A sound background in dermatopathology is essential for the diagnosis of both inflammatory dermatoses and cutaneous tumors. This book provides an introduction to the principles of dermatopathology, aimed primarily at dermatologists and pathologists in training, but useful for a wide audience Everyone interested in dermatopathology will profit from combined knowledge of 4 experienced dermatopathologists, uniform structure approach concentrating on common diagnoses, logical presentation of clinical and histological features, large clearly labeled illustrations, clues for differential diagnostic considerations. All pictures are in color, printed on high-quality paper, clearly labeled and designed to help every reader become skilled at identifying both patterns and specific diagnostic features rapidly. A dermatopathology designed to be used, not just read - written by practitioners for daily practice.

This is the second edition of a superbly illustrated manual on neck dissection that will serve as a roadmap for advanced surgeons and beginners alike. The reader is guided through the various cervical structures in a series of chapters depicting the methods employed by surgeons operating in vivo. The illustrations provide an overview of all surgical anatomy relevant to the treatment of oncologic patients. Compared with the first edition, revisions have been made when appropriate and an important new chapter has been added on microscopic anatomy and laryngeal cancer. This chapter, which will also be of interest to pathologists, documents the microscopic anatomy of the larynx, presents patterns of spread and surgical options, and depicts the major surgical procedures on the larynx with the aid of numerous photographs and line drawings.

This book aims to provide a complete overview of the diagnosis and treatment of gastrointestinal stromal tumors (GISTs). It has been conceived to be both a detailed guide for clinical practice and an updated reference for all those involved in the evaluation of GISTs imaging. The publication provides comprehensive descriptions of the full range of common imaging and non imaging techniques used in the diagnosis and followup of GISTs. Techniques reviewed include: Conventional radiography* Endoscopy and endoscopic ultrasound* Conventional, color-Doppler and contrast-enhanced ultrasound* Computed tomography* Magnetic resonance imaging, and* Contrast-enhanced PET/CT imaging. Both medical and surgical treatment strategies are also fully reviewed. Finally, the book concludes with a chapter that aims to stimulate widespread interest in the formation of new GISTs Units. Written by experts in the field, the book is enriched throughout by numerous black-and-white and color images, making it an invaluable source of information as well as an indispensable guide to interpreting images for radiologists, gastroenterologists, pathologists, oncologists and surgeons.

This practical book provides up-to-date information on the particular features of ovarian cancer in older women and the best management approach. The full range of relevant topics is covered. Guidance is provided on geriatric assessment, screening, pathology, diagnosis, and follow-up. The various treatment options are carefully explained, covering surgical approaches, chemotherapy as a first-line strategy, the use of anti-angiogenic agents, and treatment of relapse. The cognitive problems that may arise in elderly women during and after treatment of ovarian cancer are documented, with advice on response. Guidance is also provided on the design of clinical trials, and current directions in biological research are reviewed. This book will be of value to both practitioners and researchers with an interest in ovarian cancer and the elderly.

This atlas is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology. With 186 illustrations, 154 in color, this atlas contains a wealth of important information for pathologists examining the placenta. The book is highly recommended for all those engaged in pathologic examination of the placenta. The text is concise, and the book provides a rapid reference for pathologists.

2-D and 3-D anal ultrasound are among the most recent and advanced tools available for both the diagnosis and the management of anorectal diseases. They are neither expensive nor harmful for the patients and progressively replaced anal mapping with EMG electrodes for the diagnosis of sphincter's defects and anismus, which represents nearly 50% of the cases of chronic constipation. Anal US may provide the clinician with useful information for both classification, diagnosis and management of anorectal sepsis, anal incontinence and anorectal-perineal chronic pain. Almost any case presented in this Atlas shows both imaging and clinical pictures, thus allowing both the radiologist and the clinician to assess the reliability of the exam and the outcome of the selected treatment.

