This accessible book examines poisoning in various contexts of international conflict. It explores the modern-day use of poison in warfare, terrorism, assassination, mass suicide, serial poisoning within healthcare, and as capital punishment. It examines a broad range of international cases from the Americas, Europe, Japan, India and more in relation to Situational Crime Prevention and its theoretical precursors, in order to explore potential prevention strategies and the ways in which perpetrators circumvent them. Case studies include analysis of attempts on the lives of Sergei and Yulia Skripal, the Tokyo subway attacks, the crimes of Dr. Harold Shipman and the Heaven's Gate and Jonestown cults. For each, the means, motive, opportunity, location, and perpetrator-victim relationship is examined. This accessible book speaks to students of criminology and those interested in penology, careers in criminal justice, homicide detectives, anti-terrorism personnel, forensic pathologists and toxicologists.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

Selected as a Doody's Core Title for 2022! Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Neoplastic Biopsies is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily "scope-side guide," it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report. More than 1,600 high-quality photomicrographs capture the subtle morphologic spectrum of neoplastic processes of the tubular GI tract. Each image is captioned with key diagnostic considerations and includes call-outs showing subtle features and diagnostic clues. Practical tools throughout the text include: Tables that emphasize salient clinicopathologic features, management implications, and therapeutic options o Discussions of how and when to incorporate molecular tools o Checklists for key elements of the diagnostic approach and sample notes for inclusion in pathology reports Relevant endoscopic images, photographs of select gross specimens, and medical figures Brief reviews of normal histology that provide contrast to succeeding patterns "Pearls and Pitfalls" and "Near Misses" sections with lessons from real life sign-out experience "Frequently Asked Questions" sections that discuss common diagnostic dilemmas "Sample Note" sections that offer a template of how to synthesize complicated or especially challenging topics Quizzes in every chapter that provide experience with high-yield, board-style teaching topics Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This book is prepared for patients who suffer from 'Burning mouth disease', also referred to as 'Burning mouth syndrome'. It gives a comprehensive overview of the disease, its symptoms and management. Readers will learn about the terminology and definition of 'Burning mouth disease', and its suggested causes. Attention is paid to symptoms of various diseases that may mimic those of burning mouth disease. Neurological and psychogenic aspects are well covered, as are the many reported pharmacological and non-pharmacological treatment modalities. The combined training of the author in oral surgery, oral pathology and oral medicine has provided him with exceptional expertise in both the diagnosis and the management of patients with burning mouth disease. This book is a must have for everyone who is interested in this enigmatic disease.

Selected as a Doody's Core Title for 2022! Offering a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, this updated reference now incorporates recent, groundbreaking studies and major changes in the field. Global experts provide a complete guide to all diagnoses alongside major advances in tumor staging, immunohistochemistry and molecular genetics, helping you effectively evaluate thyroid tumors and non-neoplastic diseases. Features nearly 1,200 high-quality, full-color gross photographs, microphotographs, and illustrations throughout. Includes three new chapters to keep you completely up to date: Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) Thyroid Tumor Staging (with new AJCC staging system) Principles of Cytological Examination of Thyroid Nodules (with new Bethesda 2 Reporting system) Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s ), such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Adapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

The optimal use of magnetic resonance imaging poses a constant challenge as the technology is continually and rapidly advancing. This leaves the MR practitioner, beginner or experienced, in constant need of up-to-date, easily read and well illustrated material presenting the clinical constellation of pathologies as seen by an MRI scanner in such an effective way. MRI of the Whole Body sets out to educate trainee and experienced radiologists, radiographers and clinicians regarding key sequences for optimal imaging of common pathologies, with simple explanations on the choice of a particular MR sequence. The authors present typical and representative examples with relevant clinical and imaging features to assist a better understanding of these commonly encountered conditions. Every unit begins with a quick anatomy review, and each case is described in a standardised format with a clinical background, key sequences, imaging features, and practical hints as to close differentials and ways to distinguish between them. A text of this nature is essential for all MR practitioners whatever their background: medical, technical or scientific. Key features: First of its kind as no other book covers all body systems in one volume with demonstration of all key imaging sequences in the commonly diagnosed pathologies Up-to-date sequences described with reasons for choosing a particular sequence for a particular case Simplified relevant MR anatomy preceding each unit Clear high resolution images with appropriate legends Practical hints and tips section included for each pathology - close differentials and what to do next Written in a simple, lucid format and accompanied by typical illustrations to each case MRI of the Whole Body is an essential guide to understanding the 'what's, 'why's and 'how's of applied MR. It will be of particular value to trainee and practicing radiologists, as well as MR radiographers and radiography students.

