The most comprehensive reference book on diagnosing cutaneous hematologic disorders available, Hematopathology of the Skin: Clinical and Pathological Approach, 2nd Edition, provides interdisciplinary guidance from more than 40 global experts in the fields of dermatopathology, dermatology, hematopathology, and hemato/oncology. Edited by Dr. Alejandro A. Gru, Dr. Alistair Robson, and Dr. Andras "Andras" Schaffer, this concise yet comprehensive reference features a logical, consistent format heavily illustrated with high-quality clinical and pathological images throughout. Unparalleled in scope, it is a well-written, easy-to-follow resource for clinicians who care for patients with cutaneous hematologic neoplasms. Emphasizes cutaneous inflammatory conditions and reactive lymphoproliferations that resemble hematologic malignancies and often cause diagnostic dilemmas Includes new editorial board member Dr. Alistair Robson, a globally recognized world expert on skin lymphomas Uses a consistent chapter format that covers disease definition; clinical, histological, immunophenotypic, and genetic findings; detailed molecular and immune pathogenesis; detailed differential diagnoses; and a capsule summary Features hundreds of high-quality clinical and pathological images, tables, and figures that clearly explain key concepts Follows the classification guidelines of the World Health Organization and European Organization for Research and Treatment of Cancer (EORTC) Contains the most recent (2022) updates to WHO and EORTC classifications as well as an increased number of international contributing authors Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This issue of Surgical Pathology Clinics, edited by Dr. Sean R. Williamson, will focus on Genitourinary Pathology. Topics include, but are not limited to, Large ductal lesions of the prostate; Update in hereditary renal cancer; Urothelial carcinoma variants; Non-germ cell tumors of the testis; Prostate cancer (grading); Prostate cancer (staging); Renal cancer; Testis grading and staging; Bladder grading and staging; "Man from Istanbul" lesions of the genitourinary tract; Mesenchymal tumors of genitourinary tract; Translational molecular updates in renal cancer; Pathologic reporting parameters most relevant to the urologist; and Pathologic reporting parameters most relevant to the medical oncologist.

Microbial pathogenesis is the study of the mechanisms by which microbes (bacteria, viruses, protozoa, and multicellular parasites) cause infectious disease and make their hosts (humans) ill. Bacterial infections we thought were easily treatable are again a huge cause for concern with the well-publicized rise of antibiotic resistance. There are very few effective antiviral drugs and we live with the threat of epidemics such as bird flu and the outbreaks of viruses such the recent (and ongoing) Ebola crisis. Parasitic diseases such as malaria continue to pose a heavy burden in the developing world and with climate change could spread into the developed world. There is therefore an urgent need to understand microbial mechanisms, with research programmes and university courses dedicated to the subject.

AS FEATURED IN HEAT MAGAZINE AND THE SUNDAY TIMES 'I LOVE THIS SERIES!' ELLY GRIFFITHS 'TIMELY, GRITTY AND DARK' PAULA HAWKINS When the dead are silent, she will be their voice . . . Goth-girl mortuary technician Cassie Raven has seen thousands of dead bodies but when a drowned man knocks against the hull of her canalboat, it's a bit too close to home. Cassie is grappling with the loss of her 'gift' - her conviction that she could sense the last thoughts of the dead - and at first the mystery man with the golden-green eyes isn't sharing his secrets. But the case gets under her skin and when Cassie joins forces with Detective Phyllida Flyte, together they start to dredge up secrets from the past . . . Yet someone is watching, someone who's ready to kill to stop those secrets coming to the surface. PRAISE FOR THE CASSIE RAVEN SERIES: 'Spellbinding storytelling' Val McDermid 'Like Silent Witness but more believable' Susi Holliday 'Blackly humorous, with a fabulously one-of-a-kind protagonist' Heat Magazine 'Ingenious and sardonically written' Financial Times '[A] gritty novel with an engaging heroine' Sunday Times 'A terrific, well-placed plot' Spectator 'Cassie Raven is a lot of fun to spend time with' Big Issue 'Excellent fun, compulsive and Cassie Raven is a protagonist I want to meet again soon' James Oswald 'Cassie Raven is a blast of fresh air, striding onto the crime scene like a punk superstar' Sarah Hilary 'Move over Silent Witness - Cassie Raven is an utterly compelling contemporary forensic heroine' Isabelle Grey 'A fresh and exciting new series' Claire McGowan 'One of the best series openers I've read in years' Jane Casey

This practical book takes the challenge of the dermatopathology sign-out and walks the reader through a diagnostic approach, explaining how to distinguish between benign and malignant lesions and identifying histopathologic features unique to each entity. Through discussion of some 150-200 lineage-unrelated cutaneous neoplastic disorders (primary and secondary), the reader will become familiar with common and sometimes uncommon but clinically relevant conditions. Each chapter adopts a consistent style for quick and easy reading, covering typical microscopic features, clinical vignettes, histological variations, diagnostic pitfalls and differentials, and key diagnostic pearls. Chapters also explain general pathological principles, laboratory processing of specimens and medico-legal aspects of neoplastic dermatopathology. Each copy of the book is packaged with a password, providing online access to all text and images. Written by leading pathologists and educators, this is an essential resource for trainees and more experienced pathologists tackling the daily sign-out as well as board exams in dermatopathology.

