The field of forensic neuropathology covers such controversial topics as the effects of repeated brain trauma in football players and how babies probably cannot die from being shaken. Jan Leestma is one of the most respected voices in this area. A timely update to his classic reference, Forensic Neuropathology: Third Edition presents an encyclopedic exposition of neuropathological conditions that may have forensic import. Reflecting the latest research, this edition includes expanded sections on multiple trauma, one punch/one hit arterial injuries, and the physiology of respiratory control. It presents new perspectives and rules regarding expert testimony and evidence admissibility occasioned by Daubert and related Supreme Court cases. The book explores how these rulings affect forensic pathologists, neuropathologists, and other potential experts as well as how they interact with the legal system. Several chapters examine the mechanisms and pathophysiology of neuropathological conditions and discuss the biomechanical basis for neurological injury. Where possible, aging and dating methodology is included for various processes. More than 325 updated full-color illustrations complement the text along with diagrams, tables, and figures that illustrate the textual material and can be useful as exhibits in court. An extensive bibliography provides background information and facilitates further research.

This practical book takes the challenge of the dermatopathology sign-out and walks the reader through a diagnostic approach, explaining how to distinguish between benign and malignant lesions and identifying histopathologic features unique to each entity. Through discussion of some 150-200 lineage-unrelated cutaneous neoplastic disorders (primary and secondary), the reader will become familiar with common and sometimes uncommon but clinically relevant conditions. Each chapter adopts a consistent style for quick and easy reading, covering typical microscopic features, clinical vignettes, histological variations, diagnostic pitfalls and differentials, and key diagnostic pearls. Chapters also explain general pathological principles, laboratory processing of specimens and medico-legal aspects of neoplastic dermatopathology. Each copy of the book is packaged with a password, providing online access to all text and images. Written by leading pathologists and educators, this is an essential resource for trainees and more experienced pathologists tackling the daily sign-out as well as board exams in dermatopathology.

Part of the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Liver, 4th Edition, provides practical, highly illustrated information on the diagnosis and prognosis of the full range of biopsies of the liver. Practical, well-organized, and highly readable, this fully revised volume by Dr. Michael S. Torbenson addresses both common and unusual issues that arise in the day-to-day interpretation of liver biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Frames each diagnosis in its most common clinical context, explaining how the pathology can be used to make key clinical management decisions. Presents key differential features of tumors, organized according to diagnostic category Features high-quality photomicrographs and illustrations throughout, including updated images both in print (over 700) and online-more than 900 images in all. Includes two new chapters on Radiology Report Interpretation and Cytogenetics and Genomics. Provides access to more than 100 questions and answers online for self-assessment and review. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

This book aims to offer a comprehensive and up-to-date overview of male stress urinary incontinence that will serve as a useful tool and reference for urologists, andrologists, physiotherapists, general practitioners, and nurses. Detailed information is provided on diagnostic workup, including clinical assessment and the role of urodynamic evaluations and other instrumental examinations, and on the full range of potential treatments, from conservative and pharmacological interventions to surgical options. In addition to careful descriptions of the surgical procedures themselves, clear advice is given on the management of iatrogenic complications of incontinence surgery. Helpful treatment algorithms and recommendations offer further practical support. Relevant background knowledge is provided in expert reviews of topics such as the functional anatomy of the male pelvis and the pathophysiology, epidemiology, and classification of male urinary incontinence.

The optimal use of magnetic resonance imaging poses a constant challenge as the technology is continually and rapidly advancing. This leaves the MR practitioner, beginner or experienced, in constant need of up-to-date, easily read and well illustrated material presenting the clinical constellation of pathologies as seen by an MRI scanner in such an effective way. MRI of the Whole Body sets out to educate trainee and experienced radiologists, radiographers and clinicians regarding key sequences for optimal imaging of common pathologies, with simple explanations on the choice of a particular MR sequence. The authors present typical and representative examples with relevant clinical and imaging features to assist a better understanding of these commonly encountered conditions. Every unit begins with a quick anatomy review, and each case is described in a standardised format with a clinical background, key sequences, imaging features, and practical hints as to close differentials and ways to distinguish between them. A text of this nature is essential for all MR practitioners whatever their background: medical, technical or scientific. Key features: First of its kind as no other book covers all body systems in one volume with demonstration of all key imaging sequences in the commonly diagnosed pathologies Up-to-date sequences described with reasons for choosing a particular sequence for a particular case Simplified relevant MR anatomy preceding each unit Clear high resolution images with appropriate legends Practical hints and tips section included for each pathology - close differentials and what to do next Written in a simple, lucid format and accompanied by typical illustrations to each case MRI of the Whole Body is an essential guide to understanding the 'what's, 'why's and 'how's of applied MR. It will be of particular value to trainee and practicing radiologists, as well as MR radiographers and radiography students.

