR), sequencing and bioinformatics are the basic tools. The assay design and -development, combined with items of trouble-shooting are described in detail. As a foundation of reliable molecular diagnostic assays, the quality control required for validation, implementation and performance of molecular diagnostic assays is thoroughly discussed. This book also provides extensive information for those working with molecular techniques in a wide variety of research applications using conventional and real-time PCR technology, Sanger and high throughput sequencing techniques, and bioinformatics. Molecular Diagnostics Part 2 highlights the applications of the molecular diagnostic methods in the various diagnostic laboratories, comprising: - Clinical microbiology - Clinical chemistry - Clinical genetics - Clinical pathology - Molecular hematopathology - Veterinary health - Plant health - Food safety Both full-colour and well-illustrated books are particularly valuable for students, clinicians, scientists and other professionals who are interested in (designing) molecular diagnostic methods and for those who wish to broaden their knowledge on the current molecular biological revolution. The information in the books highlights the trend of the integration of multiple (clinical) disciplines into one universal molecular laboratory.

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

This book covers the complete field of head and neck pathology - from Abscess to Wegener`s Granulomatosis, Sinonasal. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Die Herausgeber, anerkannte Spezialisten und aktiv in der Interdisziplinaren Arbeitsgruppe Weichteilsarkome (IAWS) der Deutschen Krebsgesellschaft, stehen fur fundiertes Fachwissen. Das Werk zeichnet sich durch eine praxisorientierte und ubersichtliche Darstellung aller bei Weichteilsarkomen klinisch relevanten Themen aus. Ausfuhrlich wird auf Diagnostik, Klassifikation, Stadieneinteilung wie auch molekulare und genetische Aspekte als Grundlage therapeutischer Entscheidungen eingegangen. Ein weiteres zentrales Thema ist die interdisziplinare Behandlung (Chirurgie, Strahlentherapie, medikamentoese Therapie) und deren Sequenz fur die zahlreichen, unterschiedlichen Entitaten von Weichteilsarkomen. Auch spezielle Therapieverfahren, wie Extremitatenperfusion und Hyperthermie werden besprochen. AErzte in Klinik und Praxis erhalten mit diesem Buch kompetente Unterstutzung fur die optimale Betreuung von Patienten mit Weichteilsarkomen.

This issue of Surgical Pathology Clinics, guest edited by Dr. Elizabeth G. Demicco, focuses on Soft Tissue Pathology. Topics include, but are not limited to, Prognostic and therapeutic biomarkers in sarcoma, Mesenchymal tumors with SMARC deficiency, Mesenchymal tumors with EWSR1-rearrangements, Update on fatty tumors, Pleomorphic sarcomas, Update on peripheral nerve sheath tumors, Beyond leiomyosarcoma - other mesenchymal tumors of the gynecologic tract, Non-Ewing small round cell tumors, Update on myogenic sarcomas, Radiation-associated Sarcomas, Practical application of cytology, and Update on molecular diagnostics in vascular tumors.

This issue of Clinics in Laboratory Medicine, guest edited by Dr. Indira Guleria, will focus on New Pipeline of Immunoregulatory Molecules and Biomarkers in Transplantation. Topics include, but are not limited to, T Regulatory cells in Stem cells and Solid organ transplantation, Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation, microRNAs and Transplantation, Role of B Regulatory Cells in Transplant Tolerance, Complement Activation, Biomarkers in Stem Cell Transplantation, Biomarkers of Transplant Tolerance at the Fetomaternal Interface, Signaling molecules in Transplantation and Post-Transplantation Cancer, Donor specific HLA antibodies as Biomarkers of Transplant Rejection, Novel Targets of Immunosuppression in Transplantation, Nanotechnology and Immune therapies in Transplantation, Role of Costimulatory Pathways in Transplant Tolerance, and Microbiota and Immune system and Implications.

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

This book performs a distinct introduction to the pathology of the placenta and its membranes, abortion material included, with the aim to facilitate and protect the quality of the morphological placental diagnostics by the pathologists. Seven chapters with coloured figures illustrating gross anatomy, development and maturation of the placenta explain the functional morphology in its clinical correlation of single and multiple findings for the pathologists, obstetricians and neonatologists. Moreover, the book contributes to a better understanding of pre- and perinatal investigations, maternal diseases, fetal outcomes and follow up of the newborns, as well as to the prevention of worse outcome in further pregnancies. The atlas intends to stimulate the interest for perinatal pathology and to contribute to a better interdisciplinary understanding of pathologists and clinicians, midwives and nurses.