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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Acute Phase Proteins in the Acute Phase Response (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R2,864
Discovery Miles 28 640
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Acute Phase Proteins in the Acute Phase Response (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Argenteuil Symposia
Expected to ship within 10 - 15 working days
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The discovery of C-reactive protein in the laboratory of O. T.
Avery at Rockefeller University in 1929-30 was the first specific
obser- vation of the acute phase plasma protein response (Tillett
and Francis 1930). This was one of three contributions of
fundamental importance which emerged from that laboratory, the
other two being the recognition that polysaccharides could act as
antigens and that DNA transmits genetic information. In the course
of charac- terization of pneumococcal carbohydrate antigens, a
somatic poly- saccharide common to all Rand S forms of pneumococci
was identified and designated Fraction "C" (Tillet et al. 1930).
Testing of sera from patients with pneumococcal infection revealed
the presence of material which precipitated with the
C-polysaccharide but which differed from antibody in that calcium
was required for the reaction. Furthermore, the amount of reactive
material was greatest when patients were acutely ill and decreased
in the convalescent phase, the precise opposite of specific
anti-pneumo- coccal antibodies. Subsequently, the C-reactive
material was shown to be a protein and to be present in the sera of
individuals who were acutely ill with other, non-pneumococcal
infections and tissue damaging conditions, hence Avery coined the
term "acute phase" and called the protein "acute phase protein"
(Abernethy and Avery 1941; MacLeod and Avery 1941). At that time
methods were too insensitive to detect C-reative protein (CRP) in
sera of healthy subjects and it was considered to be a pathological
product.
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