Microbial pathogenesis is the study of the mechanisms by which microbes (bacteria, viruses, protozoa, and multicellular parasites) cause infectious disease and make their hosts (humans) ill. Bacterial infections we thought were easily treatable are again a huge cause for concern with the well-publicized rise of antibiotic resistance. There are very few effective antiviral drugs and we live with the threat of epidemics such as bird flu and the outbreaks of viruses such the recent (and ongoing) Ebola crisis. Parasitic diseases such as malaria continue to pose a heavy burden in the developing world and with climate change could spread into the developed world. There is therefore an urgent need to understand microbial mechanisms, with research programmes and university courses dedicated to the subject.

Offering expert guidance on the practical use of the frozen section in the management of clinical problems, Biopsy Interpretation: The Frozen Section, 3rd Edition, is a highly illustrated, authoritative reference on this intraoperative consultative option. New editor Dr. Nicole A. Cipriani, along with Drs. Aliya N. Husain, Jerome B. Taxy, and a team of expert contributing authors, focus not only on how to view and interpret a slide, but also when to do a frozen section. Fully up to date with extensive new content and images, this third edition emphasizes intraoperative consultation and patient management, explaining the role the general surgical pathologist can play in the treatment of patients. Focuses on the assets and limitations of the frozen section including the practical techniques of execution, interpretation, and the communication of results, with emphasis on the morphologic expertise of the surgical pathologist in standard hematoxylin and eosin sections and imprints. New or thoroughly updated content in multiple critical areas, including infectious disease, female genital tract, head and neck, bone and soft tissue, and CNS. Features more than 400 full-color illustrations (many of actual frozen sections, with artifacts), nearly 50 additional figures online, and bonus online videos. Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

The management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending on the site and grade of tumor. Survival rates are improving and care of patients with or recovering from gliomas is increasingly handled in the community under the care of local physicians. This book provides an authoritative, multi-disciplinary summary of glioma biology, genetics, management and social issues, based on the world-leading program at the Duke University Preston Robert Tisch Brain Tumor Center, one of the world's largest and most successful Centers to offer brain cancer treatment and translational research. The text is written by specialists from this Center, giving it a consistent approach and style. This is an important educational resource for neurologists, neurosurgeons, oncologists, psychiatrists, neurohospitalists and ancillary members of neuro-oncology teams.

Selected as a Doody's Core Title for 2022! Virtually all aspects of the pathology in children are unique in pathogenesis and histogenesis from the moment of conception to adolescence whose range includes developmental anomalies to dysembryonic neoplasms. Stocker and Dehner's Pediatric Pathology provides encyclopedic but very usable coverage of this complex subspecialty, detailing all major aspects of the pathologic anatomy of childhood disorders ranging from chromosomal syndromes and infections to forensic pathology. Upholding the standard of excellence established in previous editions, this thoroughly updated Fifth Edition offers the in-depth, richly illustrated guidance you need to confidently evaluate and dependably report your findings. Contains extensive updates throughout, including advances in diagnosis and targeted therapy, molecular and genetic findings, prognostic indicators, and clinically relevant discoveries. Focuses on key pathologic findings as well as the latest molecular genetic tools and the role that these findings play in pathologic diagnosis. Provides authoritative answers on everything from how to perform a pediatric autopsy or apply the latest molecular techniques, to diagnosing chromosomal abnormalities, congenital anomalies and malformation syndromes, inborn errors of metabolism, and congenital and acquired systemic infectious diseases; from how to approach forensic pathology and transplant pathology, to evaluating the pathologies of each organ system and pediatric tumors with the latest in staging and risk assessment. Offers quick access to essential data with 50 appendices containing multiple charts and tables in the areas of Growth and Development, Organ Weights and Body Measurements, and Placenta. Features an intuitive organization by disease classification and organ system, highlighted by more than 1,400 gross and microscopic images, including 1,200 in full color. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Filled with highly instructional visual images, An Atlas of the Clinical Microbiology of Infectious Diseases, Volume 1: Bacterial Agents contains typical and atypical presentations and identifying characteristics of microorganisms, including newly described microbial agents, covering the breadth of clinical microbiology. The book presents more than 425 color photomicrographs harvested over the author's 40-year career augmented by up-to-date text describing each microbial entity included and offering insightful comments on their clinical significance.