Since President John F. Kennedy's 1963 murder in Dallas, medical examiner and lawyer Dr. Cyril Wecht was initially inclined to accept the official theory that one person alone was responsible for the crime. But as Wecht delved into the evidence with boundless curiosity and unprecedented access, he came to understand that America had, instead, suffered a coup d'etat at the hands of rogue elements within our own government. Nobody else has Wecht's up-close and personal experience in uncovering the facts behind this assassination-and now he is sharing it with the world. Co-authored by investigative journalist Dawna Kaufmann, this comprehensive book reveals Wecht's analyses of the case's forensic and medical evidence. With his keen eye and sharp tongue, Wecht wields his scalpel on JFK's dubious autopsy report, the inept Warren Commission Report, the mishandling of crucial materials, all of the key players, and the media malpractice that has allowed the truth to remain hidden for nearly six decades.

Postmortem Toxicology addresses the various aspects of the practice of forensic postmortem toxicology from a viewpoint of elements which must be taken into consideration for proper interpretation of the toxicological result, not in a vacuum but in a more holistic and global sense. The volume examines pre-analytical factors, storage containers/conditions, prior medical interventions and therapy, along with information from the scene investigation and anatomical findings. This reference also provides explanation of the complicating conditions for the interpretation of the toxicological results due to postmortem decomposition, embalming artifacts and the postmortem redistribution of drugs. Tolerance is also discussed as an aid to interpreting results from a habitual/chronic user of medications and/or drugs of abuse. The book is geared towards the current practitioner; however, it is written to be used as a valuable reference for a graduate or post-graduate level courses in forensic toxicology or forensic pathology.

This book takes Complexity Theory and applies it to medicine where it has previously made little ground. It provides new hypotheses for multiple common but misunderstood diseases. Doctors in particular will understand that many diseases have remained unsolved due to a linear approach to what are complex biological systems, and failure to understand and apply Complexity Theory. Therefore, many common conditions have no known cause and consequently treatments are either ineffectual or non-existant, when many of these diseases are in fact preventable. There is growing interest in non-linear science, dynamic systems, chaos and complexity theory. This trend has directly involved other sciences, including biology, but has been little touched on by medicine. Readers of this book will: * Understand the difference between Linear Science and Complexity Theory, and how medicine has failed to apply the latter. * Recognise the advantages of using this understanding to generate realistic hypotheses for cause of disease. * Read how hypotheses so generated have been formulated for a number of common diseases.

This is an invaluable collection of information designed to help residents, fellows, and students - as well as any already qualified medical professional interested in revising the essentials of skin conditions - to master the basics of skin pathology. Using the principle of pattern recognition, it simplifies the multitude of dermatopathologic signs by using easy-to-memorize images of what the key features look like - photomnemonics. There are also helpful sections on the technical aspects of dermatopathology and on the key findings at each level of the skin. Organized simply and abundantly illustrated, this text will be an indispensable guide to revision for all its readers.

From ASCP Press comes the new BOC Study Guide for Phlebotomy Third Edition - a comprehensive tool designed to assist in preparing phlebotomy students and professionals for their BOC Certification Exams, and assist instructors in developing written competency assessments. Key Features: 1,669 questions. Improved and expanded with a new, larger 8x10 trim size, allowing room for note taking Color coding for explanation/citation pages for easier access More image-based questions (as applicable) Index of questions by content outline for each certification Expanded test preparation tips Expanded explanation discussions with built in images/figures from the questions (as applicable) Standard BOC reference ranges used in examination (as applicable) Answer Key Appendix for easier access Rated for both domestic and international certifications (as applicable)

This book covers the full range of pathologic conditions encountered during childhood and youth, including tumors and tumor-like conditions of all organ systems, with direct links to developmental biology pathways and genetics. It provides a user-friendly road map to the main diagnostic criteria and combines an organ-related approach with an explanation of the diagnostic approaches to various specific diseases and syndromes, including sequential segmental analysis of congenital heart disease. More than 500 new full-color macro- and microphotographs using more than 500 multi-photographic panels are included to provide a realistic basis for comparison macroscopically and under the lens, and summarizing tables highlight key information in the concise form required for at-a-glance review. Pathologists will find the book very helpful when signing out complex and challenging cases, and it will also prove invaluable for exam preparation and continuing medical education.

