Fully integrating histology, cell biology, and pathology, the 4th Edition of the award-winning Histology and Cell Biology: An Introduction to Pathology presents key concepts in an understandable, easy-to-digest manner. Authors Abraham L. Kierszenbaum, MD, PhD and Laura L. Tres MD, PhD link basic science to clinical application throughout, focusing on what you need to know for your coursework now - and how to apply that information in a clinical setting . Full-color illustrations on every page, as well as unique, student-friendly features online, help you quickly grasp the complexities of pathologic abnormalities. Get a contemporary, integrated approach to basic science and clinical knowledge, as well as histology, cell biology, and pathology with Dr. Kierszenbaum's ground-breaking text. Clearly visualize challenging concepts with the aid of vivid, full-color illustrations, diagrams, photomicrographs, and pathology photos - all fully integrated on every page of the text. Grasp key information quickly thanks to highlighted key clinical terms, clinical conditions boxes, and Essential Concepts boxes at the end of every chapter. Find clinically relevant material fast with a detailed table of contents that highlights all clinical examples in red. Understand the links between chapter concepts with new concept mapping animations online - an outstanding supplement to in-class instruction. eBook version included! For the first time, you can access the entire book online or offline across all devices with the Student Consult eBook! Build a stronger base of clinical knowledge through the integration of cell biology, histology, and pathology

Designed as an easy-to-use and comprehensive reference for practicing pathologists, Diagnostic Pathology(TM) Bone is a highly anticipated volume in the Diagnostic Pathology(TM) series offered by Amirsys(R). As readers have come to expect from Amirsys(R) reference tools, Diagnostic Pathology(TM) Bone is filled with nearly 1,000 superior medical images, including gross pathology, a wide range of pathology stains, a variety of radiology images of rare entities, and detailed medical illustrations. You'll also find a variety of quick-reference test data tables, one of the most useful hallmarks of the series. More than 75 diagnoses of various bone and cartilage tumor types are described in concise yet detailed bulleted text. This handsome volume is an essential guide to understanding bone tumor pathology and diagnosis.

Surgical pathologists play a central role in patient surveillance and treatment by surgeons, radiation oncologists, and medical oncologists. Although salivary gland tumors are uncommon overall, their histopathologic diversity and challenge command the attention of practicing surgical pathologists. Atlas of Salivary Gland Pathology focuses on the diagnostic approach to salivary gland neoplasia-one of the more challenging fields within surgical pathology-emphasizing the need to understand downstream implications with respect to patient surveillance and treatment. The presence of formidable histologic mimicry in salivary gland neoplasia is well-documented in the pathology literature and has also been observed in the consultation practice of the volume editor. This textbook is designed with the needs of practicing surgical pathologists and pathologists-in-training in mind, providing a comprehensive overview of both common and rare salivary gland neoplasms. The primary educational objectives for readers include the following: 1) distinguish benign from low-grade malignant salivary gland neoplasms, 2) effectively use histochemical, immunohistochemical, and cytogenetic studies in challenging cases, 3) understand which diagnoses merit additional surgery and/or adjuvant therapy (radiation, chemotherapy), and 4) enhance pathologist-to-clinician communication in the setting of salivary gland disease.

The Practitioner's Path in Speech-Language Pathology: The Art of School-Based Practice bridges the gap between theory and practice, evidence-based practice and practice-based evidence, and the science and artistry of speech-language pathology. This book takes a critical look at areas related to wellness, professional development, and growth that can impact the personal self along with the professional self. It examines each area through an overview of inter-disciplinary research in addition to personal narratives illustrating key principles and strategies and offers the reader a professionally balanced perspective.The first section of the book helps us understand the importance of building a foundation for our clinical path through a discussion about scientific and evidence-based principles, different types of knowledge systems, and development of wisdom. The second section of the book helps us understand the importance of supporting our foundation through an introduction to reflection, counsel and care, balance and harmony, growth and detachment. The third section of the book includes chapters that serve as pillars of practice: organizational frameworks, materials and activities, measuring progress, best practices, and the importance of community. The fourth and final section of the book highlights shared vision, clinical expertise, emotional intelligence, leadership trends, the scholarship of teaching and learning, and research dissemination.This book challenges us to consider our own perceptions about the explicit nature of professional practice, and facilitates the development of four attitudes that can have a profound impact on both clinical success and professional satisfaction: "a scientific attitude", "a therapeutic attitude", "a professional attitude", and "a leadership attitude". It contains a blend of clinical evidence and research, practitioner views, common sense, philosophical stances, and historical overviews. "The Practitioner's Path in Speech-Language Pathology" is designed for students and practitioners who are actively involved with the process of knowledge acquisition, and targets issues we encounter along our path to becoming reflective practitioners, as they relate to the excellence behind and scholarship within teaching and learning.