Kinder mit spezifischen Sprachentwicklungsstoerungen (SSES) erlernen haufig nicht in einer normalen Qualitat und Zeit das Lesen und Schreiben. Eine Ursache fur den gestoerten Schriftspracherwerb bei Kindern mit SSES wird in vorschulisch ungenugend entwickelten metaphonologischen Fahigkeiten vermutet. In diesem Buch wird der Frage nachgegangen, ob ein Zusammenhang zwischen geringem Wortschatzumfang, eingeschrankten metaphonologischen Fahigkeiten und gestoertem Erwerb der Schriftsprache besteht. Dazu werden aktuell vorliegende Erkenntnisse zum Wortschatzerwerb und zur Entwicklung metaphonologischer Fahigkeiten aufgezeigt. Insbesondere Zusammenhange zwischen Wortform und metaphonologischen Fahigkeiten sowie zum Schriftspracherwerb bei spezifisch sprachentwicklungsgestoerten und sprachnormalen Kindern finden Beachtung. Ferner wird eine empirische Untersuchung dargestellt, an der insgesamt 98 (Vor)Schulkinder teilnahmen. An zwei Testzeitpunkten konnten die zur Hypothesenabklarung notwendigen Daten gewonnen werden. Aus den Erkenntnissen lassen sich plassen sich padagogische Implikationen zur Pravention von Schriftspracherwerbsstoerungen sowie Forschungsdesiderate ableiten.

This book provides a comprehensive overview of the approach to retroperitoneal sarcomas, rare and challenging tumors requiring highly specialized, multidisciplinary management. Based on an updated review of the literature and drawing on the expertise of respected authors, it analyzes key topics - such as pre-operative work-up and staging, multimodal therapy, multi-organ resection, surgical complications and management of local recurrence and advanced disease - as well as several other debated issues. Presenting surgery as the cornerstone in the treatment of this disease, the book serves both as a guide for non-expert physicians wishing to understand the best management of RPS patients, including the need to refer them to specialized centers, and as a state-of-the-art overview for surgeons with interest in sarcoma surgery.

This new edition of the popular 2007 original text is completely updated with full color, high quality photographs and illustrations for easy reference by dermatologists, dermatology residents, primary care and emergency medicine physicians. Presented in an easily accessible manner, this second edition discusses more than 40 diseases that could lead to serious medical consequences, including death. Organized alphabetically and focusing more heavily on dermatopathology than its predecessor, Deadly Dermatologic Diseases, Second Edition contains a single clinical photograph accompanied by three photomicrographs that detail the diagnostic features of each case. Additionally, each subsection discusses a disease prognosis with a current bibliography in a succinct, bulleted manner, making this a must-have reference for clinicians and pathologists alike.

Michael Sand gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. This book is a postdoctoral thesis on miRNAs in cutaneous malignant melanoma and non-melanoma skin cancer with a focus on the miRNA processing machinery and miRNA expression profiling. The research presented in this book was performed in the Dermatologic Surgery Section at the Department of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin.

The authors discuss useful tools and tricks of the trade in pathology practice management. In-depth chapters on coding and billing by nationally known consultant Dennis Padget will prepare you to evaluate coding and billing practices. Noted law experts Jane Pine Wood and Amelia Larsen, attorneys at McDonald Hopkins, highlight key issues in employment, insurance, and hospital contracts and provide examples of how to deal with tricky issues. Sections on human resources and group dynamics take on the vexing issues that people bring to work. Finally, the authors identify current trends and reason how these might play out. In providing a broad overview of pathology practice management, each chapter employs a didactic framework, including one or more scenarios to illustrate challenges encountered by the writers. This case-based approach facilitates interactive learning and will thus be particularly useful to pathology training programs. Whatever your stage in the field-from resident to senior pathologist, including those in leadership roles-Pathology Practice Management: A Case-Based Guide is essential reading.

This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers. CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive "liquid biopsy" procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development. In recent years there has been rapid growth and worldwide developments on CTCs, which span both the basic sciences and biomedical engineering fields.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

This first of two volumes provides and in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The book is organised in themed parts exploring topics such as epidemiology, risk factors, genetic biomarkers, pathological evaluation of tumors and biopsy techniques. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.

Hypertension: from basic research to clinical practice" contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.