Death Investigation: A Field Guide, Second Edition is updated and expanded to include a chronological analysis of the death scene investigative process from the first notification to the autopsy and final report. This book is written for the standpoints of a forensic pathologist and a forensic toxicologist emphasizing essential elements of the death investigation and how the results impact the final cause and manner of death. Topics discussed include how to assess the body at the scene and how to properly investigate natural and unnatural deaths. The book discusses various means and causes of deaths, demonstrating how death manifests in various parts of the body. A section on traumatic injuries examines and illustrates with color photographs blunt force, sharp force, gunshot wounds, and a host of other injuries that the investigator is likely to confront. Natural death conditions and disease are discussed in a separate chapter devoted to the most common manner of death. The Second Edition is fully updated with new added sections which cover forensic toxicology, statutory responsibilities, documentation and photography of the scene, DNA identification and possible contamination issues, decomposition, managing and utilizing electronic medical records, anaphylaxis and allergic reactions, infectious diseases such as Covid-19, acute peritonitis, and more. Despite including over 200 full-color photos, the book retains a succinct, handy format that is invaluable to those facing, and tasked with investigating, the reality of death on a day-to-day basis. Death Investigation: A Field Guide, Second Edition continues to serve as an invaluable resource for Crime Scene Investigators (CSIs), coroners, Medical Death Investigators (MDI), and medical examiner professionals.

This powerful, easy-to-use resource presents the essentials of pathology in the popular Board Review Series outline format that highlights the most tested topics for the USMLE Step 1. Packed with new content; high-yield topics; concise descriptions; more than 450 USMLE-style questions with complete answers and explanations; and full-color illustrations, photomicrographs, and radiologic images, BRS Pathology, Sixth Edition, provides everything needed for course success and board exam prep. An easy-to-scan outline format with bolded key terms and summary tables enables concise review and exam preparation. Chapter-ending exams focus on high-yield, clinical content. An end-of-book Comprehensive Exam helps students gauge their mastery of key topics. New cross-references in the answers to the Comprehensive Exam use an outline format (section number/letter) to facilitate efficient study and easy linking in all formats. Many new full-color photomicrographs and schematic illustrations provide visual learning and review. Key topic icons help students quickly locate important content. An online interactive question bank features all the questions from the book for anytime, anywhere test preparation and review. eBook available for purchase. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more

The 10th edition of Porth's Pathophysiology: Concepts of Altered Health States continues a legacy of excellence by providing comprehensive, nursing-focused coverage designed to help grasp both the physical and psychological aspects of altered health. The book's unique emphasis on "concepts" of altered health states, as opposed to factual descriptions of diseases and disorders, helps students grasp both the physical and psychological aspects of altered health. The Tenth Edition maintains its comprehensive depth with over 1,100 illustrations to show students the complex pathophysiology. In addition, over 40 advanced 3D narrated animations that address the most clinically relevant and difficult to understand disorders, engaging unit-opening case studies that reinforce critical thinking and set the tone for the content to come, and a wide range of built-in study tools. Porth's Pathophysiology: Concepts of Altered Health States is designed to make pathophysiology an exciting exploration that relates normal body functioning to the physiologic changes that occur as a result of disease, as well as the body's remarkable ability to compensate for these changes. Indeed, it is these changes that represent the signs and symptoms of disease. Students develop a strong understanding of pathophysiology concepts with the easy-to-follow narrative that builds concepts on one another, defines words as content is presented, and reviews concepts from physiology, biochemistry, physics, and other sciences along the way. Key Features of 10E: *NEW* A new unit on Emergency Medicine . The new chapters in this section are: Bioterrorism, Emergency Psychological Issues, Burns, and Shock. The purpose of this unit is to introduce pathophysiology issues that appear in an Emergency Room or Emergency situation and are not covered elsewhere in the book. *NEW* Unfolding Patient Stories: This edition includes even more cases studies with the introduction of unfolding vSim vignettes called Unfolding Patient Stories. It is not necessary to have a vSim product to use this feature. These unfolding vignettes are designed to start conversations in the classroom by using vSim patients in the book. The vignettes are completely standalone cases but if a school is using vSim then student will be familiar with the patient. Unit opener Case Studies: Prepare for clinical practice with 14 unit-opening case studies that put a real face on pathophysiology and help you relate the clinical presentation to the underlying pathophysiology. Full-color Art: Increase your understanding of key concepts with the full-color art program comprised of over 1,100 illustrations showing the clinical manifestations of diseases and disease processes. Review exercises: Reinforce your understanding of key content with chapter-ending review exercises. Objectives and Summaries: Deepen your understanding by pausing and reviewing salient points using the easily-identified section-opening Objectives and section-ending Summaries . Key Concept Boxes: Retain and apply text information using the information in the boxes help you incorporate key information into a larger conceptual unit, rather than memorizing a string of related and unrelated facts. Lab References : Easily access useful references including lists of common suffixes and prefixes, normal laboratory values in both conventional and SI units, and a comprehensive glossary. Animations: Master the most clinically relevant and difficult to understand disorders with over 40 advanced 3D narrated animations.

