Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs. Revised and expanded from the first edition, each chapter, written by leaders in their respective field, has been updated with the latest advances that are transforming the field of endocrine pathology. Richly illustrated with color photomicrographs, useful diagrams and line drawings, each chapter includes differential diagnosis of common and uncommon lesions as well as material on molecular developments, with emphasis on the molecular findings that are most helpful in the diagnosis of specific disorders. Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition, provides a useful and well-organized resource designed not only for the endocrine pathologist and the general surgical pathologist, but also for the clinical endocrinologist and the endocrine surgeon.

Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.

Rather than an exhaustive review of all the pathologic conditions of the female breast, Breast Cancer and its Precursor Lesions focuses on the current knowledge, understanding and issues related to breast cancer and its benign lesions that are associated with an increased risk for the subsequent development of cancer. This book targets the language, diagnostic terms and critical communication that must take place between primary care physicians, breast surgeons, oncologists, and general surgical pathologists interested in the pathologist's perspective on these important diseases. The volume also reviews the current terminology and how to read or write meaningful pathology reports on these entities, the foils and nuances of the pathology and implications for management, and up to date issues in genomics and proteomics of these conditions. The text is succinct, fully informative, and written in "plain language". All chapters are presented in a uniform fashion, and supplemented by high-quality illustrations and tables. Breast Cancer and its Precursor Lesions will be of great value to pathologists as well as primary care physicians, breast surgeons, and oncologists for understanding breast pathology and its implications for management.

This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. It approaches research into the pathology and treatment of gynecologic oncology from both clinical and experimental perspectives. New insights made possible by the introduction of advanced technologies into the field are presented. This new volume will be necessary reading for clinicians and experimental researchers alike.

Fulfilling the void with a Hematopathology book that integrates clinical and experimental studies with diagnostic criteria, Neoplastic Hematopathology: Experimental and Clinical Approaches provides an overview of the discipline of hematopathology that connects the field with recent advances in immunology research and current clinical practice in the treatment of lymphomas and leukemias. Designed for both trainees and specialists in pathology and hematology-oncology, Neoplastic Hematopathology: Experimental and Clinical Approaches has separate sections on laboratory techniques, diagnostic hematopathology, treatment and stem cell transplantation. Expert chapter authors address both myeloid and lymphoid tumors, and provide much needed coverage in transplant biology. A study guide highlights key chapter points, making the text suitable for boards review in hematopathology and hematology-oncology.

Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with 'traditional' histologic approaches, and discussions of regulatory, ethical, legal, economic issues and 'newer' technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.

Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.

Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.

The neoplasms found in the female genital tract are numerous and growing more complex. Cytology and Surgical Pathology of Gynecologic Neoplasms has been written to provide a practical reference for practicing pathologists and cytopathologists in a quick and concise fashion. The primary focus of this book is on gynecological tumors, specifically common ones and their benign mimics. Emphasis is placed on morphologic recognition, resolving common diagnostic problems seen in routine practices, and discussion of current classification of gynecologic malignancies. Special references to the differential diagnosis and pitfalls of each entity are included. The role of cytology and its correlation with histology is richly illustrated and discussed. Also presented is the practical use of ancillary studies such as molecular diagnostic testing and immunohistochemistry. With a unique emphasis on the correlation between cytology and surgical pathology, Cytology and Surgical Pathology of Gynecologic Neoplasms provides a ready reference for both the practicing pathologist and pathologist in training in finding quick answers to their diagnostic challenges.

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and medical oncologists.

This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis.

Histopathologists all over the world have to report cytopathology during the course of their work and it is then that they find themselves facing diagnostic dilemmas. This practical, well-illustrated book, explicitly dedicated to this readership will serve their needs and meets their requirements in daily practice.

This is the second edition of a superbly illustrated manual on neck dissection that will serve as a roadmap for advanced surgeons and beginners alike. The reader is guided through the various cervical structures in a series of chapters depicting the methods employed by surgeons operating in vivo. The illustrations provide an overview of all surgical anatomy relevant to the treatment of oncologic patients. Compared with the first edition, revisions have been made when appropriate and an important new chapter has been added on microscopic anatomy and laryngeal cancer. This chapter, which will also be of interest to pathologists, documents the microscopic anatomy of the larynx, presents patterns of spread and surgical options, and depicts the major surgical procedures on the larynx with the aid of numerous photographs and line drawings.

This new edition differs from the preceding ones in that there has been extensive revision of most chapters. Recent advances in research gained by immunohistochemical, molecular biological, and cytogenetic methods are included, as far as they are applicable for daily diagnostic work. The chapter on neoplasms, in particular, has been greatly expanded in accordance with the new WHO International Histological Classification of genital tract tumors, covering all pertinent differential diagnostic aspects. The chapter on malignant lymphomas and hematopoetic neoplasms involving the endometrium is a new contribution to this edition (F. D. , Ulm). We have revised the chapter on gestational diseases, incorpor- ing recent advances in the differential diagnosis of gestational trophoblastic tumors. New discoveries and experiences in correlating structure and function in infertility and in h- mone replacement therapy of peri- and postmenopausal patients are also included. Many new microphotographs have been added to illustrate the advances in tumor research and in immunohistochemical detection methods. We have updated the list of references including recent relevant publications. To the correspondents and consultants who have contributed valuable observations and suggestions, bringing thereby to our attention omissions in the second edition, we acknowledge our cordial thanks. We thank Dr. Wolfram Klapper, Director of the L- phom Register of the University of Kiel, for case material for making the micropho- graphic illustrations of lymphomas. The staff of Springer-Verlag has earned our gratitude for their skill in preparing this new edition.