Offering comprehensive coverage of this fast-changing field for more than 20 years, Urologic Surgical Pathology is an expert guide to all common and rare entities in the genitourinary system. The 4th Edition keeps you fully up to date with discussions of newly recognized tumors and terminologies, the latest classification schemes, current grading approaches, molecular alterations, and commonly used ancillary diagnostic techniques. With its clinical focus on day-to-day urological pathology sign-out and an emphasis on clinicopathologic and radiographic-pathologic correlations, this thoroughly revised uropathology reference is an excellent resource for diagnostic decision making. Includes expanded coverage of differential diagnosis for all tumor types encountered in urological surgical pathology practice. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants and new histologic entities. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted therapy/personalized medicine. Covers new developments in immunohistochemistry and the latest diagnostic tumor markers. Features more than 1,600 high-quality images - all in color - including gross pictures, histopathologic and cytopathologic images, special stains, other ancillaries, drawings, and illustrations. Helps you find information quickly with a consistent chapter format; an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Head and neck pathology is increasingly becoming an attractive field for the new generations of pathologists, fully aware that in the era of specialization the information contained in the treatise of general surgical pathology, although extremely valuable to create the basis of their knowledge, does not provide in its full picture the specific knowledge required to meet current diagnostic and prognostic requirements. The book Pathology of the Head and Neck presents in a single volume the most pertinent and updated information needed by the interested readers. Its contents have been divided into ten chapters. The first one covers the spectrum of precursor and neoplastic lesions of the squamous epithelium. It is followed by chapters devoted to nasal cavities and paranasal sinuses, oral cavity, maxillofacial skeleton and teeth, salivary glands, nasopharynx and Waldeyers ring, larynx and hypopharynx, ear and temporal bone, neck and neck dissection, as well as eye and ocular adnexa. The authors of the different chapters have been selected among internationally recognized experts, all of them members of the Working Group on Head and Neck Pathology of the European Society of Pathology.

This practical book provides up-to-date information on the particular features of ovarian cancer in older women and the best management approach. The full range of relevant topics is covered. Guidance is provided on geriatric assessment, screening, pathology, diagnosis, and follow-up. The various treatment options are carefully explained, covering surgical approaches, chemotherapy as a first-line strategy, the use of anti-angiogenic agents, and treatment of relapse. The cognitive problems that may arise in elderly women during and after treatment of ovarian cancer are documented, with advice on response. Guidance is also provided on the design of clinical trials, and current directions in biological research are reviewed. This book will be of value to both practitioners and researchers with an interest in ovarian cancer and the elderly.

The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts in their respective areas, gather evidence from the perspectives of epidemiology, genetics, radiology, anatomy, developmental biology, morphology, endoscopy, ultrasound and therapeutics to give the reader a full picture of recent developments regarding the sick lobe hypothesis. Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

Cardiac disorders are an exciting area of classic pathology and recently defined disease. Cardiac Pathology: A Guide to Current Practice discusses the various disorders and also provides a backdrop of developmental embryology, diagnostic imaging and current therapeutics. Cardiac Pathology: A Guide to Current Practice aims to deliver in bench-book format a comprehensive overview of cardiac pathology that is relevant to those practicing in surgical pathology and autopsy arenas. Clear illustrations of the common styles of dissection are provided along with the normal anatomy and histology. Chapters cover the approach to the autopsy heart, ischemic heart disease, myocarditis, sudden death, valvular disease, transplant pathology, cardiomyopathy, cardiac neoplasia and congenital heart disease with a clear analysis of diagnostic criteria (macroscopic, microscopic and genetic) for both common cardiac diseases and those of rare format. The text is accompanied by high-quality macroscopic and microscopic images and references to other in-depth specialty data sources. Although aimed in particular at pathologists, Cardiac Pathology: A Guide to Current Practice should also be of value to cardiologists, cardiothoracic surgeons and other professions allied to medicine.

A book such as this, correlating radiologic findings with the associated gross and microscopic pathologic findings, has never been offered to the medical community. It contains radiologic images, in a variety of formats (ultrasound, CT scan, MRI scan) correlated with gross photos and photomicrographs of a wide spectrum of pathologic entities, including their variants, occurring in the following organs or anatomic sites. This book would be of particular interest to radiologists and radiologists-in training, who naturally are very cognizant of radiologic abnormalities, but who rarely, if ever, encounter visual images of the pathologic lesions that they diagnose. It will also be of interest to pathologists and pathologists-in-training, urologists, GU radiation oncologists, and GU medical oncologists.

Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.

A Practical Guide to Frozen Section Technique offers an easy to learn approach to frozen section technique in the form of a highly illustrated handbook intended for onsite use in the laboratory. The book begins with a novel, clearly delineated, step by step approach to learning continuous motion brush technique. Emphasis is placed on recognizing and correcting artifacts during the preparation process. The book addresses all of the steps in the preparation of slides from cutting through cover-slipping. The author's unique, original techniques for tissue embedding including face down embedding in steel well bars, frozen block cryoembedding and paper cryoembedding are detailed. Variables key to the quality of the preparation including block temperature, tissue properties and section thickness are detailed. The book also covers understanding the cryostat and basic maintenance and care.Sections covering techniques used in Mohs dermatologic surgery, and techniques used in basic animal and human research are discussed by noted experts in their field. A Practical Guide to Frozen Section Technique will be of great value to pathologists, pathology residents in training and also experimental pathology researchers that rely upon this methodology to perform tissue analysis in research.

Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic 'storm', that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.