This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

This book provides a practical guide to the diagnosis of cervical lesions. Chapters detail recent changes to diagnostic criteria and classification and the impacts these developments have on patient management. The anatomy and histology of the cervix are discussed, along with macroscopic and microscopic changes, prognostic and predictive parameters, epidemiological data, and staging systems. Atlas of Diagnostic Pathology of the Cervix: A Case-Based Approach utilizes diagnostic algorithms and highlights to offer readers appropriate management criteria and aims to give trainees, practicing pathologists, and gynecologists a case-based approach to the treatment of cervical lesions.

Part of the comprehensive Biopsy Interpretation Series, the second edition of Biopsy Interpretation of the Uterine Cervix and Corpus provides an easy-to-follow, practical approach to normal histology, non-neoplastic conditions, and neoplasia of the cervix and uterine body. Focusing on the most common biopsies, this up-to-date bench reference emphasizes morphologic features and immunohistochemistry in the diagnostic material, with close attention paid to differential diagnosis, including benign mimics of tumors.Key Features Stay up to date with what's new in gynecologic pathology with an all-new chapter on metastatic tumors, plus updated references and terminology throughout. Focus on differential diagnosis and frequently encountered pitfalls of the most common entities observed in the cervix, endometrium, and myometrium. Clearly visualize the specimens you're likely to see with hundreds of high-quality images, both in the text and online. Get up-to-date guidance on ancillary tests such as in situ hybridization for HPV and molecular studies for microsatellite instability assessment and molar pregnancy. Test your knowledge online with over 50 questions ideal for self-assessment. Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to: 50 questions for review and self-assessment, plus over 1,000 additional full-color images available only online. Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

This book provides a thorough overview of the radiologic and pathologic findings of neoplastic diseases of the biliary tract, a sound knowledge of which is essential for appropriate patient management. A key feature is the correlation of imaging findings with both gross pathologic and histopathologic findings for each disease. This is of the utmost importance in understanding true pathologic abnormalities, bearing in mind, for example, the difficulty in ascertaining disease spread and extent on the basis of pathology alone. Since the first edition of the book, conceptual understanding of neoplastic disease of the bile ducts and cholangiocarcinogenesis has evolved significantly, and in the new edition the classification of diseases is based on the most recent edition of the WHO Classification of Tumors of the Digestive System. In addition, some newly recognized pathologies are covered. The book will enhance understanding of the pathology of neoplastic diseases of the biliary tract and aid imaging interpretation. It will be a great asset for pathologists, radiologists, biliary surgeons, and gastroenterologists.

This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs

This book combines the reference material of a nephrology textbook with the everyday relevance of a clinical handbook. This second edition develops and expands upon the success of the first. All the content has been updated and entirely new chapters on acid-base disorders and stone disease have been added. Understanding Kidney Diseases includes over 60 real-life case studies and is illustrated with over 200 figures. Readers can test their knowledge with a bank of multiple-choice questions and put it into practice by answering questions that patients frequently ask. The book provides all that students, residents and fellows need in order to approach a patient with a kidney problem with confidence.

This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the characteristics of different lesions that are useful for the practical solution of a particular differential diagnosis. Chapters include description of the cytomorphology followed by a practical ICC staining pattern for each entity. Cytologic materials include serous effusions, exfoliative cytology, fine needle aspiration cytology of superficial and deep-seated masses, and squash preparation from central nervous system masses. Practical Immunocytochemistry in Diagnostic Cytology serves as a valuable resource towards understanding critical differences between tests performed on tissue samples and those carried out on cytologic samples.

This practical book takes the challenge of the dermatopathology sign-out and walks the reader through a diagnostic approach, explaining how to distinguish between benign and malignant lesions and identifying histopathologic features unique to each entity. Through discussion of some 150-200 lineage-unrelated cutaneous neoplastic disorders (primary and secondary), the reader will become familiar with common and sometimes uncommon but clinically relevant conditions. Each chapter adopts a consistent style for quick and easy reading, covering typical microscopic features, clinical vignettes, histological variations, diagnostic pitfalls and differentials, and key diagnostic pearls. Chapters also explain general pathological principles, laboratory processing of specimens and medico-legal aspects of neoplastic dermatopathology. Each copy of the book is packaged with a password, providing online access to all text and images. Written by leading pathologists and educators, this is an essential resource for trainees and more experienced pathologists tackling the daily sign-out as well as board exams in dermatopathology.