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

Atlas of Conducted Electrical Weapon Wounds and Forensic Analysis provides a comprehensive publication on the subject of Conducted Electrical Weapon (CEW) wounds and signature markings created by this class of weapon. This volume will serve as a very useful resource for all professions tasked with assisting persons that have allegedly been subjected to a CEW exposure. The volume provides an introduction to basic CEW technology and the types of CEWs currently available. It also serves as a comprehensive pictorial atlas of signature markings that CEW exposures make in the immediate and more remote post-exposure periods. Also, it discusses the ability of forensic specialty examinations of the CEW itself to aid in the determination of whether the alleged CEW exposure is consistent with the objective evidence and the subjective statements. Finally, this text addresses the important and growing area of factitious CEW markings that will be useful for consideration by investigators and litigators. Atlas of Conducted Electrical Weapon Wounds and Forensic Analysis provides an objective atlas of evidence for reference that will benefit those professionals who often must make diagnostic, treatment or legal judgments on these cases including Emergency and Primary-Care Physicians, Medical Examiners, Forensic Pathologists, Coroners, Law Enforcement Investigators, and Attorneys.

This new edition differs from the preceding ones in that there has been extensive revision of most chapters. Recent advances in research gained by immunohistochemical, molecular biological, and cytogenetic methods are included, as far as they are applicable for daily diagnostic work. The chapter on neoplasms, in particular, has been greatly expanded in accordance with the new WHO International Histological Classification of genital tract tumors, covering all pertinent differential diagnostic aspects. The chapter on malignant lymphomas and hematopoetic neoplasms involving the endometrium is a new contribution to this edition (F. D. , Ulm). We have revised the chapter on gestational diseases, incorpor- ing recent advances in the differential diagnosis of gestational trophoblastic tumors. New discoveries and experiences in correlating structure and function in infertility and in h- mone replacement therapy of peri- and postmenopausal patients are also included. Many new microphotographs have been added to illustrate the advances in tumor research and in immunohistochemical detection methods. We have updated the list of references including recent relevant publications. To the correspondents and consultants who have contributed valuable observations and suggestions, bringing thereby to our attention omissions in the second edition, we acknowledge our cordial thanks. We thank Dr. Wolfram Klapper, Director of the L- phom Register of the University of Kiel, for case material for making the micropho- graphic illustrations of lymphomas. The staff of Springer-Verlag has earned our gratitude for their skill in preparing this new edition.

Digital Pathology: Historical Perspectives, Current Concepts & Future Applications provides the authoritative text in the digital pathology domain by combining the established expertise of leaders in this diverse arena with practical applications of this transformative platform while harnessing a content rich, interactive format. In detailing a cohesive narrative from a broad, global perspective the lessons learned from the past, the obstacles to digital pathology adoption that have been overcome and the challenges that remain for full realization of the potential that computational analysis affords, this text provides readers with the latest in where the field is heading as it seeks to unlock the potential of digital pathology by leveraging cutting edge technologies and innovative tools. Digital Pathology: Historical Perspectives, Current Concepts & Future Applications will be of great value to Pathologists including Translational Researchers and Informaticists, Pathology Trainees including Residents and Informatics Fellows, Healthcare CMIOs and CIOs, Bioimaging Engineers and Computer Vision Scientists, as well as Laboratory Information Technologists.

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.

Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.

The book is not intended to be an all-encompassing atlas or textbook but rather a foundation of principles in dermatopathology, highlighting key elements in the field for trainees and will also serve as a basic resource for the pathologist in general practice. In addition to the sketches and minimal text, we envision accompanying high resolution histopathologic micrographs for ultimate correlation as well.

Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.

With its focus on narrow band imaging, this book is an excellent reference for new as well as experienced practitioners in the field of endoscopy. Narrow band imaging has brought about a revolutionary improvement in diagnostic endoscopy, enabling objective diagnosis and precise detection of lesions. It has enhanced the capability of endoscopy to facilitate qualitative diagnoses for the great benefit of patients who undergo endoscopic examinations. However, a standardized system of classification has not yet been established and many clinicians and researchers are not yet highly skilled in utilizing the technique or interpreting the images that are produced. This atlas addresses those issues, providing clear, simple and easy-to-understand descriptions illustrated with generous use of endoscopic images.