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Selected as a Doody's Core Title for 2022! Fully revised and up- to- date, Ioachim's Lymph Node Pathology, 5th Edition, offers valuable guidance in the diagnostic interpretation of lymph node biopsies. Continuing the tradition of excellence established by Dr. Harry L. Ioachim, Dr. L. Jeffrey Medeiros of The University of Texas MD Anderson Cancer Center offers a comprehensive, clinically useful approach to all the various nonmalignant lesions, lymphomas, other neoplasms, and metastatic tumors in lymph nodes. Discussion of each pathologic entity includes definition, clinical syndrome, histopathology, immunopathology, molecular genetic findings, and differential diagnosis. In addition, chapters have a useful checklist for each entity. "Brings together the background information, the morphologic descriptions, the recommended procedures, the supportive illustrations, and the interpretation of results necessary to make the correct diagnosis." (from the Preface to the fourth edition) Features expanded information on the methods of flow cytometry, immunohistochemistry, and molecular diagnosis. Contains more than 700 high-quality illustrations, including over 600 in full color. Includes sections on normal lymph node; diagnostic methods; lymphadenitides; lymphadenopathies; lymphomas; lymphoproliferative disorders associated with immune deficiencies; dendritic cell, histiocytic and granulocytic/monocytic neoplasms; spindle cell neoplasms of lymph nodes; vascular neoplasms of lymph nodes; and metastatic tumors in lymph nodes. Incorporates guidelines of the revised fourth edition of the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area in pathology for which currently there is only limited information about the practical aspects of deploying this technology. For example, there are no established selection criteria for choosing new scanners and a knowledge base with the key information. The authors of the various chapters have years of real-world experience in selecting and implementing WSI solutions in various aspects of pathology practice. This text also discusses practical tips and pearls to address the selection of a WSI vendor, technology details, implementing this technology and provide an overview of its everyday uses in all areas of pathology. Chapters include important information on how to integrate digital slides with laboratory information system and how to streamline the "digital workflow" with the intent of saving time, saving money, reducing errors, improving efficiency and accuracy, and ultimately benefiting patient outcomes. Whole Slide Imaging: Current Applications and Future Directions is designed to present a comprehensive and state-of the-art approach to WSI within the broad area of digital pathology. It aims to give the readers a look at WSI with a deeper lens and also envision the future of pathology imaging as it pertains to WSI and associated digital innovations.

Die Fortschritte der Neurowissenschaften in den vergangenen Jahrzehnten haben wesentlich dazu beigetragen, dass auch die Neuropathologie einen neuen Stellenwert in der Medizin erhalten hat. In diesem Band werden bei der Klassifikation der vielfaltigen krankhaften Veranderungen vor allem auch molekularbiologische Befunde neben den Methoden der Immunohistochemie und Elektronenmikroskopie berucksichtigt. In einer Synopsis von klinischen Daten, morphologischen Befunden und neuen Erkenntnissen der Molekularbiologie werden in Verbindung mit einer exakten Datenverarbeitung nicht nur die haufigsten Krankheiten analysiert, sondern auch die selteneren Krankheitsbilder abgehandelt. Auf der Basis einer umfangreichen Materialsammlung, einer informativen Bilddokumentation und einer vergleichenden Analyse des Schrifttums stellt der vorliegende Band eine Fundgrube uber die "Pathologie der peripherien Nerven" dar."

This volume explores the latest techniques used to study Mycobacterium ulcerans, and more specifically M. ulcerans disease (Buruli ulcer). The chapters in this book are organized into three parts and cover methods for the detection of M. ulcerans and the analysis of host-pathogen interaction; the quantification and characterization of mycolactone, the macrolide toxin of M. ulcerans; and drug development against M. ulcerans. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mycobacterium ulcerans: Methods and Protocols is a valuable resource that helps scientists advance their research on Buruli ulcer, which is still an under-researched field in infection biology.

This comprehensive yet practical text reviews the pathology of neoplastic and non-neoplastic conditions of the pleura and peritoneum, with a particular focus on mesothelioma. The anatomy and embryology of serous membranes are discussed, and the causes, epidemiology, and clinical and radiologic features of malignant mesothelioma are reviewed. A comprehensive review of immunostains used for diagnosing serous membrane lesions is given, current treatment options for patients are outlined. The markers of asbestos exposure and their significance are also assessed. The pathology of non-neoplastic conditions of serous membranes, from peritoneal cysts and endometriosis to deciduosis and gliomatosis peritonei are also covered, as are lymphomas and soft tissue tumors in serous membranes. This makes Practical Pathology of Serous Membranes an essential resource for effective diagnosis.