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Genitourinary System, by Drs. Jonathan I. Epstein and George J. Netto, covers more than 175 differential diagnoses, ranging from the most common to the less frequently seen. In every chapter of this new second edition, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the authors emphasize atypical features that can complicate diagnoses. , Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused genitourinary lesions. Contains more than 1,450 color photographs that depict the features of each entity and cover all major differential diagnoses in genitourinary pathology. Features updated content throughout, including newly described entities and terminology in all organs, especially in the kidney. Presents clinical and pathological findings for each entry in a concise, bulleted format followed by relevant images-specifically organized according to the way pathologists actually work. Ideal for practicing pathologists, pathologists in training, residents, and medical students. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

This book tackles the difficult challenge of uncovering the pathogenic cause, epidemiological mechanics and broader historical impacts of an extremely deadly third-century ancient Roman pandemic. The core of this research is embodied in a novel systems synthesis methodology that allows for ground-breaking historical-scientific problem-solving. Through precise historical and scientific problem-solving, analysis and modelling, the authors piece together a holistic puzzle portrait of an ancient plague that is fully consistent, in turn, with both the surviving ancient evidence and the latest in cutting edge twenty-first-century modern medical and molecular phylogenetic science. Demonstrating the broader relevance of the crisis-beset world of the third-century Roman Empire in providing guiding and cautionary historical lessons for the present, this innovative book provides fascinating insights for students and scholars across a range of disciplines.

Advances in Molecular Pathology is an annual review publication that covers the current practices and latest developments in the field of Molecular Pathology. Each issue is divided into sections for comprehensive coverage of all subspecialty areas within molecular pathology, including, Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid Tumors, and special topics on COVID-19. The Editor-in-Chief of the publication is Dr. Gregory Tsongalis, a leading expert in the field. Topics covered this year include but are not limited to: Phenotype Association and Variant Pathogenicity Prediction Tools in Genomic Analysis; The application of noninvasive prenatal screening to detect copy number variations; Next generation cytogenomics using optical mapping; Review of molecular in APL; NGS for MRD in acute leukemia; Review of emerging technologies as they pertain to infectious disease testing; Germline genetic variants that predict drug response; Nutrigenomics; PGx of hypertension; Genomic data for blood typing, specifically both through NGS and arrays; Preanalytic Variables and Tissue Stewardship for Reliable Next-Generation Sequencing (NGS) Clinical Analysis; and Cell-free nucleic acids in cancer: Current approaches, challenges, and future directions.

For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book is an invaluable tool for studying and reviewing key concepts in forensic pathology. Written in a question-and-answer format, this accessible guide tests readers' knowledge of manner of death, patterns of injury, lab data interpretation, postmortem radiography and imaging, and much more. Over 300 questions, more than half with visual examples, cover both common and more unusual examples of forensic pathology seen in practice. A great resource for preparing for examinations including the American Board of Pathology examination. It provides answers with explanatory rationales for both correct and incorrect answers.

This book is an invaluable tool for studying and reviewing key concepts in forensic pathology. Written in a question-and-answer format, this accessible guide tests readers' knowledge of manner of death, patterns of injury, lab data interpretation, postmortem radiography and imaging, and much more. Over 300 questions, more than half with visual examples, cover both common and more unusual examples of forensic pathology seen in practice. A great resource for preparing for examinations including the American Board of Pathology examination. It provides answers with explanatory rationales for both correct and incorrect answers.

This issue of Surgical Pathology Clinics, guest edited by Dr. Raul Gonzalez, will cover key topics in Gastrointestinal Pathology. This issue is one of four selected each year by our series consulting editor, Dr. Jason L. Hornick. Topics discussed in this issue will include: Grossing of Gastrointestinal Specimens: Best Practices and Current Controversies, Subspecialty Signout and Interobserver Variability in Gastrointestinal Pathology, Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms, Daily Dilemmas in Pediatric Gastrointestinal Pathology, Upper Gastrointestinal Tract Manifestations of Inflammatory Bowel Disease, Gastric Polyps, Approaches to Biopsy and Resection Specimens of the Ampulla, Updates in Appendix Pathology, HER2 in Colorectal Carcinoma, Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors, Diagnoses and Difficulties in Mesenteric Pathology, Advances and Annoyances in Anus Pathology, among others.