For 40 years, Bancroft's Theory and Practice of Histological Techniques has established itself as the standard reference for histotechnologists and laboratory scientists, as well as histopathologists. With coverage of the full range of histological techniques used in medical laboratories and pathology departments, it provides a strong foundation in all aspects of histological technology - from basic methods of section preparation and staining, to advanced diagnostic techniques such as immunocytochemistry and molecular testing. This revised and updated 8th Edition by Kim S. Suvarna, Christopher Layton, and John D. Bancroft is a one-stop reference for all those involved with histological preparations and applications, from student to highly advanced laboratory professional. Presents a thorough, up-to-date, and detailed approach to the theory and protocols for preparing cells and tissues for laboratory evaluation, covering topics ranging from basic to advanced Features new content on automation (computer logging and tracking, sub-sampling and archiving of samples), digital scanning techniques for slides used in remote/telepathology, and specialist molecular techniques. Provides superb visual guidance through the use of vivid color illustrations, including additional illustrations of diagnostic modalities and techniques. Contains more summary tables, charts, and boxes throughout for quick reference. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

The stifling, atmospheric, gothic crime novel with a unique protagonist and killer twist, perfect for fans of The Woman in Black, The Silent Companions, and Little Strangers **************** 1904. Thomas Bexley, one of the first forensic photographers, is called to the sleepy Welsh village of Dinas Powys. A yound girl named Betsan Tilny has been found murdered in the woodland. One night, he develops the crime scene photographs in the cellar of his lodgings. There, he finds a face dimly visible in the photographs - the shadowed spectre of Betsan Tilny. In the days that follow, Thomas senses a growing presence watching him as he tries to uncover what the villagers of Dinas Powys are so intent on keeping secret... **************** 'Gothic, claustrophobic and wonderfully dark' - GUARDIAN 'Top notch historical crime fiction, with a dash of the supernatural. A gorgeous book and a riveting tale' - DAVID YOUNG 'An intriguing debut' - THE TIMES

This is an invaluable collection of information designed to help residents, fellows, and students - as well as any already qualified medical professional interested in revising the essentials of skin conditions - to master the basics of skin pathology. Using the principle of pattern recognition, it simplifies the multitude of dermatopathologic signs by using easy-to-memorize images of what the key features look like - photomnemonics. There are also helpful sections on the technical aspects of dermatopathology and on the key findings at each level of the skin. Organized simply and abundantly illustrated, this text will be an indispensable guide to revision for all its readers.

This book is an invaluable tool for studying and reviewing key concepts in forensic pathology. Written in a question-and-answer format, this accessible guide tests readers' knowledge of manner of death, patterns of injury, lab data interpretation, postmortem radiography and imaging, and much more. Over 300 questions, more than half with visual examples, cover both common and more unusual examples of forensic pathology seen in practice. A great resource for preparing for examinations including the American Board of Pathology examination. It provides answers with explanatory rationales for both correct and incorrect answers.

This book is an invaluable tool for studying and reviewing key concepts in forensic pathology. Written in a question-and-answer format, this accessible guide tests readers' knowledge of manner of death, patterns of injury, lab data interpretation, postmortem radiography and imaging, and much more. Over 300 questions, more than half with visual examples, cover both common and more unusual examples of forensic pathology seen in practice. A great resource for preparing for examinations including the American Board of Pathology examination. It provides answers with explanatory rationales for both correct and incorrect answers.

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Genitourinary System, by Drs. Jonathan I. Epstein and George J. Netto, covers more than 175 differential diagnoses, ranging from the most common to the less frequently seen. In every chapter of this new second edition, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the authors emphasize atypical features that can complicate diagnoses. , Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused genitourinary lesions. Contains more than 1,450 color photographs that depict the features of each entity and cover all major differential diagnoses in genitourinary pathology. Features updated content throughout, including newly described entities and terminology in all organs, especially in the kidney. Presents clinical and pathological findings for each entry in a concise, bulleted format followed by relevant images-specifically organized according to the way pathologists actually work. Ideal for practicing pathologists, pathologists in training, residents, and medical students. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

An understanding of microbiology is essential for both medical students and newly qualified doctors, and is key knowledge for a working doctor. Learning Microbiology through Clinical Consultation introduces the subject with a wealth of life-like case scenarios, each linked with the relevant microbiology. Spanning 14 categories of infection, the cases within the book allow the reader to listen-in on clinical consultations with patients exhibiting an array of symptoms. Each case then describes the examination and the specimen taking techniques. The results of the samples taken in the story provide a clear link to the more technical information on microbiology which is then discussed. The structure of the book is laid out for easy navigation and has clear case-story headings to enable 'just in time learning' between patients, as well as 'just in case learning' when preparing for exams. Learning Microbiology through Clinical Consultation is a highly accessible text that describes the basic science of microbiology within the practice setting in an insightful and informative way. The material is presented in an integrated fashion and is therefore an ideal text for medical students on a systems-based or problem-based course, or for the newly qualified doctor looking to consolidate their knowledge.