A Practical Guide to Frozen Section Technique offers an easy to learn approach to frozen section technique in the form of a highly illustrated handbook intended for onsite use in the laboratory. The book begins with a novel, clearly delineated, step by step approach to learning continuous motion brush technique. Emphasis is placed on recognizing and correcting artifacts during the preparation process. The book addresses all of the steps in the preparation of slides from cutting through cover-slipping. The author's unique, original techniques for tissue embedding including face down embedding in steel well bars, frozen block cryoembedding and paper cryoembedding are detailed. Variables key to the quality of the preparation including block temperature, tissue properties and section thickness are detailed. The book also covers understanding the cryostat and basic maintenance and care.Sections covering techniques used in Mohs dermatologic surgery, and techniques used in basic animal and human research are discussed by noted experts in their field. A Practical Guide to Frozen Section Technique will be of great value to pathologists, pathology residents in training and also experimental pathology researchers that rely upon this methodology to perform tissue analysis in research.

The spleen is an organ which has diverse functions including immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the normal and pathologic conditions that afflict the spleen. This extraordinary collection of high quality digital images will materially aid in continuing efforts to recognize, understand, and accurately interpret the gross and light microscopic findings in spleens.

Surgical pathology is the cornerstone in the management of neoplastic disorders. Written for the practicing surgical pathologist in mind, Surgical Pathology of Endocrine and Neuroendocrine Tumors provides an up-to-date text on surgical pathology of endocrine and neuroendocrine tumors. The text begins with radiological imaging of tumors, followed by a section on fine needle aspiration biopsy. The main section focuses on surgical pathology of endocrine and neuroendocrine tumors. The volume closes with applications of molecular techniques and their potential for the future. Surgical Pathology of Endocrine and Neuroendocrine Tumors is written by a panel of internationally recognized pathologists who are not only experts in their fields, but who also contribute their own valuable insights making this new book an essential resource for practicing general and specialist surgical pathologists and pathologists in training.

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Fecal incontinence is a common and embarrassing condition with a devastating impact on patients' lives. Since it may result from a variety of pathophysiological situations, an accurate diagnostic work-up is crucial. A range of therapies is available, but choosing the correct option is pivotal to successful management. This book reviews the latest advances in the epidemiologic, socio-economic, psychological, diagnostic, and therapeutic aspects of fecal incontinence, helping to establish effective treatment guidelines.

This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis.

This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and procedure. It then presents four separate sections on infectious disease, oncology, pre/post-natal, and identity testing, with specific chapters clearly outlining clinical protocols used in daily practice. Modern Clinical Molecular Techniques cuts to the heart of what is essential for the practicing molecular laboratory scientist. It is an outstanding resource for those operating within or looking to set up a clinical molecular laboratory.

This new volume fills the gap in the literature as it will guide urologists and pathologists in the proper utilization of a variety of laboratory methods that are currently available to determine the presence, persistence or progression of tumors of the lower urinary tract. The volume emphasizes cytology of the urinary tract which is preferred over other methods (i.e. biochemical, immunological and cytogenetic) for its accuracy, especially for the important high grade tumors. This volume will appeal to urologists as well as pathologists, cytopathologists and related professions. The illustrations, nearly all in color, stress the key points of the text and enhance basic understanding of urothelial and other tumors of the urinary tract.

Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology. Richly illustrated with color photomicrographs, useful diagrams and line drawings, each chapter includes differential diagnosis of common and uncommon lesions as well as material on molecular developments, with emphasis on the molecular findings that are most helpful in the diagnosis of specific disorders. Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition, provides a useful and well-organized resource designed not only for the endocrine pathologist and the general surgical pathologist, but also for the clinical endocrinologist and the endocrine surgeon.