A NEW EYE-OPENING ILLUSTRATED EDITION OF MEERA SENTHILINGAM'S TIMELY GUIDE For decades scientists have been warning of a global pandemic, and the Covid-19 coronavirus outbreak has realised their worst fears. Covid-19 and monkeypox make Outbreaks & Pandemics an essential guide to the future. It narrates a disquieting journey through the history, science, and politics of humankind's ongoing war against contagion; investigates modern responses; and assesses the chances of eradicating disease in the future. it also reveals how globalisation, mobile populations, climate change, vaccine hesitancy, and drug-resistant pathogens have combined to create the perfect conditions for pandemics to spread. This updated and illustrated edition is essential reading, combining extensive research with illuminating photographs and infographics to chart the pattern of outbreaks and reveal the microscopic world at their heart.

Dr Taylor's book analyses the disease concept as it developed in medical history and seeks to clarify it with the help of concepts largely derived from logical class theories. A solution is proposed to the problem of how to distinguish between the class of 'patients' and the class of 'healthy persons' which corresponds to the actual diagnostic practices of doctors. The earliest theories of disease postulated concrete entities which exist independently of the body. The notion of disease entity has lost its original ontological connotations and instead its important feature has become the possession of a unitary and self-contained character. Dr Taylor describes the modern theories as essentially 'reactive' in character, that is the symptoms of a disease are the bodily reactions to the 'noxae'. After seeing the subject in its historical content, Dr Taylor goes on to discuss in detail the notion of the classification of diseases, making extensive use of modern views on the logic of classes.

Since the 4th Series of this Fascicle was published, there have been considerable advances in our understanding of tumors within the serosal membranes, in particular the classification of mesothelial tumors and their genetics. This 5th Series Fascicle aligns with the terminology recommended by the WHO in its most recent edition for pleural and pericardial tumors, with expansion to reflect serosal membranes at other sites and including recognition of mesothelioma in situ.

Essential Pathophysiology for Nursing and Healthcare Students is the perfect quick reference and study guide for students covering pathophysiology, disease and therapeutics as part of a nursing or other healthcare course. It clearly and simply explains the underpinning processes of disease, covering cellular physiology, genetics, fluids, electrolytes and the immune system, and the main diseases and conditions that can occur within each.Each chapter is written in a quick reference format so it can be used for study, exam preparation or use on student placement. The book covers body systems including: CardiovascularRespiratoryImmuneLymphaticNervousDigestiveEndocrineReproductive Developed with the reader in mind, each chapter includes clinical tips, case studies, diagrams, and self-assessment questions to make pathophysiology accessible and digestible - this is a must-have book for students of nursing and healthcare."Essential Pathophysiology for Nursing and Healthcare Students is a book that should be kept no further than an arm's reach away. The book is easy to navigate and easy to understand. Nursing and healthcare students will find that this book is essential in helping them comprehend and learn about the systems and mechanisms of the human body in health and ill health. This book would also be a good read for anybody working with or teaching students as a refresher on pathophysiology." Rebecca Bailey-McHale, Lecturer, Faculty of Health and Social Care, University of Chester, UK "This detailed but accessible book covers this subject in sufficient depth to give a good understanding of the topic without becoming overwhelming. As well as giving the evidence behind the text, this is a good resource if more in-depth reading is required. The authors have succeeded in writing a quick reference book that is remarkably in-depth and easy to read. This book would be suitable for any healthcare student who needs an understanding of the concept of pathophysiology however it would also be relevant for those seeking a general overview of the subject or more senior staff who wish to consolidate or refresh their knowledge." Rebecca Myatt, Guy's and St Thomas' NHS Foundation Trust, UK