Crash Course - your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated - with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today's medical students, although the range of other health students and professionals who need rapid access to the essentials of pathology will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you! Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-memoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats - confirm your understanding and improve exam technique fast

In the years since the publication of the third edition, awareness of the remarkable morphologic diversity of thyroid carcinoma has notably expanded, and great advances have been made in unravelling the molecular genetic features of thyroid and parathyroid tumours. There has also been an increased interest in the use of the fine-needle aspiration technique for the diagnosis and management of thyroid tumours, and in the role of the pathologist in the operative handling of the hyperfunctioning parathyroid gland. This volume documents the most significant advances that have taken place since the previous edition, emphasising those with a practical application at the clinical level. The format remains similar to that of the previous versions, but the two thyroid and parathyroid editions have been merged into one, and most of the black and white images and photomicrographs have been replaced with colour. The authors include a number of the most recent references, but have not ignored the classic works in the field, many of which have descriptions, illustrations, and insights that cannot be bettered. This edition fulfils the original goal of this series, which is that of helping the pathologist diagnose and anticipate the behavior of the tumours and tumour-like lesions included in this publication.

Head and neck pathology is increasingly becoming an attractive field for the new generations of pathologists, fully aware that in the era of specialization the information contained in the treatise of general surgical pathology, although extremely valuable to create the basis of their knowledge, does not provide in its full picture the specific knowledge required to meet current diagnostic and prognostic requirements. The book Pathology of the Head and Neck presents in a single volume the most pertinent and updated information needed by the interested readers. Its contents have been divided into ten chapters. The first one covers the spectrum of precursor and neoplastic lesions of the squamous epithelium. It is followed by chapters devoted to nasal cavities and paranasal sinuses, oral cavity, maxillofacial skeleton and teeth, salivary glands, nasopharynx and Waldeyers ring, larynx and hypopharynx, ear and temporal bone, neck and neck dissection, as well as eye and ocular adnexa. The authors of the different chapters have been selected among internationally recognized experts, all of them members of the Working Group on Head and Neck Pathology of the European Society of Pathology.

Davis Advantage for Pathophysiology combines an innovative text with an immersive online program that make this challenging but must-know content easier to master. An access code inside new, printed textbooks unlocks an ebook, as well as access to Davis Advantage. Or choose the all-digital Instant Access option, which includes the ebook and immediate access to Davis Advantage. THE TEXTBOOK The 2nd Edition continues to connect what students are learning in class to the real world in which they will practice... introducing them to the pathophysiologic processes of the conditions they'll encounter in clinical settings. Chapters organized by body systems help students understand the relationships between the underlying pathology and the patient assessment data, laboratory findings, and diagnostic testing results. Real-world perspectives bridge the gap between the science of disease and clinical patient care. Students clearly see "how" to interpret assessment findings and "why" to choose interventions. ONLINE (DAVIS ADVANTAGE) Using a unique and proven approach across a Learn-Apply-Assess continuum, Davis Advantage engages students and helps them make the connections to key topics. Whether teaching in-person or online, this complete, integrated solution aligns seamlessly with the textbook and equips instructors with actionable analytics to track students' progress, remediate where needed, and facilitate an active learning environment. LEARN - Personalized Learning The foundation of the Davis Advantage platform, Personalized Learning, immerses students in an online learning experience tailored to their needs. Students are assessed on their comprehension of key topics from the text, and then are guided through animated mini-lecture videos and dynamic activities to reinforce learning and bring concepts to life. APPLY - Clinical Judgment Clinical Judgment is now included in the Davis Advantage platform to elevate students' critical thinking and clinical reasoning, helping them to build the clinical judgment skills they need to practice safe and effective nursing care and to prepare for the Next Generation NCLEX (R) with confidence. Progressive case studies featuring real-life, complex clinical situations challenge students to apply knowledge, make informed decisions, and evaluate outcomes. ASSESS - Quizzing Quizzing uses NCLEX (R)-style questions for assessment and remediation. Its adaptive, question-based format provides the additional practice students need to test their knowledge, master course content, and perform well on course and board exams.