This is the second edition of a practice-oriented, well-illustrated manual on the microscopic grading of tumors. After an introduction on the history and basic tenets of tumor grading, subsequent chapters focus on specific organ systems. In each case, the most widely used system for grading common tumors is presented and discussed. Throughout, careful attention is paid to the principles of microscopic tumor grading, ancillary methods to improve grading, and the latest techniques used in evaluating tumors and formulating prognosis. Since the first edition, all chapters have been updated to reflect revisions in the clinical practice of pathology and to explain the role of novel immunohistochemistry and molecular biology techniques. In addition, a new chapter is devoted to the latest trends in cancer grading, and further illustrations have been included. Cancer Grading Manual is a superb resource for both diagnostic surgical pathologists and pathology residents.

Over the last decades the incidence of skin cancers is dramatically increasing world-wide. This is not only confined to the incidence of melanoma but includes also other skin cancers such as basal cell carcinomas. Based on the recent WHO classification of skin cancers, this lavishly illustrated reference book covers comprehensively the epidemiology, histology and pathology, as well as diagnostic signs and treatment options of skin cancers. Homogenously and reader-friendly structured, it links the diagnostic and genetic features of each disease in order to guide the reader to the most appropriate therapeutic strategies for the best possible treatment outcome. In order to demonstrate the world wide activities in the field, all chapters cover the variations of the individual experiences and expertise in different nations.

A sound background in dermatopathology is essential for the diagnosis of both inflammatory dermatoses and cutaneous tumors. This book provides an introduction to the principles of dermatopathology, aimed primarily at dermatologists and pathologists in training, but useful for a wide audience Everyone interested in dermatopathology will profit from combined knowledge of 4 experienced dermatopathologists, uniform structure approach concentrating on common diagnoses, logical presentation of clinical and histological features, large clearly labeled illustrations, clues for differential diagnostic considerations. All pictures are in color, printed on high-quality paper, clearly labeled and designed to help every reader become skilled at identifying both patterns and specific diagnostic features rapidly. A dermatopathology designed to be used, not just read - written by practitioners for daily practice.

Fecal incontinence is a common and embarrassing condition with a devastating impact on patients' lives. Since it may result from a variety of pathophysiological situations, an accurate diagnostic work-up is crucial. A range of therapies is available, but choosing the correct option is pivotal to successful management. This book reviews the latest advances in the epidemiologic, socio-economic, psychological, diagnostic, and therapeutic aspects of fecal incontinence, helping to establish effective treatment guidelines.

This book aims to provide a complete overview of the diagnosis and treatment of gastrointestinal stromal tumors (GISTs). It has been conceived to be both a detailed guide for clinical practice and an updated reference for all those involved in the evaluation of GISTs imaging. The publication provides comprehensive descriptions of the full range of common imaging and non imaging techniques used in the diagnosis and followup of GISTs. Techniques reviewed include: Conventional radiography* Endoscopy and endoscopic ultrasound* Conventional, color-Doppler and contrast-enhanced ultrasound* Computed tomography* Magnetic resonance imaging, and* Contrast-enhanced PET/CT imaging. Both medical and surgical treatment strategies are also fully reviewed. Finally, the book concludes with a chapter that aims to stimulate widespread interest in the formation of new GISTs Units. Written by experts in the field, the book is enriched throughout by numerous black-and-white and color images, making it an invaluable source of information as well as an indispensable guide to interpreting images for radiologists, gastroenterologists, pathologists, oncologists and surgeons.

Inflammatory Dermatopathology: A Pathologist's Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist's Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.

Atlas of Thyroid Lesions provides a broad overview of the variety of lesions in the thyroid gland and their different characteristics and features, in the unique combination of ultrasound, cytologic and histologic appearance. Nodules in the thyroid gland are quite common. Studies estimate that more than 70% of the adult population in the United States has thyroid lesions when examined by ultrasound. More than 80% of thyroid nodules are benign. Too many benign nodules are surgically resected due to insufficient diagnostics, and too many malignant tumors do not get adequate primary surgical treatment. This book demonstrates how multidisciplinary approaches can increase the quality of the complex thyroid diagnoses and thereby secure correct treatment. This atlas presents: *Comprehensive description and overview of all thyroid lesions, tumor types, nodules and neck lymph node metastases *High quality ultrasound and pathology images *Easy to find images of anticipated tumor types *Didactic tools for how to improve diagnostic accuracy in the field

Bone is a living tissue prone to develop a diverse array of inflammatory, metabolic, genetic, reactive, circulatory and neoplastic abnormalities. The Atlas of Bone Pathology describes and selectively illustrates the normal and pathologic conditions that afflict human bone, focusing heavily on tumor and tumor-like conditions of bone and their non-neoplastic mimics. Supplemented with radiographic and special study images, this extraordinary collection of high quality digital images aid continuing efforts to recognize, understand, and accurately interpret the light microscopic findings in bone specimens. Authored by nationally and internationally recognized pathologists, The Atlas of Bone Pathology is a concise and useful resource for both novice and seasoned pathologists alike.

This atlas is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology. With 186 illustrations, 154 in color, this atlas contains a wealth of important information for pathologists examining the placenta. The book is highly recommended for all those engaged in pathologic examination of the placenta. The text is concise, and the book provides a rapid reference for pathologists.

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.