The field of forensic neuropathology covers such controversial topics as the effects of repeated brain trauma in football players and how babies probably cannot die from being shaken. Jan Leestma is one of the most respected voices in this area. A timely update to his classic reference, Forensic Neuropathology: Third Edition presents an encyclopedic exposition of neuropathological conditions that may have forensic import. Reflecting the latest research, this edition includes expanded sections on multiple trauma, one punch/one hit arterial injuries, and the physiology of respiratory control. It presents new perspectives and rules regarding expert testimony and evidence admissibility occasioned by Daubert and related Supreme Court cases. The book explores how these rulings affect forensic pathologists, neuropathologists, and other potential experts as well as how they interact with the legal system. Several chapters examine the mechanisms and pathophysiology of neuropathological conditions and discuss the biomechanical basis for neurological injury. Where possible, aging and dating methodology is included for various processes. More than 325 updated full-color illustrations complement the text along with diagrams, tables, and figures that illustrate the textual material and can be useful as exhibits in court. An extensive bibliography provides background information and facilitates further research.

New in the Differential Diagnosis in Surgical Pathology series, this abundantly illustrated title helps you systematically solve tough diagnostic challenges in pancreatic and biliary pathology. It uses select images of clinical and pathological findings, together with succinct, expert instructions and diagnostic pearls, to guide you through the decision-making process. By presenting material according to the way pathologists actually work, this user-friendly volume helps you quickly differentiate commonly confused entities that have overlapping morphologic features. Presents nearly 100 differential diagnoses in pancreatic and biliary pathology, including the most common entities as well as selected rare diseases. Provides concise, bulleted summaries of clinical and pathological findings and relevant pictorial examples on the corresponding pages. Features 1,000 high-quality, full-color images of similar-looking lesions side by side for easy comparison with respect to clinicopathologic features and ancillary tests. Includes more than 30 detailed chapters on the pancreas, as well as coverage of the ampulla, extrahepatic bile duct, and gallbladder. Ideal for practicing pathologists, pathologists in training, residents, and medical students. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This book concisely summarises non-neoplastic gastrointestinal (GI) pathology and provides histopathologists aiming to refresh or expand their knowledge with a practical approach to the interpretation of biopsies. It focuses on GI biopsies, but also covers the pathology of resections and other organs where appropriate. The editor and contributors bring their expertise as practicing diagnostic pathologists across Europe and the US. Examples of topics include inflammatory bowel disease, infections, vascular disorders, and inflammatory conditions specific to various anatomical sites. Fact sheets, practice points and tables facilitate rapid assimilation of information and enhance the reader's experience, and with additional access to the full online version, including expandable images on Cambridge Core; achieve accuracy every time. High-quality illustrations are also numerous, and references are relevant and reliable. This book is a practical, readable and up-to-date asset for any pathologist encountering GI biopsies.

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

THE SUNDAY TIMES BESTSELLER A RADIO 4 BOOK OF THE WEEK CHOSEN AS A BOOK OF THE YEAR BY THE TELEGRAPH AND THE NEW STATESMAN "A marvellous book" Rev Richard Coles "Gripping... filled with compassion." Sunday Times "Remarkable... hopeful and uplifting." Mail on Sunday "An antidote to despair" Daily Mirror "Enthralling... vivid and humane" Observer "Exemplary" New Statesman When a plane crashes, a bomb explodes, a city floods or a pandemic begins, Lucy Easthope's phone starts to ring. Lucy is a world-leading authority on recovering from disaster. She holds governments to account, supports survivors and helps communities to rebuild. She has been at the centre of the most seismic events of the last few decades, advising on everything from the 2004 tsunami and the 7/7 bombings to the Grenfell fire and the war in Ukraine. Lucy's job is to pick up the pieces and get us ready for what comes next. Lucy takes us behind the police tape to scenes of chaos, and into government briefing rooms where confusion can reign. She also looks back at the many losses and loves of her life and career, and tells us how we can all build back after disaster. When the Dust Settles lifts us up, showing that humanity, hope and humour can - and must - be found on the darkest days.

This book aims to offer a comprehensive and up-to-date overview of male stress urinary incontinence that will serve as a useful tool and reference for urologists, andrologists, physiotherapists, general practitioners, and nurses. Detailed information is provided on diagnostic workup, including clinical assessment and the role of urodynamic evaluations and other instrumental examinations, and on the full range of potential treatments, from conservative and pharmacological interventions to surgical options. In addition to careful descriptions of the surgical procedures themselves, clear advice is given on the management of iatrogenic complications of incontinence surgery. Helpful treatment algorithms and recommendations offer further practical support. Relevant background knowledge is provided in expert reviews of topics such as the functional anatomy of the male pelvis and the pathophysiology, epidemiology, and classification of male urinary incontinence.