Since the 4th Series of this Fascicle was published, there have been considerable advances in our understanding of tumors within the serosal membranes, in particular the classification of mesothelial tumors and their genetics. This 5th Series Fascicle aligns with the terminology recommended by the WHO in its most recent edition for pleural and pericardial tumors, with expansion to reflect serosal membranes at other sites and including recognition of mesothelioma in situ.

This book provides a comprehensive overview of the approach to retroperitoneal sarcomas, rare and challenging tumors requiring highly specialized, multidisciplinary management. Based on an updated review of the literature and drawing on the expertise of respected authors, it analyzes key topics - such as pre-operative work-up and staging, multimodal therapy, multi-organ resection, surgical complications and management of local recurrence and advanced disease - as well as several other debated issues. Presenting surgery as the cornerstone in the treatment of this disease, the book serves both as a guide for non-expert physicians wishing to understand the best management of RPS patients, including the need to refer them to specialized centers, and as a state-of-the-art overview for surgeons with interest in sarcoma surgery.

As in the second edition, the third edition of Handbook of Practical Immunohistochemistry - Frequently Asked Questions is written in a question and answer (Q&A) format and intended to be a practical, user-friendly, quick reference for information related to using the most up-to-date immunohistochemistry and in situ hybridization in clinical diagnosis. The new edition demonstrates a significant revision and improvement over the second edition. Five new chapters have been added that cover the following: 1) Immunohistochemistry: Leica's perspective; 2) Immunohistochemistry: Maixin perspective; 3) RNA in situ hybridization: Applications in anatomic pathology; 4) Applications of rapid immunohistochemistry on frozen tissue sections during intraoperative pathologic diagnosis; and 5) Cutaneous lymphomas. In addition to extensive additions and changes, over 150 new questions and answers were added throughout this new edition. All chapters have been updated to include relevant new questions, new markers, more refined IHC panels, representative pictures, and current references. An extensive set of high-quality color pictures and diagnostic algorithms, if available, is included in each chapter to illustrate some of the key antibodies, including many recently discovered and substantiated antibodies used in that chapter. Written by experts in the field, Handbook of Practical Immunohistochemistry Third Edition is a comprehensive and practical guide for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Comprehensive and practical, Mills and Sternberg's Diagnostic Surgical Pathology, 7th Edition, presents advanced diagnostic techniques for differential diagnosis of the surgical specimen and the latest information on all currently known diseases. Led by Drs. Teri A. Longacre, Joel K. Greenson, Jason, L. Hornick, and Victor E. Reuter, a virtual "who's who" of experts in the field provide authoritative guidance on the diagnostic evaluation of every type of specimen from every anatomic site. Visually stunning and thoroughly up to date, this classic two-volume reference is a must-have resource no matter what your level of training or expertise. Covers virtually all diseases seen by surgical pathologists, grouped anatomically and focused on differential diagnosis for each type of specimen. Emphasizes practical, real-world guidance that mimics a personal consultation with expert colleagues, offering the authors' personal approaches to biopsy evaluation throughout. Includes significant updates in key areas of the field, particularly in immunohistochemistry and molecular pathology. Features more than 4,500 full-color illustrations, each color-balanced to dramatically improve image quality. Incorporates updated World Health Organization (WHO) terminology regarding tumor diagnosis. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

Bei diesem Buch handelt es sich um eine Zusammenstellung zahlreicher Artikelund Beitr{ge, die 1989 in diversen neurologischen Fachzeitschriften und B}chern zum Thema "Hydrozephalus" erschienen sind.