This book focuses on bladder cancer pathology, including primary bladder malignancies and other tumor varieties, with an emphasis on diagnostic pitfalls and clinical relevance. It also describes normal bladder histology, benign abnormalities with cancer mimickers, and cancer carcinogenesis, which are important subject matter for understanding bladder cancers, correct diagnosis, and differential diagnoses. Accurate diagnosis of bladder cancer plays a central role in daily pathology practice, clinical management, and prognosis. Advances in immunohistochemistry and molecular pathology have enhanced the accuracy of cancer pathology diagnoses. In addition to covering the anatomic and histologic features of bladder tumors, this book also reviews recent molecular and immunohistochemical advances in these areas. Recently updated clinical management information is also presented in this book. Written by experts in the field, Urinary Bladder Pathology serves as a useful resource for practicing pathologists, pathology trainees, and other health professionals who treat patients with bladder cancers.

This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

This volume provides a comprehensive outline of the current methods used to detect, characterize, and investigate Shiga toxin-producing E. coli (STEC) and Shiga toxins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Shiga Toxin-Producing E. coli: Methods and Protocols aims to be a valuable resource for clinicians, epidemiologists, and researchers interested in STEC pathogenesis.

This updated second edition provides a practical and succinct overview of basic neuropathology. Key concepts and basic principles are covered and discussed with particular focus on recent advances, classification, and genetics. Practical points are included to detail how to best use the neuropathology service and interpret the results of pathological tests. Neuropathology Simplified aims to aid the development of multidisciplinary teams and help clinical trainees understand recent advances in neuropathological disorders. The book is also relevant to trainee and resident neurologists, pathologists, and neurosurgeons.

Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

This updated second edition provides surgical pathologists with comprehensive knowledge of anatomic pathology in disease, salient microscopic features, and immunohistochemistry as an aid in diagnostic pathology. Highlights include: Gross and lucid descriptions of lesions in pathology (both simple and complex). Diagnostic and salient microscopic features essential in arriving at a diagnosis. Details on differential diagnosis in each lesion and the ability to differentiate one from the other in grey zone areas. The importance of immunohistochemistry as an aid in diagnosis. Synoptic reporting and the importance of a planned format in reporting with an emphasis on point-wise completion, e.g. resection margin involvement, grade and stage of tumours in reports.

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

This book utilizes a uniform approach to provide a framework for the diagnosis of mesenchymal tumors of the breast while highlighting their mimics. Emphasis is placed on a practical approach to the morphologic interpretation and useful ancillary tests while exploring the differential diagnoses in depth. Given the overall low incidence of mesenchymal lesions of the breast along with their mimics, surgical pathologists are not consistently exposed to these spindle cell lesions. Compounding this problem is the broad differential that these lesions engender, with entities ranging from reactive/reparative lesions to poorly differentiated spindle cell malignancies. Furthering the challenge, the diagnoses may be complicated by fixation issues, sampling method, small sample size, lack of clinical history and prior treatment effects. The goal of this book is to introduce readers to the spectrum of these lesions while providing a systematic approach that helps establish accurate diagnoses that in turn drive appropriate clinical follow up and treatment. Chapters cover the spectrum of benign and malignant mesenchymal tumors and their mimics that are found in the breast in an easy to read format with richly detailed images to aid in diagnoses. The text also discusses practical components to aid in establishing and evaluating the differential diagnosis. Given how morphologically and clinically diverse these lesions are, Mesenchymal Tumors of the Breast and Their Mimics provides a construct for integrating the varied components that go into establishing a diagnosis for this challenging aspect of breast pathology.

This book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on pneumonias of different bacterial aetiologies, influenza, and other viral infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infections and virus-bacterial pneumonias, as well as pathological changes in modern tuberculosis, lung granuloma, and respiratory tract inflammation in different age groups.

This book provides a current experience in the diagnostic techniques and treatment approaches available for unusual cutaneous lymphomas. It features concise case-based chapters with a particular emphasis on instances of mature T-cell and NK-cell neoplasms, mature B-cell neoplasms, immature hematopoietic malignancies, and other lymphoproliferative disorders. Clinically-oriented cases emphasize the importance of physical examination along with modern tests of laboratory diagnostics and clinico-pathological correlations. Cutaneous Lymphomas: Unusual Cases 3 presents a range of difficult and rare cases, which would be uncommon even to the specialists in this field. Therefore, it is a vital reference source for dermatologists, dermatophatologists, cutaneous oncologists, hematooncologists, pathologists, oncologists, and other medical professionals who treat these patients.