The authors discuss useful tools and tricks of the trade in pathology practice management. In-depth chapters on coding and billing by nationally known consultant Dennis Padget will prepare you to evaluate coding and billing practices. Noted law experts Jane Pine Wood and Amelia Larsen, attorneys at McDonald Hopkins, highlight key issues in employment, insurance, and hospital contracts and provide examples of how to deal with tricky issues. Sections on human resources and group dynamics take on the vexing issues that people bring to work. Finally, the authors identify current trends and reason how these might play out. In providing a broad overview of pathology practice management, each chapter employs a didactic framework, including one or more scenarios to illustrate challenges encountered by the writers. This case-based approach facilitates interactive learning and will thus be particularly useful to pathology training programs. Whatever your stage in the field-from resident to senior pathologist, including those in leadership roles-Pathology Practice Management: A Case-Based Guide is essential reading.

The optimal use of magnetic resonance imaging poses a constant challenge as the technology is continually and rapidly advancing. This leaves the MR practitioner, beginner or experienced, in constant need of up-to-date, easily read and well illustrated material presenting the clinical constellation of pathologies as seen by an MRI scanner in such an effective way. MRI of the Whole Body sets out to educate trainee and experienced radiologists, radiographers and clinicians regarding key sequences for optimal imaging of common pathologies, with simple explanations on the choice of a particular MR sequence. The authors present typical and representative examples with relevant clinical and imaging features to assist a better understanding of these commonly encountered conditions. Every unit begins with a quick anatomy review, and each case is described in a standardised format with a clinical background, key sequences, imaging features, and practical hints as to close differentials and ways to distinguish between them. A text of this nature is essential for all MR practitioners whatever their background: medical, technical or scientific. Key features: First of its kind as no other book covers all body systems in one volume with demonstration of all key imaging sequences in the commonly diagnosed pathologies Up-to-date sequences described with reasons for choosing a particular sequence for a particular case Simplified relevant MR anatomy preceding each unit Clear high resolution images with appropriate legends Practical hints and tips section included for each pathology - close differentials and what to do next Written in a simple, lucid format and accompanied by typical illustrations to each case MRI of the Whole Body is an essential guide to understanding the 'what's, 'why's and 'how's of applied MR. It will be of particular value to trainee and practicing radiologists, as well as MR radiographers and radiography students.

This first of two volumes provides and in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The book is organised in themed parts exploring topics such as epidemiology, risk factors, genetic biomarkers, pathological evaluation of tumors and biopsy techniques. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.

The placenta is an organ often neglected by surgical pathologists and clinicians alike. Placental diagnoses provide risk assessment for infant prognosis, recurrent risk for future pregnancies, and explanatory findings. There is widespread interest in placental diagnosis for the antenatal determinants of adult disease, inborn errors of metabolism, specific infections, malignancies, and assessing placental function in real time with the ultimate goal of affecting treatment. Due to the difficulties inherent in studying human gestation and gestational pathologies, much of what is known about the relevance of placental pathology is biased toward personal experience and retrospective studies. However, this book presents evidence-based information to the reader. The authors emphasize the need for an educated and directed sampling of the placenta through gross examination which will result in a better and more useful final diagnosis.

This new edition of the popular 2007 original text is completely updated with full color, high quality photographs and illustrations for easy reference by dermatologists, dermatology residents, primary care and emergency medicine physicians. Presented in an easily accessible manner, this second edition discusses more than 40 diseases that could lead to serious medical consequences, including death. Organized alphabetically and focusing more heavily on dermatopathology than its predecessor, Deadly Dermatologic Diseases, Second Edition contains a single clinical photograph accompanied by three photomicrographs that detail the diagnostic features of each case. Additionally, each subsection discusses a disease prognosis with a current bibliography in a succinct, bulleted manner, making this a must-have reference for clinicians and pathologists alike.