* PRE-ORDER YOUR COPY TODAY * The compelling and moving memoir of forensic psychiatrist Dr Duncan Harding

Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

My lifetime encompasses the postwar subsidence in the early 1920s of the greatest influenza pandemic in history, direct encounters with FM1 virus at Fort Mon mouth in 1947, the care of influenza patients in the 1950s, the pursuit of the in fluenza virus through the modern pandemics of 1957 and 1968, and a present in which the genes of the virus have dissembled in the DNA of vaccinia virus and Escherichia coli through the wand of "high tech. " If my corpus could be fossilized for archival and archaeological purposes, it would be found to contain immune cells branded with the imprint of the "swine" influenza virus of post-1918 and brain cells no less imprinted with memories of the abortive return of its descendant during America's bicentennial. But before that unlikely event, I wanted to try to make some sense out of this baffling dis ease and its viruses-expecting no definitive revelations but hoping for a sharper definition of problems. Hence this book. It is an audacious act in these days of specialization to essay a book such as this singlehandedly, but I have done so for selfish reasons. I wanted to reexam ine old questions about the nature of influenza and its epidemics in the light of the dazzling advances in molecular biology of the past few years. No virus has been better studied, but few diseases are less well understood."

The Association Internationale de Recherche sur la Circulation Osseuse, A.R.C.O., was founded in London in December 1989 by a small group of doctors, surgeons and researchers in basic sciences who had been involved for many years in the study of bone circulation and its disorders. They had met several times in Toulouse, during the International Symposia on Bone Circulation held there since 1973 and they wished to carry their contacts further. In founding A.R.C.O., they established as their primary aims the encouragement and furtherance of research, organisation of meetings and promotion of knowledge on the subject. At the present time, the Association has over a hundred members from more than bone tissue twenty countries in Europe, America and Asia. All have the conviction that and its pathology can only be truly known and studied if one has an understanding of its vascular system and the way its circulation functions. This concept, apparently beyond question, has not yet been adopted by all physicians and scientists who are interested in bone. From time to time, one comes across teaching programmes on bone patho logy which make no mention of bone circulation.

THE SUNDAY TIMES BESTSELLER A RADIO 4 BOOK OF THE WEEK CHOSEN AS A BOOK OF THE YEAR BY THE TELEGRAPH AND THE NEW STATESMAN "A marvellous book" Rev Richard Coles "Gripping... filled with compassion." Sunday Times "Remarkable... hopeful and uplifting." Mail on Sunday "An antidote to despair" Daily Mirror "Enthralling... vivid and humane" Observer "Exemplary" New Statesman When a plane crashes, a bomb explodes, a city floods or a pandemic begins, Lucy Easthope's phone starts to ring. Lucy is a world-leading authority on recovering from disaster. She holds governments to account, supports survivors and helps communities to rebuild. She has been at the centre of the most seismic events of the last few decades, advising on everything from the 2004 tsunami and the 7/7 bombings to the Grenfell fire and the war in Ukraine. Lucy's job is to pick up the pieces and get us ready for what comes next. Lucy takes us behind the police tape to scenes of chaos, and into government briefing rooms where confusion can reign. She also looks back at the many losses and loves of her life and career, and tells us how we can all build back after disaster. When the Dust Settles lifts us up, showing that humanity, hope and humour can - and must - be found on the darkest days.

The Italian Study Group on Cardiomyopathies organized in Florence in April 1997, eight years after the first successful meeting, the second international symposium devoted to "Advances in Cardiomyopathies". In these years exceptional progress has been made in the field of heart muscle diseases, in clinical research as well as in molecular biology, molec- ular genetics., pathophysiology and treatment. Many of these advances were presented and discussed in Florence by a distinguished team of international experts. Hypertrophic cardiomyopathy was addressed in ten papers; in the first one Seidman reported the results obtained by the use of molecular genetic tech- niques which showed that hypertrophic cardiomyopathy is a heterogeneous disorder caused by different mutations of different genes and discussed the clinical role and significance of genetic testing. Original data regarding the natural history and prognosis of symptomatic patients were obtained in the Italian multicentric study (Cecchi, Lazzeroni), while Baroldi discussed the clinico-pathologic spectrum of the disease in severely symptomatic patients treated with heart transplantation. Sudden death in the young (Basso), the identification and management of high risk patients (Elliott), the clinical importance and the problems of detec- tion of ischemia (Camici) were deeply discussed as well as the indications and results of different types of treatment: medical, surgical, DDD pacing (Spirito, Betocchi, Schoendube).