The authors discuss useful tools and tricks of the trade in pathology practice management. In-depth chapters on coding and billing by nationally known consultant Dennis Padget will prepare you to evaluate coding and billing practices. Noted law experts Jane Pine Wood and Amelia Larsen, attorneys at McDonald Hopkins, highlight key issues in employment, insurance, and hospital contracts and provide examples of how to deal with tricky issues. Sections on human resources and group dynamics take on the vexing issues that people bring to work. Finally, the authors identify current trends and reason how these might play out. In providing a broad overview of pathology practice management, each chapter employs a didactic framework, including one or more scenarios to illustrate challenges encountered by the writers. This case-based approach facilitates interactive learning and will thus be particularly useful to pathology training programs. Whatever your stage in the field-from resident to senior pathologist, including those in leadership roles-Pathology Practice Management: A Case-Based Guide is essential reading.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

This second edition expands upon the previous volume with additional emphasis on recent innovation in basic renal research and has a more holistic approach on associated disorders such as complications associated with peritoneal dialysis, ischemic acute kidney injury, the sympathetic nervous system, and vascular calcification. The book is divided into five parts: Part I provides a number of in vitro, in vivo, and ex vivo models of kidney disease and associated complications; Part II looks at recent advances in imaging techniques; Part III covers recent developments in studying metabolism in renal ischemia and reperfusion; Part IV addresses study and measurement of vascular calcification; and Part V explores analytical techniques that are both topical and of widespread relevance to the study of experimental renal disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Research: Experimental Protocols, Second Edition is a valuable collection of protocols useful to new and experienced researchers who are interested in the field of Nephrology.

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

This first of two volumes provides and in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The book is organised in themed parts exploring topics such as epidemiology, risk factors, genetic biomarkers, pathological evaluation of tumors and biopsy techniques. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.

In 1910, Karl Jaspers wrote a seminal essay on morbid jealousy in which he laid the foundation for the psychopathological phenomenology that through his work and the work of Hans Gruhle and Kurt Schneider, among others, would become the hallmark of the Heidelberg school of psychiatry. In "General Psychopathology," his most important contribution to the Heidelberg school, Jaspers critiques the scientific aspirations of psychotherapy, arguing that in the realm of the human, the explanation of behavior through the observation of regularity and patterns in it ( "Erklarende Psychologie") must be supplemented by an understanding of the "meaning-relations" experienced by human beings ( "Verstehende Psychologie").

Early diagnosis of parasitic diseases, especially of the opportunistic infections, is gaining importance daily and pathologists now have the chance to make rapid diagnoses of these disorders by examining tissues and body fluids. Though parasitic infections and infestations occur mainly in subtropical and tropical areas, they are increasingly imported into other areas, where the pathologist must be able to recognize them. This new full-colour atlas, containing over 500 photographs, many diagrams and tables, with extensive references and index, concentrates on histology, differential diagnosis and on the structure of parasitic elements such as eggs, larvae and adult worms, in and outside tissues. The atlas will be invaluable as a bench manual for the practising pathologists to keep by the microscope, as well as for physicians, surgeons, dermatologists and pathologists in training, and all those who are concerned with parasitic infections.

Hypertension: from basic research to clinical practice" contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

This new edition of the popular 2007 original text is completely updated with full color, high quality photographs and illustrations for easy reference by dermatologists, dermatology residents, primary care and emergency medicine physicians. Presented in an easily accessible manner, this second edition discusses more than 40 diseases that could lead to serious medical consequences, including death. Organized alphabetically and focusing more heavily on dermatopathology than its predecessor, Deadly Dermatologic Diseases, Second Edition contains a single clinical photograph accompanied by three photomicrographs that detail the diagnostic features of each case. Additionally, each subsection discusses a disease prognosis with a current bibliography in a succinct, bulleted manner, making this a must-have reference for clinicians and pathologists alike.