Used by generations of physicians who encounter patients with dermatological diseases, Lever's Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a "primer" on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis-all in an easy-to-navigate, highly readable format. More than 2,000 larger, full-color illustrations, including photomicrographs and clinical photographs, help you visualize and make the most of the clinical diagnostic process Clinical Summaries provide a concise clinical review before presenting histologic features, and Principles of Management sections summarize today's complex treatment modalities in one convenient place Ultrastructural, immunohistochemical, and molecular techniques are discussed where they have value in identifying particular diseases Numerous tables summarize or compare and contrast similar groups of diseases A chapter dedicated to algorithmic classification of skin diseases according to histologic pattern features helps you develop a differential diagnosis for unknown cases An outstanding resource for dermatopathologists, pathologists, and dermatologists in training, practice, and teaching Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Molecular Hematopathology: An Integrated Case-Based Approach, provides readers an integrated case-informed learning experience of Molecular Hematopathology focused on best-practice neoplastic hematopoietic disorders and related conditions. Through reviews of diagnostic approaches in which a combination of morphologic analysis, flow cytometry, and genetic testing (cytogenetics, FISH, PCR, and/or NGS) are used to best advantage, readers should significantly expand their understanding. The text is not simply a catalog of every hematologic neoplasm having a defined cytogenetic or molecular abnormality, but rather a study of cases whose evaluations illustrate how specific chromosomal and molecular findings are used for diagnosis, prognosis, and for consideration for targeted therapy. Most of the individual chapters include summary tables that compare the described malignancy with similar entities, so that a very broad set of specific hematologic is considered throughout the text. Two sets of quiz questions are also provided for aiding in self-study. The Appendices include a concise overview of cytogenetic and molecular techniques, including a complete guide to reading next generation sequencing (NGS) data. Standard nomenclature (2017 WHO Classification compliant) is used throughout. Hematopathology has undergone several revolutionary periods, including the development of a classification system defining distinct, "real" entities (later evolved to the current WHO classification of hematologic neoplasms), advances in sophisticated immunophenotyping such as flow cytometry, and most recently, an explosion in molecular/genetic testing that greatly expands how we understand the pathophysiology of hematologic disease. The extent, applications, and ramifications of the genomic revolution are still being developed and explored. This book demonstrates how novel advances in molecular and cellular biology translate to modern pathology practice.

"Practical Immunology" is an introductory text aimed at immunology students and researchers who need a comprehensive overview of the methodology of immunology. Now in its fourth edition, Practical Immunology will appeal to students of immunology; graduate students embarking on bench science; and specialised immunologists who need to use an immunological technique outside their sphere of expertise.

The rapid and startling innovations in immunology over the past two decades have their root in sound experimental practice. Practical Immunology gives straightforward descriptions of the commonest techniques that are often covered, but not always well explained in current literature. It explains how to perform the basic techniques that form the anatomy of experimental immunology, and includes tips for improving the techniques, troubleshooting and other handy advice. Where possible, the techniques are explained in a way that ensures that the purchase of specialist kits is avoidable. For those who are a little rusty on their basic immunology the book also gives background information, making it a highly useful "one stop shop."

This latest edition has been fully revised to include the basic techniques of molecular biology, with a revised section on cytokines, an expanded section on clinical immunology and new techniques in epitope mapping and the study of cell adhersion molecules.

Physician Assistant Clinics aims to provide an authoritative and continuously updated clinical information resource that covers all of the relevant PA specialties. Our clinical review articles address the key points, diagnosis, prognosis, clinical management, and complications of disease and techniques, evidence, and controversies in the field. Information for quick reference, as well as in-depth coverage of a topic, is a hallmark of the Clinics' series. This issue of Physician assistant Clinics, guest edited by Kim Zuber, PA-C and Jane S. Davis, DNP, CRNP, brings together expert PAs, NPs, and MDs to give PAs deep insights into the latest advancements in renal disease and show how they are applicable in practice. Articles in this issue include: Will the Real Kidney Patient Please Stand Up?; Introduction of the Kidney Patient; The Surgical Kidney Patient; CardioRenal: The Pump and the Filter; Dosing the Kidney Patient; ABCs of the ICU; Pediatrics: Forgotten Stepchild of Nephrology; Acute Kidney Injury (AKI); Outpatient Management of the CKD Patient; Nephrolithiasis: The Rolling Stones; Transplant and the New Protocols; Health Disparities in Kidney Disease; and Diet and the Kidney.

Since the 4th Series of this Fascicle was published, there have been considerable advances in our understanding of tumors within the serosal membranes, in particular the classification of mesothelial tumors and their genetics. This 5th Series Fascicle aligns with the terminology recommended by the WHO in its most recent edition for pleural and pericardial tumors, with expansion to reflect serosal membranes at other sites and including recognition of mesothelioma in situ.